Qihua Tan, Mads Thomassen, Kirsten M. Jochumsen, Ole Mogensen, Kaare Christensen, Torben A. Kruse
Different from significant gene expression analysis which looks for genes that are differentially regulated, feature selection in the microarray-based prognostic gene expression analysis aims at...
Qihua Tan, Mads Thomassen, Kirsten M. Jochumsen, Ole Mogensen, Kaare Christensen, Torben A. Kruse
Different from significant gene expression analysis which looks for genes that are differentially regulated, feature selection in the microarray-based prognostic gene expression analysis aims at...
Thomassen, Mads, Tan, Qihua, Kruse, Torben A
Abstract Background Metastasis is believed to progress in several steps including different pathways but the determination and understanding of these mechanisms is still fragmentary. Microarray...
Qihua Tan, Mads Thomassen, Torben A. Kruse
Abstract: Among the major issues in gene expression profi le classifi cation, feature selection is an important and necessary step in achieving and creating good classifi cation rules given the high...
Werner Vach, Rene Depont Christensen, Ole Mogensen, Anne Kjærgaard Callesen, Ole Nørregaard Jensen, Jonna Skov Madsen, ...
detection in mass spectrometry data using repeated
Tan, Qihua, Thomassen, Mads, Christensen, Kaare, Kruse, Torben A.
Different from significant gene expression analysis which looks for all genes that are differentially regulated, feature selection in prognostic gene expression analysis aims at finding a subset of...
Tan, Qihua, Thomassen, Mads, Christensen, Kaare, Kruse, Torben A.
Different from significant gene expression analysis which looks for all genes that are differentially regulated, feature selection in prognostic gene expression analysis aims at finding a subset of...
Tan, Qihua, Christiansen, Lene, Brasch-Andersen, Charlotte, Zhao, Jing, Li, Shuxia, Kruse, Torben A, ...
Abstract Background The etiology of multifactorial human diseases involves complex interactions between numerous environmental factors and alleles of many genes. Efficient statistical tools are...
Qihua Tan, Mads Thomassen, Torben A. Kruse
Among the major issues in gene expression profile classification, feature selection is an important and necessary step in achieving and creating good classification rules given the high...
Qihua Tan, Mads Thomassen, Torben A. Kruse
Among the major issues in gene expression profile classification, feature selection is an important and necessary step in achieving and creating good classification rules given the high...
Tan, Qihua, Dahlgaard, Jesper, Vach, Werner, Abdallah, Basem M, Kassem, Moustapha, Kruse, Torben A
Abstract We introduce a non-parametric approach using bootstrap-assisted correspondence analysis to identify and validate genes that are differentially expressed in factorial microarray experiments....
Estimating haplotype relative risks on human survival in population-based association studies (2005)
Tan, Qihua, Christiansen, Lene, Bathum, Lise, Zhao, Jing H., Yashin, Anatoli I., Vaupel, James W., ...
Association-based linkage disequilibrium (LD) mapping is an increasingly important tool for localizing genes that show potential influence on human aging and longevity. As haplotypes contain more LD...
Tan, Qihua, Christiansen, Lene, Bathum, Lise, Zhao, Jing H., Vach, Werner, Vaupel, James W., ...
Haplotype based linkage disequilibrium (LD) mapping exhibits higher power than the single locus approach because it makes use of the LD information contained in the flanking markers. New statistical...
Tan, Qihua, Zhao, Jing H., Iachine, Ivan A., Hjelmborg, Jacob, Vach, Werner, Vaupel, James W., ...
This report investigates the power issue in applying the non-parametric linkage analysis of affected sib-pairs (ASP) [Kruglyak and Lander, 1995: Am J Hum Genet 57:439-454] to localize genes that...
Multidisciplinary approaches in genetic studies of human aging and longevity (2004)
Tan, Qihua, Yashin, Anatoli I., Christensen, Kaare, Jeune, Bernard, De Benedictis, Giovanna, Kruse, Torben A., ...
The amount of research on human aging and longevity has been growing rapidly in recent years. Multidisciplinary approaches, which integrate classic population genetics methods with the principles of...
Assessing genetic association with human survival at multi-allelic loci (2004)
Tan, Qihua, De Benedictis, Giovanna, Yashin, Anatoli I., Bathum, Lise, Christiansen, Lene, Dahlgaard, Jesper, ...
Genetic variation plays an important role in natural selection and population evolution. However, it also presents geneticists interested in aging research with problems in data analysis because of...
Tan, Qihua, Bathum, Lise, Christiansen, Lene, De Benedictis, Giovanna, Dahlgaard, Jesper, Frizner, N, ...
In this paper, we apply logistic regression models to measure genetic association with human survival for highly polymorphic and pleiotropic genes. By modelling genotype frequency as a function of...
α-cardiac actin is a novel disease gene in familial hypertrophic cardiomyopathy
Mogensen, Jens, Klausen, Ib C., Pedersen, Anders K., Egeblad, Henrik, Bross, Peter, Kruse, Torben A., ...
We identified the α-cardiac actin gene (ACTC) as a novel disease gene in a pedigree suffering from familial hypertrophic cardiomyopathy (FHC). Linkage analyses excluded all the previously reported...
Tan, Qihua, Christiansen, Lene, Bathum, Lise, Li, Shuxia, Kruse, Torben A., Christensen, Kaare
Although the case-control or the cross-sectional design has been popular in genetic association studies of human longevity, such a design is prone to false positive results due to sampling bias and a...
α-cardiac actin is a novel disease gene in familial hypertrophic cardiomyopathy
Mogensen, Jens, Klausen, Ib C., Pedersen, Anders K., Egeblad, Henrik, Bross, Peter, Kruse, Torben A., ...
We identified the α-cardiac actin gene (ACTC) as a novel disease gene in a pedigree suffering from familial hypertrophic cardiomyopathy (FHC). Linkage analyses excluded all the previously reported...
Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part III: Bipolar Disorder
Segurado, Ricardo, Detera-Wadleigh, Sevilla D., Levinson, Douglas F., Lewis, Cathryn M., Gill, Michael, ...
Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an...
Tan, Qihua, Christiansen, Lene, Bathum, Lise, Li, Shuxia, Kruse, Torben A., Christensen, Kaare
Although the case-control or the cross-sectional design has been popular in genetic association studies of human longevity, such a design is prone to false positive results due to sampling bias and a...
Tan, Qihua, Christiansen, Lene, Brasch-Andersen, Charlotte, Zhao, Jing Hua, Li, Shuxia, Kruse, Torben A, ...
Skov, Vibe, Glintborg, Dorte, Knudsen, Steen, Tan, Qihua, Jensen, Thomas, Kruse, Torben A., ...
Insulin resistance is a common metabolic abnormality in women with PCOS and leads to an elevated risk of type 2 diabetes. Studies have shown that thiazolidinediones (TZDs) improve metabolic...
Feature Selection for Predicting Tumor Metastases in Microarray Experiments using Paired Design
Tan, Qihua, Thomassen, Mads, Kruse, Torben A.
Among the major issues in gene expression profile classification, feature selection is an important and necessary step in achieving and creating good classification rules given the high...
Power for Genetic Association Study of Human Longevity Using the Case-Control Design
Tan, Qihua, Zhao, Jing Hua, Zhang, Dongfeng, Kruse, Torben A., Christensen, Kaare
The efficiency of the popular case-control design in gene-longevity association studies needs to be verified because, different from a binary trait, longevity represents only the extreme end of the...