Nishimura, Satoshi, Kawai, Yasuo, Nakajima, Toshiaki, Hosoya, Yumiko, Fujita, Hideo, Katoh, Masayoshi, ...
Objective: To elucidate the interdependence between the mechanical state of the myocardium and its electrical activity, previous studies have been performed at the cellular level. However, the...
Jinnai, Nobuyoshi, Sakagami, Takuro, Sekigawa, Takashi, Kakihara, Miho, Nakajima, Toshiaki, Yoshida, Kenichi, ...
Aspirin-intolerant asthma (AIA) is a subtype of bronchial asthma characterized by development of bronchoconstriction evoked by nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs inhibit the...
Jinnai, Nobuyoshi, Sakagami, Takuro, Sekigawa, Takashi, Kakihara, Miho, Nakajima, Toshiaki, Yoshida, Kenichi, ...
Aspirin-intolerant asthma (AIA) is a subtype of bronchial asthma characterized by development of bronchoconstriction evoked by non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs inhibit the...
Jinnai, Nobuyoshi, Sakagami, Takuro, Sekigawa, Takashi, Kakihara, Miho, Nakajima, Toshiaki, Yoshida, Kenichi, ...
Aspirin-intolerant asthma (AIA) is a subtype of bronchial asthma characterized by development of bronchoconstriction evoked by nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs inhibit the...
Yonemura, Katsuhiko, Nakajima, Toshiaki, Suzuki, Takayuki, Ando, Shinichiro, Genma, Rieko, Nakamura, Hirotoshi, ...
Background. There is little information on the differences in pituitary–thyroid function between undialysed and haemodialysed patients. Methods. Serum concentrations of free thyroxine...
Kawada, Tomie, Nakazawa, Mikio, Nakauchi, Sakura, Yamazaki, Ken, Shimamoto, Ryoichi, Urabe, Masashi, ...
The hereditary form comprises ≈1/5 of patients with dilated cardiomyopathy (DCM) and is a major cause of advanced heart failure. Medical and socioeconomic settings require novel treatments other...
Toyo-Oka, Teruhiko, Kawada, Tomie, Nakata, Jumi, Xie, Han, Urabe, Masashi, Masui, Fujiko, ...
Advanced heart failure (HF) is the leading cause of death in developed countries. The mechanism underlying the progression of cardiac dysfunction needs to be clarified to establish approaches to...
Genomewide-Linkage and Haplotype-Association Studies Map Intracranial Aneurysm to Chromosome 7q11
Onda, Hideaki, Kasuya, Hidetoshi, Yoneyama, Taku, Takakura, Kintomo, Hori, Tomokatsu, Takeda, Jun, ...
Rupture of intracranial aneurysms (IAs) causes subarachnoid hemorrhage, a devastating condition with high morbidity and mortality. Angiographic and autopsy studies show that IA is a common disorder,...
Kawada, Tomie, Nakazawa, Mikio, Nakauchi, Sakura, Yamazaki, Ken, Shimamoto, Ryoichi, Urabe, Masashi, ...
The hereditary form comprises ≈1/5 of patients with dilated cardiomyopathy (DCM) and is a major cause of advanced heart failure. Medical and socioeconomic settings require novel treatments other...
Nucleotide Diversity and Haplotype Structure of the Human Angiotensinogen Gene in Two Populations
Nakajima, Toshiaki, Jorde, Lynn B., Ishigami, Tomoaki, Umemura, Satoshi, Emi, Mitsuru, Lalouel, Jean-Marc, ...
Variation in the angiotensinogen gene, AGT, has been associated with variation in plasma angiotensinogen levels. In addition, the T235M polymorphism in the AGT product is associated with an increased...
Toyo-Oka, Teruhiko, Kawada, Tomie, Nakata, Jumi, Xie, Han, Urabe, Masashi, Masui, Fujiko, ...
Advanced heart failure (HF) is the leading cause of death in developed countries. The mechanism underlying the progression of cardiac dysfunction needs to be clarified to establish approaches to...
Tanaka, Toshihiro, Ikari, Katsunori, Furushima, Kozo, Okada, Akihiro, Tanaka, Hiroshi, Furukawa, Ken-Ichi, ...
Ossification of the posterior longitudinal ligament (OPLL) of the spine is a subset of “bone-forming” diseases, characterized by ectopic ossification in the spinal ligaments. OPLL is a common...
Nakajima, Toshiaki, Wooding, Stephen, Sakagami, Takuro, Emi, Mitsuru, Tokunaga, Katsushi, Tamiya, Gen, ...
Several lines of evidence suggest that patterns of genetic variability in the human angiotensinogen gene (AGT) contribute to phenotypic variability in human hypertension. The A(−6) promoter variant...
Genomewide-Linkage and Haplotype-Association Studies Map Intracranial Aneurysm to Chromosome 7q11
Onda, Hideaki, Kasuya, Hidetoshi, Yoneyama, Taku, Takakura, Kintomo, Hori, Tomokatsu, Takeda, Jun, ...
Rupture of intracranial aneurysms (IAs) causes subarachnoid hemorrhage, a devastating condition with high morbidity and mortality. Angiographic and autopsy studies show that IA is a common disorder,...
Quorum Sensing Regulates Denitrification in Pseudomonas aeruginosa PAO1▿
Toyofuku, Masanori, Nomura, Nobuhiko, Fujii, Tatsuya, Takaya, Naoki, Maseda, Hideaki, Sawada, Isao, ...
Anaerobic growth of Pseudomonas aeruginosa PAO1 was affected by quorum sensing. Deletion of genes that produce N-acyl-l-homoserine lactone signals resulted in an increase in denitrification activity,...
Asano, Michiko, Nakajima, Toshiaki, Iwasawa, Kuniaki, Hazama, Hisanori, Omata, Masao, Soma, Masaaki, ...
The effects of ω-3 polyunsaturated fatty acids on receptor-mediated non-selective cation current (Icat) and K+ current were investigated in aortic smooth muscle cells from foetal rat aorta (A7r5...
Antiarrhythmic effect and its underlying ionic mechanism of 17β-estradiol in cardiac myocytes
Nakajima, Toshiaki, Iwasawa, Kuniaki, Oonuma, Hitoshi, Morita, Toshihiro, Goto, Atsuro, Wang, Yuepeng, ...
The effects of oestrogens on action potential and membrane currents were examined in single guinea-pig atrial myocytes.17β-estradiol (3–10 μM) shortened the action potential duration without...
Asano, Michiko, Nakajima, Toshiaki, Iwasawa, Kuniaki, Morita, Toshihiro, Nakamura, Fumitaka, Imuta, Hiroyuki, ...
The effects of troglitazone and pioglitazone on agonist-induced Ca2+ mobilization and cell proliferation were studied using fluorescent Ca2+ indicator fura-2 AM and incorporation of [3H]-thymidine in...
Nakajima, Toshiaki, Okuda, Yukichi, Chisaki, Keigo, Shin, Wee-Soo, Iwasawa, Kuniaki, Morita, Toshihiro, ...
The effects of bile acids on intracellular Ca2+ concentration [Ca2+]i and nitric oxide production were investigated in vascular endothelial cells.Whole-cell patch clamp techniques and fluorescence...
Iida, Haruko, Jo, Taisuke, Iwasawa, Kuniaki, Morita, Toshihiro, Hikiji, Hisako, Takato, Tsuyoshi, ...
The A-type voltage-dependent K+ current (IA) has been identified in several types of smooth muscle cells including the pulmonary artery (PA), but little is known about the pharmacological and...
Tashiro, Yosuke, Nomura, Nobuhiko, Nakao, Ryoma, Senpuku, Hidenobu, Kariyama, Reiko, Kumon, Hiromi, ...
Pseudomonas aeruginosa is an opportunistic bacterial pathogen that is one of the most refractory to therapy when it forms biofilms in the airways of cystic fibrosis patients. To date, studies...
Influence of the Pseudomonas Quinolone Signal on Denitrification in Pseudomonas aeruginosa▿
Toyofuku, Masanori, Nomura, Nobuhiko, Kuno, Eriko, Tashiro, Yosuke, Nakajima, Toshiaki, Uchiyama, Hiroo
Denitrification is a well-studied respiratory system that is also important in the biogeochemical nitrogen cycle. Environmental signals such as oxygen and N-oxides have been demonstrated to regulate...