Li, Ying Ji, Azuma, Arata, Usuki, Jiro, Abe, Shinji, Matsuda, Kuniko, Sunazuka, Toshiaki, ...
Abstract Background Fourteen-membered ring macrolides have been effective in reducing chronic airway inflammation and also preventing lung injury and fibrosis in bleomycin-challenged mice via...
Structure activity relationships of spiramycins (1985)
Omura, Satoshi, Sano, Hiroshi, Sunazuka, Toshiaki
Sixty-six derivatives of spiramycin I and neospiramycin I were synthesized and evaluated by four parameters, MIC, affinity to ribosomes (ID50), therapeutic effect in mice and retention time in HPLC....
Ōmura, Satoshi, Miyadera, Hiroko, Ui, Hideaki, Shiomi, Kazuro, Yamaguchi, Yuuichi, Masuma, Rokuro, ...
Infections with parasitic helminths are important causes of morbidity and mortality worldwide. New drugs that are parasite specific and minimally toxic to the host are needed to counter these...
Tsuchihashi, Yoshiko, Oishi, Kazunori, Yoshimine, Hiroyuki, Suzuki, Shoichi, Kumatori, Atsushi, Sunazuka, Toshiaki, ...
A 14-member macrolide was found to inhibit interleukin-8 (IL-8) synthesis in lipopolysaccharide-stimulated neutrophils but did not accelerate apoptosis in activated neutrophils. These data suggest...
Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130
Hayashi, Masahiko, Rho, Mun-Chual, Enomoto, Akiko, Fukami, Akiko, Kim, Yong-Pil, Kikuchi, Yuji, ...
IL-6 is a multifunctional cytokine involved in regulation of differentiation, antibody production, and growth of certain types of tumor cells. Its excessive production plays a major role in...
Desaki, Masashi, Okazaki, Hitoshi, Sunazuka, Toshiaki, Omura, Satoshi, Yamamoto, Kazuhiko, Takizawa, Hajime
Long-term macrolide therapy has been proven to improve survival in patients with diffuse panbronchiolitis. Although its mechanisms remain unknown, previous studies have suggested the effects of...
Matsui, Hidenori, Eguchi, Masahiro, Ohsumi, Katsufumi, Nakamura, Akio, Isshiki, Yasunori, Sekiya, Kachiko, ...
The present study shows that a sub-MIC of the macrolide antibiotic azithromycin (AZM) diminishes the virulence function of Salmonella enterica serovar Typhimurium. We first constructed an...
Gouda, Hiroaki, Sunazuka, Toshiaki, Ui, Hideaki, Handa, Masaki, Sakoh, Yusuke, Iwai, Yuzuru, ...
The absolute stereostructure of luminamicin, an anaerobic antibiotic, has been determined by using conformational analysis via high-temperature molecular dynamics, NMR spectroscopy, and the modified...
Ōmura, Satoshi, Miyadera, Hiroko, Ui, Hideaki, Shiomi, Kazuro, Yamaguchi, Yuuichi, Masuma, Rokuro, ...
Infections with parasitic helminths are important causes of morbidity and mortality worldwide. New drugs that are parasite specific and minimally toxic to the host are needed to counter these...
Tsuchihashi, Yoshiko, Oishi, Kazunori, Yoshimine, Hiroyuki, Suzuki, Shoichi, Kumatori, Atsushi, Sunazuka, Toshiaki, ...
A 14-member macrolide was found to inhibit interleukin-8 (IL-8) synthesis in lipopolysaccharide-stimulated neutrophils but did not accelerate apoptosis in activated neutrophils. These data suggest...
Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130
Hayashi, Masahiko, Rho, Mun-Chual, Enomoto, Akiko, Fukami, Akiko, Kim, Yong-Pil, Kikuchi, Yuji, ...
IL-6 is a multifunctional cytokine involved in regulation of differentiation, antibody production, and growth of certain types of tumor cells. Its excessive production plays a major role in...
Desaki, Masashi, Okazaki, Hitoshi, Sunazuka, Toshiaki, Omura, Satoshi, Yamamoto, Kazuhiko, Takizawa, Hajime
Long-term macrolide therapy has been proven to improve survival in patients with diffuse panbronchiolitis. Although its mechanisms remain unknown, previous studies have suggested the effects of...
Matsui, Hidenori, Eguchi, Masahiro, Ohsumi, Katsufumi, Nakamura, Akio, Isshiki, Yasunori, Sekiya, Kachiko, ...
The present study shows that a sub-MIC of the macrolide antibiotic azithromycin (AZM) diminishes the virulence function of Salmonella enterica serovar Typhimurium. We first constructed an...
Gouda, Hiroaki, Sunazuka, Toshiaki, Ui, Hideaki, Handa, Masaki, Sakoh, Yusuke, Iwai, Yuzuru, ...
The absolute stereostructure of luminamicin, an anaerobic antibiotic, has been determined by using conformational analysis via high-temperature molecular dynamics, NMR spectroscopy, and the modified...
Komuro, Iwao, Sunazuka, Toshiaki, Akagawa, Kiyoko S., Yokota, Yasuko, Iwamoto, Aikichi, Ōmura, Satoshi
Macrophages (MΦs) are a major source of HIV-1 especially in patients with tuberculosis. There are MΦs that are permissive and those that restrict HIV-1. Regulation of hematopoietic cell kinase...