Timothy P. O'Brien

Publication List Details

Period

1992 - 2008

Number

16

Co-Authors

Resurgence of Emerald Shiners Notropis atherinoides in Lake Huron's Main Basin (2008)

Jeffrey S. Schaeffer, David M. Warner, Timothy P. O'Brien

Emerald shiners Notropis atherinoides were formerly common in Lakes Huron and Michigan, but declined during the 1960s as the exotic alewife Alosa pseudoharengus proliferated. The Lake Huron emerald...

Evidence of Widespread Natural Reproduction by Lake Trout Salvelinus namaycush in the Michigan Waters of Lake Huron (2007)

Stephen C. Riley, Ji X. He, James E. Johnson, Timothy P. O'Brien, Jeffrey S. Schaeffer

Localized natural reproduction of lake trout Salvelinus namaycush in Lake Huron has occurred since the 1980s near Thunder Bay, Michigan. During 2004–2006, USGS spring and fall bottom trawl surveys...

Genome Function and Nuclear Architecture: From Gene Expression to Nanoscience (2003)

O'Brien, Timothy P., Bult, Carol J., Cremer, Christoph, Grunze, Michael, Knowles, Barbara B., Langowski, Jörg, ...

Biophysical, chemical, and nanoscience approaches to the study of nuclear structure and activity have been developing recently and hold considerable promise. A selection of fundamental problems in...

Notch signaling regulates left–right asymmetry determination by inducing Nodal expression

Krebs, Luke T., Iwai, Naomi, Nonaka, Shigenori, Welsh, Ian C., Lan, Yu, Jiang, Rulang, ...

Generation of left–right asymmetry is an integral part of the establishment of the vertebrate body plan. Here we show that the Notch signaling pathway plays a primary role in the establishment of...

Development of an enhanced GFP-based dual-color reporter to facilitate genetic screens for the recovery of mutations in mice

Frank, Aubrey C., Meyers, Kimberly A., Welsh, Ian C., O'Brien, Timothy P.

Mutagenesis screens to isolate a variety of alleles leading to null and non-null phenotypes represent an important approach for the characterization of gene function. Genetic schemes that use visible...

Evidence for a Conserved Function in Synapse Formation Reveals Phr1 as a Candidate Gene for Respiratory Failure in Newborn Mice

Burgess, Robert W., Peterson, Kevin A., Johnson, Michael J., Roix, Jeffrey J., Welsh, Ian C., O'Brien, Timothy P.

Genetic studies using a set of overlapping deletions centered at the piebald locus on distal mouse chromosome 14 have defined a genomic region associated with respiratory distress and lethality at...

Moving forward with chemical mutagenesis in the mouse

O'Brien, Timothy P, Frankel, Wayne N

The study of genetic variation in mice offers a powerful experimental platform for understanding gene function. Complex trait analysis, gene-targeting and gene-trapping technologies, as well as...

Notch signaling regulates left–right asymmetry determination by inducing Nodal expression

Krebs, Luke T., Iwai, Naomi, Nonaka, Shigenori, Welsh, Ian C., Lan, Yu, Jiang, Rulang, ...

Generation of left–right asymmetry is an integral part of the establishment of the vertebrate body plan. Here we show that the Notch signaling pathway plays a primary role in the establishment of...

Development of an enhanced GFP-based dual-color reporter to facilitate genetic screens for the recovery of mutations in mice

Frank, Aubrey C., Meyers, Kimberly A., Welsh, Ian C., O'Brien, Timothy P.

Mutagenesis screens to isolate a variety of alleles leading to null and non-null phenotypes represent an important approach for the characterization of gene function. Genetic schemes that use visible...

Evidence for a Conserved Function in Synapse Formation Reveals Phr1 as a Candidate Gene for Respiratory Failure in Newborn Mice

Burgess, Robert W., Peterson, Kevin A., Johnson, Michael J., Roix, Jeffrey J., Welsh, Ian C., O'Brien, Timothy P.

Genetic studies using a set of overlapping deletions centered at the piebald locus on distal mouse chromosome 14 have defined a genomic region associated with respiratory distress and lethality at...

Moving forward with chemical mutagenesis in the mouse

O'Brien, Timothy P, Frankel, Wayne N

The study of genetic variation in mice offers a powerful experimental platform for understanding gene function. Complex trait analysis, gene-targeting and gene-trapping technologies, as well as...

Folding and organization of a contiguous chromosome region according to the gene distribution pattern in primary genomic sequence

Shopland, Lindsay S., Lynch, Christopher R., Peterson, Kevin A., Thornton, Kathleen, Kepper, Nick, Hase, Johann Von, ...

Specific mammalian genes functionally and dynamically associate together within the nucleus. Yet, how an array of many genes along the chromosome sequence can be spatially organized and folded...