Voltage-gated ion channels and gating modifier toxins. (2007)
Catterall, William, Cestèle, Sandrine, Yarov-Yarovoy, Vladimir, Yu, Frank, Konoki, Keiichi, Scheuer, Todd
Voltage-gated sodium, calcium, and potassium channels generate electrical signals required for action potential generation and conduction and are the molecular targets for a broad range of potent...
Voltage-gated ion channels and gating modifier toxins. (2007)
Catterall, William, Cestèle, Sandrine, Yarov-Yarovoy, Vladimir, Yu, Frank, Konoki, Keiichi, Scheuer, Todd
Voltage-gated sodium, calcium, and potassium channels generate electrical signals required for action potential generation and conduction and are the molecular targets for a broad range of potent...
Voltage-gated ion channels and gating modifier toxins. (2007)
Catterall, William, Cestèle, Sandrine, Yarov-Yarovoy, Vladimir, Yu, Frank, Konoki, Keiichi, Scheuer, Todd
Voltage-gated sodium, calcium, and potassium channels generate electrical signals required for action potential generation and conduction and are the molecular targets for a broad range of potent...
Frank H Yu, Massimo Mantegazza, Ruth E Westenbroek, Carol A Robbins, Franck Kalume, Kimberly A Burton, ...
Voltage-gated ion channels and gating modifier toxins. (2007)
Catterall, William, Cestèle, Sandrine, Yarov-Yarovoy, Vladimir, Yu, Frank, Konoki, Keiichi, Scheuer, Todd
Voltage-gated sodium, calcium, and potassium channels generate electrical signals required for action potential generation and conduction and are the molecular targets for a broad range of potent...
Voltage-gated ion channels and gating modifier toxins. (2007)
Catterall, William, Cestèle, Sandrine, Yarov-Yarovoy, Vladimir, Yu, Frank, Konoki, Keiichi, Scheuer, Todd
Voltage-gated sodium, calcium, and potassium channels generate electrical signals required for action potential generation and conduction and are the molecular targets for a broad range of potent...
Voltage-gated ion channels and gating modifier toxins. (2007)
Catterall, William, Cestèle, Sandrine, Yarov-Yarovoy, Vladimir, Yu, Frank, Konoki, Keiichi, Scheuer, Todd
Voltage-gated sodium, calcium, and potassium channels generate electrical signals required for action potential generation and conduction and are the molecular targets for a broad range of potent...
Voltage-gated ion channels and gating modifier toxins. (2007)
Catterall, William, Cestèle, Sandrine, Yarov-Yarovoy, Vladimir, Yu, Frank, Konoki, Keiichi, Scheuer, Todd
Voltage-gated sodium, calcium, and potassium channels generate electrical signals required for action potential generation and conduction and are the molecular targets for a broad range of potent...
Voltage-gated ion channels and gating modifier toxins. (2007)
Catterall, William, Cestèle, Sandrine, Yarov-Yarovoy, Vladimir, Yu, Frank, Konoki, Keiichi, Scheuer, Todd
Voltage-gated sodium, calcium, and potassium channels generate electrical signals required for action potential generation and conduction and are the molecular targets for a broad range of potent...
Frank H Yu, Massimo Mantegazza, Ruth E Westenbroek, Carol A Robbins, Franck Kalume, Kimberly A Burton, ...
Cestèle, Sandrine, Yarov-Yarovoy, Vladimir, Qu, Yusheng, Sampieri, François, Scheuer, Todd, Catterall, William
Voltage sensing by voltage-gated sodium channels determines the electrical excitability of cells, but the molecular mechanism is unknown. beta-Scorpion toxins bind specifically to neurotoxin receptor...
Cestèle, Sandrine, Yarov-Yarovoy, Vladimir, Qu, Yusheng, Sampieri, François, Scheuer, Todd, Catterall, William
Voltage sensing by voltage-gated sodium channels determines the electrical excitability of cells, but the molecular mechanism is unknown. beta-Scorpion toxins bind specifically to neurotoxin receptor...
Cestèle, Sandrine, Yarov-Yarovoy, Vladimir, Qu, Yusheng, Sampieri, François, Scheuer, Todd, Catterall, William
Voltage sensing by voltage-gated sodium channels determines the electrical excitability of cells, but the molecular mechanism is unknown. beta-Scorpion toxins bind specifically to neurotoxin receptor...
Cestèle, Sandrine, Yarov-Yarovoy, Vladimir, Qu, Yusheng, Sampieri, François, Scheuer, Todd, Catterall, William
Voltage sensing by voltage-gated sodium channels determines the electrical excitability of cells, but the molecular mechanism is unknown. beta-Scorpion toxins bind specifically to neurotoxin receptor...
Cestèle, Sandrine, Yarov-Yarovoy, Vladimir, Qu, Yusheng, Sampieri, François, Scheuer, Todd, Catterall, William
Voltage sensing by voltage-gated sodium channels determines the electrical excitability of cells, but the molecular mechanism is unknown. beta-Scorpion toxins bind specifically to neurotoxin receptor...
Cestèle, Sandrine, Yarov-Yarovoy, Vladimir, Qu, Yusheng, Sampieri, François, Scheuer, Todd, Catterall, William
Voltage sensing by voltage-gated sodium channels determines the electrical excitability of cells, but the molecular mechanism is unknown. beta-Scorpion toxins bind specifically to neurotoxin receptor...
Cestèle, Sandrine, Yarov-Yarovoy, Vladimir, Qu, Yusheng, Sampieri, François, Scheuer, Todd, Catterall, William
Voltage sensing by voltage-gated sodium channels determines the electrical excitability of cells, but the molecular mechanism is unknown. beta-Scorpion toxins bind specifically to neurotoxin receptor...
Cestèle, Sandrine, Yarov-Yarovoy, Vladimir, Qu, Yusheng, Sampieri, François, Scheuer, Todd, Catterall, William
Voltage sensing by voltage-gated sodium channels determines the electrical excitability of cells, but the molecular mechanism is unknown. beta-Scorpion toxins bind specifically to neurotoxin receptor...
Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP (2005)
V. Monica Bricelj, Laurie Connell, Keiichi Konoki, Scott P. MacQuarrie, Todd Scheuer, William A. Catterall, ...
Reciprocal regulation of P/Q-type Ca2+ channels by SNAP-25,syntaxin and synaptotagmin (1999)
Huijun Zhong, Charles T. Yokoyama, Todd Scheuer, William A. Catterall
Ca2+/calmodulin binds to and modulates P/Q-type calcium channels (1999)
Amy Lee, Scott T. Wong, Daniel Gallagher, Bin Li, Daniel R. Storm, Todd Scheuer, ...
McHugh, Damian, Sharp, Elizabeth M., Scheuer, Todd, Catterall, William A.
We have investigated the mechanism underlying the modulation of the cardiac L-type Ca2+ current by protein kinase C (PKC). Using the patch-clamp technique, we found that PKC activation by...
Potent blockade of sodium channels and protection of brain tissue from ischemia by BIII 890 CL
Carter, Adrian J., Grauert, Matthias, Pschorn, Uwe, Bechtel, Wolf Dietrich, Bartmann-Lindholm, Christina, Qu, Yusheng, ...
We have synthesized a new benzomorphan derivative, 2R-[2α,3(S*),6α]-1,2,3,4,5,6-hexahydro-6,11,11-trimethyl-3-[2-(phenylmethoxy)propyl]-2,6-methano-3-benzazocin-10-ol hydrochloride (BIII 890 CL),...
Herlitze, Stefan, Hockerman, Gregory H., Scheuer, Todd, Catterall, William A.
Synaptic transmission is regulated by G protein-coupled receptors whose activation releases G protein βγ subunits that modulate presynaptic Ca2+ channels. The sequence motif QXXER has been proposed...
Burton, Kimberly A., Johnson, Barry D., Hausken, Zachary E., Westenbroek, Ruth E., Idzerda, Rejean L., Scheuer, Todd, ...
Preferential phosphorylation of specific proteins by cAMP-dependent protein kinase (PKA) may be mediated in part by the anchoring of PKA to a family of A-kinase anchor proteins (AKAPs) positioned in...
Linford, Nancy J., Cantrell, Angela R., Qu, Yusheng, Scheuer, Todd, Catterall, William A.
The voltage-gated sodium channel is the site of action of more than six classes of neurotoxins and drugs that alter its function by interaction with distinct, allosterically coupled receptor sites....
Hockerman, Gregory H., Peterson, Blaise Z., Sharp, Elizabeth, Tanada, Timothy N., Scheuer, Todd, Catterall, William A.
The activity of l-type Ca2+ channels is increased by dihydropyridine (DHP) agonists and inhibited by DHP antagonists, which are widely used in the therapy of cardiovascular disease. These drugs bind...
Herlitze, Stefan, Zhong, Huijun, Scheuer, Todd, Catterall, William A.
N-type and P/Q-type Ca2+ channels are inhibited by neurotransmitters acting through G protein-coupled receptors in a membrane-delimited pathway involving Gβγ subunits. Inhibition is caused by a...
Zhong, Huijun, Li, Bin, Scheuer, Todd, Catterall, William A.
N-type Ca2+ channels can be inhibited by neurotransmitter-induced release of G protein βγ subunits. Two isoforms of Cav2.2 α1 subunits of N-type calcium channels from rat brain (Cav2.2a and...
Role of the C-terminal domain in inactivation of brain and cardiac sodium channels
Mantegazza, Massimo, Yu, Frank H., Catterall, William A., Scheuer, Todd
Inactivation is a fundamental characteristic of Na+ channels, and small changes cause skeletal muscle paralysis and myotonia, epilepsy, and cardiac arrhythmia. Brain Nav1.2a channels have faster...
Maier, Sebastian K. G., Westenbroek, Ruth E., Schenkman, Kenneth A., Feigl, Eric O., Scheuer, Todd, Catterall, William A.
Voltage-gated sodium channels composed of pore-forming α and auxiliary β subunits are responsible for the rising phase of the action potential in cardiac muscle, but the functional roles of...
Chen, Chunling, Bharucha, Vandana, Chen, Yuan, Westenbroek, Ruth E., Brown, Angus, Malhotra, Jyoti Dhar, ...
Sodium channel β-subunits modulate channel gating, assembly, and cell surface expression in heterologous cell systems. We generated β2−/− mice to investigate the role of β2 in control of...
Mochida, Sumiko, Westenbroek, Ruth E., Yokoyama, Charles T., Zhong, Huijun, Myers, Scott J., Scheuer, Todd, ...
Cav2.1 channels, which conduct P/Q-type Ca2+ currents, were expressed in superior cervical ganglion neurons in cell culture, and neurotransmission initiated by these exogenously expressed Ca2+...
Maier, Sebastian K. G., Westenbroek, Ruth E., Yamanushi, T. T., Dobrzynski, H., Boyett, Mark R., Catterall, William A., ...
Voltage-gated Na+ channels are composed of pore-forming α and auxiliary β subunits. The majority of Na+ channels in the heart contain tetrodotoxin (TTX)-insensitive Nav1.5 α subunits, but...
Hulme, Joanne T., Lin, Teddy W.-C., Westenbroek, Ruth E., Scheuer, Todd, Catterall, William A.
Activation of β-adrenergic receptors and consequent phosphorylation by cAMP-dependent protein kinase A (PKA) greatly increases the L-type Ca2+ current through CaV1.2 channels in isolated cardiac...
Molecular determinants of Ca2+/calmodulin-dependent regulation of Cav2.1 channels
Lee, Amy, Zhou, Hong, Scheuer, Todd, Catterall, William A.
Ca2+-dependent facilitation and inactivation (CDF and CDI) of Cav2.1 channels modulate presynaptic P/Q-type Ca2+ currents and contribute to activity-dependent synaptic plasticity. This dual feedback...
Zhao, Yong, Scheuer, Todd, Catterall, William A.
Members of the voltage-gated-like ion channel superfamily have a conserved pore structure. Transmembrane helices that line the pore (M2 or S6) are thought to gate it at the cytoplasmic end by bending...
Johnson, Barry D., Scheuer, Todd, Catterall, William A.
The skeletal muscle L-type Ca2+ channel (CaV1.1), which is responsible for initiating muscle contraction, is regulated by phosphorylation by cAMP-dependent protein kinase (PKA) in a voltage-dependent...
Differential modulation of Cav2.1 channels by calmodulin and Ca2+-binding protein 1
Lee, Amy, Westenbroek, Ruth E., Haeseleer, Françoise, Palczewski, Krzysztof, Scheuer, Todd, Catterall, William A.
Cav2.1 channels, which mediate P/Q-type Ca2+ currents, undergo Ca2+/calmodulin (CaM)-dependent inactivation and facilitation that can significantly alter synaptic efficacy. Here we report that the...
McHugh, Damian, Sharp, Elizabeth M., Scheuer, Todd, Catterall, William A.
We have investigated the mechanism underlying the modulation of the cardiac L-type Ca2+ current by protein kinase C (PKC). Using the patch-clamp technique, we found that PKC activation by...
Potent blockade of sodium channels and protection of brain tissue from ischemia by BIII 890 CL
Carter, Adrian J., Grauert, Matthias, Pschorn, Uwe, Bechtel, Wolf Dietrich, Bartmann-Lindholm, Christina, Qu, Yusheng, ...
We have synthesized a new benzomorphan derivative, 2R-[2α,3(S*),6α]-1,2,3,4,5,6-hexahydro-6,11,11-trimethyl-3-[2-(phenylmethoxy)propyl]-2,6-methano-3-benzazocin-10-ol hydrochloride (BIII 890 CL),...
Herlitze, Stefan, Hockerman, Gregory H., Scheuer, Todd, Catterall, William A.
Synaptic transmission is regulated by G protein-coupled receptors whose activation releases G protein βγ subunits that modulate presynaptic Ca2+ channels. The sequence motif QXXER has been proposed...
Burton, Kimberly A., Johnson, Barry D., Hausken, Zachary E., Westenbroek, Ruth E., Idzerda, Rejean L., Scheuer, Todd, ...
Preferential phosphorylation of specific proteins by cAMP-dependent protein kinase (PKA) may be mediated in part by the anchoring of PKA to a family of A-kinase anchor proteins (AKAPs) positioned in...
Linford, Nancy J., Cantrell, Angela R., Qu, Yusheng, Scheuer, Todd, Catterall, William A.
The voltage-gated sodium channel is the site of action of more than six classes of neurotoxins and drugs that alter its function by interaction with distinct, allosterically coupled receptor sites....
Hockerman, Gregory H., Peterson, Blaise Z., Sharp, Elizabeth, Tanada, Timothy N., Scheuer, Todd, Catterall, William A.
The activity of l-type Ca2+ channels is increased by dihydropyridine (DHP) agonists and inhibited by DHP antagonists, which are widely used in the therapy of cardiovascular disease. These drugs bind...
Herlitze, Stefan, Zhong, Huijun, Scheuer, Todd, Catterall, William A.
N-type and P/Q-type Ca2+ channels are inhibited by neurotransmitters acting through G protein-coupled receptors in a membrane-delimited pathway involving Gβγ subunits. Inhibition is caused by a...
Zhong, Huijun, Li, Bin, Scheuer, Todd, Catterall, William A.
N-type Ca2+ channels can be inhibited by neurotransmitter-induced release of G protein βγ subunits. Two isoforms of Cav2.2 α1 subunits of N-type calcium channels from rat brain (Cav2.2a and...
Role of the C-terminal domain in inactivation of brain and cardiac sodium channels
Mantegazza, Massimo, Yu, Frank H., Catterall, William A., Scheuer, Todd
Inactivation is a fundamental characteristic of Na+ channels, and small changes cause skeletal muscle paralysis and myotonia, epilepsy, and cardiac arrhythmia. Brain Nav1.2a channels have faster...
Maier, Sebastian K. G., Westenbroek, Ruth E., Schenkman, Kenneth A., Feigl, Eric O., Scheuer, Todd, Catterall, William A.
Voltage-gated sodium channels composed of pore-forming α and auxiliary β subunits are responsible for the rising phase of the action potential in cardiac muscle, but the functional roles of...
Chen, Chunling, Bharucha, Vandana, Chen, Yuan, Westenbroek, Ruth E., Brown, Angus, Malhotra, Jyoti Dhar, ...
Sodium channel β-subunits modulate channel gating, assembly, and cell surface expression in heterologous cell systems. We generated β2−/− mice to investigate the role of β2 in control of...
Mochida, Sumiko, Westenbroek, Ruth E., Yokoyama, Charles T., Zhong, Huijun, Myers, Scott J., Scheuer, Todd, ...
Cav2.1 channels, which conduct P/Q-type Ca2+ currents, were expressed in superior cervical ganglion neurons in cell culture, and neurotransmission initiated by these exogenously expressed Ca2+...
Maier, Sebastian K. G., Westenbroek, Ruth E., Yamanushi, T. T., Dobrzynski, H., Boyett, Mark R., Catterall, William A., ...
Voltage-gated Na+ channels are composed of pore-forming α and auxiliary β subunits. The majority of Na+ channels in the heart contain tetrodotoxin (TTX)-insensitive Nav1.5 α subunits, but...
Hulme, Joanne T., Lin, Teddy W.-C., Westenbroek, Ruth E., Scheuer, Todd, Catterall, William A.
Activation of β-adrenergic receptors and consequent phosphorylation by cAMP-dependent protein kinase A (PKA) greatly increases the L-type Ca2+ current through CaV1.2 channels in isolated cardiac...
Molecular determinants of Ca2+/calmodulin-dependent regulation of Cav2.1 channels
Lee, Amy, Zhou, Hong, Scheuer, Todd, Catterall, William A.
Ca2+-dependent facilitation and inactivation (CDF and CDI) of Cav2.1 channels modulate presynaptic P/Q-type Ca2+ currents and contribute to activity-dependent synaptic plasticity. This dual feedback...
Zhao, Yong, Scheuer, Todd, Catterall, William A.
Members of the voltage-gated-like ion channel superfamily have a conserved pore structure. Transmembrane helices that line the pore (M2 or S6) are thought to gate it at the cytoplasmic end by bending...
Johnson, Barry D., Scheuer, Todd, Catterall, William A.
The skeletal muscle L-type Ca2+ channel (CaV1.1), which is responsible for initiating muscle contraction, is regulated by phosphorylation by cAMP-dependent protein kinase (PKA) in a voltage-dependent...
Hulme, Joanne T., Westenbroek, Ruth E., Scheuer, Todd, Catterall, William A.
During the fight-or-flight response, epinephrine and norepinephrine released by the sympathetic nervous system increase L-type calcium currents conducted by CaV1.2a channels in the heart, which...
Few, W. Preston, Scheuer, Todd, Catterall, William A.
In hippocampal pyramidal cells, dopamine acts at D1 receptors to reduce peak Na+ currents by activation of phosphorylation by PKA anchored via an A kinase-anchoring protein (AKAP15). However, the...
Hulme, Joanne T, Yarov-Yarovoy, Vladimir, Lin, Teddy W-C, Scheuer, Todd, Catterall, William A
Voltage-gated Ca2+ channels of the CaV1 family initiate excitation–contraction coupling in cardiac, smooth, and skeletal muscle and are primary targets for regulation by the sympathetic nervous...
Modulation of CaV1.2 Channels by Mg2+ Acting at an EF-hand Motif in the COOH-terminal Domain
Brunet, Sylvain, Scheuer, Todd, Klevit, Rachel, Catterall, William A.
Magnesium levels in cardiac myocytes change in cardiovascular diseases. Intracellular free magnesium (Mgi) inhibits L-type Ca2+ currents through CaV1.2 channels in cardiac myocytes, but the mechanism...
Cestèle, Sandrine, Scheuer, Todd, Mantegazza, Massimo, Rochat, Hervé, Catterall, William A.
β-Scorpion toxins shift the voltage dependence of activation of sodium channels to more negative membrane potentials, but only after a strong depolarizing prepulse to fully activate the channels....
Kellenberger, Stephan, West, James W., Scheuer, Todd, Catterall, William A.
Fast Na+ channel inactivation is thought to involve binding of phenylalanine 1489 in the hydrophobic cluster IFM in LIII-IV of the rat brain type IIA Na+ channel. We have analyzed macroscopic and...
Kellenberger, Stephan, West, James W., Catterall, William A., Scheuer, Todd
During inactivation of Na+ channels, the intracellular loop connecting domains III and IV is thought to fold into the channel protein and occlude the pore through interaction of the hydrophobic motif...
Increased Expression of the Cardiac L-type Calcium Channel in Estrogen Receptor–deficient Mice
Johnson, Barry D., Zheng, Wei, Korach, Kenneth S., Scheuer, Todd, Catterall, William A., Rubanyi, Gabor M.
Steroid hormones control the expression of many cellular regulators, and a role for estrogen in cardiovascular function and disease has been well documented. To address whether the activity of the...
Jiang, Xin, Lautermilch, Nathan J., Watari, Hirofumi, Westenbroek, Ruth E., Scheuer, Todd, Catterall, William A.
Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a key regulator of synaptic responses in the postsynaptic density, but understanding of its mechanisms of action in the presynaptic neuron is...
Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation
DeCaen, Paul G., Yarov-Yarovoy, Vladimir, Zhao, Yong, Scheuer, Todd, Catterall, William A.
The S4 transmembrane segments of voltage-gated ion channels move outward on depolarization, initiating a conformational change that opens the pore, but the mechanism of S4 movement is unresolved. One...
Sokolov, Stanislav, Scheuer, Todd, Catterall, William A.
Some inherited periodic paralyses are caused by mutations in skeletal muscle NaV1.4 sodium channels that alter channel gating and impair action potential generation. In the case of hypokalemic...
Temperature- and age-dependent seizures in a mouse model of severe myoclonic epilepsy in infancy
Oakley, John C., Kalume, Franck, Yu, Frank H., Scheuer, Todd, Catterall, William A.
Heterozygous loss-of-function mutations in the α subunit of the type I voltage-gated sodium channel NaV1.1 cause severe myoclonic epilepsy in infancy (SMEI), an infantile-onset epileptic...
Brunet, Sylvain, Scheuer, Todd, Catterall, William A.
L-type Ca2+ currents conducted by Cav1.2 channels initiate excitation–contraction coupling in cardiac myocytes. Intracellular Mg2+ (Mgi) inhibits the ionic current of Cav1.2 channels. Because Mgi...
Sequential formation of ion pairs during activation of a sodium channel voltage sensor
DeCaen, Paul G., Yarov-Yarovoy, Vladimir, Sharp, Elizabeth M., Scheuer, Todd, Catterall, William A.
Electrical signaling in biology depends upon a unique electromechanical transduction process mediated by the S4 segments of voltage-gated ion channels. These transmembrane segments are driven outward...