Tiziano M. Scarabelli

STAT3 deletion sensitizes cells to oxidative stress (2009)

Barry, Seán P., Townsend, Paul A., McCormick, James, Knight, Richard A., Scarabelli, Tiziano M., Latchman, David S., ...

The transcription factor STAT1 plays a role in promoting apoptotic cell death, whereas the related STAT3 transcription factor protects cardiac myocytes from ischemia/reperfusion (I/R) injury or...

Amino acid supplementation differentially modulates STAT1 and STAT3 activation in the myocardium exposed to ischemia/reperfusion injury (2008)

Scarabelli, Tiziano M., Townsend, Paul A., Chen Scarabelli, Carol, Yuan, Zhaokan, McCauley, Roy B., Di Rezze, Justin, ...

We have previously demonstrated that the transcription factor STAT1 plays a critical role in promoting apoptotic cell death, whereas the related STAT3 family member may antagonize STAT1 and protect...

Urocortin prevents mitochondrial permeability transition in response to reperfusion injury indirectly by reducing oxidative stress (2007)

Townsend, Paul A., Davidson, Sean M., Clarke, Samantha J., Khaliulin, Igor, Carroll, Christopher J., Scarabelli, Tiziano M., ...

Urocortin (UCN) protects hearts against ischemia and reperfusion injury whether given before ischemia or at reperfusion. Here we investigate the roles of PKC, reactive oxygen species, and the...

Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury (2006)

Valentim, Lauren, Laurence, Kevin M., Townsend, Paul A., Carroll, Christopher J., Soond, Surinder, Scarabelli, Tiziano M., ...

Autophagy is known to be a feature of cardiomyopathies and chronic ischaemia. Here we demonstrate that autophagy is also induced by a single cycle of ischaemia/reperfusion (I/R in neonatal and adult...

Clinical implications of apoptosis in ischemic myocardium (2006)

Scarabelli, Tiziano M., Knight, Richard, Stephanou, Anastasis, Townsend, Paul, Chen-Scarabelli, Carol, Lawrence, Kevin, ...

Apoptosis, a genetically programmed form of cell death, contributes to myocyte cell loss in a variety of cardiac pathologies, including cardiac failure and those related to ischemia/reperfusion...

BAG-1 proteins protect cardiac myocytes from simulated ischemia/reperfusion-induced apoptosis via an alternate mechanism of cell survival independent of the proteasome (2004)

Townsend, Paul A., Cutress, Ramsey I., Carroll, Christopher J., Lawrence, Kevin M., Scarabelli, Tiziano M., Packham, Graham, ...

BAG-1 (Bcl-2-associated athanogene-1) proteins interact with the HSC70 and HSP70 heat shock proteins and have been proposed to promote cell survival by coordinating the function of these chaperones...

Minocycline inhibits caspase activation and reactivation, increases the ratio of XIAP to smac/DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO (2004)

Scarabelli, Tiziano M., Stephanou, Anastasis, Pasini, Evasio, Gitti, Gianluca, Townsend, Paul, Lawrence, Kevin, ...

Objectives: This study is aimed at investigating the novel use of minocycline for cardiac protection during ischemia/reperfusion (I/R) injury, as well as its mechanism of action. Background:...

STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis (2004)

Townsend, Paul A., Scarabelli, Tiziano M., Davidson, Sean M., Knight, Richard A., Latchman, David S., Stephanou, Anastasis

The STAT-1 transcription factor has been implicated as a tumor suppressor by virtue of its ability to inhibit cell growth and promoting apoptosis. However, the mechanisms by which STAT-1 mediates...

Warm blood cardioplegic arrest induces mitochondrial-mediated cardiomyocyte apoptosis associated with increased urocortin expression in viable cells (2004)

Scarabelli, Tiziano M., Pasini, Evasio, Ferrari, Gianna, Ferrari, Mario, Stephanou, Anastasis, Lawrence, Kevin, ...

Objectives This study assesses the mechanisms of apoptosis in patients after on-pump coronary artery bypass graft surgery and the potential involvement of the endogenous cardiac peptide urocortin as...

The carboxyl-terminal activation domain of the STAT-1 transcription factor enhances ischemia/reperfusion-induced apoptosis in cardiac myocytes (2002)

Stephanou, Anastasis, Scarabelli, Tiziano M., Townsend, Paul A., Bell, Robert, Yellon, Derek, Knight, Richard A., ...

We have demonstrated previously that the STAT-1 transcription factor plays a key role in ischemia/reperfusion (I/R)-induced apoptosis in cardiac myocytes. In the present study we assessed which...

Neurocardiogenic syncope

Chen-Scarabelli, Carol, Scarabelli, Tiziano M

Neurocardiogenic syncope

Chen-Scarabelli, Carol, Scarabelli, Tiziano M

STAT3 deletion sensitizes cells to oxidative stress

Barry, Seán P., Townsend, Paul A., McCormick, James, Knight, Richard A., Scarabelli, Tiziano M., Latchman, David S., ...

The transcription factor STAT1 plays a role in promoting apoptotic cell death, whereas the related STAT3 transcription factor protects cardiac myocytes from ischemia/reperfusion (I/R) injury or...