Tomokazu Matsuda

Reduced Insulin Signaling and Endoplasmic Reticulum Stress Act Synergistically to Deteriorate Pancreatic β Cell Function (2008)

Matsuda, Tomokazu, Kido, Yoshiaki, Uchida, Tohru, Kasuga, Masato

The total pancreatic β cell mass is reduced in individuals with type 2 diabetes. Weanalyzed the islets of leptin receptor-deficient (Lepr-/-) mice, a model animal for type 2diabetes with obesity....

PKCλ regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic β cells

Hashimoto, Naoko, Kido, Yoshiaki, Uchida, Tohru, Matsuda, Tomokazu, Suzuki, Kazuhisa, Inoue, Hiroshi, ...

Altered regulation of insulin secretion by glucose is characteristic of individuals with type 2 diabetes mellitus, although the mechanisms that underlie this change remain unclear. We have now...

PKCλ regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic β cells

Hashimoto, Naoko, Kido, Yoshiaki, Uchida, Tohru, Matsuda, Tomokazu, Suzuki, Kazuhisa, Inoue, Hiroshi, ...

Altered regulation of insulin secretion by glucose is characteristic of individuals with type 2 diabetes mellitus, although the mechanisms that underlie this change remain unclear. We have now...

Biphasic Response of Pancreatic β-Cell Mass to Ablation of Tuberous Sclerosis Complex 2 in Mice▿

Shigeyama, Yutaka, Kobayashi, Toshiyuki, Kido, Yoshiaki, Hashimoto, Naoko, Asahara, Shun-ichiro, Matsuda, Tomokazu, ...

Recent studies have demonstrated the importance of insulin or insulin-like growth factor 1 (IGF-1) for regulation of pancreatic β-cell mass. Given the role of tuberous sclerosis complex 2 (TSC2) as...