Watanabe, Akiharu, Higashi, Toshihiro, Nagashima, Hideo
A mixture with essential and nonessential amino acids high in branched chain amino acids and low in aromatic amino acids (Fischer solution), and another synthetic mixture of branched chain amino...
An animal model of fulminant hepatic failure in the rat. (2007)
Watanabe, Akiharu, Higashi, Toshihiro, Nagashima, Hideo
A reproducible animal model of fulminant hepatic failure was developed by intraperitoneal administration of D-galactosamine hydrochloride to Sprague-Dawley rats. Biochemical and morphological hepatic...
Watanabe, Akiharu, Higashi, Toshihiro, Endo, Hiroshi, Nagashima, Hideo
Three patients at various stages of remission from leukemia died following the development of massive liver necrosis within only 4-6 days. All had either hepatitis B surface antigen or antibody in...
Effects of insulin and glucagon on serum amino acid concentrations in liver disease. (2007)
Watanabe, Akiharu, Higashi, Toshihiro, Hayashi, Shosaku, Obata, Takahiro, Sakata, Tatsuro, Takei, Nobuyuki, ...
The effects of insulin and glucagon administration on serum amino acid levels were investigated in patients with severe liver disease, since simultaneous injection of pancreatic hormones has been...
Hyperbilirubinemia and enhanced mitosis of hepatocytes in phalloidin-treated female rats. (2007)
Obata, Takahiro, Watanabe, Akiharu, Hayashi, Shosuku, Takei, Nobuyuki, Sakata, Tatsuro, Shiota, Tetsuya, ...
Cholestasis with htperbilirubinemia was induced in female, but not male, Sprague-Dawley rats by daily treatment with phalloidin for 7 days. Increases in serum direct bilirubin level and alkaline...
Hyperbilirubinemia and enhanced mitosis of hepatocytes in phalloidin-treated female rats. (2007)
Obata, Takahiro, Watanabe, Akiharu, Hayashi, Shosaku, Takei, Nobuyuki, Sakata, Tatsuro, Shiota, Tetsuya, ...
Cholestasis with hyperbilirubinemia was induced in female, but not male, Sprague-Dawley rats by daily treatment with phalloidin for 7 days. Increases in serum direct bilirubin level and alkaline...
Kuwahara, Naoaki, Higashi, Toshihiro, Nouso, Kazuhiro, Ito, Toshio, Tsuji, Takao
Tissue PIVKA-II was examined in 32 hepatocellular carcinomas and 2 metastatic liver tumors using indirect immunofluorescence, and the results were compared with the size, histological grading and...
Satoh, Yasumasa, Higashi, Toshihiro, Nouso, Kazuhiro, Shiota, Tetsuya, Kinugasa, Nobuyuki, Yoshida, Keigo, ...
Cathepsin B, a thiol protease, is involved in cancer metastasis. To clarify the role of cathepsin B in tumor progression in human colorectal cancer, the relationship between its activity,...
Satoh, Yasumasa, Higashi, Toshihiro, Nouso, Kazuhiro, Shiota, Tetsuya, Kinugasa, Nobuyuki, Yoshida, Keigo, ...
Cathepsin B, a thiol protease, has been reported to be involved in cancer progression and metastasis. The suppressive effects of two kinds of protease inhibitors, leupeptin and dietary camostate...
Kimura, Yoshihiro, Higashi, Toshihiro, Kuwahara, Naoaki, Nouso, Kazuhiro, Ohguchi, Shouhei, Hino, Naoki, ...
To diagnose hepatocellular carcinoma (HCC) functionally and immediately, we examined the usefulness of indocyanine green (ICG) injection during ultrasound-guided liver biopsy. Liver specimens were...
Nouso, Kazuhiro, Battula, Narayama, Thorgeirsson, Snorri S, Higashi, Toshihiro, Tsuji, Takao
We expressed mouse cytochrome P1-450 and P3-450 using recombinant vaccinia virus gene expression system in HeLa cells that were devoid of significant basal levels of P-450. HeLa cells were infected...
Ling, Liu, Higashi, Toshihiro, Tsuchida, Shigeki, Sato, Kiyomi, Tsuji, Takao
Reduced indocyanine green (ICG) uptake is one of the functional changes of human hepatocellular carcinoma (HCC). To clarify the mechanisms of loss of ICG uptake, and determine which subunit of...
Hino, Naoki, Higashi, Toshihiro, Ueki, Tooru, Nakatsukasa, Harushige, Ooguchi, Souhei, Ashida, Kouzou, ...
We report here a case of hepatocellular carcinoma (HCC) with multiple lung metastases, which were disappeared by treatment of OK-432. The patient was a 65-year-old man and was diagnosed in 1986 with...
Sato, Atsuhiko, Higashi, Toshihiro, Ling, Liu, Shiota, Tetsuya, Tsuji, Takao
Indocyanine green (ICG) was injected into rat liver nodules induced by 2-acetylaminofluorene (2-AAF) via portal vein. The relationship between ICG staining and cell atypism of liver nodules was...
Itoshima, Tatsuya, Fedail, Sulieman S., Suliman, Ikhlas, Ali, Abbas K., Higashi, Toshihiro, Tsuji, Takao
Markers of hepatitis A and B virus were tested in 88 adult Sudanese subjects in Khartoum, Sudan. The subjects consisted of 25 control hospitalized patients, 21 volunteer blood donors, 23 patients...
The secretion of high molecular weight cathepsin B from cultured human liver cancers. (2007)
Ohsawa, Toshiya, Higashi, Toshihiro, Tsuji, Takao
The biochemical characteristics of cathepsin B secreted from cultured human liver cancer cells were examined. The enzyme activity of culture medium against a synthetic substrate,...
Ultrasonographic characteristics of small hepatocellular carcinoma. (2007)
Higashi, Toshihiro, Tobe, Kazuo, Asano, Ken-ichiro, Ikeda, Hiroshi, Ohsawa, Toshiya, Iwasaki, Yoshiaki, ...
The ultrasonographic characteristics of hepatocellular carcinomas (HCC) were investigated. Four typical features of HCCs, "mosaic internal echo pattern", "halo", "lateral shadow" and "posterior echo...
Detection of type V collagen-degrading enzyme activity in human liver. (2007)
Kobayashi, Michio, Nakatsukasa, Harushige, Watanabe, Akiharu, Yamauchi, Yasuhiko, Fujiwara, Masachika, Hashimoto, Makoto, ...
Type V collagen-degrading enzyme activity was detected as a metalloprotease acting at neutral pH in the human liver. Type V collagen extracted from human placenta and labeled with [1-14C] acetic...
Assay procedures for cathepsin B, H and L activities in rat tissue homogenates. (2007)
Higashi, Toshihiro, Hashimoto, Makoto, Watanabe, Masatomo, Yamauchi, Yasuhiko, Fujiwara, Masachika, Nakatsukasa, Harushige, ...
Cathepsin B, H and L activities in small amounts of rat tissue homogenates corresponding to 10 micrograms protein were determined with 7-amino-4-methyl-coumarin conjugates as substrates. A new...
Cerebral edema associated with acute hepatic failure. (2007)
Fujiwara, Masachika, Watanabe, Akiharu, Yamauchi, Yasuhiko, Hashimoto, Makoto, Nakatsukasa, Harushige, Kobayashi, Michio, ...
The clinicopathological findings of cerebral edema were investigated in patients with acute hepatic failure autopsied at Okayama University Hospital between 1970 and 1980 retrospectively. Nine (64%)...
Shiota, Tetsuya, Watanabe, Akiharu, Higashi, Toshihiro, Nagashima, Hideo
The prevention of hepatic encephalopathy by the intravenous infusion of a branched chain amino acid (BCAA)-enriched solution was investigated in methionine and ammonium acetate-treated rats whose...
Yoshida, Yasuhiro, Higashi, Toshihiro, Nouso, Kazuhiro, Nakatsukasa, Harushige, Nakamura, Shin-ichiro, Watanabe, Akiharu, ...
Hepatic encephalopathy is one of the major complications in decompensated liver cirrhosis. The current study was conducted to clarify the mechanisms of zinc deficiency in liver cirrhosis and its...
Kyoto University (京都大学)
Identification of proacrosin binding protein sp32 precursor as a human cancer/testis antigen
Ono, Toshiro, Kurashige, Takushi, Harada, Naoki, Noguchi, Yuji, Saika, Takashi, Niikawa, Norio, ...
Serological expression cloning of antigens eliciting a humoral immune response to a syngeneic mouse sarcoma identified pem (mouse placenta and embryonic expression gene) as a new member of the...
Identification of proacrosin binding protein sp32 precursor as a human cancer/testis antigen
Ono, Toshiro, Kurashige, Takushi, Harada, Naoki, Noguchi, Yuji, Saika, Takashi, Niikawa, Norio, ...
Serological expression cloning of antigens eliciting a humoral immune response to a syngeneic mouse sarcoma identified pem (mouse placenta and embryonic expression gene) as a new member of the...