Toshie Shinagawa

p53 Suppresses c-Myb-induced trans-Activation and Transformation by Recruiting the Corepressor mSin3A (2004)

Tanikawa, Jun, Nomura, Teruaki, Macmillan, Elizabeth M., Shinagawa, Toshie, Jin, Wanzhu, Kokura, Kenji, ...

Comment: This paper illustrates another major theme – transformation by MYB - and describes an interaction between MYB and the tumour suppressor, p53 which is clearly one of the most important in...

p53 Suppresses c-Myb-induced trans-Activation and Transformation by Recruiting the Corepressor mSin3A (2004)

Tanikawa, Jun, Nomura, Teruaki, Macmillan, Elizabeth M., Shinagawa, Toshie, Jin, Wanzhu, Kokura, Kenji, ...

p53 is known to repress transcription of a number of genes, but the mechanism of p53 recruitment to these target genes is unknown. The c-myb proto-oncogene product (c-Myb) positively regulates...

p53 Suppresses c-Myb-induced trans-Activation and Transformation by Recruiting the Corepressor mSin3A (2004)

Tanikawa, Jun, Nomura, Teruaki, Macmillan, Elizabeth M., Shinagawa, Toshie, Jin, Wanzhu, Kokura, Kenji, ...

Comment: This paper illustrates another major theme – transformation by MYB - and describes an interaction between MYB and the tumour suppressor, p53 which is clearly one of the most important in...

p53 Suppresses c-Myb-induced trans-Activation and Transformation by Recruiting the Corepressor mSin3A (2004)

Tanikawa, Jun, Nomura, Teruaki, Macmillan, Elizabeth M., Shinagawa, Toshie, Jin, Wanzhu, Kokura, Kenji, ...

p53 is known to repress transcription of a number of genes, but the mechanism of p53 recruitment to these target genes is unknown. The c-myb proto-oncogene product (c-Myb) positively regulates...

Generation of Ski-knockdown mice by expressing a long double-strand RNA from an RNA polymerase II promoter (2003)

Shinagawa, Toshie, Ishii, Shunsuke

We have developed a new vector, named pDECAP, to express long double-strand RNA (ds-RNA) from an RNA polymerase II (Pol II) promoter. Because the transcripts from pDECAP lack both the 5′-cap...

Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3

Dai, Ping, Shinagawa, Toshie, Nomura, Teruaki, Harada, Jun, Kaul, Sunil C., Wadhwa, Renu, ...

Transcription factor Glioblastoma-3 (Gli3) is cleaved in the anterior region of the limb bud to generate its repressor form. In contrast, Sonic hedgehog (Shh) signaling from the posterior zone of...

Generation of Ski-knockdown mice by expressing a long double-strand RNA from an RNA polymerase II promoter

Shinagawa, Toshie, Ishii, Shunsuke

We have developed a new vector, named pDECAP, to express long double-strand RNA (ds-RNA) from an RNA polymerase II (Pol II) promoter. Because the transcripts from pDECAP lack both the 5′-cap...

The sno gene, which encodes a component of the histone deacetylase complex, acts as a tumor suppressor in mice

Shinagawa, Toshie, Dong, Hai-Dong, Xu, Ming, Maekawa, Toshio, Ishii, Shunsuke

The Ski and Sno oncoproteins are components of a macromolecular complex containing the co-repressor N-CoR/SMRT, mSin3 and histone deacetylase. This complex has been implicated in the transcriptional...

Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3

Dai, Ping, Shinagawa, Toshie, Nomura, Teruaki, Harada, Jun, Kaul, Sunil C., Wadhwa, Renu, ...

Transcription factor Glioblastoma-3 (Gli3) is cleaved in the anterior region of the limb bud to generate its repressor form. In contrast, Sonic hedgehog (Shh) signaling from the posterior zone of...

Generation of Ski-knockdown mice by expressing a long double-strand RNA from an RNA polymerase II promoter

Shinagawa, Toshie, Ishii, Shunsuke

We have developed a new vector, named pDECAP, to express long double-strand RNA (ds-RNA) from an RNA polymerase II (Pol II) promoter. Because the transcripts from pDECAP lack both the 5′-cap...

The sno gene, which encodes a component of the histone deacetylase complex, acts as a tumor suppressor in mice

Shinagawa, Toshie, Dong, Hai-Dong, Xu, Ming, Maekawa, Toshio, Ishii, Shunsuke

The Ski and Sno oncoproteins are components of a macromolecular complex containing the co-repressor N-CoR/SMRT, mSin3 and histone deacetylase. This complex has been implicated in the transcriptional...

Reduced Levels of ATF-2 Predispose Mice to Mammary Tumors† ▿

Maekawa, Toshio, Shinagawa, Toshie, Sano, Yuji, Sakuma, Takahiko, Nomura, Shintaro, Nagasaki, Koichi, ...

Transcription factor ATF-2 is a nuclear target of stress-activated protein kinases, such as p38, which are activated by various extracellular stresses, including UV light. Here, we show that ATF-2...

A B-Myb complex containing clathrin and filamin is required for mitotic spindle function

Yamauchi, Tomohiro, Ishidao, Takefumi, Nomura, Teruaki, Shinagawa, Toshie, Tanaka, Yasunori, Yonemura, Shigenobu, ...

B-Myb is one member of the vertebrate Myb family of transcription factors and is ubiquitously expressed. B-Myb activates transcription of a group of genes required for the G2/M cell cycle transition...