Kawasaki, Aya, Ito, Ikue, Hikami, Koki, Ohashi, Jun, Hayashi, Taichi, Goto, Daisuke, ...
Abstract Introduction Recent studies identified STAT4 (signal transducers and activators of transcription-4) as a susceptibility gene for systemic lupus erythematosus (SLE). STAT1 is encoded...
Leukocyte Antigens And, Damini Jawaheer, Wentian Li, Robert R. Graham, Wei Chen, Aarti Damle, ...
are present within the major histocompatibility complex. One of these lies within a 497-kb region in the central portion of the HLA complex, an interval that excludes DRB1. This genetic risk factor...
Jason W. Bauer, Emily C. Baechler, Michelle Petri, Franak M. Batliwalla, Dianna Crawford, Ward A. Ortmann, ...
BackgroundSystemic lupus erythematosus (SLE) is a serious systemic autoimmune disorder that affects multiple organ systems and is characterized by unpredictable flares of disease. Recent evidence...
Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells (2005)
Lina E. Tze, Brian R. Schram, Kong-Peng Lam, Kristin A. Hogquist, Keli L. Hippen, Jiabin Liu, ...
Gene rearrangement is a hallmark of B cell maturation. By interrupting basal cell signaling through the rearranged IgM receptor, immature B cells "back-differentiate" to an earlier stage in their...
Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells (2005)
Lina E. Tze, Brian R. Schram, Kong-Peng Lam, Kristin A. Hogquist, Keli L. Hippen, Jiabin Liu, ...
In developing B lymphocytes, a successful V(D)J heavy chain (HC) immunoglobulin (Ig) rearrangement establishes HC allelic exclusion and signals pro-B cells to advance in development to the pre-B...
Graham, Robert R, Langefeld, Carl D, Gaffney, Patrick M, Ortmann, Ward A, Selby, Scott A, Baechler, Emily C, ...
Abstract Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies to a wide range of self-antigens. Recent genome screens have implicated...
Gaffney, Patrick M., Kearns, Grainne M., Shark, Katherine B., Ortmann, Ward A., Selby, Scott A., Malmgren, Michelle L., ...
Systemic lupus erythematosus (SLE) is an autoimmune multisystem inflammatory disease characterized by the production of pathogenic autoantibodies. Previous genetic studies have suggested associations...
Graham, Robert R, Langefeld, Carl D, Gaffney, Patrick M, Ortmann, Ward A, Selby, Scott A, Baechler, Emily C, ...
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies to a wide range of self-antigens. Recent genome screens have implicated numerous...
Baechler, Emily C., Batliwalla, Franak M., Karypis, George, Gaffney, Patrick M., Ortmann, Ward A., Espe, Karl J., ...
Systemic lupus erythematosus (SLE) is a complex, inflammatory autoimmune disease that affects multiple organ systems. We used global gene expression profiling of peripheral blood mononuclear cells to...
Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells
Tze, Lina E, Schram, Brian R, Lam, Kong-Peng, Hogquist, Kristin A, Hippen, Keli L, Liu, Jiabin, ...
In developing B lymphocytes, a successful V(D)J heavy chain (HC) immunoglobulin (Ig) rearrangement establishes HC allelic exclusion and signals pro-B cells to advance in development to the pre-B...
Gaffney, Patrick M., Ortmann, Ward A., Selby, Scott A., Shark, Katherine B., Ockenden, Theresa C., Rohlf, Kristine E., ...
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a loss of immunologic tolerance to a multitude of self-antigens. Epidemiological data suggest an important role for genes...
Batliwalla, Franak M., Li, Wentian, Ritchlin, Christopher T., Xiao, Xiangli, Brenner, Max, Laragione, Teresina, ...
Psoriatic arthritis (PsA) is a chronic and erosive form of arthritis of unknown cause. We aimed to characterize the PsA phenotype using gene expression profiling and comparing it with healthy control...
Gaffney, Patrick M., Langefeld, Carl D., Graham, Robert R., Ortmann, Ward A., Williams, Adrienne H., Rodine, Peter R., ...
The presence of systemic lupus erythematosus (SLE) susceptibility genes on chromosome 20 is suggested by the observation of genetic linkage in several independent SLE family collections. To further...
Gaffney, Patrick M., Kearns, Grainne M., Shark, Katherine B., Ortmann, Ward A., Selby, Scott A., Malmgren, Michelle L., ...
Systemic lupus erythematosus (SLE) is an autoimmune multisystem inflammatory disease characterized by the production of pathogenic autoantibodies. Previous genetic studies have suggested associations...
Graham, Robert R, Langefeld, Carl D, Gaffney, Patrick M, Ortmann, Ward A, Selby, Scott A, Baechler, Emily C, ...
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies to a wide range of self-antigens. Recent genome screens have implicated numerous...
Baechler, Emily C., Batliwalla, Franak M., Karypis, George, Gaffney, Patrick M., Ortmann, Ward A., Espe, Karl J., ...
Systemic lupus erythematosus (SLE) is a complex, inflammatory autoimmune disease that affects multiple organ systems. We used global gene expression profiling of peripheral blood mononuclear cells to...
Visualizing Human Leukocyte Antigen Class II Risk Haplotypes in Human Systemic Lupus Erythematosus
Graham, Robert R., Ortmann, Ward A., Langefeld, Carl D., Jawaheer, Damini, Selby, Scott A., Rodine, Peter R., ...
Human leukocyte antigen (HLA) class I and class II alleles are implicated as genetic risk factors for many autoimmune diseases. However, the role of the HLA loci in human systemic lupus erythematosus...
Jawaheer, Damini, Li, Wentian, Graham, Robert R., Chen, Wei, Damle, Aarti, Xiao, Xiangli, ...
Rheumatoid arthritis (RA) is an inflammatory disease with a complex genetic component. An association between RA and the human leukocyte antigen (HLA) complex has long been observed in many different...
Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells
Tze, Lina E, Schram, Brian R, Lam, Kong-Peng, Hogquist, Kristin A, Hippen, Keli L, Liu, Jiabin, ...
In developing B lymphocytes, a successful V(D)J heavy chain (HC) immunoglobulin (Ig) rearrangement establishes HC allelic exclusion and signals pro-B cells to advance in development to the pre-B...
Genetic Association of the R620W Polymorphism of Protein Tyrosine Phosphatase PTPN22 with Human SLE
Kyogoku, Chieko, Langefeld, Carl D., Ortmann, Ward A., Lee, Annette, Selby, Scott, Carlton, Victoria E. H., ...
We genotyped 525 independent North American white individuals with systemic lupus erythematosus (SLE) for the PTPN22 R620W polymorphism and compared the results with data generated from 1,961 white...
Criswell, Lindsey A., Pfeiffer, Kirsten A., Lum, Raymond F., Gonzales, Bonnie, Novitzke, Jill, Kern, Marlena, ...
Autoimmune disorders constitute a diverse group of phenotypes with overlapping features and a tendency toward familial aggregation. It is likely that common underlying genes are involved in these...
Gaffney, Patrick M., Ortmann, Ward A., Selby, Scott A., Shark, Katherine B., Ockenden, Theresa C., Rohlf, Kristine E., ...
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a loss of immunologic tolerance to a multitude of self-antigens. Epidemiological data suggest an important role for genes...
Batliwalla, Franak M., Li, Wentian, Ritchlin, Christopher T., Xiao, Xiangli, Brenner, Max, Laragione, Teresina, ...
Psoriatic arthritis (PsA) is a chronic and erosive form of arthritis of unknown cause. We aimed to characterize the PsA phenotype using gene expression profiling and comparing it with healthy control...
Gaffney, Patrick M., Langefeld, Carl D., Graham, Robert R., Ortmann, Ward A., Williams, Adrienne H., Rodine, Peter R., ...
The presence of systemic lupus erythematosus (SLE) susceptibility genes on chromosome 20 is suggested by the observation of genetic linkage in several independent SLE family collections. To further...
Bauer, Jason W, Baechler, Emily C, Petri, Michelle, Batliwalla, Franak M, Crawford, Dianna, Ortmann, Ward A, ...
A comprehensive survey of the serologic proteome in human SLE suggests that severely disrupted chemokine gradients may contribute to the systemic autoimmunity observed.
Baechler, Emily C, Bauer, Jason W, Slattery, Catherine A, Ortmann, Ward A, Espe, Karl J, Novitzke, Jill, ...
Recent studies have shown increased expression of interferon (IFN)-regulated genes in the peripheral blood cells of patients with systemic lupus erythematosus. A similar interferon signature has been...
Graham, Robert R., Kyogoku, Chieko, Sigurdsson, Snaevar, Vlasova, Irina A., Davies, Leela R. L., Baechler, Emily C., ...
Systematic genome-wide studies to map genomic regions associated with human diseases are becoming more practical. Increasingly, efforts will be focused on the identification of the specific...
Role for Msh5 in the regulation of Ig class switch recombination
Sekine, Hideharu, Ferreira, Ricardo C., Pan-Hammarström, Qiang, Graham, Robert R., Ziemba, Beth, De Vries, Sandra S., ...
Ig class switch recombination (CSR) and somatic hypermutation serve to diversify antibody responses and are orchestrated by the activity of activation-induced cytidine deaminase and many proteins...
Visualization of the Genesis and Fate of Isotype-switched B Cells during a Primary Immune Response
Pape, Kathryn A., Kouskoff, Valerie, Nemazee, David, Tang, H. Lucy, Cyster, Jason G., Tze, Lina E., ...
The life history of isotype-switched B cells is unclear, in part, because of an inability to detect rare antigen-specific B cells at early times during the immune response. To address this issue, a...
Takahashi, Yoshimasa, Cerasoli, Douglas M., Dal Porto, Joseph M., Shimoda, Michiko, Freund, Robert, Fang, Wei, ...
The role of apoptosis in affinity maturation was investigated by determining the affinity of (4-hydroxy-3-nitrophenyl)acetyl (NP)-specific antibody-forming cells (AFCs) and serum antibody in...
Cd5 Maintains Tolerance in Anergic B Cells
Hippen, Keli L., Tze, Lina E., Behrens, Timothy W.
Clonal anergy of autoreactive B cells is a key mechanism regulating tolerance. Here, we show that anergic B cells express significant surface levels of CD5, a molecule normally found on T cells and a...
Snyder, Heidi Link, Bačík, Igor, Bennink, Jack R., Kearns, Grainne, Behrens, Timothy W., Bächi, Thomas, ...
Jaw1 is an endoplasmic reticulum (ER) resident protein representative of a class of proteins post translationally inserted into membranes via a type II membrane anchor (cytosolic NH2 domain, lumenal...
Transgene Expression of bcl-xL Permits Anti-immunoglobulin (Ig)–induced Proliferation in xid B Cells
Solvason, Nanette, Wu, Wei Wei, Kabra, Nisha, Lund-Johansen, Fridjtof, Roncarolo, Maria Grazia, Behrens, Timothy W., ...
Mutations in the tyrosine kinase, Btk, result in a mild immunodeficiency in mice (xid). While B lymphocytes from xid mice do not proliferate to anti-immunoglobulin (Ig), we show here induction of the...
Taylor, Kimberly E., Remmers, Elaine F., Lee, Annette T., Ortmann, Ward A., Plenge, Robert M., Tian, Chao, ...
Systemic lupus erythematosus (SLE) is a genetically complex disease with heterogeneous clinical manifestations. A polymorphism in the STAT4 gene has recently been established as a risk factor for...
Liu, Chunyu, Batliwalla, Franak, Li, Wentian, Lee, Annette, Roubenoff, Ronenn, Beckman, Evan, ...
The prediction of response (or non-response) to anti-TNF treatment for rheumatoid arthritis (RA) is a pressing clinical problem. We conducted a genome-wide association study using the Illumina...
Barcellos, Lisa F., May, Suzanne L., Ramsay, Patricia P., Quach, Hong L., Lane, Julie A., Nititham, Joanne, ...
A substantial genetic contribution to systemic lupus erythematosus (SLE) risk is conferred by major histocompatibility complex (MHC) gene(s) on chromosome 6p21. Previous studies in SLE have lacked...