Scientific Commons: Tong-Ming Fu

Manipulation of cytotoxic T lymphocyte (CTL) epitopes for enhancement of CTL recognition in vitro and induction of CTL responses in vivo /--by Tong-Ming Fu. (1994)

Fu, Tong-Ming

Thesis (Ph. D.)--Pennsylvania State University. The Milton S. Hershey Medical Center.

Putative Immunodominant Human Immunodeficiency Virus-Specific CD8+ T-Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype

Betts, Michael R., Casazza, Joseph P., Patterson, Brent A., Waldrop, Shar, Trigona, Wendy, Fu, Tong-Ming, ...

Recent studies of human immunodeficiency virus (HIV)-specific CD8+ T cells have focused on responses to single, usually HLA-A2-restricted epitopes as surrogate measures of the overall response to...

Protective CD4+ and CD8+ T Cells against Influenza Virus Induced by Vaccination with Nucleoprotein DNA

Ulmer, Jeffrey B., Fu, Tong-Ming, Deck, R. Randall, Friedman, Arthur, Guan, Liming, DeWitt, Corrille, ...

DNA vaccination is an effective means of eliciting both humoral and cellular immunity, including cytotoxic T lymphocytes (CTL). Using an influenza virus model, we previously demonstrated that...

Immunization with a Single Major Histocompatibility Complex Class I-Restricted Cytotoxic T-Lymphocyte Recognition Epitope of Herpes Simplex Virus Type 2 Confers Protective Immunity

Blaney, Joseph E., Nobusawa, Eri, Brehm, Michael A., Bonneau, Robert H., Mylin, Lawrence M., Fu, Tong-Ming, ...

We have evaluated the potential of conferring protective immunity to herpes simplex virus type 2 (HSV-2) by selectively inducing an HSV-specific CD8+ cytotoxic T-lymphocyte (CTL) response directed...

Evaluation of Cytotoxic T-Lymphocyte Responses in Human and Nonhuman Primate Subjects Infected with Human Immunodeficiency Virus Type 1 or Simian/Human Immunodeficiency Virus

Fu, Tong-Ming, Freed, Daniel C., Trigona, Wendy L., Guan, Liming, Zhu, Lan, Long, Romnie, ...

Cytotoxic T-lymphocyte (CTL) responses have been implicated as playing an important role in control of human immunodeficiency virus (HIV) infection. However, it is technically difficult to...

Elicitation of High-Frequency Cytotoxic T-Lymphocyte Responses against both Dominant and Subdominant Simian-Human Immunodeficiency Virus Epitopes by DNA Vaccination of Rhesus Monkeys

Barouch, Dan H., Craiu, Abie, Santra, Sampa, Egan, Michael A., Schmitz, Jörn E., Kuroda, Marcelo J., ...

Increasing evidence suggests that the generation of cytotoxic T-lymphocyte (CTL) responses specific for a diversity of viral epitopes will be needed for an effective human immunodeficiency virus type...

An Endoplasmic Reticulum-Targeting Signal Sequence Enhances the Immunogenicity of an Immunorecessive Simian Virus 40 Large T Antigen Cytotoxic T-Lymphocyte Epitope

Fu, Tong-Ming, Mylin, Lawrence M., Schell, Todd D., Bacik, Igor, Russ, Gustav, Yewdell, Jonathan W., ...

An immunological hierarchy among three H-2Db-restricted cytotoxic T lymphocyte (CTL) determinants in simian virus 40 (SV40) large T antigen (Tag) was described previously: determinants I and II/III...

Vaccine-Induced Immune Responses in Rodents and Nonhuman Primates by Use of a Humanized Human Immunodeficiency Virus Type 1 pol Gene

Casimiro, Danilo R., Tang, Aimin, Perry, Helen C., Long, Romnie S., Chen, Minchun, Heidecker, Gwendolyn J., ...

A synthetic gene consisting of the reverse transcriptase (RT) and integrase (IN) domains of human immunodeficiency virus type 1 (HIV-1) pol was constructed using codons most frequently used in...

Priming of Human Papillomavirus Type 11-Specific Humoral and Cellular Immune Responses in College-Aged Women with a Virus-Like Particle Vaccine

Emeny, Rebecca T., Wheeler, Cosette M., Jansen, Kathrin U., Hunt, William C., Fu, Tong-Ming, Smith, Judith F., ...

In this study, we evaluated the potency of a human papillomavirus (HPV) virus-like particle (VLP)-based vaccine at generating HPV type 11 (HPV-11)-specific cellular and humoral immune responses in...

Sustained Peptide-Specific Gamma Interferon T-Cell Response in Rhesus Macaques Immunized with Human Immunodeficiency Virus gag DNA Vaccines

Caulfield, Michael J., Wang, Su, Smith, Jeffrey G., Tobery, Timothy W., Liu, Xu, Davies, Mary-Ellen, ...

We examined the influence of dose and method of antigen delivery on the dynamics and durability of T-cell responses to candidate human immunodeficiency virus (HIV) vaccines. Codon-optimized sequences...

Mamu-A∗01 Allele-Mediated Attenuation of Disease Progression in Simian-Human Immunodeficiency Virus Infection

Zhang, Zhi-Qiang, Fu, Tong-Ming, Casimiro, Danilo R., Davies, Mary-Ellen, Liang, Xiaoping, Schleif, William A., ...

Expression of several major histocompatibility complex (MHC) class I alleles is associated with a protective effect against disease progression in both human immunodeficiency virus type 1 and simian...

Vaccine-Induced Immunity in Baboons by Using DNA and Replication-Incompetent Adenovirus Type 5 Vectors Expressing a Human Immunodeficiency Virus Type 1 gag Gene

Casimiro, Danilo R., Tang, Aimin, Chen, Ling, Fu, Tong-Ming, Evans, Robert K., Davies, Mary-Ellen, ...

The cellular immunogenicity of formulated plasmid DNA and replication-defective human adenovirus serotype 5 (Ad5) vaccine vectors expressing a codon-optimized human immunodeficiency virus type 1 gag...

Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual

Geels, Mark J., Cornelissen, Marion, Schuitemaker, Hanneke, Anderson, Kiersten, Kwa, David, Maas, Jolanda, ...

Control of viremia in natural human immunodeficiency virus type 1 (HIV-1) infection in humans is associated with a virus-specific T-cell response. However, still much is unknown with regard to the...

Heterologous Human Immunodeficiency Virus Type 1 Priming-Boosting Immunization Strategies Involving Replication-Defective Adenovirus and Poxvirus Vaccine Vectors

Casimiro, Danilo R., Bett, Andrew J., Fu, Tong-ming, Davies, Mary-Ellen, Tang, Aimin, Wilson, Keith A., ...

We compared the human immunodeficiency virus type 1 (HIV-1)-specific cellular immune responses elicited in nonhuman primates by HIV-1 gag-expressing replication-defective adenovirus serotype 5 (Ad5)...

Universal Influenza B Vaccine Based on the Maturational Cleavage Site of the Hemagglutinin Precursor

Bianchi, Elisabetta, Liang, Xiaoping, Ingallinella, Paolo, Finotto, Marco, Chastain, Michael A., Fan, Jiang, ...

Conventional influenza vaccines can prevent infection, but their efficacy depends on the degree of antigenic “match” between the strains used for vaccine preparation and those circulating in the...

High-Potency Human Immunodeficiency Virus Vaccination Leads to Delayed and Reduced CD8+ T-Cell Expansion but Improved Virus Control

Davenport, Miles P., Zhang, Lei, Bagchi, Ansuman, Fridman, Arthur, Fu, Tong-Ming, Schleif, William, ...

CD8+ T lymphocytes are thought to play an important role in the control of acute and chronic human immunodeficiency virus infections. However, there is a significant delay between infection and the...

Vectored Gag and Env but Not Tat Show Efficacy against Simian-Human Immunodeficiency Virus 89.6P Challenge in Mamu-A*01-Negative Rhesus Monkeys

Liang, Xiaoping, Casimiro, Danilo R., Schleif, William A., Wang, Fubao, Davies, Mary-Ellen, Zhang, Zhi-Qiang, ...

Simian-human immunodeficiency virus (SHIV) challenge studies in rhesus macaques were conducted to evaluate the efficacy of adenovirus-based vaccines in the context of different major...

Attenuation of Simian Immunodeficiency Virus SIVmac239 Infection by Prophylactic Immunization with DNA and Recombinant Adenoviral Vaccine Vectors Expressing Gag

Casimiro, Danilo R., Wang, Fubao, Schleif, William A., Liang, Xiaoping, Zhang, Zhi-Qiang, Tobery, Timothy W., ...

The prophylactic efficacy of DNA and replication-incompetent adenovirus serotype 5 (Ad5) vaccine vectors expressing simian immunodeficiency virus (SIV) Gag was examined in rhesus macaques using an...

Comparative Immunogenicity in Rhesus Monkeys of DNA Plasmid, Recombinant Vaccinia Virus, and Replication-Defective Adenovirus Vectors Expressing a Human Immunodeficiency Virus Type 1 gag Gene

Casimiro, Danilo R., Chen, Ling, Fu, Tong-Ming, Evans, Robert K., Caulfield, Michael J., Davies, Mary-Ellen, ...

Cellular immune responses, particularly those associated with CD3+ CD8+ cytotoxic T lymphocytes (CTL), play a primary role in controlling viral infection, including persistent infection with human...

A Novel Adenovirus Type 6 (Ad6)-Based Hepatitis C Virus Vector That Overcomes Preexisting Anti-Ad5 Immunity and Induces Potent and Broad Cellular Immune Responses in Rhesus Macaques

Capone, Stefania, Meola, Annalisa, Ercole, Bruno Bruni, Vitelli, Alessandra, Pezzanera, Monica, Ruggeri, Lionello, ...

Success in resolving hepatitis C virus (HCV) infection has been correlated to vigorous, multispecific, and sustained CD8+ T-cell response in humans and chimpanzees. The efficacy of inducing...