Hawley, Simon A, Boudeau, Jérôme, Reid, Jennifer L, Mustard, Kirsty J, Udd, Lina, Mäkelä, Tomi P, ...
Abstract Background The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy charge that acts as a 'metabolic master switch' and inhibits cell proliferation. Activation requires...
Growth arrest by the LKB1 tumor suppressor: induction of p21WAF1/CIP1 (2002)
Tiainen, Marianne, Vaahtomeri, Kari, Ylikorkala, Antti, Mäkelä, Tomi P.
Germline mutations of the LKB1 tumor suppressor gene lead to Peutz–Jeghers syndrome (PJS), with a predisposition to cancer. LKB1 encodes for a nuclear and cytoplasmic serine/threonine kinase,...
An Alu variable polyA repeat polymorphism upstream of L-myc at 1p32 (1992)
Mäkelä, Tomi P., Hellsten, Elina, Vesa, Jouni, Alitalo, Kari, Peltonen, Leena
Growth suppression by Lkb1 is mediated by a G1 cell cycle arrest
Tiainen, Marianne, Ylikorkala, Antti, Mäkelä, Tomi P.
Germ-line mutations of LKB1 (STK11) lead to Peutz–Jeghers syndrome characterized by gastrointestinal polyps and cancer of different organ systems. The mutations lead to loss or severe impairment of...
CAK-independent Activation of CDK6 by a Viral Cyclin
Kaldis, Philipp, Ojala, Päivi M., Tong, Lily, Mäkelä, Tomi P., Solomon, Mark J.
In normal cells, activation of cyclin-dependent kinases (cdks) requires binding to a cyclin and phosphorylation by the cdk-activating kinase (CAK). The Kaposi's sarcoma-associated herpesvirus encodes...
Inability to enter S phase and defective RNA polymerase II CTD phosphorylation in mice lacking Mat1
Rossi, Derrick J., Londesborough, Anou, Korsisaari, Nina, Pihlak, Arno, Lehtonen, Eero, Henkemeyer, Mark, ...
The trimeric Cdk7–cyclin H–Mat1 complex comprises the kinase subunit of basal transcription factor TFIIH and has been shown to function as a cyclin-dependent kinase (Cdk)-activating kinase....
Petrova, Tatiana V., Mäkinen, Taija, Mäkelä, Tomi P., Saarela, Janna, Virtanen, Ismo, Ferrell, Robert E., ...
Lymphatic vessels are essential for fluid homeostasis, immune surveillance and fat adsorption, and also serve as a major route for tumor metastasis in many types of cancer. We found that isolated...
Induction of cyclooxygenase-2 in a mouse model of Peutz–Jeghers polyposis
Rossi, Derrick J., Ylikorkala, Antti, Korsisaari, Nina, Salovaara, Reijo, Luukko, Keijo, Launonen, Virpi, ...
Inactivating germ-line mutations of LKB1 lead to Peutz–Jeghers syndrome (PJS). We have generated mice heterozygous for a targeted inactivating allele of Lkb1 and found that they develop severe...
Specificity of Cdk activation in vivo by the two Caks Mcs6 and Csk1 in fission yeast
Hermand, Damien, Westerling, Thomas, Pihlak, Arno, Thuret, Jean-Yves, Vallenius, Tea, Tiainen, Marianne, ...
Activating phosphorylation of cyclin-dependent kinases (Cdks) is mediated by at least two structurally distinct types of Cdk-activating kinases (Caks): the trimeric Cdk7–cyclin H–Mat1 complex in...
Hawley, Simon A, Boudeau, Jérôme, Reid, Jennifer L, Mustard, Kirsty J, Udd, Lina, Mäkelä, Tomi P, ...
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
Lizcano, Jose M, Göransson, Olga, Toth, Rachel, Deak, Maria, Morrice, Nick A, Boudeau, Jérôme, ...
We recently demonstrated that the LKB1 tumour suppressor kinase, in complex with the pseudokinase STRAD and the scaffolding protein MO25, phosphorylates and activates AMP-activated protein kinase...
The Histidine Triad Protein Hint Is Not Required for Murine Development or Cdk7 Function
Korsisaari, Nina, Rossi, Derrick J., Luukko, Keijo, Huebner, Kay, Henkemeyer, Mark, Mäkelä, Tomi P.
The histidine triad (HIT) protein Hint has been found to associate with mammalian Cdk7, as well as to interact both physically and genetically with the budding yeast Cdk7 homologue Kin28. To study...
Growth suppression by Lkb1 is mediated by a G1 cell cycle arrest
Tiainen, Marianne, Ylikorkala, Antti, Mäkelä, Tomi P.
Germ-line mutations of LKB1 (STK11) lead to Peutz–Jeghers syndrome characterized by gastrointestinal polyps and cancer of different organ systems. The mutations lead to loss or severe impairment of...
CAK-independent Activation of CDK6 by a Viral Cyclin
Kaldis, Philipp, Ojala, Päivi M., Tong, Lily, Mäkelä, Tomi P., Solomon, Mark J.
In normal cells, activation of cyclin-dependent kinases (cdks) requires binding to a cyclin and phosphorylation by the cdk-activating kinase (CAK). The Kaposi's sarcoma-associated herpesvirus encodes...
Inability to enter S phase and defective RNA polymerase II CTD phosphorylation in mice lacking Mat1
Rossi, Derrick J., Londesborough, Anou, Korsisaari, Nina, Pihlak, Arno, Lehtonen, Eero, Henkemeyer, Mark, ...
The trimeric Cdk7–cyclin H–Mat1 complex comprises the kinase subunit of basal transcription factor TFIIH and has been shown to function as a cyclin-dependent kinase (Cdk)-activating kinase....
Petrova, Tatiana V., Mäkinen, Taija, Mäkelä, Tomi P., Saarela, Janna, Virtanen, Ismo, Ferrell, Robert E., ...
Lymphatic vessels are essential for fluid homeostasis, immune surveillance and fat adsorption, and also serve as a major route for tumor metastasis in many types of cancer. We found that isolated...
Induction of cyclooxygenase-2 in a mouse model of Peutz–Jeghers polyposis
Rossi, Derrick J., Ylikorkala, Antti, Korsisaari, Nina, Salovaara, Reijo, Luukko, Keijo, Launonen, Virpi, ...
Inactivating germ-line mutations of LKB1 lead to Peutz–Jeghers syndrome (PJS). We have generated mice heterozygous for a targeted inactivating allele of Lkb1 and found that they develop severe...
Specificity of Cdk activation in vivo by the two Caks Mcs6 and Csk1 in fission yeast
Hermand, Damien, Westerling, Thomas, Pihlak, Arno, Thuret, Jean-Yves, Vallenius, Tea, Tiainen, Marianne, ...
Activating phosphorylation of cyclin-dependent kinases (Cdks) is mediated by at least two structurally distinct types of Cdk-activating kinases (Caks): the trimeric Cdk7–cyclin H–Mat1 complex in...
The Histidine Triad Protein Hint Is Not Required for Murine Development or Cdk7 Function
Korsisaari, Nina, Rossi, Derrick J., Luukko, Keijo, Huebner, Kay, Henkemeyer, Mark, Mäkelä, Tomi P.
The histidine triad (HIT) protein Hint has been found to associate with mammalian Cdk7, as well as to interact both physically and genetically with the budding yeast Cdk7 homologue Kin28. To study...
Hawley, Simon A, Boudeau, Jérôme, Reid, Jennifer L, Mustard, Kirsty J, Udd, Lina, Mäkelä, Tomi P, ...
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
Lizcano, Jose M, Göransson, Olga, Toth, Rachel, Deak, Maria, Morrice, Nick A, Boudeau, Jérôme, ...
We recently demonstrated that the LKB1 tumour suppressor kinase, in complex with the pseudokinase STRAD and the scaffolding protein MO25, phosphorylates and activates AMP-activated protein kinase...
Cdk8 Is Essential for Preimplantation Mouse Development▿†
Westerling, Thomas, Kuuluvainen, Emilia, Mäkelä, Tomi P.
The Cdk8 kinase and associated proteins form a nonessential transcriptional repressor module of the Mediator in the budding yeast Saccharomyces cerevisiae. Genetic analyses of this module have...
Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization
Partanen, Johanna I., Nieminen, Anni I., Mäkelä, Tomi P., Klefstrom, Juha
Cellular organization into epithelial architecture maintains structural integrity and homeostasis by suppressing cell proliferation and apoptosis. However, it is unclear whether the epithelial...
Mat1 Inhibits Peroxisome Proliferator-Activated Receptor γ-Mediated Adipocyte Differentiation▿ †
Helenius, Katja, Yang, Ying, Alasaari, Jukka, Mäkelä, Tomi P.
Mammalian Cdk7, cyclin H, and Mat1 form the kinase submodule of transcription factor IIH (TFIIH) and have been considered ubiquitously expressed elements of the transcriptional machinery. Here we...