Aoe, Tomohiko, Okamoto, Yasuhiro, Arase, Hisashi, Ikuta, Koichi, Miyazaki, Jun-ichi, Ono, Satoru, ...
Antigen recognition signals by the TCR are transduced through activation motifs present in the cytoplasmic region of CD3 chains. In vitro analysis has suggested that the CD3ζ chain mediates...
Aoe, Tomohiko, Goto, Shigemasa, Ohno, Hiroshi, Saito, Takashi
The TCR complex transduces the antigen recognition signal through common activation motifs present in both CD3γδϵ chains and ζ, dimers within the complex. We have investigated functional...
Ohno, Hiroshi, Aoe, Tomohiko, Ra, Chisel, Yamamoto, Tadashi, Saito, Takashi, Arai, K.
The structure and function of the TCR-CD3 complex containing a homodimer of the gamma chain of the high affinity receptor for IgE (FcRγ) (FcRγ+ TCR) was investigated by transfecting the FcRγ...
Aoe, Tomohiko, Ohno, Hiroshi, Sonta, Shin-ichi, Saito, Takashi, Watanebe, T.
Specific inactivation of the CD3ζ or CD3&eegr;; gene was introduced into a murine T cell hybridoma cell line by homologous recombination to elucidate the role of the CD3ζ chain in the assembly of...
Aoe, Tomohiko, Lee, Agnes J., Van Donselaar, Elly, Peters, Peter J., Hsu, Victor W.
Intracellular transport is best understood for how proteins are shuttled among different compartments of the secretory pathway by membrane-bound transport carriers. However, it remains unclear...
Otsuji, Mizuto, Kimura, Yoshimitsu, Aoe, Tomohiko, Okamoto, Yasuhiro, Saito, Takashi
One of the important mechanisms of immunosuppression in the tumor-bearing status has been attributed to the down-modulation of the CD3 ζ chain and its associated signaling molecules in T cells....
Yamamoto, Katsushi, Fujii, Rika, Toyofuku, Yukiko, Saito, Takashi, Koseki, Haruhiko, Hsu, Victor W., ...
Newly synthesized proteins in the endoplasmic reticulum (ER) must fold and assemble correctly before being transported to their final cellular destination. While some misfolded or partially assembled...
Hamada, Hiromichi, Suzuki, Masashi, Yuasa, Shigeki, Mimura, Naoya, Shinozuka, Norihiro, Takada, Yuki, ...
Aberrant protein folding beyond the capacity of endoplasmic reticulum (ER) quality control leads to stress response in the ER. The Lys-Asp-Glu-Leu (KDEL) receptor, a retrieval receptor for ER...
Aoe, Tomohiko, Lee, Agnes J., Van Donselaar, Elly, Peters, Peter J., Hsu, Victor W.
Intracellular transport is best understood for how proteins are shuttled among different compartments of the secretory pathway by membrane-bound transport carriers. However, it remains unclear...
Otsuji, Mizuto, Kimura, Yoshimitsu, Aoe, Tomohiko, Okamoto, Yasuhiro, Saito, Takashi
One of the important mechanisms of immunosuppression in the tumor-bearing status has been attributed to the down-modulation of the CD3 ζ chain and its associated signaling molecules in T cells....
Yamamoto, Katsushi, Fujii, Rika, Toyofuku, Yukiko, Saito, Takashi, Koseki, Haruhiko, Hsu, Victor W., ...
Newly synthesized proteins in the endoplasmic reticulum (ER) must fold and assemble correctly before being transported to their final cellular destination. While some misfolded or partially assembled...
Hamada, Hiromichi, Suzuki, Masashi, Yuasa, Shigeki, Mimura, Naoya, Shinozuka, Norihiro, Takada, Yuki, ...
Aberrant protein folding beyond the capacity of endoplasmic reticulum (ER) quality control leads to stress response in the ER. The Lys-Asp-Glu-Leu (KDEL) receptor, a retrieval receptor for ER...
Mimura, Naoya, Yuasa, Shigeki, Soma, Miho, Jin, Hisayo, Kimura, Keita, Goto, Shigemasa, ...
Binding immunoglobulin protein (BiP) is an endoplasmic reticulum (ER) molecular chaperone that is central to ER function. We examined knock-in mice expressing a mutant BiP in order to elucidate...