Toshio Fujioka

Analysis of virulence factors of Helicobacter pyloriisolated from a Vietnamese population (2009)

Uchida, Tomohisa, Nguyen, Lam, Takayama, Akiko, Okimoto, Tadayoshi, Kodama, Masaaki, Murakami, Kazunari, ...

Abstract Background The incidence of gastric cancer differs among countries in Asia, and it has been suggested that virulence factors associated with Helicobacter pylori are partly responsible. The...

Psychosocial Factors Affecting the Therapeutic Decision-making and Postoperative Mood States in Japanese Breast Cancer Patients who underwent Various Types of Surgery: Body Image and Sexuality (2007)

Adachi, Keiichiro, Ueno, Tokumi, Fujioka, Toshio, Fujitomi, Yutaka, Ueo, Hiroaki

Objective We conducted an empirical study to clarify how psychosocial factors (e.g. body image and sexuality) influence therapeutic decision-making and to identify the factors that affect...

Antimicrobial Susceptibilities of Helicobacter pylori Isolates under Microaerophilic Atmospheres Established by Two Different Methods

Kobayashi, Intetsu, Muraoka, Hiroe, Saika, Takeshi, Nishida, Minoru, Fujioka, Toshio, Nasu, Masaru

The MICs of clarithromycin, amoxicillin, and metronidazole for 150 Helicobacter pylori isolates were determined using the AnaeroPack system and were compared with those determined using a...

Serological Assessment of the Early Response to Eradication Therapy Using an Immunodominant Outer Membrane Protein of Helicobacter pylori

Nishizono, Akira, Gotoh, Takayuki, Fujioka, Toshio, Murakami, Kazunari, Kubota, Toshihiro, Nasu, Masaru, ...

Eradication of Helicobacter pylori infection cures gastritis and prevents recurrence of peptic ulcers. Endoscopy is usually used to evaluate the effectiveness of eradication therapy. We designed a...

Diversity in Protein Synthesis and Viability of Helicobacter pylori Coccoid Forms in Response to Various Stimuli

Mizoguchi, Hiromoto, Fujioka, Toshio, Kishi, Kenji, Nishizono, Akira, Kodama, Reiji, Nasu, Masaru

The viability of the coccoid forms of Helicobacter pylori was evaluated by assessing protein synthesis. Metabolic labeling studies showed the synthesis of proteins and the specific protein profiles...

Local Secretory Immunoglobulin A and Postimmunization Gastritis Correlate with Protection against Helicobacter pylori Infection after Oral Vaccination of Mice

Goto, Takayuki, Nishizono, Akira, Fujioka, Toshio, Ikewaki, Junko, Mifune, Kumato, Nasu, Masaru

C57BL/6 mice were orally immunized with five weekly doses of 2 mg, 200 μg, or 2 μg of Helicobacter pylori (Sydney strain) whole-cell sonicate combined with cholera toxin. One week after the last...

Effect of Sucralfate on Antibiotic Therapy for Helicobacter pylori Infection in Mice

Watanabe, Koichiro, Murakami, Kazunari, Sato, Ryugo, Kashimura, Koji, Miura, Masahiro, Ootsu, Satoshi, ...

It has been documented that sucralfate, a basic aluminum salt, enhances the efficacies of antibiotics against Helicobacter pylori, resulting in eradication rates comparable to those associated with...

Transfer of Antigen-Pulsed Dendritic Cells Induces Specific T-Cell Proliferation and a Therapeutic Effect against Long-Term Helicobacter pylori Infection in Mice

Otsu, Satoshi, Gotoh, Kazuyo, Yamashiro, Tetsu, Yamagata, Junpei, Shin, Kouichirou, Fujioka, Toshio, ...

Helicobacter pylori causes persistent infection of the stomach and results in chronic gastritis and peptic ulcers. Jaws II cells, derived from mouse bone marrow, were pulsed with live or...

Antimicrobial Susceptibilities of Helicobacter pylori Isolates under Microaerophilic Atmospheres Established by Two Different Methods

Kobayashi, Intetsu, Muraoka, Hiroe, Saika, Takeshi, Nishida, Minoru, Fujioka, Toshio, Nasu, Masaru

The MICs of clarithromycin, amoxicillin, and metronidazole for 150 Helicobacter pylori isolates were determined using the AnaeroPack system and were compared with those determined using a...

Serological Assessment of the Early Response to Eradication Therapy Using an Immunodominant Outer Membrane Protein of Helicobacter pylori

Nishizono, Akira, Gotoh, Takayuki, Fujioka, Toshio, Murakami, Kazunari, Kubota, Toshihiro, Nasu, Masaru, ...

Eradication of Helicobacter pylori infection cures gastritis and prevents recurrence of peptic ulcers. Endoscopy is usually used to evaluate the effectiveness of eradication therapy. We designed a...

Diversity in Protein Synthesis and Viability of Helicobacter pylori Coccoid Forms in Response to Various Stimuli

Mizoguchi, Hiromoto, Fujioka, Toshio, Kishi, Kenji, Nishizono, Akira, Kodama, Reiji, Nasu, Masaru

The viability of the coccoid forms of Helicobacter pylori was evaluated by assessing protein synthesis. Metabolic labeling studies showed the synthesis of proteins and the specific protein profiles...

Local Secretory Immunoglobulin A and Postimmunization Gastritis Correlate with Protection against Helicobacter pylori Infection after Oral Vaccination of Mice

Goto, Takayuki, Nishizono, Akira, Fujioka, Toshio, Ikewaki, Junko, Mifune, Kumato, Nasu, Masaru

C57BL/6 mice were orally immunized with five weekly doses of 2 mg, 200 μg, or 2 μg of Helicobacter pylori (Sydney strain) whole-cell sonicate combined with cholera toxin. One week after the last...

Effect of Sucralfate on Antibiotic Therapy for Helicobacter pylori Infection in Mice

Watanabe, Koichiro, Murakami, Kazunari, Sato, Ryugo, Kashimura, Koji, Miura, Masahiro, Ootsu, Satoshi, ...

It has been documented that sucralfate, a basic aluminum salt, enhances the efficacies of antibiotics against Helicobacter pylori, resulting in eradication rates comparable to those associated with...

Transfer of Antigen-Pulsed Dendritic Cells Induces Specific T-Cell Proliferation and a Therapeutic Effect against Long-Term Helicobacter pylori Infection in Mice

Otsu, Satoshi, Gotoh, Kazuyo, Yamashiro, Tetsu, Yamagata, Junpei, Shin, Kouichirou, Fujioka, Toshio, ...

Helicobacter pylori causes persistent infection of the stomach and results in chronic gastritis and peptic ulcers. Jaws II cells, derived from mouse bone marrow, were pulsed with live or...

Changing Antimicrobial Susceptibility Epidemiology of Helicobacter pylori Strains in Japan between 2002 and 2005▿

Kobayashi, Intetsu, Murakami, Kazunari, Kato, Mototsugu, Kato, Seiichi, Azuma, Takeshi, Takahashi, Shin'ichi, ...

Surveillance of Helicobacter pylori antimicrobial susceptibility reflecting the general population in Japan is limited. The antimicrobial susceptibilities of 3,707 H. pylori strains isolated from...

Cytotoxic-T-Lymphocyte-Associated Antigen 4 Blockade Abrogates Protection by Regulatory T Cells in a Mouse Model of Microbially Induced Innate Immune-Driven Colitis▿

Watanabe, Koichiro, Rao, Varada P., Poutahidis, Theofilos, Rickman, Barry H., Ohtani, Masahiro, Xu, Shilu, ...

Cytotoxic-T-lymphocyte-associated antigen 4 (CTLA-4) expressed at high levels by CD4+ CD25+ CD45RBlow regulatory T cells (Treg) is essential to their homeostatic and immunoregulatory functions....