Induction of fimbriated Vibrio cholerae O139 (1998)
Ehara, Masahiko, Iwami, Mamoru, Ichinose, Yoshio, Hirayama, Toshiya, Albert, M. John, Sack, R. Bradley, ...
Several fimbriated phases of Vibrio cholerae O139 strains were selectively induced and compared immunologically and biochemically with those of V. cholerae O1. Fimbrial antigens were detected on the...
HIRAYAMA, Toshiya, NAGAYAMA, Hideo, MATSUDA, Kazuo
Kinetic studies of the two β-glucosidase isozymes, GB-1 and GB-2, which were purified from the culture filtrate of a phytopathogenic fungus Pyricularia oryzae, revealed that the latter isozyme was...
HIRAYAMA, Toshiya, NAGAYAMA, Hideo, MATSUDA, Kazuo
To determine the relationship between the induction patterns of three components of β-glucosidase of Pyricularia oryzae and carbon sources in the growth medium, various culture conditions were...
HIRAYAMA, Toshiya, HORIE, Sigeo, NAGAYAMA, Hideo, MATSUDA, Kazuo
Three components (GA, GB-1, and GB-2) of β-glucosidase were detected in the culture filtrate of Pyricularia oryzae grown in a cellulose or cellulose derivative medium. Among them, GB-1 was induced...
Sar, Borann, Oishi, Kazunori, Wada, Akihiro, Hirayama, Toshiya, Matsushima, Kouji, Nagatake, Tsuyoshi
We have recently reported that nitrite reductase, a bifunctional enzyme located in the periplasmic space of Pseudomonas aeruginosa, could induce interleukin-8 (IL-8) generation in a variety of...
Mori, Naoki, Wada, Akihiro, Hirayama, Toshiya, Parks, Thomas P., Stratowa, Christian, Yamamoto, Naoki
Interactions between leukocytes and epithelial cells may play a key role in Helicobacter pylori-associated gastric mucosal inflammation. This process is mediated by various cell adhesion molecules....
Induction of Monocyte Chemoattractant Protein 1 by Helicobacter pylori Involves NF-κB
Mori, Naoki, Ueda, Atsuhisa, Geleziunas, Romas, Wada, Akihiro, Hirayama, Toshiya, Yoshimura, Teizo, ...
Helicobacter pylori stimulates secretion of monocyte chemoattractant protein 1 (MCP-1) from gastric epithelial cells. Secretion of this chemokine may be instrumental in monocyte infiltration of the...
Induction of Fimbriated Vibrio cholerae O139
Ehara, Masahiko, Iwami, Mamoru, Ichinose, Yoshio, Hirayama, Toshiya, Albert, M. John, Sack, R. Bradley, ...
Several fimbriated phases of Vibrio cholerae O139 strains were selectively induced and compared immunologically and biochemically with those of V. cholerae O1. Fimbrial antigens were detected on the...
ADP ribosylation of human neutrophil peptide-1 regulates its biological properties
Paone, Gregorino, Wada, Akihiro, Stevens, Linda A., Matin, Abul, Hirayama, Toshiya, Levine, Rodney L., ...
In human airways, epithelial cells lining the lumen and intraluminal cells (e.g., polymorphonuclear cells) participate in the innate immune response. These cells secrete or express on their surfaces...
Helicobacter pylori Induces RANTES through Activation of NF-κB
Mori, Naoki, Krensky, Alan M., Geleziunas, Romas, Wada, Akihiro, Hirayama, Toshiya, Sasakawa, Chihiro, ...
Helicobacter pylori-infected gastric mucosa displays a conspicuous infiltration of mononuclear cells and neutrophils. RANTES (short for “regulated upon activation, normal T cell expressed and...
Suzuki, Junko, Ohnsihi, Hirohide, Shibata, Hiroshi, Wada, Akihiro, Hirayama, Toshiya, Iiri, Taroh, ...
The Helicobacter pylori–produced cytotoxin VacA induces intracellular vacuolation. To elucidate the molecular mechanism of vacuole formation by VacA, we examined the participation of dynamin, a...
Suzuki, Junko, Ohnishi, Hirohide, Shibata, Hiroshi, Wada, Akihiro, Hirayama, Toshiya, Iiri, Taroh, ...
Noda, Masatoshi, Kato, Iwao, Matsuda, Futami, Hirayama, Toshiya
The binding of 125I-labeled S component to rabbit polymorphonuclear leukocytes was found to be concentration dependent and saturable at 37°C. Scatchard analysis of the binding curve gave a straight...
Noda, Masatoshi, Kato, Iwao, Hirayama, Toshiya, Matsuda, Futami
Staphylococcal leukocidin is resolved by chromatography on carboxymethyl cellulose columns into two components, which are designated F (fast) and S (slow). Fixation and inactivation of both...
Yokoyama, Kazuyuki, Higashi, Hideaki, Ishikawa, Susumu, Fujii, Yumiko, Kondo, Satoshi, Kato, Hiroyuki, ...
Chronic infection with cagA-positive Helicobacter pylori is associated with the development of atrophic gastritis, peptic ulcers, and gastric adenocarcinoma. The cagA gene product CagA is injected...
Sar, Borann, Oishi, Kazunori, Wada, Akihiro, Hirayama, Toshiya, Matsushima, Kouji, Nagatake, Tsuyoshi
We have recently reported that nitrite reductase, a bifunctional enzyme located in the periplasmic space of Pseudomonas aeruginosa, could induce interleukin-8 (IL-8) generation in a variety of...
Mori, Naoki, Wada, Akihiro, Hirayama, Toshiya, Parks, Thomas P., Stratowa, Christian, Yamamoto, Naoki
Interactions between leukocytes and epithelial cells may play a key role in Helicobacter pylori-associated gastric mucosal inflammation. This process is mediated by various cell adhesion molecules....
Induction of Monocyte Chemoattractant Protein 1 by Helicobacter pylori Involves NF-κB
Mori, Naoki, Ueda, Atsuhisa, Geleziunas, Romas, Wada, Akihiro, Hirayama, Toshiya, Yoshimura, Teizo, ...
Helicobacter pylori stimulates secretion of monocyte chemoattractant protein 1 (MCP-1) from gastric epithelial cells. Secretion of this chemokine may be instrumental in monocyte infiltration of the...
Induction of Fimbriated Vibrio cholerae O139
Ehara, Masahiko, Iwami, Mamoru, Ichinose, Yoshio, Hirayama, Toshiya, Albert, M. John, Sack, R. Bradley, ...
Several fimbriated phases of Vibrio cholerae O139 strains were selectively induced and compared immunologically and biochemically with those of V. cholerae O1. Fimbrial antigens were detected on the...
ADP ribosylation of human neutrophil peptide-1 regulates its biological properties
Paone, Gregorino, Wada, Akihiro, Stevens, Linda A., Matin, Abul, Hirayama, Toshiya, Levine, Rodney L., ...
In human airways, epithelial cells lining the lumen and intraluminal cells (e.g., polymorphonuclear cells) participate in the innate immune response. These cells secrete or express on their surfaces...
Helicobacter pylori Induces RANTES through Activation of NF-κB
Mori, Naoki, Krensky, Alan M., Geleziunas, Romas, Wada, Akihiro, Hirayama, Toshiya, Sasakawa, Chihiro, ...
Helicobacter pylori-infected gastric mucosa displays a conspicuous infiltration of mononuclear cells and neutrophils. RANTES (short for “regulated upon activation, normal T cell expressed and...
Suzuki, Junko, Ohnsihi, Hirohide, Shibata, Hiroshi, Wada, Akihiro, Hirayama, Toshiya, Iiri, Taroh, ...
The Helicobacter pylori–produced cytotoxin VacA induces intracellular vacuolation. To elucidate the molecular mechanism of vacuole formation by VacA, we examined the participation of dynamin, a...
Suzuki, Junko, Ohnishi, Hirohide, Shibata, Hiroshi, Wada, Akihiro, Hirayama, Toshiya, Iiri, Taroh, ...
Noda, Masatoshi, Kato, Iwao, Matsuda, Futami, Hirayama, Toshiya
The binding of 125I-labeled S component to rabbit polymorphonuclear leukocytes was found to be concentration dependent and saturable at 37°C. Scatchard analysis of the binding curve gave a straight...
Noda, Masatoshi, Kato, Iwao, Hirayama, Toshiya, Matsuda, Futami
Staphylococcal leukocidin is resolved by chromatography on carboxymethyl cellulose columns into two components, which are designated F (fast) and S (slow). Fixation and inactivation of both...
Yokoyama, Kazuyuki, Higashi, Hideaki, Ishikawa, Susumu, Fujii, Yumiko, Kondo, Satoshi, Kato, Hiroyuki, ...
Chronic infection with cagA-positive Helicobacter pylori is associated with the development of atrophic gastritis, peptic ulcers, and gastric adenocarcinoma. The cagA gene product CagA is injected...
Nakayama, Masaaki, Hisatsune, Jyunzo, Yamasaki, Eiki, Nishi, Yoshito, Wada, Akihiro, Kurazono, Hisao, ...
Helicobacter pylori vacuolating cytotoxin, VacA, induces multiple effects on epithelial cells through different cellular events: one involves pore formation, leading to vacuolation, mitochondrial...
Hisatsune, Junzo, Yamasaki, Eiki, Nakayama, Masaaki, Shirasaka, Daisuke, Kurazono, Hisao, Katagata, Yohtaro, ...
Treatment of AZ-521 cells with Helicobacter pylori VacA increased cyclooxygenase 2 (COX-2) mRNA in a time- and dose-dependent manner. A p38 mitogen-activated protein kinase (MAPK) inhibitor,...
Mashima, Hirosato, Suzuki, Junko, Hirayama, Toshiya, Yoshikumi, Yukako, Ohno, Hideki, Ohnishi, Hirohide, ...
Helicobacter pylori-produced cytotoxin VacA induces intracellular vacuolation. The VacA-induced vacuole is assumed to represent the pathological status of intracellular trafficking. The fusion...
Helicobacter pylori-Induced Interleukin-12 p40 Expression▿
Takeshima, Eriko, Tomimori, Koh, Teruya, Hiromitsu, Ishikawa, Chie, Senba, Masachika, D'Ambrosio, Daniele, ...
Interleukin-12 (IL-12) is a heterodimeric cytokine produced by antigen-presenting cells that promotes the development of T-helper lymphocyte 1 (Th1). Chronic gastritis induced by Helicobacter pylori...