Toshihiro Tsuneyoshi

Absence of germline mono-allelic promoter hypermethylation of the CDH1gene in gastric cancer patients (2009)

Yamada, Hidetaka, Shinmura, Kazuya, Goto, Masanori, Iwaizumi, Moriya, Konno, Hiroyuki, Kataoka, Hideki, ...

Abstract Background Germline mono-allelic promoter hypermethylation of the MLH1 or MSH2 gene in families with hereditary nonpolyposis colorectal cancer has recently been reported. The purpose of this...

Altered expression of the human base excision repair gene NTH1 in gastric cancer (2009)

Goto, Masanori, Shinmura, Kazuya, Igarashi, Hisaki, Kobayashi, Minatsu, Konno, Hiroyuki, Yamada, Hidetaka, ...

A base excision repair enzyme, NTH1, has activity that is capable of removing oxidized pyrimidines, such as thymine glycol (Tg), from DNA. To clarify whether the NTH1 gene is involved in gastric...

Fluorescence-labeled Methylation-sensitive Amplified Fragment Length Polymorphism (FL-MS-AFLP) Analysis for Quantitative Determination of DNA Methylation and Demethylation Status (2008)

Kageyama, Shinji, Shinmura, Kazuya, Yamamoto, Hiroko, Goto, Masanori, Suzuki, Koichi, Tanioka, Fumihiko, ...

The PCR-based DNA fingerprinting method called the methylation-sensitive amplified fragment length polymorphism (MS-AFLP) analysis is used for genome-wide scanning of methylation status. In this...

Identification and characterization of a novel germ line p53 mutation in familial gastric cancer in the Japanese population (2007)

Yamada, Hidetaka, Shinmura, Kazuya, Okudela, Koji, Goto, Masanori, Suzuki, Masaya, Kuriki, Ken, ...

Germ line mutations of the p53 gene are known to cause Li-Fraumeni syndrome, and a germ line p53 mutation has recently been reported in a small subset of familial gastric cancer (FGC) in Europe and...

The role of cyclooxygenase-2 (COX-2) in two different morphological stages of intestinal polyps in APC{Delta}474 knockout mice (2002)

Sunayama, Ken-ichi, Konno, Hiroyuki, Nakamura, Toshio, Kashiwabara, Hidehumi, Shoji, Tsuyoshi, Tsuneyoshi, Toshihiro, ...

The expression of COX-2 participates strongly in polyp formation of adenomatous polyposis coli (APC)-mutated mice. However, the mechanism of growth inhibition by COX-2 inhibition remains unclear. The...