Monogamy Evolves through Multiple Mechanisms: Evidence from V1aR in Deer Mice (2010)
Turner, Leslie M., Young, Adrian R., Römpler, Holger, Schöneberg, Torsten, Phelps, Steven M., Hoekstra, Hopi E.
Genetic variation in Avpr1a, the locus encoding the arginine vasopressin receptor 1A (V1aR), has been implicated in pair-bonding behavior in voles (genus Microtus) and humans, raising the possibility...
Monogamy evolves through multiple mechanisms: evidence from V1aR in deer mice (2010)
Turner, Leslie M., Young, Adrian R., Römpler, Holger, Schöneberg, Torsten, Phelps, Steven M., Hoekstra, Hopi E.
Genetic variation in Avpr1a, the locus encoding the arginine vasopressin receptor 1A (V1aR), has been implicated in pair-bonding behavior in voles (genus Microtus) and humans, raising the possibility...
Thor, Doreen, Le Duc, Diana, Strotmann, Rainer, Schöneberg, Torsten
Abstract Background Controlling enzyme activity by ligand binding to a regulatory domain of choice may have many applications e.g. as biosensors and as tools in regulating cellular functions....
Reduction in corpora lutea number in obese melanocortin-4-receptor-deficient mice (2009)
Sandrock, Mara, Schulz, Angela, Merkwitz, Claudia, Schöneberg, Torsten, Spanel-Borowski, Katharina, Ricken, Albert
Abstract Obese melanocortin-4-receptor-deficient (MC4R-/-) male mice are reported to have erectile dysfunction, while homozygous MC4R-/- female mice are apparently fertile. A recently established...
Steiner, Cynthia C., Römpler, Holger, Boettger, Linda M., Schöneberg, Torsten, Hoekstra, Hopi E.
Convergent evolution is a widespread phenomenon seen in diverse organisms inhabiting similar selective environments. However, it is unclear if similar phenotypes are produced by the same or different...
Genetic Architecture of Tameness in a Rat Model of Animal Domestication (2009)
Albert, Frank W., Carlborg, O., Plyusnina, Irina Z., Besnier, F., Hedwig, Daniela, Lautenschläger, Susann, ...
Albert, Frank W., Shchepina, Olesya, Winter, Christine, Römpler, Holger, Teupser, Daniel, Palme, Rupert, ...
Parallel Selection on TRPV6 in Human Populations (2008)
Hughes, David A., Tang, Kun, Stoneking, Mark, Schöneberg, Torsten, Prenen, Jean, Nilius, Bernd
Parallel selection on TRPV6 in human populations (2008)
Tang, Kun, Strotmann, Rainer, Schöneberg, Torsten, Prenen, Jean, ...
We identified and examined a candidate gene for local directional selection in Europeans, TRPV6, and conclude that selection has acted on standing genetic variation at this locus, creating parallel...
Learning from the past: evolution of GPCR functions (2007)
Schöneberg, Torsten, Hofreiter, Michael, Schulz, Angela, Römpler, Holger
A Melanocortin 1 Receptor Allele Suggests Varying Pigmentation Among Neanderthals (2007)
Lalueza-Fox, Carles, Römpler, Holger, Caramelli, David, Stäubert, Claudia, Catalano, Giulio, Hughes, David A., ...
G Protein-Coupled Time Travel: Evolutionary Aspects of GPCR Research (2007)
Römpler, Holger, Stäubert, Claudia, Thor, Doreen, Schulz, Angela, Hofreiter, Michael, Schöneberg, Torsten
Multiplex amplification of ancient DNA (2006)
Holger Römpler, Paul H Dear, Johannes Krause, Matthias Meyer, Nadin Rohland, Torsten Schöneberg, ...
Multiplex amplification of ancient DNA (2006)
Römpler, Holger, Dear, Paul H., Krause, Johannes, Meyer, Matthias, Rohland, Nadin, Schöneberg, Torsten, ...
Nuclear Gene Indicates Coat-Color Polymorphism in Mammoths (2006)
Römpler, Holger, Rohland, Nadin, Lalueza-Fox, Carles, Willerslev, Eske, Kuznetsova, Tatyana, Rabeder, Gernot, ...
Nephrogenic diabetes insipidus, thiazide treatment and renal cell carcinoma (2006)
Zaki, Mohamed, Schöneberg, Torsten, Ajrawi, Tareq Al, Said, Abdul Nasser Al, Sangkuhl, Katrin, Römpler, Holger
Nephrogenic diabetes insipidus, thiazide treatment and renal cell carcinoma (2006)
Zaki, Mohamed, Schöneberg, Torsten, Al Ajrawi, Tareq, Al Said, Abdul Nasser, Sangkuhl, Katrin, Römpler, Holger
Nephrogenic diabetes insipidus, thiazide treatment and renal cell carcinoma (2006)
Mohamed, Zaki, Schöneberg, Torsten, Al Ajrawi, Tareq, Al Said, Abdul Nasser, Katrin, Sangkuhl, Römpler, Holger
Nephrogenic diabetes insipidus, thiazide treatment and renal cell carcinoma (2006)
Zaki, Mohamed, Schöneberg, Torsten, Ajrawi, Tareq Al, Said, Abdul Nasser Al, Sangkuhl, Katrin, Römpler, Holger
The rise and fall of the chemoattractant receptor GPR33 (2005)
Römpler, Holger, Schulz, Angela, Pitra, C., Coop, Graham, Przeworski, Molly, Pääbo, Svante, ...
Chemokine and chemoattractant receptors are members of the large superfamily of G protein- coupled receptors ( GPCR), which control leukocyte chemotaxis. In addition to their physiological role,...
Sangkuhl, Katrin, Schulz, Angela, Römpler, Holger, Yun, June, Wess, Jürgen, Schöneberg, Torsten
Many human diseases are caused by inactivating mutations in specific G-protein-coupled receptors (GPCRs). In about 10% of these cases, a premature stop codon leads to the generation of a truncated,...
Sangkuhl, Katrin, Schulz, Angela, Römpler, Holger, Yun, June, Wess, Jürgen, Schöneberg, Torsten
Many human diseases are caused by inactivating mutations in specific G-protein-coupled receptors (GPCRs). In about 10% of these cases, a premature stop codon leads to the generation of a...
Sangkuhl, Katrin, Schulz, Angela, Römpler, Holger, Yun, June, Wess, Jürgen, Schöneberg, Torsten
Many human diseases are caused by inactivating mutations in specific G-protein-coupled receptors (GPCRs). In about 10% of these cases, a premature stop codon leads to the generation of a truncated,...
Nuclear envelope proteomics: Novel integral membrane proteins of the inner nuclear membrane
Dreger, Mathias, Bengtsson, Luiza, Schöneberg, Torsten, Otto, Henning, Hucho, Ferdinand
The nuclear envelope (NE) is one of the least characterized structures of eukaryotic cells. The study of its functional roles is hampered by the small number of proteins known to be specifically...
Generation and phenotype of mice harboring a nonsense mutation in the V2 vasopressin receptor gene
Yun, June, Schöneberg, Torsten, Liu, Jie, Schulz, Angela, Ecelbarger, Carolyn A., Promeneur, Dominique, ...
The V2 vasopressin receptor (V2R) plays a key role in the maintenance of a normal body water balance. To generate an in vivo model that allows the physiological and molecular analysis of the role of...
Nuclear envelope proteomics: Novel integral membrane proteins of the inner nuclear membrane
Dreger, Mathias, Bengtsson, Luiza, Schöneberg, Torsten, Otto, Henning, Hucho, Ferdinand
The nuclear envelope (NE) is one of the least characterized structures of eukaryotic cells. The study of its functional roles is hampered by the small number of proteins known to be specifically...
Generation and phenotype of mice harboring a nonsense mutation in the V2 vasopressin receptor gene
Yun, June, Schöneberg, Torsten, Liu, Jie, Schulz, Angela, Ecelbarger, Carolyn A., Promeneur, Dominique, ...
The V2 vasopressin receptor (V2R) plays a key role in the maintenance of a normal body water balance. To generate an in vivo model that allows the physiological and molecular analysis of the role of...
Regulated and constitutive activation of specific signalling pathways by the human S1P5 receptor
Niedernberg, Anke, Blaukat, Andree, Schöneberg, Torsten, Kostenis, Evi
We tested the hypothesis, whether G Protein-coupled receptors (GPCRs) may differentially regulate specific signalling pathways by constitutive and agonist-induced activation using the human...
Parallel Selection on TRPV6 in Human Populations
Hughes, David A., Tang, Kun, Strotmann, Rainer, Schöneberg, Torsten, Prenen, Jean, Nilius, Bernd, ...
We identified and examined a candidate gene for local directional selection in Europeans, TRPV6, and conclude that selection has acted on standing genetic variation at this locus, creating parallel...
Structural and functional evolution of the P2Y12-like receptor group
Schöneberg, Torsten, Hermsdorf, Thomas, Engemaier, Eva, Engel, Kathrin, Liebscher, Ines, Thor, Doreen, ...
Metabotropic pyrimidine and purine nucleotide receptors (P2Y receptors) belong to the superfamily of G protein-coupled receptors (GPCR). They are distinguishable from adenosine receptors (P1) as they...
Bloch, Wilhelm, Fan, Yun, Han, Ji, Xue, Sheng, Schöneberg, Torsten, Ji, Guanju, ...
β1 integrins play a crucial role as cytoskeletal anchorage proteins. In this study, the coupling of the cytoskeleton and intracellular signaling pathways was investigated in β1 integrin deficient...
Reduction in corpora lutea number in obese melanocortin-4-receptor-deficient mice
Sandrock, Mara, Schulz, Angela, Merkwitz, Claudia, Schöneberg, Torsten, Spanel-Borowski, Katharina, Ricken, Albert
Obese melanocortin-4-receptor-deficient (MC4R-/-) male mice are reported to have erectile dysfunction, while homozygous MC4R-/- female mice are apparently fertile. A recently established obese mouse...
Involvement of the V2 Vasopressin Receptor in Adaptation to Limited Water Supply
Böselt, Iris, Römpler, Holger, Hermsdorf, Thomas, Thor, Doreen, Busch, Wibke, Schulz, Angela, ...
Mammals adapted to a great variety of habitats with different accessibility to water. In addition to changes in kidney morphology, e.g. the length of the loops of Henle, several hormone systems are...
Luciferase activity under direct ligand-dependent control of a muscarinic acetylcholine receptor
Thor, Doreen, Le Duc, Diana, Strotmann, Rainer, Schöneberg, Torsten
Genetic Architecture of Tameness in a Rat Model of Animal Domestication
Albert, Frank W., Carlborg, Örjan, Plyusnina, Irina, Besnier, Francois, Hedwig, Daniela, Lautenschläger, Susann, ...
A common feature of domestic animals is tameness—i.e., they tolerate and are unafraid of human presence and handling. To gain insight into the genetic basis of tameness and aggression, we studied...
Interdomain Interactions Control Ca2+-Dependent Potentiation in the Cation Channel TRPV4
Strotmann, Rainer, Semtner, Marcus, Kepura, Frauke, Plant, Tim D., Schöneberg, Torsten
Several Ca2+-permeable channels, including the non-selective cation channel TRPV4, are subject to Ca2+-dependent facilitation. Although it has been clearly demonstrated in functional experiments that...
Stäubert, Claudia, Böselt, Iris, Bohnekamp, Jens, Römpler, Holger, Enard, Wolfgang, Schöneberg, Torsten
The family of trace amine-associated receptors (TAAR) comprises 9 mammalian TAAR subtypes, with intact gene and pseudogene numbers differing considerably even between closely related species. To date...
Molecular and functional basis of phenotypic convergence in white lizards at White Sands
Rosenblum, Erica Bree, Römpler, Holger, Schöneberg, Torsten, Hoekstra, Hopi E.
There are many striking examples of phenotypic convergence in nature, in some cases associated with changes in the same genes. But even mutations in the same gene may have different biochemical...