CNTRICS Final Task Selection: Executive Control (2009)
Barch, Deanna M., Braver, Todd S., Carter, Cameron S., Poldrack, Russell A., Robbins, Trevor W.
The third meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) was focused on selecting promising measures for each of the cognitive constructs...
Williams-Gray, Caroline H., Evans, Jonathan R., Goris, An, Foltynie, Thomas, Ban, Maria, Robbins, Trevor W., ...
Cognitive abnormalities are common in Parkinson's disease, with important social and economic implications. Factors influencing their evolution remain unclear but are crucial to the development of...
Adam Hampshire, Trevor W. Robbins, Adrian M. Owen, Roger A. Barker
Cognitive dysfunction commonly occurs even in the early stages of Parkinson’s disease (PD). Impairment on frontostriatally based executive tasks is particularly well described but affects only a...
Philip R. Corlett, Ba Garry, D. Honey, Phd Anthony Dickinson, Edith Pomarol-clotet, ...
Context: Establishing a neurobiological account of delusion formation that links cognitive processes, brain activity, and symptoms is important to furthering our understanding of psychosis....
Incentive motivation in first-episode psychosis: A behavioural study (2008)
Murray, Graham K, Clark, Luke, Corlett, Philip R, Blackwell, Andrew D, Cools, Roshan, Jones, Peter B, ...
Abstract Background: It has been proposed that there are abnormalities in incentive motivational processing in psychosis, possibly secondary to subcortical dopamine abnormalities, but few empirical...
and Clinical Neuroscience (2008)
Trevor W. Robbins, Rudolf N. Cardinal, Patricia Diciano, Peter W. Halligan, ...
Stop-Signal Reaction-Time Task Performance: Role of Prefrontal Cortex and Subthalamic Nucleus (2008)
Eagle, Dawn M., Baunez, Christelle, Hutcheson, Daniel M., Lehmann, Olivia, Shah, Aarti P., Robbins, Trevor W.
The stop-signal reaction-time (SSRT) task measures inhibition of a response that has already been initiated, that is, the ability to stop. Human subjects classified as “impulsive,” for example,...
Lara Menzies, Sophie Achard, Samuel R. Chamberlain, Naomi Fineberg, Chi-hua Chen, Natalia Del, ...
Endophenotypes (intermediate phenotypes) are objective, heritable, quantitative traits hypothesized to represent genetic risk for polygenic disorders at more biologically tractable levels than distal...
Psychopharmacology DOI 10.1007/s00213-007-1051-1 ORIGINAL INVESTIGATION (2007)
Karen D. Ersche, Jonathan P. Roiser, Trevor W. Robbins, Barbara J. Sahakian, K. D. Ersche, T. W. Robbins, ...
Chronic cocaine but not chronic amphetamine use is associated with perseverative responding in humans
Neurocognitive endophenotypes of obsessive-compulsive disorder (2007)
Menzies, Lara, Achard, Sophie, Chamberlain, Samuel R., Fineberg, Naomi, Chen, Chi-Hua, Del Campo, Natalia, ...
Endophenotypes (intermediate phenotypes) are objective, heritable, quantitative traits hypothesized to represent genetic risk for polygenic disorders at more biologically tractable levels than distal...
Winstanley, Catharine A., Theobald, David E.H., Dalley, Jeffrey W., Cardinal, Rudolf N., Robbins, Trevor W.
Dysregulation of the prefrontal cortex (PFC) has been implicated in impulse control disorders, including attention deficit hyperactivity disorder. A growing body of evidence suggests that impulsivity...
Winstanley, Catharine A., Theobald, David E.H., Dalley, Jeffrey W., Cardinal, Rudolf N., Robbins, Trevor W.
Dysregulation of the prefrontal cortex (PFC) has been implicated in impulse control disorders, including attention deficit hyperactivity disorder. A growing body of evidence suggests that impulsivity...
Synthesizing Schizophrenia: A Bottom-Up, Symptomatic Approach (2005)
The cognitive deficits in schizophrenia are discussed in terms of the other symptoms of the disorder, as well as according to a translational approach that involves using similar or analogous tests...
Nuechterlein, Keith H., Robbins, Trevor W., Einat, Haim
At the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) New Approaches Conference, a discussion group focused on directions for future research that are critical to...
Synthesizing Schizophrenia: A Bottom-Up, Symptomatic Approach (2005)
The cognitive deficits in schizophrenia are discussed in terms of the other symptoms of the disorder, as well as according to a translational approach that involves using similar or analogous tests...
Nuechterlein, Keith H, Robbins, Trevor W, Einat, Haim
At the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) New Approaches Conference, a discussion group focused on directions for future research that are critical to...
Winstanley, Catharine A., Theobald, David E.H., Dalley, Jeffrey W., Cardinal, Rudolf N., Robbins, Trevor W.
Dysregulation of the prefrontal cortex (PFC) has been implicated in impulse control disorders, including attention deficit hyperactivity disorder. A growing body of evidence suggests that impulsivity...
Synthesizing Schizophrenia: A Bottom-Up, Symptomatic Approach (2005)
The cognitive deficits in schizophrenia are discussed in terms of the other symptoms of the disorder, as well as according to a translational approach that involves using similar or analogous tests...
Nuechterlein, Keith H., Robbins, Trevor W., Einat, Haim
At the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) New Approaches Conference, a discussion group focused on directions for future research that are critical to...
Hutton, Samuel B., Huddy, Vyv, Barnes, Thomas R. E., Robbins, Trevor W., Crawford, Trevor J., Kennard, Christopher, ...
Background Both oculomotor and neuropsychologic deficits have been used to support the hypothesis that schizophrenia is associated with prefrontal cortex dysfunction, but studies that have...
2004 Chemistry of the adaptive mind (2004)
Roshan Cools, Trevor W. Robbins
A failure to adapt to novel or changing environmental demands is a core feature of a wide variety of neuropsychiatric disorders as well as the normal states of stress and fatigue. We review the...
Chudasama, Yogita, Dalley, Jeffrey W., Nathwani, Falgyni, Bouger, Pascale, Robbins, Trevor W.
Two experiments examined the effects of reductions in cortical cholinergic function on performance of a novel task that allowed for the simultaneous assessment of attention to a visual stimulus and...
Aron, Adam R., Monsell, Stephen, Sahakian, Barbara J., Robbins, Trevor W.
Executive functions such as task-set switching are thought to depend on the frontal cortex. However, more precision is required in identifying which components of such high-level processes relate to...
Turner, Danielle C., Aitken, Michael R.F., Shanks, David R., Sahakian, Barbara J., Robbins, Trevor W., Schwarzbauer, Christian, ...
Prediction error -- a mismatch between expected and actual outcome -- is critical to associative accounts of inferential learning. However, it has proven difficult to explore the effects of...
Dalley, Jeffrey W., Theobald, David E., Bouger, Pascale, Chudasama, Yogita, Cardinal, Rudolf N., Robbins, Trevor W.
Lesions of the basal forebrain (BF) cortical cholinergic system impair performance on a rodent five-choice visual attentional task. This study examines the effects on the same task of selective...
Aron, Adam R., Monsell, Stephen, Sahakian, Barbara J., Robbins, Trevor W.
Executive functions such as task‐set switching are thought to depend on the frontal cortex. However, more precision is required in identifying which components of such high‐level processes...
Turner, Danielle C., Aitken, Michael R.F., Shanks, David R., Sahakian, Barbara J., Robbins, Trevor W., Schwarzbauer, Christian, ...
Prediction error — a mismatch between expected and actual outcome — is critical to associative accounts of inferential learning. However, it has proven difficult to explore the effects of...
Dalley, Jeffrey W., Theobald, David E., Bouger, Pascale, Chudasama, Yogita, Cardinal, Rudolf N., Robbins, Trevor W.
Lesions of the basal forebrain (BF) cortical cholinergic system impair performance on a rodent five-choice visual attentional task. This study examines the effects on the same task of selective...
Foltynie, Thomas, Brayne, Carol E. G., Robbins, Trevor W., Barker, Roger A.
We have used multiple sources to identify a population‐representative cohort of newly diagnosed patients with parkinsonism and Parkinson’s disease in the UK over a 2‐year period. All...
Aron, Adam R., Monsell, Stephen, Sahakian, Barbara J., Robbins, Trevor W.
Executive functions such as task-set switching are thought to depend on the frontal cortex. However, more precision is required in identifying which components of such high-level processes relate to...
Turner, Danielle C., Aitken, Michael R.F., Shanks, David R., Sahakian, Barbara J., Robbins, Trevor W., Schwarzbauer, Christian, ...
Prediction error -- a mismatch between expected and actual outcome -- is critical to associative accounts of inferential learning. However, it has proven difficult to explore the effects of...
Dalley, Jeffrey W., Theobald, David E., Bouger, Pascale, Chudasama, Yogita, Cardinal, Rudolf N., Robbins, Trevor W.
Lesions of the basal forebrain (BF) cortical cholinergic system impair performance on a rodent five-choice visual attentional task. This study examines the effects on the same task of selective...
Foltynie, Thomas, Brayne, Carol E. G., Robbins, Trevor W., Barker, Roger A.
We have used multiple sources to identify a population-representative cohort of newly diagnosed patients with parkinsonism and Parkinson’s disease in the UK over a 2-year period. All patients have...
Pavese, Nicola, Andrews, Thomasin C., Brooks, David J., Ho, Aileen K., Rosser, Anne E., Barker, Roger A., ...
We have studied the progression of striatal and extrastriatal post‐synaptic dopaminergic changes in a group of 12 patients with Huntington’s disease using serial 11C‐raclopride PET, a...
Foltynie, Thomas, Brayne, Carol E. G., Robbins, Trevor W., Barker, Roger A.
We have used multiple sources to identify a population-representative cohort of newly diagnosed patients with parkinsonism and Parkinson’s disease in the UK over a 2-year period. All patients have...
Roshan Cools, Luke Clark, Adrian M. Owen, Trevor W. Robbins
Event-related functional magnetic resonance imaging was used to measure blood oxygenation level-dependent responses in 13 young healthy human volunteers during performance of a probabilistic...
Passetti, Filippo, Chudasama, Yogita, Robbins, Trevor W.
A previous study using a rodent five-choice test of attention found poor choice accuracy and increased perseverative responding following medial prefrontal cortex (mPFC) lesions. As this rat cortical...
Cools, Roshan, Stefanova, Elka, Barker, Roger A., Robbins, Trevor W., Owen, Adrian M.
This study examined the effects of l‐dopa medication in patients with Parkinson’s disease on cortical and subcortical blood flow changes during two tasks known to involve frontostriatal...
Rudolf N. Cardinal, Nathaniel Daw, Trevor W. Robbins, Barry J. Everitt
analysis of behaviour in the adjusting-delay task for assessing
Cools, Roshan, Barker, Roger A., Sahakian, Barbara J., Robbins, Trevor W.
We investigated how dopamine (DA) systems contribute to cognitive performance in the domain of learning and attentional flexibility by examining effects of withdrawing DA-ergic medication in patients...
Mechanisms of cognitive set flexibility in Parkinson's disease (2001)
Cools, Roshan, Barker, Roger A., Sahakian, Barbara J., Robbins, Trevor W.
Previous research on cognitive set shifting in patients with Parkinson's disease has often been confounded by concept formation, rule learning, working memory and/or general slowing of cognitive...
Decision-making in mania: a PET study (2001)
Rubinsztein, Judy S., Fletcher, Paul C., Rogers, Robert D., Ho, Luk W., Aigbirhio, Franklin I., Paykel, Eugene S., ...
Poor decision-making is often observed clinically in the manic syndrome. In normal volunteers, decision-making has been associated with activation in the ventral prefrontal cortex and the anterior...
Lawrence, Andrew D., Watkins, Laura H. A., Sahakian, Barbara J., Hodges, John R., Robbins, Trevor W.
The primate visual system contains two major streams of visual information processing. The ventral stream is directed into the inferior temporal cortex and is concerned with visual object cognition,...
Specific cognitive deficits in mild frontal variant frontotemporal dementia (1999)
Rahman, Shibley, Sahakian, Barbara J., Hodges, John R., Rogers, Robert D., Robbins, Trevor W.
Eight patients with relatively mild frontal variant frontotemporal dementia (fvFTD) were compared with age- and IQ-matched control volunteers on tests of executive and mnemonic function. Tests of...
Owen, Adrian M., Morris, Robin G., Sahakian, Barbara J., Polkey, Charles E., Robbins, Trevor W.
Thirty-two neurosurgical patients with unilateral or bilateral frontal lobe excisions, 41 patients with unilateral temporal lobe lesions and 19 patients who had undergone unilateral...
Executive and mnemonic functions in early Huntington's disease (1996)
Lawrence, Andrew D., Sahakian, Barbara J., Hodges, John R., Rosser, Anne E., Lange, Klaus W., Robbins, Trevor W.
Eighteen patients with early Huntington's disease were compared with age- and IQ-matched control volunteers on tests of executive and mnemonic function taken from the Cambridge Neuropsychological...
Muir, Janice L., Everitt, Barry J., Robbins, Trevor W.
Dissociable effects of bilateral excitotoxic lesions of different regions of the rat neocortex, including medial prefrontal and anterior cingulate cortices, were investigated in a five-choice serial...
Owen, Adrian M., Roberts, Angela C., Hodges, John R., Robbins, Trevor W.
Tests which assess the ability to shift cognitive set modelled after the Wisconsin Card Sorting Test are particularly sensitive to impairments in patients with Parkinson's disease as well as in...
BROWN, VERITY J., ROBBINS, TREVOR W.
Rats were trained to perform a visual spatial discrimination, where stimulus luminance provided information regarding the required direction of response. The visual stimuli were presented either in...
The Case for Frontostriatal Dysfunction in Schizophrenia (1990)
A frontostriatal hypothesis of schizophrenia is advanced which takes into account evidence from studies of neurochemical pathology functional imaging, cognitive neuropsychology, and experimental and...
SAHAKIAN, BARBARA J., MORRIS, ROBIN G., EVENDEN, JOHN L., HEALD, ANDREW, LEVY, RAYMOND, PHILPOT, MICHAEL, ...
Groups of patients with dementia of Alzheimer type (DAT) and idiopathic Parkinson's disease, together with age and IQ-matched normal controls, were compared on several computerized tests of...
Associative plasticity in striatal transplants
Brasted, Peter J., Watts, Colin, Robbins, Trevor W., Dunnett, Stephen B.
Striatal lesions disrupt both motor and cognitive performance in rats, many aspects of which can be restored by striatal transplants. Because the normal striatum is involved in the formation and...
Chudasama, Yogita, Dalley, Jeffrey W., Nathwani, Falgyni, Bouger, Pascale, Robbins, Trevor W.
Two experiments examined the effects of reductions in cortical cholinergic function on performance of a novel task that allowed for the simultaneous assessment of attention to a visual stimulus and...
Associative plasticity in striatal transplants
Brasted, Peter J., Watts, Colin, Robbins, Trevor W., Dunnett, Stephen B.
Striatal lesions disrupt both motor and cognitive performance in rats, many aspects of which can be restored by striatal transplants. Because the normal striatum is involved in the formation and...
Chudasama, Yogita, Dalley, Jeffrey W., Nathwani, Falgyni, Bouger, Pascale, Robbins, Trevor W.
Two experiments examined the effects of reductions in cortical cholinergic function on performance of a novel task that allowed for the simultaneous assessment of attention to a visual stimulus and...
Dalley, Jeffrey W., Lääne, Kristjan, Theobald, David E. H., Armstrong, Hannah C., Corlett, Philip R., Chudasama, Yogita, ...
Recent research has implicated the nucleus accumbens (NAc) in consolidating recently acquired goal-directed appetitive memories, including spatial learning and other instrumental processes. However,...
Behavioural pharmacology: 40+ years of progress, with a focus on glutamate receptors and cognition
Robbins, Trevor W., Murphy, Emily R.
Behavioural pharmacology is an interdisciplinary field at the intersection of several research areas that ultimately lead to the development of drugs for clinical use and build understanding of how...
Winstanley, Catharine A., Eagle, Dawn M., Robbins, Trevor W.
Impulsivity, broadly defined as action without foresight, is a component of numerous psychiatric illnesses including attention deficit/hyperactivity disorder (ADHD), mania and substance abuse. In...
Incentive motivation in first-episode psychosis: A behavioural study
Murray, Graham K, Clark, Luke, Corlett, Philip R, Blackwell, Andrew D, Cools, Roshan, Jones, Peter B, ...
Leeson, Verity C., Robbins, Trevor W., Matheson, Elizabeth, Hutton, Samuel B., Ron, María A., Barnes, Thomas R.E., ...
Everitt, Barry J, Belin, David, Economidou, Daina, Pelloux, Yann, Dalley, Jeffrey W, Robbins, Trevor W
We hypothesize that drug addiction can be viewed as the endpoint of a series of transitions from initial voluntary drug use through the loss of control over this behaviour, such that it becomes...