Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice (2009)
Kuo, Ya-Huei, Zaidi, Sayyed K., Gornostaeva, Svetlana, Komori, Toshihisa, Stein, Gary S., Castilla, Lucio H.
The core-binding factor (CBF) is a master regulator of developmental and differentiation programs, and CBF alterations are frequently associated with acute leukemia. The role of the CBF member RUNX2...
Isono, Kyoichi, Mizutani-Koseki, Yoko, Komori, Toshihisa, Schmidt-Zachmann, Marion S., Koseki, Haruhiko
Polycomb group (PcG) proteins are responsible for the stable repression of homeotic (Hox) genes by forming multimeric protein complexes. We show (1) physical interaction between components of the U2...
Yoshida, Carolina A., Yamamoto, Hiromitsu, Fujita, Takashi, Furuichi, Tatsuya, Ito, Kosei, Inoue, Ken-ichi, ...
The differentiation of mesenchymal cells into chondrocytes and chondrocyte proliferation and maturation are fundamental steps in skeletal development. Runx2 is essential for osteoblast...
Skeletal development through the regulation of chondrocyte and osteoblast differentiation by Runx2
Runx2 is a transcription factor that belongs to Runx family (Runx1, Runx2, and Runx3). Runx2 interacts with many other transcription factors and co-regulators in the transcriptional regulation of its...
Lee, Kyeong-Sook, Kim, Hyun-Jung, Li, Qing-Lin, Chi, Xin-Zi, Ueta, Chisato, Komori, Toshihisa, ...
When C2C12 pluripotent mesenchymal precursor cells are treated with transforming growth factor β1 (TGF-β1), terminal differentiation into myotubes is blocked. Treatment with bone morphogenetic...
Jiménez, Maria J. G., Balbín, Milagros, López, José M., Alvarez, Jesús, Komori, Toshihisa, López-Otín, Carlos
Collagenase 3 (MMP-13) is a recently identified member of the matrix metalloproteinase (MMP) gene family that is expressed at high levels in diverse human carcinomas and in articular cartilage from...
Yoshida, Carolina A., Yamamoto, Hiromitsu, Fujita, Takashi, Furuichi, Tatsuya, Ito, Kosei, Inoue, Ken-ichi, ...
The differentiation of mesenchymal cells into chondrocytes and chondrocyte proliferation and maturation are fundamental steps in skeletal development. Runx2 is essential for osteoblast...
Isono, Kyoichi, Mizutani-Koseki, Yoko, Komori, Toshihisa, Schmidt-Zachmann, Marion S., Koseki, Haruhiko
Polycomb group (PcG) proteins are responsible for the stable repression of homeotic (Hox) genes by forming multimeric protein complexes. We show (1) physical interaction between components of the U2...
Lee, Kyeong-Sook, Kim, Hyun-Jung, Li, Qing-Lin, Chi, Xin-Zi, Ueta, Chisato, Komori, Toshihisa, ...
When C2C12 pluripotent mesenchymal precursor cells are treated with transforming growth factor β1 (TGF-β1), terminal differentiation into myotubes is blocked. Treatment with bone morphogenetic...
Jiménez, Maria J. G., Balbín, Milagros, López, José M., Alvarez, Jesús, Komori, Toshihisa, López-Otín, Carlos
Collagenase 3 (MMP-13) is a recently identified member of the matrix metalloproteinase (MMP) gene family that is expressed at high levels in diverse human carcinomas and in articular cartilage from...
Yoshida, Carolina A., Yamamoto, Hiromitsu, Fujita, Takashi, Furuichi, Tatsuya, Ito, Kosei, Inoue, Ken-ichi, ...
The differentiation of mesenchymal cells into chondrocytes and chondrocyte proliferation and maturation are fundamental steps in skeletal development. Runx2 is essential for osteoblast...
Isono, Kyoichi, Mizutani-Koseki, Yoko, Komori, Toshihisa, Schmidt-Zachmann, Marion S., Koseki, Haruhiko
Polycomb group (PcG) proteins are responsible for the stable repression of homeotic (Hox) genes by forming multimeric protein complexes. We show (1) physical interaction between components of the U2...
Skeletal development through the regulation of chondrocyte and osteoblast differentiation by Runx2
Runx2 is a transcription factor that belongs to Runx family (Runx1, Runx2, and Runx3). Runx2 interacts with many other transcription factors and co-regulators in the transcriptional regulation of its...
Characterization of GATA-1+ hemangioblastic cells in the mouse embryo
Yokomizo, Tomomasa, Takahashi, Satoru, Mochizuki, Naomi, Kuroha, Takashi, Ema, Masatsugu, Wakamatsu, Asami, ...
Hemangioblasts are thought to be one of the sources of hematopoietic progenitors, yet little is known about their localization and fate in the mouse embryo. We show here that a subset of cells...
Fujita, Takashi, Azuma, Yasutaka, Fukuyama, Ryo, Hattori, Yuji, Yoshida, Carolina, Koida, Masao, ...
Runx2 and phosphatidylinositol 3-kinase (PI3K)–Akt signaling play important roles in osteoblast and chondrocyte differentiation. We investigated the relationship between Runx2 and PI3K-Akt...
Liu, Wenguang, Toyosawa, Satoru, Furuichi, Tatsuya, Kanatani, Naoko, Yoshida, Carolina, Liu, Yang, ...
Targeted disruption of core binding factor α1 (Cbfa1) showed that Cbfa1 is an essential transcription factor in osteoblast differentiation and bone formation. Furthermore, both in vitro and in vivo...
Ueta, Chisato, Iwamoto, Masahiro, Kanatani, Naoko, Yoshida, Carolina, Liu, Yang, Enomoto-Iwamoto, Motomi, ...
During skeletogenesis, cartilage develops to either permanent cartilage that persists through life or transient cartilage that is eventually replaced by bone. However, the mechanism by which...
Jiménez, Maria J.G., Balbín, Milagros, Alvarez, Jesús, Komori, Toshihisa, Bianco, Paolo, Holmbeck, Kenn, ...
Tissue-remodeling processes are largely mediated by members of the matrix metalloproteinase (MMP) family of endopeptidases whose expression is strictly controlled both spatially and temporally. In...
Tanaka, Toru, Sato, Hiroko, Doi, Hiroshi, Yoshida, Carolina A., Shimizu, Takehisa, Matsui, Hiroki, ...
Phenotypic plasticity and the switching of vascular smooth muscle cells (SMCs) play a critical role in atherosclerosis. Although Runx2, a key osteogenic transcription factor, is expressed in...
Bone morphogenetic protein rescues the lack of secondary cartilage in Runx2-deficient mice
Fukuoka, Hiroki, Shibata, Shunichi, Suda, Naoto, Yamashita, Yasuo, Komori, Toshihisa
Secondary cartilages including mandibular condylar cartilage have unique characteristics. They originate from alkaline phosphatase (ALP)-positive progenitor cells of the periosteum, and exhibit...