Timothy P. Endy

A comparative study of leptospirosis and dengue in thai children (2007)

Libraty, Daniel H., Myint, Khin S. A., Murray, Clinton K., Gibbons, Robert V., Mammen, Mammen P., Endy, Timothy P., ...

BACKGROUND: Leptospirosis is an emerging zoonosis that is often under-recognized in children and commonly confused with dengue in tropical settings. An enhanced ability to distinguish leptospirosis...

Virus-induced decline in soluble vascular endothelial growth receptor 2 is associated with plasma leakage in dengue hemorrhagic Fever (2006)

Srikiatkhachorn, Anon, Ajariyakhajorn, Chuanpis, Endy, Timothy P., Kalayanarooj, Siripen, Libraty, Daniel H., Green, Sharone, ...

Some individuals infected with dengue virus develop dengue hemorrhagic fever (DHF), a viral hemorrhagic disease characterized by a transient period of localized plasma leakage. To determine the...

Cynomolgus Macaque as an Animal Model for Severe Acute Respiratory Syndrome (2006)

James V. Lawler, Timothy P. Endy, Lisa E. Hensley, Aura Garrison, Elizabeth A. Fritz, May Lesar, ...

Jason Paragas and colleagues report the first findings of measurable clinical disease in nonhuman primates infected with the virus that causes SARS, SARS-CoV.

Cynomolgus Macaque as an Animal Model for Severe Acute Respiratory Syndrome (2006)

James V. Lawler, Timothy P. Endy, Lisa E. Hensley, Aura Garrison, Elizabeth A. Fritz, May Lesar, ...

BackgroundThe emergence of severe acute respiratory syndrome (SARS) in 2002 and 2003 affected global health and caused major economic disruption. Adequate animal models are required to study the...

Cynomolgus Macaque as an Animal Model for Severe Acute Respiratory Syndrome (2006)

Lawler, James V., Endy, Timothy P., Hensley, Lisa E., Garrison, Aura, Fritz, Elizabeth A., Lesar, May, ...

The emergence of severe acute respiratory syndrome (SARS) in 2002 - 2003 had a tremendous global impact. Adequate animal models are required to study the underlying pathogenesis of SARS-associated...

High Circulating Levels of the Dengue Virus Nonstructural Protein NS1 Early in Dengue Illness Correlate with the Development of Dengue Hemorrhagic Fever (2002)

Daniel H. Libraty, Paul R. Young, Darren Pickering, Timothy P. Endy, Siripen Kalayanarooj, Sharone Green, ...

This paper builds clinical experience onto our earlier development and publication (Young et al, Journal of Clinical Microbiology, 2000) of an antigen capture assay for dengue diagnosis. The assay...

High Circulating Levels of the Dengue Virus Nonstructural Protein NS1 Early in Dengue Illness Correlate with the Development of Dengue Hemorrhagic Fever (2002)

Daniel H. Libraty, Paul R. Young, Darren Pickering, Timothy P. Endy, Siripen Kalayanarooj, Sharone Green, ...

This paper builds clinical experience onto our earlier development and publication (Young et al, Journal of Clinical Microbiology, 2000) of an antigen capture assay for dengue diagnosis. The assay...

High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever (2002)

Libraty, Daniel H., Young, Paul R., Pickering, Darren, Endy, Timothy P., Kalayanarooj, Siripen, Green, Sharone, ...

Infection with any 1 of 4 dengue viruses produces a spectrum of clinical illness ranging from a mild undifferentiated febrile illness to dengue fever (DF) to dengue hemorrhagic fever (DHF), a...

High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever (2002)

Libraty, Daniel H., Young, Paul R., Pickering, Darren, Endy, Timothy P., Kalayanarooj, Siripen, Green, Sharone, ...

Infection with any 1 of 4 dengue viruses produces a spectrum of clinical illness ranging from a mild undifferentiated febrile illness to dengue fever (DF) to dengue hemorrhagic fever (DHF), a...

Epidemiology of Inapparent and Symptomatic Acute Dengue Virus Infection: A Prospective Study of Primary School Children in Kamphaeng Phet, Thailand (2002)

Endy, Timothy P., Chunsuttiwat, Supamit, Nisalak, Ananda, Libraty, Daniel H., Green, Sharone, Rothman, Alan L., ...

Dengue viruses are a major cause of morbidity in tropical and subtropical regions of the world. Knowledge about the epidemiology and host determinants of inapparent and severe dengue virus infections...

Spatial and Temporal Circulation of Dengue Virus Serotypes: A Prospective Study of Primary School Children in Kamphaeng Phet, Thailand (2002)

Endy, Timothy P., Nisalak, Ananda, Chunsuttiwat, Supamit, Libraty, Daniel H., Green, Sharone, Rothman, Alan L., ...

Dengue virus occurs as four distinct serotypes, each of which causes epidemics throughout the tropical and subtropical regions of the world. Few studies have examined co-circulation of multiple...

Human dendritic cells are activated by dengue virus infection: enhancement by gamma interferon and implications for disease pathogenesis (2001)

Libraty, Daniel H., Pichyangkul, Sathit, Ajariyakhajorn, Chuanpis, Endy, Timothy P., Ennis, Francis A.

The ability of dendritic cells (DCs) to shape the adaptive immune response to viral infection is mediated largely by their maturation and activation state as determined by the surface expression of...

A Simple Assay for Determining Antiviral Activity Against Crimean-Congo Hemorrhagic Fever Virus (1998)

Paragas, Jason, Whitehouse, Chris A., Endy, Timothy P., Bray, Mike

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus that is emerging as a significant human pathogen in many regions of the world, including Africa, Asia, and Europe. In this report,...

History of U.S. Military Contributions to the Study of Viral Hemorrhagic Fevers (1998)

Thomas, Stephen J., Lawler, James V., Endy, Timothy P.

The viral hemorrhagic fever viruses represent a unique group of viruses that can produce large outbreaks of both animal and human disease and produce severe, highly fatal, human illnesses. The viral...

Evaluation of a New Commercially Available Immunoglobulin M Capture Enzyme-Linked Immunosorbent Assay for Diagnosis of Japanese Encephalitis Infections

Cuzzubbo, Andrea J., Endy, Timothy P., Vaughn, David W., Solomon, Tom, Nisalak, Ananda, Kalayanarooj, Siripen, ...

A new commercial enzyme-linked immunosorbent assay (ELISA) for the diagnosis of Japanese encephalitis virus infections showed a sensitivity of 88% with sera and 81% with cerebrospinal fluid and a...

Use of Recombinant Envelope Proteins for Serological Diagnosis of Dengue Virus Infection in an Immunochromatographic Assay

Cuzzubbo, Andrea J., Endy, Timothy P., Nisalak, Ananda, Kalayanarooj, Siripen, Vaughn, David W., Ogata, Steven A., ...

An immunochromatographic test that incorporates recombinant antigens (Dengue Duo Rapid Strip Test; PanBio, Brisbane, Australia) has recently become commercially available. This assay is performed in...

Human Dendritic Cells Are Activated by Dengue Virus Infection: Enhancement by Gamma Interferon and Implications for Disease Pathogenesis

Libraty, Daniel H., Pichyangkul, Sathit, Ajariyakhajorn, Chuanpis, Endy, Timothy P., Ennis, Francis A.

The ability of dendritic cells (DCs) to shape the adaptive immune response to viral infection is mediated largely by their maturation and activation state as determined by the surface expression of...

Cynomolgus Macaque as an Animal Model for Severe Acute Respiratory Syndrome

Lawler, James V, Endy, Timothy P, Hensley, Lisa E, Garrison, Aura, Fritz, Elizabeth A, Lesar, May, ...

Jason Paragas and colleagues report the first findings of measurable clinical disease in nonhuman primates infected with the virus that causes SARS, SARS-CoV.

Evaluation of Diagnostic Assays for Hepatitis E Virus in Outbreak Settings

Myint, Khin Saw Aye, Endy, Timothy P., Gibbons, Robert V., Laras, Kanti, Mammen, Mammen P., Sedyaningsih, Endang R., ...

Hepatitis E virus (HEV) is a major cause of hepatitis. We evaluated five HEV antibody diagnostic assays by using outbreak specimens. The Abbott immunoglobulin G (IgG), Genelabs IgG, and Walter Reed...

Identification of Acinetobacter Species and Genotyping of Acinetobacter baumannii by Multilocus PCR and Mass Spectrometry

Ecker, Joseph A., Massire, Christian, Hall, Thomas A., Ranken, Raymond, Pennella, Thuy-Trang D., Agasino Ivy, Cristina, ...

Members of the genus Acinetobacter are ubiquitous in soil and water and are an important cause of nosocomial infections. A rapid method is needed to genotype Acinetobacter isolates to determine...

Evaluation of a New Commercially Available Immunoglobulin M Capture Enzyme-Linked Immunosorbent Assay for Diagnosis of Japanese Encephalitis Infections

Cuzzubbo, Andrea J., Endy, Timothy P., Vaughn, David W., Solomon, Tom, Nisalak, Ananda, Kalayanarooj, Siripen, ...

A new commercial enzyme-linked immunosorbent assay (ELISA) for the diagnosis of Japanese encephalitis virus infections showed a sensitivity of 88% with sera and 81% with cerebrospinal fluid and a...

Use of Recombinant Envelope Proteins for Serological Diagnosis of Dengue Virus Infection in an Immunochromatographic Assay

Cuzzubbo, Andrea J., Endy, Timothy P., Nisalak, Ananda, Kalayanarooj, Siripen, Vaughn, David W., Ogata, Steven A., ...

An immunochromatographic test that incorporates recombinant antigens (Dengue Duo Rapid Strip Test; PanBio, Brisbane, Australia) has recently become commercially available. This assay is performed in...

Human Dendritic Cells Are Activated by Dengue Virus Infection: Enhancement by Gamma Interferon and Implications for Disease Pathogenesis

Libraty, Daniel H., Pichyangkul, Sathit, Ajariyakhajorn, Chuanpis, Endy, Timothy P., Ennis, Francis A.

The ability of dendritic cells (DCs) to shape the adaptive immune response to viral infection is mediated largely by their maturation and activation state as determined by the surface expression of...

Cynomolgus Macaque as an Animal Model for Severe Acute Respiratory Syndrome

Lawler, James V, Endy, Timothy P, Hensley, Lisa E, Garrison, Aura, Fritz, Elizabeth A, Lesar, May, ...

Jason Paragas and colleagues report the first findings of measurable clinical disease in nonhuman primates infected with the virus that causes SARS, SARS-CoV.

Evaluation of Diagnostic Assays for Hepatitis E Virus in Outbreak Settings

Myint, Khin Saw Aye, Endy, Timothy P., Gibbons, Robert V., Laras, Kanti, Mammen, Mammen P., Sedyaningsih, Endang R., ...

Hepatitis E virus (HEV) is a major cause of hepatitis. We evaluated five HEV antibody diagnostic assays by using outbreak specimens. The Abbott immunoglobulin G (IgG), Genelabs IgG, and Walter Reed...

Identification of Acinetobacter Species and Genotyping of Acinetobacter baumannii by Multilocus PCR and Mass Spectrometry

Ecker, Joseph A., Massire, Christian, Hall, Thomas A., Ranken, Raymond, Pennella, Thuy-Trang D., Agasino Ivy, Cristina, ...

Members of the genus Acinetobacter are ubiquitous in soil and water and are an important cause of nosocomial infections. A rapid method is needed to genotype Acinetobacter isolates to determine...

Virus-Induced Decline in Soluble Vascular Endothelial Growth Receptor 2 Is Associated with Plasma Leakage in Dengue Hemorrhagic Feverâ–¿

Srikiatkhachorn, Anon, Ajariyakhajorn, Chuanpis, Endy, Timothy P., Kalayanarooj, Siripen, Libraty, Daniel H., Green, Sharone, ...

Some individuals infected with dengue virus develop dengue hemorrhagic fever (DHF), a viral hemorrhagic disease characterized by a transient period of localized plasma leakage. To determine the...

A Comparative Study of Leptospirosis and Dengue in Thai Children

Libraty, Daniel H., Myint, Khin S. A., Murray, Clinton K., Gibbons, Robert V., Mammen, Mammen P., Endy, Timothy P., ...

Two of the most common causes of acute febrile illnesses among children in the tropics are leptospirosis and dengue. Early in illness, these two conditions are often indistinguishable and rapid...

Microevolution of Dengue Viruses Circulating among Primary School Children in Kamphaeng Phet, Thailandâ–¿

Jarman, Richard G., Holmes, Edward C., Rodpradit, Prinyada, Klungthong, Chonticha, Gibbons, Robert V., Nisalak, Ananda, ...

To determine the extent and structure of genetic variation in dengue viruses (DENV) on a restricted spatial and temporal scale, we sequenced the E (envelope) genes of DENV-1, -2, and -3 isolates...

Hospital-based Diagnosis of Hemorrhagic Fever, Encephalitis, and Hepatitis in Cambodian Children

Chhour, Y. Meng, Ruble, Gaye, Hong, Rathavuth, Minn, Kyi, Kdan, Yuvatha, Sok, Touch, ...

Surveillance was conducted for three clinical syndromes (hemorrhagic fever, encephalitis, and hepatitis) in Cambodian children admitted to the National Pediatric Hospital in Phnom Penh from July 1996...

Dengue Hemorrhagic Fever in Infants: Research Opportunities Ignored

Halstead, Scott B., Lan, Nguyen Trong, Myint, Thein Thein, Shwe, Than Nu, Nisalak, Ananda, Kalyanarooj, Siripen, ...

The age distribution of cases of dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS) in infants under the age of 1 year are reported from Bangkok, Thailand, and for the first time for Ho Chi...