Tom R. Gaunt

A study of relationships between single nucleotide polymorphisms from the growth hormone-insulin-like growth factor axis and bone mass: the Hertfordshire cohort study (2009)

Dennison, Elaine M., Syddall, Holly E., Jameson, Karen A., Sayer, Avan Aihie, Gaunt, Tom R., Rodriguez, Santiago, ...

Objective: we sought evidence of association of candidate single nucleotide polymorphisms (SNP) within the growth hormone-insulin-like growth factor 1 (IGF1) axis, largely selected on the basis of...

Hardy-Weinberg Equilibrium Testing of Biological Ascertainment for Mendelian Randomization Studies (2009)

Rodriguez, Santiago, Gaunt, Tom R., Day, Ian N. M.

Mendelian randomization (MR) permits causal inference between exposures and a disease. It can be compared with randomized controlled trials. Whereas in a randomized controlled trial the randomization...

TAS2R38 (phenylthiocarbamide) haplotypes, coronary heart disease traits, and eating behavior in the British Women’s Heart and Health Study 1–4 (2008)

Nic J Timpson, Mikkel Christensen, Debbie A Lawlor, Tom R Gaunt, Ian N Day, Shah Ebrahim, ...

Background: Variation in the perception of bitter tastes has been associated with eating behavior, body composition, and cardiovascular disease. Recent observations have implicated 2 common...

Cubic exact solutions for the estimation of pairwise haplotype frequencies: implications for linkage disequilibrium analyses and a web tool 'CubeX' (2007)

Gaunt, Tom R, Rodríguez, Santiago, Day, Ian NM

Abstract Background The frequency of a haplotype comprising one allele at each of two loci can be expressed as a cubic equation (the 'Hill equation'), the solution of which gives that frequency. Most...

Quantitated transcript haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186:A>C), and relevance to metabolic syndrome traits (2007)

Abdollahi, Mohammad R., Lewis, Rohan M., Gaunt, Tom R., Cumming, Debbie V.E., Rodriguez, Santiago, Rose-Zerilli, Matthew, ...

The angiotensin II type 1 receptor (AGTR1) is the main target through which angiotensin II influences cardiovascular tone, cell growth, and fluid and electrolyte balance. AGTR1 polymorphism has been...

Quantitated transcript haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186:A>C), and relevance to metabolic syndrome traits17 (2007)

Abdollahi, Mohammad R., Lewis, Rohan M., Gaunt, Tom R., Cumming, Debbie V., Rodriguez, Santiago, Rose-Zerilli, Matthew, ...

The angiotensin II type 1 receptor (AGTR1) is the main target through which angiotensin II influences cardiovascular tone, cell growth, and fluid and electrolyte balance. AGTR1 polymorphism has been...

Interaction between birthweight and polymorphism in the calcium-sensing receptor gene in determination of adult bone mass: the Hertfordshire cohort study (2007)

Lips, Mirjam A., Syddall, Holly E., Gaunt, Tom R., Rodriguez, Santiago, Day, Ian N.M., Cooper, Cyrus, ...

OBJECTIVE: We sought evidence of interaction between single-nucleotide polymorphisms (SNP) in the calcium-sensing receptor (CASR) gene and early life in determination of bone mineral density (BMD)...

The association of the paraoxonase (PON1) Q192R polymorphism with depression in older women: findings from the British women's heart and health study (2007)

Lawlor, Debbie A., Day, Ian N.M., Gaunt, Tom R., Hinks, Lesley J., Timpson, Nick, Ebrahim, Shah, ...

Background: The association between the R allele of PON1 Q192R and symptoms reported by sheep dippers and Gulf War veterans has been used to suggest a biological basis for these symptoms. In the...

Comment on: Marchand and Polychronakos (2007) Evaluation of polymorphic splicing in the mechanism of the association of the insulin gene with diabetes: Diabetes 56:709-713 (2007)

Rodriguez, Santiago, Gaunt, Tom R., Vorechovsky, Igor, Kralovicova, Jana, Wood, Peter J., Day, Ian N.M.

Questioning INS VNTR role in obesity and diabetes: subclasses tag IGF2-INS-TH haplotypes; and -23HphI as a STEP (splicing and translational efficiency polymorphism) (2006)

Day, Ian N.M., Rodriguez, Santiago, Kralovicova, Jana, Wood, Peter J., Vorechovsky, Igor, Gaunt, Tom R.

MIDAS: software for analysis and visualisation of interallelic disequilibrium between multiallelic markers (2006)

Gaunt, Tom R, Rodriguez, Santiago, Zapata, Carlos, Day, Ian NM

Abstract Background Various software tools are available for the display of pairwise linkage disequilibrium across multiple single nucleotide polymorphisms. The HapMap project also presents these...

MIDAS: software for analysis and visualisation of interallelic disequilibrium between multiallelic markers (2006)

Gaunt, Tom R., Rodriguez, Santiago, Zapata, Carlos, Day, Ian N.M.

Background Various software tools are available for the display of pairwise linkage disequilibrium across multiple single nucleotide polymorphisms. The HapMap project also presents these graphics...

The association of the PON1 Q192R polymorphism with complications and outcomes of pregnancy: findings from the British Women's Heart and Health cohort study (2006)

Lawlor, Debbie A., Gaunt, Tom R., Hinks, Lesley J., Smith, George Davey, Timpson, Nick, Day, Ian N.M., ...

It has been hypothesised that paraoxonase genes would be related to adverse pregnancy outcomes, via a maternal or fetal effect on placental hypoperfusion and thrombosis. To date only two studies have...

Variants in the Human Insulin Gene That Affect Pre-mRNA Splicing: Is -23HphI a Functional Single Nucleotide Polymorphism at IDDM2? (2006)

Královiová, Jana, Gaunt, Tom R., Rodriguez, Santiago, Wood, Peter J., Day, Ian N.M., Voechovsky, Igor

Predisposition to type 1 diabetes and juvenile obesity is influenced by the susceptibility locus IDDM2 that includes the insulin gene (INS). Although the risk conferred by IDDM2 has been attributed...

A study of TH01 and IGF2-INS-TH haplotypes in relation to smoking initiation in three independent surveys (2006)

Rodriguez, Santiago, Huang, Shuwen, Chen, Xiao-he, Gaunt, Tom R., Syddall, Holly E., Gilg, Julie A., ...

OBJECTIVES: Recent studies suggest an association between a microsatellite locus (TH01) located in intron 1 of the tyrosine hydroxylase gene (TH) and nicotine dependence. We aimed here to study...

Replication of IGF2-INS-TH*5 haplotype effect on obesity in older men and study of related phenotypes (2006)

Rodríguez, Santiago, Gaunt, Tom R., Dennison, Elaine, Chen, Xiao-he, Syddall, Holly E., Phillips, David I.W., ...

Interindividual variation of the IGF2-INS-TH region influences risk of a variety of diseases and complex traits. Previous studies identified a haplotype (designated IGF2-INS-TH*5 and tagged by allele...

A study of TH01 and IGF2-INS-TH haplotypes in relation to smoking initiation in three independent surveys (2006)

Rodriguez, Santiago, Huang, Shuwen, Chen, Xiao-he, Gaunt, Tom R., Syddall, Holly E., Gilg, Julie A., ...

Objectives: Recent studies suggest an association between a microsatellite locus (TH01) located in intron 1 of the tyrosine hydroxylase gene (TH) and nicotine dependence. We aimed here to study...

Variants in the human insulin gene that affect Pre-mRNA splicing: is -23HphI a functional single nucleotide polymorphism at IDDM2? (2006)

Kralovicova, Jana, Gaunt, Tom R., Rodriguez, Santiago, Wood, Peter J., Day, Ian N.M., Vorechovsky, Igor

Predisposition to type 1 diabetes and juvenile obesity is influenced by the susceptibility locus IDDM2 that includes the insulin gene (INS). Although the risk conferred by IDDM2 has been attributed...

Replication of IGF2-INS-TH(*)5 haplotype effect on obesity in older men and study of related phenotypes (2006)

Rodriguez, Santiago, Gaunt, Tom R., Dennison, Elaine, Chen, Xiao-he, Syddall, Holly E., Phillips, Davide I.W., ...

Interindividual variation of the IGF2-INS-TH region influences risk of a variety of diseases and complex traits. Previous studies identified a haplotype (designated IGF2-INS-TH(*)5 and tagged by...

Experience applying light typerTM methodology to human SNPs relevant to growth and cardiovascular risk (2006)

Gaunt, Tom R., Hinks, Lesley J., Christensen, Mikkel B., Kiessling, Matthew, Day, Ian N.M.

Madge-based technologies for identification of unknown mutations at the population level: MeltMADGE and EndoVII-MADGE (2006)

Smith, Mathew J., Alharbi, Khalid K., Aldahmesh, Mohammed A., Hou, Guangwei, Chen, Xiao-he, ...

C-reactive protein and its role in metabolic syndrome: mendelian randomisation study (2005)

Timpson, Nicholas J., Lawlor, Debbie A., Harbord, Roger M., Gaunt, Tom R., Day, Proflan N.M., Palmer, Lyle J., ...

BACKGROUND: Circulating C-reactive protein (CRP) is associated with the metabolic syndrome and might be causally linked to it. Our aim was to generate estimates of the association between plasma CRP...

Microplate array diagonal gel electrophoresis for SNP and microsatellite genotyping and for mutation scanning (2004)

Day, Ian N.M., Gaunt, Tom R., Chen, Xiao-he, Ganderton, Rosalind H.

Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster (2004)

Day, Ian N. M., Chen, Xiao-He, Gaunt, Tom R., King, Tabitha H. T., Voropanov, Anca, Ye, Shu, ...

Low rates of fetal and infant growth are associated with the metabolic syndrome and cardiovascular disease in later life. We investigated common genetic variation in the GH-CSH gene cluster on...

Experience applying Light TyperTM methodology to human SNPs relevant to growth and cardiovascular risk (2004)

Gaunt, Tom R., Hinks, Lesley J., Christensen, Mikkel B., Kiessling, Matthew, Day, Ian N.M.

MADGE-based technologies for identification of unknown mutations at the population level: MeltMADGE and EndoVII-MADGE (2004)

Smith, Matthew J., Alharbi, Khalid K., Aldahmesh, Mohammed A., Hou, Guangwei, Chen, Xiao-he, ...

The association of the PON1Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis (2004)

Lawlor, Debbie A, Day, Ian NM, Gaunt, Tom R, Hinks, Lesley J, Briggs, Patricia J, Kiessling, Matthew, ...

Abstract Background There have been inconsistent results from case-control studies assessing the association of the PON1 Q192R polymorphism with coronary heart disease (CHD). Most studies have...

The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis (2004)

Lawlor, Debbie A., Day, Ian N.M., Gaunt, Tom R., Hinks, Lesley J., Briggs, Patricia J., Kiessling, Matthew, ...

Background There have been inconsistent results from case-control studies assessing the association of the PON1 Q192R polymorphism with coronary heart disease (CHD). Most studies have included...

The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis (2004)

Lawlor, Debbie A., Day, Ian N.M., Gaunt, Tom R., Hinks, Lesley J., Briggs, Patricia J., Kiessling, Matthew, ...

Background There have been inconsistent results from case-control studies assessing the association of the PON1 Q192R polymorphism with coronary heart disease (CHD). Most studies have included...

Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster (2004)

Day, Ian N., Chen, Xiao-he, Gaunt, Tom R., King, Tabitha H.T., Voropanov, Anca, Ye, Shu, ...

Low rates of fetal and infant growth are associated with the metabolic syndrome and cardiovascular disease in later life. We investigated common genetic variation in the GH-CSH gene cluster on...

risk (2004)

Santiago Rodríguez, Tom R. Gaunt, Ra D. O’dell, Xiao-he Chen, Emma Hawe, George J Miller, ...

analyses of the IGF2-INS-TH gene cluster in relation to cardiovascular

Haplotypic analyses of the IGF2-INS-TH gene cluster in relation to cardiovascular risk traits (2004)

Rodríguez, Santiago, Gaunt, Tom R., O'Dell, Sandra D., Chen, Xiao-he, Gu, Dongfeng, Hawe, Emma, ...

The IGF2-INS-TH genomic region has been implicated in various common disorders including the metabolic syndrome, type 2 diabetes and coronary heart disease (CHD). Here we present detailed haplotype...

Haplotypic analyses of the IGF2-INS-TH gene cluster in relation to cardiovascular risk traits (2004)

Rodríguez, Santiago, Gaunt, Tom R., O'Dell, Sandra D., Chen, Xiao-he, Gu, Dongfeng, Hawe, Emma, ...

The IGF2–INS–TH genomic region has been implicated in various common disorders including the metabolic syndrome, type 2 diabetes and coronary heart disease (CHD). Here we present detailed...

Haplotypic analyses of the IGF2-INS-TH gene cluster in relation to cardiovascular risk traits (2004)

Rodríguez, Santiago, Gaunt, Tom R., O'Dell, Sandra D., Chen, Xiao-he, Gu, Dongfeng, Hawe, Emma, ...

The IGF2-INS-TH genomic region has been implicated in various common disorders including the metabolic syndrome, type 2 diabetes and coronary heart disease (CHD). Here we present detailed haplotype...

Common polymorphism in the growth hormone gene cluster and its relationship with cardiovascular disease and metabolic syndrome (2003)

Gaunt, Tom R., Chen, Xiao-he, King, Tabitha H.T., Voropanov, Anca, Shu, Ye, Rodriguez, Santiago, ...

Manual 768 or 384 well microplate gel 'dry' electrophoresis for PCR checking and SNP genotyping (2003)

Gaunt, Tom R., Hinks, Lesley J., Rassoulian, Hamid, Day, Ian N.M.

Electrophoresis continues to be a mainstay in molecular genetic laboratories for checking, sizing and separating both PCR products, nucleic acids derived from in vivo or in vitro sources and nucleic...

Manual 768 or 384 well microplate gel 'dry' electrophoresis for PCR checking and SNP genotyping (2003)

Gaunt, Tom R., Hinks, Lesley J., Rassoulian, Hamid, Day, Ian N.M.

Electrophoresis continues to be a mainstay in molecular genetic laboratories for checking, sizing and separating both PCR products, nucleic acids derived from in vivo or in vitro sources and nucleic...

Manual 768 or 384 well microplate gel 'dry' electrophoresis for PCR checking and SNP genotyping (2003)

Gaunt, Tom R., Hinks, Lesley J., Rassoulian, Hamid, Day, Ian N. M.

Electrophoresis continues to be a mainstay in molecular genetic laboratories for checking, sizing and separating both PCR products, nucleic acids derived from in vivo or in vitro sources and nucleic...

Null mutation in human ciliary neurotrophic factor gene confers higher body mass index in males (2002)

O'Dell, Sandra D., Syddall, Holly E., Sayer, Avan Aihie, Cooper, Cyrus, Fall, Caroline H.D., Dennison, Elaine M., ...

Ciliary neurotrophic factor (CNTF) administration reduces weight in leptin-resistant mice via the signalling pathway normally activated by leptin. A G>A null mutation in the CNTF gene results in...

Positive associations between single nucleotide polymorphisms in the IGF2 gene region and body mass index in adult males (2001)

Gaunt, Tom R., Cooper, Jacqueline A., Miller, George J., Day, Ian N.M., O'Dell, Sandra D.

We previously demonstrated an association between the insulin-like growth factor 2 (IGF2) gene 3'-untranslated region (3'-UTR) ApaI polymorphism and body mass index (BMI) in over 2500 middle-aged...

Positive associations between single nucleotide polymorphisms in the IGF2 gene region and body mass index in adult males (2001)

Gaunt, Tom R., Cooper, Jacqueline A., Miller, George J., Day, Ian N.M., O'Dell, Sandra

We previously demonstrated an association between the insulin-like growth factor 2 (IGF2) gene 3'-untranslated region (3'-UTR) ApaI polymorphism and body mass index (BMI) in over 2500 middle-aged...

Positive associations between single nucleotide polymorphisms in the IGF2 gene region and body mass index in adult males (2001)

Gaunt, Tom R., Cooper, Jacqueline A., Miller, George J., Day, Ian N.M., O’Dell, Sandra D.

We previously demonstrated an association between the insulin-like growth factor 2 (IGF2) gene 3′-untranslated region (3′-UTR) ApaI polymorphism and body mass index (BMI) in over 2500 middle-aged...

Manual 768 or 384 well microplate gel ‘dry’ electrophoresis for PCR checking and SNP genotyping

Gaunt, Tom R., Hinks, Lesley J., Rassoulian, Hamid, Day, Ian N. M.

Electrophoresis continues to be a mainstay in molecular genetic laboratories for checking, sizing and separating both PCR products, nucleic acids derived from in vivo or in vitro sources and nucleic...

The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis

Lawlor, Debbie A, Day, Ian NM, Gaunt, Tom R, Hinks, Lesley J, Briggs, Patricia J, Kiessling, Matthew, ...

MIDAS: software for analysis and visualisation of interallelic disequilibrium between multiallelic markers

Gaunt, Tom R, Rodriguez, Santiago, Zapata, Carlos, Day, Ian NM

Manual 768 or 384 well microplate gel ‘dry’ electrophoresis for PCR checking and SNP genotyping

Gaunt, Tom R., Hinks, Lesley J., Rassoulian, Hamid, Day, Ian N. M.

Electrophoresis continues to be a mainstay in molecular genetic laboratories for checking, sizing and separating both PCR products, nucleic acids derived from in vivo or in vitro sources and nucleic...

The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis

Lawlor, Debbie A, Day, Ian NM, Gaunt, Tom R, Hinks, Lesley J, Briggs, Patricia J, Kiessling, Matthew, ...

MIDAS: software for analysis and visualisation of interallelic disequilibrium between multiallelic markers

Gaunt, Tom R, Rodriguez, Santiago, Zapata, Carlos, Day, Ian NM

Cubic exact solutions for the estimation of pairwise haplotype frequencies: implications for linkage disequilibrium analyses and a web tool 'CubeX'

Gaunt, Tom R, Rodríguez, Santiago, Day, Ian NM

The Association of C-Reactive Protein and CRP Genotype with Coronary Heart Disease: Findings from Five Studies with 4,610 Cases amongst 18,637 Participants

Lawlor, Debbie A., Harbord, Roger M., Timpson, Nic J., Lowe, Gordon D. O., Rumley, Ann, Gaunt, Tom R., ...

Hardy-Weinberg Equilibrium Testing of Biological Ascertainment for Mendelian Randomization Studies

Rodriguez, Santiago, Gaunt, Tom R., Day, Ian N. M.

Mendelian randomization (MR) permits causal inference between exposures and a disease. It can be compared with randomized controlled trials. Whereas in a randomized controlled trial the randomization...