Ting-Kai Li

Transitions In and Out of Alcohol Use Disorders: Their Associations with Conditional Changes in Quality of Life Over a 3-Year Follow-Up Interval (2009)

Dawson, Deborah A., Li, Ting-Kai, Chou, S. Patricia, Grant, Bridget F.

Aims: The aim of this study was to investigate longitudinal changes in quality of life (QOL) as a function of transitions in alcohol use disorders (AUD) over a 3-year follow-up of a general US...

The Role of acetaldehyde in the central effects of ethanol (2005)

Quertemont, Etienne, Grant, Kathleen A., Correa, Mercè, Arizzi, Maria N., Salamone, John D., Tambour, Sophie, ...

This article represents the proceedings of a symposium at the 2004 annual meeting of the Research Society on Alcoholism in Vancouver, Canada. The symposium was organized by Etienne Quertemont and...

The role of acetaldehyde in the central effects of ethanol (2005)

Quertemont, Etienne, Grant, Kathleen A., Correa, Merce, Arizzi, Maria N., Salamone, John D., Tambour, Sophie, ...

This article represents the proceedings of a symposium at the 2004 annual meeting of the Research Society on Alcoholism in Vancouver, Canada. The symposium was organized by Etienne Quertemont and...

A PILOT STUDY OF ALCOHOL EXPOSURE AND PHARMACOKINETICS IN WOMEN WITH OR WITHOUT CHILDREN WITH FETAL ALCOHOL SYNDROME (2004)

KHAOLE, NATHANIEL C. O., RAMCHANDANI, VIJAY A., VILJOEN, DENIS L., LI, TING-KAI

Aims: To determine the alcohol exposure and pharmacokinetics of alcohol in a group of women who had given birth to children with FAS, compared with women who had not given birth to FAS children....

A PILOT STUDY OF ALCOHOL EXPOSURE AND PHARMACOKINETICS IN WOMEN WITH OR WITHOUT CHILDREN WITH FETAL ALCOHOL SYNDROME (2004)

KHAOLE, NATHANIEL C. O., RAMCHANDANI, VIJAY A., VILJOEN, DENIS L., LI, TING-KAI

Aims: To determine the alcohol exposure and pharmacokinetics of alcohol in a group of women who had given birth to children with FAS, compared with women who had not given birth to FAS children....

A PILOT STUDY OF ALCOHOL EXPOSURE AND PHARMACOKINETICS IN WOMEN WITH OR WITHOUT CHILDREN WITH FETAL ALCOHOL SYNDROME (2004)

KHAOLE, NATHANIEL C. O., RAMCHANDANI, VIJAY A., VILJOEN, DENIS L., LI, TING-KAI

Aims: To determine the alcohol exposure and pharmacokinetics of alcohol in a group of women who had given birth to children with FAS, compared with women who had not given birth to FAS children....

A PILOT STUDY OF ALCOHOL EXPOSURE AND PHARMACOKINETICS IN WOMEN WITH OR WITHOUT CHILDREN WITH FETAL ALCOHOL SYNDROME (2004)

KHAOLE, NATHANIEL C. O., RAMCHANDANI, VIJAY A., VILJOEN, DENIS L., LI, TING-KAI

Aims: To determine the alcohol exposure and pharmacokinetics of alcohol in a group of women who had given birth to children with FAS, compared with women who had not given birth to FAS children....

A PILOT STUDY OF ALCOHOL EXPOSURE AND PHARMACOKINETICS IN WOMEN WITH OR WITHOUT CHILDREN WITH FETAL ALCOHOL SYNDROME (2004)

KHAOLE, NATHANIEL C. O., RAMCHANDANI, VIJAY A., VILJOEN, DENIS L., LI, TING-KAI

Aims: To determine the alcohol exposure and pharmacokinetics of alcohol in a group of women who had given birth to children with FAS, compared with women who had not given birth to FAS children....

Neuroscience Networks (2003)

Thomas R. Insel, Nora D. Volkow, Ting-Kai Li, James F. Battey, Story C. Landis

To study the brain from molecules to behaviour, neuroscientists face the challenge of communicating an emerging wealth of information in coherent accessible forms.

GENETIC AND NEUROBIOLOGICAL BASIS OF ALCOHOL-SEEKING BEHAVIOR (1994)

LI, TING-KAI, LUMENG, LAWRENCE, McBRIDE, WILLIAM J., MURPHY, JAMES M.

Through selective breeding, rat lines exhibiting high and low alcohol drinking preference have been developed as useful animal models for studying the neurobiological basis of alcohol-seeking...

ALCOHOL AND ALDEHYDE DEHYDROGENASE (1990)

EHRIG, TORSTEN, BOSRON, WILLIAM F., LI, TING-KAI

The enzymes mainly responsible for ethanol degradation in humans are liver alcohol dehydrogenases (ADH) and aldehyde dehydrogenases (ALDH). Polymorphisms occur in both enzymes, with marked...

Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus

Porjesz, Bernice, Almasy, Laura, Edenberg, Howard J., Wang, Kongming, Chorlian, David B., Foroud, Tatiana, ...

Human brain oscillations represent important features of information processing and are highly heritable. A common feature of beta oscillations (13–28 Hz) is the critical involvement of networks of...

α-Synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alcohol-preferring and -nonpreferring rats

Liang, Tiebing, Spence, John, Liu, Lixiang, Strother, Wendy N., Chang, Hwai Wen, Ellison, Julie A., ...

Total gene expression analysis (TOGA) was used to identify genes that are differentially expressed in brain regions between the alcohol-naïve, inbred alcohol-preferring (iP), and -nonpreferring...

Neuroscience Networks: Data-sharing in an Information Age

Insel, Thomas R, Volkow, Nora D, Li, Ting-Kai, Battey, James F, Landis, Story C

To study the brain from molecules to behaviour, neuroscientists face the challenge of communicating an emerging wealth of information in coherent accessible forms

Vitamin B6 Metabolism in Chronic Alcohol Abuse: PYRIDOXAL PHOSPHATE LEVELS IN PLASMA AND THE EFFECTS OF ACETALDEHYDE ON PYRIDOXAL PHOSPHATE SYNTHESIS AND DEGRADATION IN HUMAN ERYTHROCYTES

Lumeng, Lawrence, Li, Ting-Kai

The plasma pyridoxal-5′-phosphate (PLP) level of alcoholic subjects has been compared with that of non-alcoholic individuals in order to ascertain the incidence of abnormal vitamin B6 metabolism in...

Isolation of II-alcohol dehydrogenase of human liver: Is it a determinant of alcoholism?

Li, Ting-Kai, Bosron, William F., Dafeldecker, Werner P., Lange, Louis G.

Human liver alcohol dehydrogenase (alcohol: NAD+ oxidoreductase, EC 1.1.1.1), homogeneous by physicochemical criteria, has been available in quantity only recently [Lange, L. G. & Vallee, B. L....

Response to: “Rescuing the NIH before it is too late”

Alexander, Duane F., Alving, Barbara M., Battey, James F., Berg, Jeremy M., Collins, Francis S., Fauci, Anthony S., ...

We, the directors of the 27 NIH institutes and centers, wanted to respond to the points made by Andrew Marks in his recent editorial. While we appreciate that the scientific community has concerns,...

Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus

Porjesz, Bernice, Almasy, Laura, Edenberg, Howard J., Wang, Kongming, Chorlian, David B., Foroud, Tatiana, ...

Human brain oscillations represent important features of information processing and are highly heritable. A common feature of beta oscillations (13–28 Hz) is the critical involvement of networks of...

α-Synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alcohol-preferring and -nonpreferring rats

Liang, Tiebing, Spence, John, Liu, Lixiang, Strother, Wendy N., Chang, Hwai Wen, Ellison, Julie A., ...

Total gene expression analysis (TOGA) was used to identify genes that are differentially expressed in brain regions between the alcohol-naïve, inbred alcohol-preferring (iP), and -nonpreferring...

Neuroscience Networks: Data-sharing in an Information Age

Insel, Thomas R, Volkow, Nora D, Li, Ting-Kai, Battey, James F, Landis, Story C

To study the brain from molecules to behaviour, neuroscientists face the challenge of communicating an emerging wealth of information in coherent accessible forms

Vitamin B6 Metabolism in Chronic Alcohol Abuse: PYRIDOXAL PHOSPHATE LEVELS IN PLASMA AND THE EFFECTS OF ACETALDEHYDE ON PYRIDOXAL PHOSPHATE SYNTHESIS AND DEGRADATION IN HUMAN ERYTHROCYTES

Lumeng, Lawrence, Li, Ting-Kai

The plasma pyridoxal-5′-phosphate (PLP) level of alcoholic subjects has been compared with that of non-alcoholic individuals in order to ascertain the incidence of abnormal vitamin B6 metabolism in...

Isolation of II-alcohol dehydrogenase of human liver: Is it a determinant of alcoholism?

Li, Ting-Kai, Bosron, William F., Dafeldecker, Werner P., Lange, Louis G.

Human liver alcohol dehydrogenase (alcohol: NAD+ oxidoreductase, EC 1.1.1.1), homogeneous by physicochemical criteria, has been available in quantity only recently [Lange, L. G. & Vallee, B. L....

Variations in GABRA2, Encoding the α2 Subunit of the GABAA Receptor, Are Associated with Alcohol Dependence and with Brain Oscillations

Edenberg, Howard J., Dick, Danielle M., Xuei, Xiaoling, Tian, Huijun, Almasy, Laura, Bauer, Lance O., ...

Alcoholism is a complex disease with both genetic and environmental risk factors. To identify genes that affect the risk for alcoholism, we systematically ascertained and carefully assessed...

Response to: “Rescuing the NIH before it is too late”

Alexander, Duane F., Alving, Barbara M., Battey, James F., Berg, Jeremy M., Collins, Francis S., Fauci, Anthony S., ...

We, the directors of the 27 NIH institutes and centers, wanted to respond to the points made by Andrew Marks in his recent editorial. While we appreciate that the scientific community has concerns,...

The Alcohol Flushing Response: An Unrecognized Risk Factor for Esophageal Cancer from Alcohol Consumption

Brooks, Philip J, Enoch, Mary-Anne, Goldman, David, Li, Ting-Kai, Yokoyama, Akira

Philip Brooks and colleagues discuss evidence linking the alcohol flushing response (predominantly due to ALDH2 deficiency) with a much higher risk of esophageal cancer from alcohol consumption.