Immunological Approach to the Identification and Development of Vaccines to Various Toxins (2003)
Chanh, Tran C., Armstrong, Deborah, Kennedy, Ronald
Monoclonal antibodies specific for the sodium channel blockers saxitoxin (STX) and tetrodotoxin (TDT) have been generated and characterized as to their abilities to protect against toxin-induced in...
Immunological Approach to the Identification and Development of Vaccines to Various Toxins (2003)
Chanh, Tran C., Armstrong, Deborah, Kennedy, Ronald C.
Monoclonal antibodies of relatively high binding affinity constants specific for the sodium channel blockers saxitoxin and tetrodotoxin, and the synthesis inhibitor mycotoxin T-2 were generated. Two...
Immunological Approach to the Identification and Development of Vaccines to Various Toxins (2003)
Chanh, Tran C., Kanda, Patrick, Armstrong, Deborah L.
Murine monoclonal anti-saxitoxin and anti-ricin antibodies capable of protecting against the in vitro toxicity of saxitoxin and ricin, respectively, have been generated. These protective anti-toxin...
Immunologic Approach to the Identification and Development of Vaccines to Various Toxins (2003)
Chanh, Tran C., Kanda, Patrick, Armstrong, Debroah
The extreme toxicity of the protein synthesis inhibitor ricin, and the sodium channel blocker saxitoxin render them unsafe as vaccines in the elicitation of active and protective immunity against...
Immunologic Approach to the Identification and Development of Vaccines to Various Toxins (2002)
We have used the protein synthesis inhibitor ricin and the sodium channelblocker saxitoxin (STX) as model toxic agents to investigate the feasibility of developing safe and effective vaccines against...
Developing Novel Conjugate HIV-1 Subunit Therapeutic Vaccines. (1999)
Over the past several years, conjugate vaccines have met with much greater success and a number of these vaccines have received United States Food and Drug Administration (FDA) approval for use in...
HTLV III Virus Isolation Studies. (1998)
A systematic viral isolation study has been performed on peripheral blood lymphocytes obtained from Air Force personnel positive for antibodies to the human immunodeficiency virus (HIV-1) as assessed...
Immunological Approach to the Identification and Development of Vaccines to Various Toxins. (1998)
Chanh, Tran C., Armstrong, Deborah, Kennedy, Ronald C.
Monoclonal antibodies specific for saxitoxin and tetrodotoxin with higher binding affinities than those generated under this contract are still being sought for. Attempts to generate internal image...
Trevino, Sylvia R., Permenter, Amy R., England, Marilyn J., Parthasarathy, Narayanan, Gibbs, Paul H., Waag, David M., ...
Glanders is a debilitating disease with no vaccine available. Murine monoclonal antibodies were produced against Burkholderia mallei, the etiologic agent of glanders, and were shown to be effective...
Amemiya, Kei, Meyers, Jennifer L., Trevino, Sylvia R., Chanh, Tran C., Norris, Sarah L., Wagg, David M.
We evaluated the effect of interleukin (IL)-12 on the immune response to Burkholderia mallei in BALB/c mice. Mice were vaccinated with non-viable B. mallei cells with or without IL-12. There was a...
Amemiya, Kei, Meyers, Jennifer L., Trevino, Sylvia R., Chanh, Tran C., Norris, Sarah L., Waag, David M.
We evaluated the effect of interleukin (IL)-12 on the immune response to Burkholderia mallei in BALB/c mice. Mice were vaccinated with non-viable B. mallei cells with or without IL-12. There was a...
Typescript (Photocopy)
Erwin, James L., DaSilva, Luis M., Bavari, Sina, Little, Stephen F., Friedlander, Arthur M., Chanh, Tran C.
We present evidence that Bacillus anthracis lethal toxin (LT) suppresses rather than induces proinflammatory cytokine production in macrophages. Suppression is observed with extremely low levels of...
Monoclonal Antibodies Passively Protect BALB/c Mice against Burkholderia mallei Aerosol Challenge
Treviño, Sylvia R., Permenter, Amy R., England, Marilyn J., Parthasarathy, Narayanan, Gibbs, Paul H., Waag, David M., ...
Glanders is a debilitating disease with no vaccine available. Murine monoclonal antibodies were produced against Burkholderia mallei, the etiologic agent of glanders, and were shown to be effective...
Erwin, James L., DaSilva, Luis M., Bavari, Sina, Little, Stephen F., Friedlander, Arthur M., Chanh, Tran C.
We present evidence that Bacillus anthracis lethal toxin (LT) suppresses rather than induces proinflammatory cytokine production in macrophages. Suppression is observed with extremely low levels of...
Monoclonal Antibodies Passively Protect BALB/c Mice against Burkholderia mallei Aerosol Challenge
Treviño, Sylvia R., Permenter, Amy R., England, Marilyn J., Parthasarathy, Narayanan, Gibbs, Paul H., Waag, David M., ...
Glanders is a debilitating disease with no vaccine available. Murine monoclonal antibodies were produced against Burkholderia mallei, the etiologic agent of glanders, and were shown to be effective...