Todd A. Carter

Mechanisms of aging in senescence-accelerated mice (2005)

Carter, Todd A, Greenhall, Jennifer A, Yoshida, Shigeo, Fuchs, Sebastian, Helton, Robert, Swaroop, Anand, ...

Abstract Background Progressive neurological dysfunction is a key aspect of human aging. Because of underlying differences in the aging of mice and humans, useful mouse models have been difficult to...

An inbred 129SvEv GFPCre transgenic mouse that deletes loxP-flanked genes in all tissues (2003)

Scheel, John R., Garrett, Lisa J., Allen, Duane M., Carter, Todd A., Randolph-Moore, Lynne, Gambello, Micheal J., ...

A common method for generating mice with subtle genetic manipulations uses homologous recombination (HR) in embryonic stem (ES) cells to replace a wild‐type gene with a slightly modified one....

Regional and strain-specific gene expression mapping in the adult mouse brain

Sandberg, Rickard, Yasuda, Rie, Pankratz, Daniel G., Carter, Todd A., Del Rio, Jo A., Wodicka, Lisa, ...

To determine the genetic causes and molecular mechanisms responsible for neurobehavioral differences in mice, we used highly parallel gene expression profiling to detect genes that are differentially...

Mice with a targeted mutation in the thyroid hormone β receptor gene exhibit impaired growth and resistance to thyroid hormone

Kaneshige, Masahiro, Kaneshige, Kumiko, Zhu, Xu-guang, Dace, Alexandra, Garrett, Lisa, Carter, Todd A., ...

Patients with mutations in the thyroid hormone receptor β (TRβ) gene manifest resistance to thyroid hormone (RTH), resulting in a constellation of variable phenotypic abnormalities. To understand...

An inbred 129SvEv GFPCre transgenic mouse that deletes loxP-flanked genes in all tissues

Scheel, John R., Garrett, Lisa J., Allen, Duane M., Carter, Todd A., Randolph-Moore, Lynne, Gambello, Micheal J., ...

A common method for generating mice with subtle genetic manipulations uses homologous recombination (HR) in embryonic stem (ES) cells to replace a wild-type gene with a slightly modified one....

Mechanisms of aging in senescence-accelerated mice

Carter, Todd A, Greenhall, Jennifer A, Yoshida, Shigeo, Fuchs, Sebastian, Helton, Robert, Swaroop, Anand, ...

Gene-expression analysis and polymorphism screening to study molecular senescence of the retina and hippocampus in two rare inbred mouse models of accelerated neurological senescence as well as a...

Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases

Carter, Todd A., Wodicka, Lisa M., Shah, Neil P., Velasco, Anne Marie, Fabian, Miles A., Treiber, Daniel K., ...

To realize the full potential of targeted protein kinase inhibitors for the treatment of cancer, it is important to address the emergence of drug resistance in treated patients. Mutant forms of...

Ataxia telangiectasia mutated is essential during adult neurogenesis

Allen, Duane M., Van Praag, Henriette, Ray, Jasodhara, Weaver, Zoë, Winrow, Christopher J., Carter, Todd A., ...

Ataxia telangiectasia (A-T) is an autosomal recessive disease characterized by normal brain development followed by progressive neurodegeneration. The gene mutated in A-T (ATM) is a serine protein...

Regional and strain-specific gene expression mapping in the adult mouse brain

Sandberg, Rickard, Yasuda, Rie, Pankratz, Daniel G., Carter, Todd A., Del Rio, Jo A., Wodicka, Lisa, ...

To determine the genetic causes and molecular mechanisms responsible for neurobehavioral differences in mice, we used highly parallel gene expression profiling to detect genes that are differentially...

Mice with a targeted mutation in the thyroid hormone β receptor gene exhibit impaired growth and resistance to thyroid hormone

Kaneshige, Masahiro, Kaneshige, Kumiko, Zhu, Xu-guang, Dace, Alexandra, Garrett, Lisa, Carter, Todd A., ...

Patients with mutations in the thyroid hormone receptor β (TRβ) gene manifest resistance to thyroid hormone (RTH), resulting in a constellation of variable phenotypic abnormalities. To understand...

An inbred 129SvEv GFPCre transgenic mouse that deletes loxP-flanked genes in all tissues

Scheel, John R., Garrett, Lisa J., Allen, Duane M., Carter, Todd A., Randolph-Moore, Lynne, Gambello, Micheal J., ...

A common method for generating mice with subtle genetic manipulations uses homologous recombination (HR) in embryonic stem (ES) cells to replace a wild-type gene with a slightly modified one....

Ataxia telangiectasia mutated is essential during adult neurogenesis

Allen, Duane M., Van Praag, Henriette, Ray, Jasodhara, Weaver, Zoë, Winrow, Christopher J., Carter, Todd A., ...

Ataxia telangiectasia (A-T) is an autosomal recessive disease characterized by normal brain development followed by progressive neurodegeneration. The gene mutated in A-T (ATM) is a serine protein...

Mechanisms of aging in senescence-accelerated mice

Carter, Todd A, Greenhall, Jennifer A, Yoshida, Shigeo, Fuchs, Sebastian, Helton, Robert, Swaroop, Anand, ...

Gene-expression analysis and polymorphism screening to study molecular senescence of the retina and hippocampus in two rare inbred mouse models of accelerated neurological senescence as well as a...

Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases

Carter, Todd A., Wodicka, Lisa M., Shah, Neil P., Velasco, Anne Marie, Fabian, Miles A., Treiber, Daniel K., ...

To realize the full potential of targeted protein kinase inhibitors for the treatment of cancer, it is important to address the emergence of drug resistance in treated patients. Mutant forms of...