Recruitment of BAD by the Chlamydia trachomatis Vacuole Correlates with Host-Cell Survival (2006)
Philippe Verbeke, Lynn Welter-Stahl, Songmin Ying, Jon Hansen, Georg Häcker, Toni Darville, ...
Chlamydiae replicate intracellularly in a vacuole called an inclusion. Chlamydial-infected host cells are protected from mitochondrion-dependent apoptosis, partly due to degradation of BH3-only...
Recruitment of BAD by the Chlamydia trachomatis Vacuole Correlates with Host-Cell Survival. (2006)
Verbeke, Philippe, Welter-Stahl, Lynn, Ying, Songmin, Hansen, Jon, Hacker, Georg, Darville, Toni, ...
Chlamydiae replicate intracellularly in a vacuole called an inclusion. Chlamydial-infected host cells are protected from mitochondrion-dependent apoptosis, partly due to degradation of BH3-only...
Recruitment of BAD by the Chlamydia trachomatis Vacuole Correlates with Host-Cell Survival. (2006)
Verbeke, Philippe, Welter-Stahl, Lynn, Ying, Songmin, Hansen, Jon, Hacker, Georg, Darville, Toni, ...
Chlamydiae replicate intracellularly in a vacuole called an inclusion. Chlamydial-infected host cells are protected from mitochondrion-dependent apoptosis, partly due to degradation of BH3-only...
Recruitment of BAD by the Chlamydia trachomatis Vacuole Correlates with Host-Cell Survival. (2006)
Verbeke, Philippe, Welter-Stahl, Lynn, Ying, Songmin, Hansen, Jon, Hacker, Georg, Darville, Toni, ...
Chlamydiae replicate intracellularly in a vacuole called an inclusion. Chlamydial-infected host cells are protected from mitochondrion-dependent apoptosis, partly due to degradation of BH3-only...
Recruitment of BAD by the Chlamydia trachomatis Vacuole Correlates with Host-Cell Survival. (2006)
Verbeke, Philippe, Welter-Stahl, Lynn, Ying, Songmin, Hansen, Jon, Hacker, Georg, Darville, Toni, ...
Chlamydiae replicate intracellularly in a vacuole called an inclusion. Chlamydial-infected host cells are protected from mitochondrion-dependent apoptosis, partly due to degradation of BH3-only...
Perfettini, Jean-Luc, Darville, Toni, Gachelin, Gabriel, Souque, Philippe, Huerre, Michel, Dautry-Varsat, Alice, ...
The pathology observed during Chlamydia infection is due initially to localized tissue damage caused by the infection itself, followed by deleterious host inflammatory responses that lead to...
Darville, Toni, Andrews, Charles W., Sikes, James D., Fraley, Patrick L., Rank, Roger. G.
In this study, we expand on the examination of genetically determined differences in host responses that correlate with clearance of Chlamydia trachomatis from the genital tract. We infected C57BL/6,...
Darville, Toni, Andrews, Charles W., Sikes, James D., Fraley, Patrick L., Braswell, Leah, Rank, Roger G.
Vaginal infection with the mouse pneumonitis agent of Chlamydia trachomatis (MoPn) produces shorter courses of infection in C57BL/6 and BALB/c mice than in C3H/HeN mice, while C57BL/6 mice are more...
Darville, Toni, Andrews, C. W., Rank, R. G.
The role of tumor necrosis factor alpha (TNF-α) in host defense against chlamydial infection remains unclear. In order to further evaluate the relevance of TNF-α to host resistance in chlamydial...
A Role for Interleukin-6 in Host Defense against Murine Chlamydia trachomatis Infection
Williams, Dwight M., Grubbs, Barry G., Darville, Toni, Kelly, Kathleen, Rank, Roger G.
Interleukin-6-deficient (IL-6−/−) knockout mice had significantly increased Chlamydia trachomatis levels in lung tissue and increased mortality compared to B6129F2/J controls early after...
Perfettini, Jean-Luc, Darville, Toni, Dautry-Varsat, Alice, Rank, Roger G., Ojcius, David M.
The effect of gamma interferon (IFN-γ) on apoptosis due to infection by Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis) was studied in epithelial cells in culture and in...
Rank, Roger G., Bowlin, Anne K., Reed, Ronald L., Darville, Toni
A major problem in the study of chlamydial genital infections in animal models has been the use of varied doses of chlamydiae for infection in different laboratories. It is clearly desirable to use a...
Mansour, Adel M., Frenck, Robert W., Darville, Toni, Nakhla, Isabelle A., Wierzba, Thomas F., Sultan, Yehia, ...
Cerebrospinal fluid gamma interferon (IFN-γ) and interleukin-10 levels in 39 patients with tuberculous meningitis were serially measured. Cytokine levels did not predict intracranial granuloma (IG)...
Recruitment of BAD by the Chlamydia trachomatis Vacuole Correlates with Host-Cell Survival
Verbeke, Philippe, Welter-Stahl, Lynn, Ying, Songmin, Hansen, Jon, Häcker, Georg, Darville, Toni, ...
Chlamydiae replicate intracellularly in a vacuole called an inclusion. Chlamydial-infected host cells are protected from mitochondrion-dependent apoptosis, partly due to degradation of BH3-only...
Perfettini, Jean-Luc, Darville, Toni, Gachelin, Gabriel, Souque, Philippe, Huerre, Michel, Dautry-Varsat, Alice, ...
The pathology observed during Chlamydia infection is due initially to localized tissue damage caused by the infection itself, followed by deleterious host inflammatory responses that lead to...
Darville, Toni, Andrews, Charles W., Sikes, James D., Fraley, Patrick L., Rank, Roger. G.
In this study, we expand on the examination of genetically determined differences in host responses that correlate with clearance of Chlamydia trachomatis from the genital tract. We infected C57BL/6,...
Darville, Toni, Andrews, Charles W., Sikes, James D., Fraley, Patrick L., Braswell, Leah, Rank, Roger G.
Vaginal infection with the mouse pneumonitis agent of Chlamydia trachomatis (MoPn) produces shorter courses of infection in C57BL/6 and BALB/c mice than in C3H/HeN mice, while C57BL/6 mice are more...
Darville, Toni, Andrews, C. W., Rank, R. G.
The role of tumor necrosis factor alpha (TNF-α) in host defense against chlamydial infection remains unclear. In order to further evaluate the relevance of TNF-α to host resistance in chlamydial...
A Role for Interleukin-6 in Host Defense against Murine Chlamydia trachomatis Infection
Williams, Dwight M., Grubbs, Barry G., Darville, Toni, Kelly, Kathleen, Rank, Roger G.
Interleukin-6-deficient (IL-6−/−) knockout mice had significantly increased Chlamydia trachomatis levels in lung tissue and increased mortality compared to B6129F2/J controls early after...
Perfettini, Jean-Luc, Darville, Toni, Dautry-Varsat, Alice, Rank, Roger G., Ojcius, David M.
The effect of gamma interferon (IFN-γ) on apoptosis due to infection by Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis) was studied in epithelial cells in culture and in...
Rank, Roger G., Bowlin, Anne K., Reed, Ronald L., Darville, Toni
A major problem in the study of chlamydial genital infections in animal models has been the use of varied doses of chlamydiae for infection in different laboratories. It is clearly desirable to use a...
Mansour, Adel M., Frenck, Robert W., Darville, Toni, Nakhla, Isabelle A., Wierzba, Thomas F., Sultan, Yehia, ...
Cerebrospinal fluid gamma interferon (IFN-γ) and interleukin-10 levels in 39 patients with tuberculous meningitis were serially measured. Cytokine levels did not predict intracranial granuloma (IG)...
Recruitment of BAD by the Chlamydia trachomatis Vacuole Correlates with Host-Cell Survival
Verbeke, Philippe, Welter-Stahl, Lynn, Ying, Songmin, Hansen, Jon, Häcker, Georg, Darville, Toni, ...
Chlamydiae replicate intracellularly in a vacuole called an inclusion. Chlamydial-infected host cells are protected from mitochondrion-dependent apoptosis, partly due to degradation of BH3-only...
Reeves, Dawn M., Nagarajan, Uma, O'Connell, Catherine, Andrews, Charles W., Darville, Toni
Mice treated with antibiotics early or late after active infection had resolved were examined for chlamydial DNA in endocervical swabs. The early eradication of infection limited oviduct pathology,...
Type I Interferon Signaling Exacerbates Chlamydia muridarum Genital Infection in a Murine Model▿
Nagarajan, Uma M., Prantner, Daniel, Sikes, James D., Andrews, Charles W., Goodwin, Anna M., Nagarajan, Shanmugam, ...
Type I interferons (IFNs) induced during in vitro chlamydial infection exert bactericidal and immunomodulatory functions. To determine the precise role of type I IFNs during in vivo chlamydial...