Yanada, Masamitsu, Kiyoi, Hitoshi, Murata, Makoto, Suzuki, Momoko, Iwai, Masanori, Yokozawa, Toshiya, ...
祖父江 元,高橋 雅英,吉田 純,貝淵 弘三,直江 知樹,村松 喬,鍋島 俊隆,二村 雄次,妹尾 久雄,西山 幸廣,古川 鋼一,錫村 明生,濱口 道成,村田 善晴,藤本...
Mechanism-based Therapy for Leukemia: A Lesson from Atra Therapy (2001)
In the past two decades, there has been a tremendous increase in our understanding of the molecular mechanism of human leukemias. Leukemias are now recognized as a deregulated state of cell...
Acute myeloid leukemia in the elderly : 159 Nagoya case studies (1999)
Nagura, Eiichi, Minami, Saburo, Nagata, Koichiro, Morishita, Yoshihisa, Takeyama, Hideo, Sao, Hiroshi, ...
To obtain background information on elderly acute myeloid leukemia (AML), unselected data covering 159 patients aged 60 years or over with AML from 14 hospitals in Nagoya, Japan was analyzed...
Matsui, Taei, Kunishima, Shinji, Hamako, Jiharu, Katayama, Masahiko, Kamiya, Tadashi, Naoe, Tomoki, ...
The binding of human von Willebrand factor (vWF) to a variety of extracellular matrix components immobilized on plates and the binding of vWF to platelet glycoprotein Ib (GPIb) after interacting with...
Nozaki, Naohito, Naoe, Tomoki, Okazaki, Tuneko
c-Myc protein contains a basic helix-loop-helix and leucine zipper (bHLHLZ) structure in its carboxyl terminal region, forms heterodimers with Max, and binds to the CACGTG sequence in DNA. A number...
Fukutani, Hisashi, Naoe, Tomoki, Saito, Hidehiko, Ohshima, Toshiteru, Omine, Mitsuhiro, Yasusada, Miura, ...
N-(2S, 3R)-3-amino-2-hydroxy-4-phenylbutyryl-L-leucine (ubenimex) was administered orally, to patients with myelodysplastic syndromes (MDS) and acute leukemia derived from MDS, in a multi- institute...
Kitagawa, Norihiko, Goto, Miyuki, Kurozumi, Kimikazu, Maruo, Seiji, Fukayama, Masashi, Naoe, Tomoki, ...
Akata and Mutu cell lines are derived from Burkitt’s lymphoma (BL) and retain the in vivo phenotype of Epstein–Barr virus (EBV) expression that is characterized by expression of EBV-determined...
Asano, Haruhiko, Murate, Takashi, Naoe, Tomoki, Saito, Hidehiko, Stamatoyannopoulos, George
We have cloned a gene, ZFF29 (zinc-finger protein of human fetal liver erythroid cells 29), from human fetal liver erythroid cells. Two types of mature mRNA were identified and designated ZFF29a and...
Kitagawa, Norihiko, Goto, Miyuki, Kurozumi, Kimikazu, Maruo, Seiji, Fukayama, Masashi, Naoe, Tomoki, ...
Akata and Mutu cell lines are derived from Burkitt’s lymphoma (BL) and retain the in vivo phenotype of Epstein–Barr virus (EBV) expression that is characterized by expression of EBV-determined...
Asano, Haruhiko, Murate, Takashi, Naoe, Tomoki, Saito, Hidehiko, Stamatoyannopoulos, George
We have cloned a gene, ZFF29 (zinc-finger protein of human fetal liver erythroid cells 29), from human fetal liver erythroid cells. Two types of mature mRNA were identified and designated ZFF29a and...
Hirose, Yuka, Kiyoi, Hitoshi, Itoh, Katsuhiko, Kato, Koji, Saito, Hidehiko, Naoe, Tomoki
Umbilical cord blood (CB) has been widely used instead of bone marrow (BM) and peripheral blood (PB) for stem cell transplantation (SCT). However, problems of sustained immunodeficiency after CB...
Yoshida, Hitoshi, Ichikawa, Hitoshi, Tagata, Yusuke, Katsumoto, Takuo, Ohnishi, Kazunori, Akao, Yukihiro, ...
PML and PU.1 play important roles in myeloid differentiation. PML-deficient mice have an impaired capacity for terminal maturation of their myeloid precursor cells. This finding has been explained,...
Xu, Jinglan, Suzuki, Momoko, Niwa, Yousuke, Hiraga, Junji, Nagasaka, Tetsuro, Ito, Masafumi, ...
Wnt signaling activates the canonical pathway and induces the accumulation of non-phosphorylated beta-catenin (NPBC) in the nucleus. Although this pathway plays an important role in the maintenance...
Wakui, Moe, Kuriyama, Kazutaka, Miyazaki, Yasushi, Hata, Tomoko, Taniwaki, Masafumi, Ohtake, Shigeki, ...
We reviewed and categorized 638 of 809 patients who were registered in the Japan Adult Leukemia Study Group acute myeloid leukemia (AML)-97 protocol using morphological means. Patients with the M3...
Akatsuka, Yoshiki, Nishida, Tetsuya, Kondo, Eisei, Miyazaki, Mikinori, Taji, Hirohumi, Iida, Hiroatsu, ...
We report the identification of two novel minor histocompatibility antigens (mHAgs), encoded by two separate single nucleotide polymorphisms on a single gene, BCL2A1, and restricted by human...
BCR-ABL-transformed GMP as myeloid leukemic stem cells
Minami, Yosuke, Stuart, Scott A., Ikawa, Tomokatsu, Jiang, Yong, Banno, Asoka, Hunton, Irina C., ...
During blast crisis of chronic myelogenous leukemia (CML), abnormal granulocyte macrophage progenitors (GMP) with nuclear β-catenin acquire self-renewal potential and may function as leukemic stem...
Nakayama, Takayuki, Matsushita, Tadashi, Yamamoto, Koji, Mutsuga, Noriko, Kojima, Tetsuhito, Katsumi, Akira, ...
von Willebrand factor (VWF) performs its hemostatic functions through binding to various proteins. The A1 domain of VWF contains binding sites of not only physiologically important ligands, but also...