Miller, David M., Thornley, Thomas B., Pearson, Todd, Kruger, Annie Joseph, Yamazaki, Masahiro, Shultz, Leonard D., ...
Activation of TLR4 by administration of LPS shortens the survival of skin allografts in mice treated with costimulation blockade through a CD8 T cell-dependent, MyD88-dependent, and type I IFN...
Miller, David M., Thornley, Thomas B., Pearson, Todd, Yamazaki, Masahiro, Brehm, Michael A., Rossini, Aldo A., ...
We investigated the mechanisms by which Toll-like receptor (TLR) agonists affect the induction of mixed chimerism and skin allograft survival in mice treated with co-stimulation blockade (CB). We...
Mangada, Julie A., Pearson, Todd, Brehm, Michael A., Wicker, Linda S., Peterson, Laurence B., Shultz, Leonard D., ...
OBJECTIVE: NOD mice model human type 1 diabetes and are used to investigate tolerance induction protocols for islet transplantation in a setting of autoimmunity. However, costimulation blockade-based...
Pearson, Todd, Shultz, Leonard D., Miller, David M., King, Marie A., Laning, Joseph, Fodor, William, ...
Immunodeficient hosts engrafted with human lymphohaematopoietic cells hold great promise as a preclinical bridge for understanding human haematopoiesis and immunity. We now describe a new...
T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice (2008)
Kumar, Priti D., Ban, Hong-Seok, Kim, Sang-Soo, Wu, Haoquan, Pearson, Todd, Greiner, Dale L., ...
Evaluation of the therapeutic potential of RNAi for HIV infection has been hampered by the challenges of siRNA delivery and lack of suitable animal models. Using a delivery method for T cells, we...
Giassi, Lisa J., Pearson, Todd, Shultz, Leonard D., Laning, Joseph, Biber, Kristin, Kraus, Morey, ...
Umbilical cord blood (UCB) is increasingly being used for human hematopoietic stem cell (HSC) transplantation in children but often requires pooling multiple cords to obtain sufficient numbers for...
Pearson, Todd, Shultz, Leonard D., Lief, J., Burzenski, Lisa M., Gott, Bruce, Chase, T., ...
AIMS/HYPOTHESIS: To develop and validate a new immunodeficient mouse strain that spontaneously develops a non-autoimmune hyperglycaemia to serve as a diabetic host for human islets and human beta...
Creation of "humanized" mice to study human immunity (2008)
Pearson, Todd, Greiner, Dale L., Shultz, Leonard D.
"Humanized" mice are a promising translational model for studying human hematopoiesis and immunity. Their utility has been enhanced by the development of new stocks of immunodeficient hosts, most...
King, Marie A., Pearson, Todd, Shultz, Leonard D., Leif, Jean H., Bottino, Rita, Trucco, Massimo, ...
Immunodeficient NOD-scid mice bearing a targeted mutation in the IL2 receptor common gamma chain (Il2rgamma(null)) readily engraft with human stem cells. Here we analyzed human peripheral blood...
A novel alloantigen-specific CD8+PD1+ regulatory T cell induced by ICOS-B7h blockade in vivo (2007)
Izawa, Atsushi, Yamaura, Kazuhiro, Albin, Monica J., Jurewicz, Mollie, Tanaka, Katsunori, Clarkson, Michael R., ...
Delayed ICOS-B7h signal blockade promotes significant prolongation of cardiac allograft survival in wild-type but not in CD8-deficient C57BL/6 recipients of fully MHC-mismatched BALB/c heart...
Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice (2007)
Yamazaki, Masahiro, Pearson, Todd, Brehm, Michael A., Miller, David M., Mangada, Julie A., Markees, Thomas G., ...
Regulatory T cells (Treg) are important in peripheral tolerance, but their role in establishing and maintaining hematopoietic mixed chimerism and generating central tolerance is unclear. We now show...
Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity (2007)
King, Marie A., Pearson, Todd, Shultz, Leonard D., Leif, Jean H., Bottino, Rita, Trucco, Massimo, ...
The use of "humanized" mice represents an appealing translational model for studies of the pathogenesis of immune-mediated diseases and for the evaluation of potential therapeutics. The utility of...
Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity (2007)
King, Marie A., Pearson, Todd, Shultz, Leonard D., Leif, Jean, Bottino, Rita, Trucco, Massimo, ...
The use of "humanized" mice represents an appealing translational model for studies of the pathogenesis of immune-mediated diseases and for the evaluation of potential therapeutics. The utility of...
Humanized NOD/LtSz-scid IL2 receptor common gamma chain knockout mice in diabetes research (2007)
Shultz, Leonard D., Pearson, Todd, King, Marie A., Giassi, Lisa J., Carney, Lisa, Gott, Bruce, ...
There are many rodent models of autoimmune diabetes that have been used to study the pathogenesis of human type 1 diabetes (T1D), including the non-obese diabetic (NOD) mouse, the biobreeding (BB)...
Serreze, David V., Osborne, Melissa A., Chen, Yi-Guang, Chapman, Harold D., Pearson, Todd, Brehm, Michael A., ...
In both humans and NOD mice, particular combinations of MHC genes provide the primary risk factor for development of the autoreactive T cell responses causing type 1 diabetes (T1D). Conversely, other...
Brehm, Michael A., Mangada, Julie A., Markees, Thomas G., Pearson, Todd, Daniels, Keith A., Thornley, Thomas B., ...
Allograft transplantation requires chronic immunosuppression, but there is no effective strategy to evaluate the long-term maintenance of immunosuppression other than assessment of graft function....
Markees, Thomas G., Pearson, Todd, Cuthbert, Amy, Pearson, Andrea L., Shultz, Leonard D., Leif, Jean H., ...
BACKGROUND: Treatment with anti-CD154 monoclonal antibody (mAb) plus a donor-specific transfusion (DST) of spleen cells prolongs skin allograft survival in mice through a mechanism involving deletion...
Pearson, Todd, Weiser, Peter, Markees, Thomas G., Serreze, David V., Wicker, Linda S., Peterson, Laurence B., ...
NOD mice develop type 1 autoimmune diabetes and exhibit genetically dominant resistance to transplantation tolerance induction. These two phenotypes are genetically separable. Costimulation blockade...
Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms (2003)
Pearson, Todd, Markees, Thomas G., Serreze, David V., Pierce, Melissa A., Wicker, Linda S., Peterson, Laurence B., ...
Recent advances in islet transplantation have enabled physicians to cure type 1 autoimmune diabetes, but at the cost of lifelong immunosuppression with its attendant side effects and long-term health...
Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice (2003)
Pearson, Todd, Markees, Thomas G., Serreze, David V., Pierce, Melissa A., Wicker, Linda S., Peterson, Laurence B., ...
Pearson, Todd, Markees, Thomas G., Serreze, David V., Pierce, Melissa A., Marron, Michele P., Wicker, Linda S., ...
Curing type 1 diabetes by islet transplantation requires overcoming both allorejection and recurrent autoimmunity. This has been achieved with systemic immunosuppression, but tolerance induction...
The NOD mouse is a widely studied model of type 1 diabetes. The loss of self-tolerance leading to autoimmune diabetes in NOD mice involves at least 27 genetic loci. Curing type I diabetes in mice and...
Pearson, Todd, Markees, Thomas G., Wicker, Linda S., Serreze, David V., Peterson, Laurence B., Mordes, John P., ...
The loss of self-tolerance leading to autoimmune type 1 diabetes in the NOD mouse model involves at least 19 genetic loci. In addition to their genetic defects in self-tolerance, NOD mice resist...
Thesis (Ph. D.)--University of Massachusetts Graduate School of Biomedical Sciences, 2003.
Stavnezer, Janet, Bradley, Sean P., Rousseau, Norman, Pearson, Todd, Shanmugam, Ananth, Waite, Debra J., ...
Ab class switching is induced upon B cell activation in vivo by immunization or infection or in vitro by treatment with mitogens, e. g. LPS, and results in the expression of different heavy chain...
Brehm, Michael A., Mangada, Julie, Markees, Thomas G., Pearson, Todd, Daniels, Keith A., Thornley, Thomas B., ...
Allograft transplantation requires chronic immunosuppression, but there is no effective strategy to evaluate the long-term maintenance of immunosuppression other than assessment of graft function....