Toshiyuki Kawashima

Mammalian Twisted Gastrulation Is Essential for Skeleto-Lymphogenesis

Nosaka, Tetsuya, Morita, Sumiyo, Kitamura, Hidetomo, Nakajima, Hideaki, Shibata, Fumi, Morikawa, Yoshihiro, ...

Dorsoventral patterning depends on the local concentrations of the morphogens. Twisted gastrulation (TSG) regulates the extracellular availability of a mesoderm inducer, bone morphogenetic protein 4...

Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple-lineage leukemogenesis

Ono, Ryoichi, Nakajima, Hideaki, Ozaki, Katsutoshi, Kumagai, Hidetoshi, Kawashima, Toshiyuki, Taki, Tomohiko, ...

The mechanisms by which mixed-lineage leukemia (MLL) fusion products resulting from in utero translocations in 11q23 contribute to leukemogenesis and infant acute leukemia remain elusive. It is still...

The Constitutive Centromere Component CENP-50 Is Required for Recovery from Spindle Damage‡

Minoshima, Yukinori, Hori, Tetsuya, Okada, Masahiro, Kimura, Hiroshi, Haraguchi, Tokuko, Hiraoka, Yasushi, ...

We identified CENP-50 as a novel kinetochore component. We found that CENP-50 is a constitutive component of the centromere that colocalizes with CENP-A and CENP-H throughout the cell cycle in...

Mammalian Twisted Gastrulation Is Essential for Skeleto-Lymphogenesis

Nosaka, Tetsuya, Morita, Sumiyo, Kitamura, Hidetomo, Nakajima, Hideaki, Shibata, Fumi, Morikawa, Yoshihiro, ...

Dorsoventral patterning depends on the local concentrations of the morphogens. Twisted gastrulation (TSG) regulates the extracellular availability of a mesoderm inducer, bone morphogenetic protein 4...

Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple-lineage leukemogenesis

Ono, Ryoichi, Nakajima, Hideaki, Ozaki, Katsutoshi, Kumagai, Hidetoshi, Kawashima, Toshiyuki, Taki, Tomohiko, ...

The mechanisms by which mixed-lineage leukemia (MLL) fusion products resulting from in utero translocations in 11q23 contribute to leukemogenesis and infant acute leukemia remain elusive. It is still...

The Constitutive Centromere Component CENP-50 Is Required for Recovery from Spindle Damage‡

Minoshima, Yukinori, Hori, Tetsuya, Okada, Masahiro, Kimura, Hiroshi, Haraguchi, Tokuko, Hiraoka, Yasushi, ...

We identified CENP-50 as a novel kinetochore component. We found that CENP-50 is a constitutive component of the centromere that colocalizes with CENP-A and CENP-H throughout the cell cycle in...

Rac1 and a GTPase-activating protein, MgcRacGAP, are required for nuclear translocation of STAT transcription factors

Kawashima, Toshiyuki, Bao, Ying Chun, Nomura, Yasushi, Moon, Yuseok, Tonozuka, Yukio, Minoshima, Yukinori, ...

STAT transcription factors are tyrosine phosphorylated upon cytokine stimulation and enter the nucleus to activate target genes. We show that Rac1 and a GTPase-activating protein, MgcRacGAP, bind...

A Rac GTPase-Activating Protein, MgcRacGAP, Is a Nuclear Localizing Signal-Containing Nuclear Chaperone in the Activation of STAT Transcription Factors▿ †

Kawashima, Toshiyuki, Bao, Ying Chun, Minoshima, Yukinori, Nomura, Yasushi, Hatori, Tomonori, Hori, Tetsuya, ...

In addition to their pleiotropic functions under physiological conditions, transcription factors STAT3 and STAT5 also have oncogenic activities, but how activated STATs are transported to the nucleus...