Auto-Inhibition of Ets-1 Is Counteracted by DNA Binding Cooperativity with Core-Binding Factor α2
Goetz, Tamara L., Gu, Ting-Lei, Speck, Nancy A., Graves, Barbara J.
Auto-inhibition is a common transcriptional control mechanism that is well characterized in the regulatory transcription factor Ets-1. Autoinhibition of Ets-1 DNA binding works through an inhibitory...
Gu, Ting-Lei, Goetz, Tamara L., Graves, Barbara J., Speck, Nancy A.
Core-binding factor α2 (CBFα2; otherwise known as AML1 or PEBP2αB) is a DNA-binding subunit in the family of core-binding factors (CBFs), heterodimeric transcription factors that play pivotal...
Mohi, M. Golam, Boulton, Christina, Gu, Ting-Lei, Sternberg, David W., Neuberg, Donna, Griffin, James D., ...
Abnormal protein tyrosine kinases (PTKs) cause many human leukemias. For example, BCR/ABL causes chronic myelogenous leukemia (CML), whereas FLT3 mutations contribute to the pathogenesis of acute...
Auto-Inhibition of Ets-1 Is Counteracted by DNA Binding Cooperativity with Core-Binding Factor α2
Goetz, Tamara L., Gu, Ting-Lei, Speck, Nancy A., Graves, Barbara J.
Auto-inhibition is a common transcriptional control mechanism that is well characterized in the regulatory transcription factor Ets-1. Autoinhibition of Ets-1 DNA binding works through an inhibitory...
Gu, Ting-Lei, Goetz, Tamara L., Graves, Barbara J., Speck, Nancy A.
Core-binding factor α2 (CBFα2; otherwise known as AML1 or PEBP2αB) is a DNA-binding subunit in the family of core-binding factors (CBFs), heterodimeric transcription factors that play pivotal...
Mohi, M. Golam, Boulton, Christina, Gu, Ting-Lei, Sternberg, David W., Neuberg, Donna, Griffin, James D., ...
Abnormal protein tyrosine kinases (PTKs) cause many human leukemias. For example, BCR/ABL causes chronic myelogenous leukemia (CML), whereas FLT3 mutations contribute to the pathogenesis of acute...
Mercher, Thomas, Wernig, Gerlinde, Moore, Sandra A., Levine, Ross L., Gu, Ting-Lei, Fröhling, Stefan, ...
Acute megakaryoblastic leukemia (AMKL) is a subtype of acute myeloid leukemia associated with a poor prognosis. However, there are relatively few insights into the genetic etiology of AMKL. We...
Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles
Matheny, Christina J, Speck, Maren E, Cushing, Patrick R, Zhou, Yunpeng, Corpora, Takeshi, Regan, Michael, ...
Monoallelic RUNX1 mutations cause familial platelet disorder with predisposition for acute myelogenous leukemia (FPD/AML). Sporadic mono- and biallelic mutations are found at high frequencies in AML...
A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia
Gu, Ting-lei, Mercher, Thomas, Tyner, Jeffrey W., Goss, Valerie L., Walters, Denise K., Cornejo, Melanie G., ...
Activated tyrosine kinases have been frequently implicated in the pathogenesis of cancer, including acute myeloid leukemia (AML), and are validated targets for therapeutic intervention with...
Dong, Shaozhong, Kang, Sumin, Gu, Ting-Lei, Kardar, Sean, Fu, Haian, Lonial, Sagar, ...
Human 8p11 stem cell leukemia/lymphoma syndrome usually presents as a myeloproliferative disorder (MPD) that evolves to acute myeloid leukemia and/or lymphoma. The syndrome associated with...
Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cells
Tam, Winnie F., Gu, Ting-Lei, Chen, Jing, Lee, Benjamin H., Bullinger, Lars, Fröhling, Stefan, ...
Oncogenic tyrosine kinases, such as BCR-ABL, TEL-ABL, TEL-PDGFβR, and FLT3-ITD, play a major role in the development of hematopoietic malignancy. They activate many of the same signal transduction...
Kang, Sumin, Elf, Shannon, Dong, Shaozhong, Hitosugi, Taro, Lythgoe, Katherine, Guo, Ailan, ...
Dysregulation of the receptor tyrosine kinase fibroblast growth factor receptor 3 (FGFR3) plays a pathogenic role in a number of human hematopoietic malignancies and solid tumors. These include...