Trevor J. Shuttleworth

Agonist activation of arachidonate-regulated Ca2+-selective (ARC) channels in murine parotid and pancreatic acinar cells

Mignen, Olivier, Thompson, Jill L, Yule, David I, Shuttleworth, Trevor J

ARC channels (arachidonate-regulated Ca2+-selective channels) are a novel type of highly Ca2+-selective channel that are specifically activated by low concentrations of agonist-induced arachidonic...

Arachidonate-regulated Ca2+-selective (ARC) channel activity is modulated by phosphorylation and involves an A-kinase anchoring protein

Mignen, Olivier, Thompson, Jill L, Shuttleworth, Trevor J

In many non-excitable cells, the predominant mode of agonist-activated Ca2+ entry switches from the arachidonic acid-regulated Ca2+ (ARC) channels at low agonist concentrations, to store-operated...

Agonist activation of arachidonate-regulated Ca2+-selective (ARC) channels in murine parotid and pancreatic acinar cells

Mignen, Olivier, Thompson, Jill L, Yule, David I, Shuttleworth, Trevor J

ARC channels (arachidonate-regulated Ca2+-selective channels) are a novel type of highly Ca2+-selective channel that are specifically activated by low concentrations of agonist-induced arachidonic...

Arachidonate-regulated Ca2+-selective (ARC) channel activity is modulated by phosphorylation and involves an A-kinase anchoring protein

Mignen, Olivier, Thompson, Jill L, Shuttleworth, Trevor J

In many non-excitable cells, the predominant mode of agonist-activated Ca2+ entry switches from the arachidonic acid-regulated Ca2+ (ARC) channels at low agonist concentrations, to store-operated...

STIM1 regulates Ca2+ entry via arachidonate-regulated Ca2+-selective (ARC) channels without store depletion or translocation to the plasma membrane

Mignen, Olivier, Thompson, Jill L, Shuttleworth, Trevor J

Recent studies have indicated a critical role for STIM (stromal interacting molecule) proteins in the regulation of the store-operated mode of receptor-activated Ca2+ entry. Current models emphasize...

Cytosolic Ca2+ and Ca2+-activated Cl− current dynamics: insights from two functionally distinct mouse exocrine cells

Giovannucci, David R, Bruce, Jason I. E, Straub, Stephen V, Arreola, Jorge, Sneyd, James, Shuttleworth, Trevor J, ...

The dynamics of Ca2+ release and Ca2+-activated Cl− currents in two related, but functionally distinct exocrine cells, were studied to gain insight into how the molecular specialization of Ca2+...

Both Orai1 and Orai3 are essential components of the arachidonate-regulated Ca2+-selective (ARC) channels

Mignen, Olivier, Thompson, Jill L, Shuttleworth, Trevor J

Agonist-activated Ca2+ signals in non-excitable cells are profoundly influenced by calcium entry via both store-operated and store-independent conductances. Recent studies have demonstrated that...

Orai1 subunit stoichiometry of the mammalian CRAC channel pore

Mignen, Olivier, Thompson, Jill L, Shuttleworth, Trevor J

Agonist-activated Ca2+ entry plays a critical role in Ca2+ signalling in non-excitable cells. One mode of such entry is activated as a consequence of the depletion of intracellular Ca2+ stores. This...