Neurogenetic networks for startle-induced locomotion in Drosophila melanogaster (2008)
Mackay, Trudy F. C, Anholt, Robert R. H
Understanding how the genome empowers the nervous system to express behaviors remains a critical challenge in behavioral genetics. The startle response is an attractive behavioral model for studies...
Yamamoto, Akihiko, Zwarts, Liesbeth, Callaerts-Végh, Zsuzsanna, ...
Behaviors are complex traits influenced by multiple pleiotropic genes. Understanding the mechanisms that give rise to complex behaviors requires an understanding of how variation in transcriptional...
Quantitative trait loci affecting starvation resistance in Drosophila melanogaster (2004)
Yamamoto, Akihiko H, Fanara, Juan J, Mackay, Trudy F C
The ability to withstand periods of scarce food resources is an important fitness trait. Starvation resistance is a quantitative trait controlled by multiple interacting genes and exhibits...
Enabling Population and Quantitative Genomics (2002)
Gibson, Greg, Mackay, Trudy F. C.
Dissection of quantitative traits to the nucleotide level requires phenotypic and genotypic analysis of traits on a genome scale. Here we discuss the set of community-wide genetic and molecular...
Introducción a la genética cuantitativa (2001)
Falconer, D.S., Mackay, Trudy F.C.
Traducción de: Introduction to Quantitative Genetics
Introducción a la genética cuantitativa / D.S. Falconer , Trudy F. C. Mackay (2001)
Falconer, Douglas Scott, Mackay, Trudy F. C.
Traducción de: Introduction to quantitativa genetics
Functional Genomics of Odor-guided Behavior in Drosophila melanogaster (2001)
Anholt, Robert R.H., Fanara, Juan José, Fedorowicz, Grazyna M., Ganguly, Indrani, Kulkarni, Nalini H., Mackay, Trudy F.C., ...
The avoidance response to repellent odorants in Drosophila melanogaster, a response essential for survival, provides an advantageous model for studies on the genetic architecture of olfactory...
Thesis (M. Sc.)--Dalhousie University, 1976.
Sex-specific quantitative trait loci affecting longevity in Drosophila melanogaster
Nuzhdin, Sergey V., Pasyukova, Elena G., Dilda, Christy L., Zeng, Zhao-Bang, Mackay, Trudy F. C.
Senescence, the decline in survivorship and fertility with increasing age, is a near-universal property of organisms. Senescence and limited lifespan are thought to arise because weak natural...
Genetics and genomics of Drosophila mating behavior
Mackay, Trudy F. C., Heinsohn, Stefanie L., Lyman, Richard F., Moehring, Amanda J., Morgan, Theodore J., Rollmann, Stephanie M.
The first steps of animal speciation are thought to be the development of sexual isolating mechanisms. In contrast to recent progress in understanding the genetic basis of postzygotic isolating...
Transposable Element-Induced Response to Artificial Selection in DROSOPHILA MELANOGASTER
The P family of transposable elements in Drosophila melanogaster transpose with exceptionally high frequency when males from P strains carrying multiple copies of these elements are crossed to...
The Effect of Combining Alleles into Electrophoretic Classes on Detecting Linkage Disequilibrium
Zouros, E., Golding, G. B., MacKay, Trudy F. C.
When alleles are combined into few detectable classes, linkage correlations are underestimated most of the time. The probability that the linkage correlation will be underestimated is a function of...
Mackay, Trudy F. C., Lyman, Richard F., Lawrence, Faye
Our ability to predict long-term responses to artificial and natural selection, and understand the mechanisms by which naturally occurring variation for quantitative traits is maintained, depends on...
Quantitative Trait Loci With Age-Specific Effects on Fecundity in Drosophila melanogaster
Leips, Jeff, Gilligan, Paul, Mackay, Trudy F. C.
Life-history theory and evolutionary theories of aging assume the existence of alleles with age-specific effects on fitness. While various studies have documented age-related changes in the genetic...
Carbone, Mary Anna, Llopart, Ana, DeAngelis, Matthew, Coyne, Jerry A., Mackay, Trudy F. C.
Using quantitative trait locus (QTL) mapping, we studied the genetic basis of the difference in pigmentation between two sister species of Drosophila: Drosophila yakuba, which, like other members of...
Moehring, Amanda J., Llopart, Ana, Elwyn, Susannah, Coyne, Jerry A., Mackay, Trudy F. C.
A major unresolved challenge of evolutionary biology is to determine the nature of the allelic variants of “speciation genes”: those alleles whose interaction produces inviable or infertile...
Moehring, Amanda J., Llopart, Ana, Elwyn, Susannah, Coyne, Jerry A., Mackay, Trudy F. C.
Sexual isolating mechanisms that act before fertilization are often considered the most important genetic barriers leading to speciation in animals. While progress has been made toward understanding...
Quantitative trait loci for inflorescence development in Arabidopsis thaliana.
Ungerer, Mark C, Halldorsdottir, Solveig S, Modliszewski, Jennifer L, Mackay, Trudy F C, Purugganan, Michael D
Variation in inflorescence development patterns is a central factor in the evolutionary ecology of plants. The genetic architectures of 13 traits associated with inflorescence developmental timing,...
Kulkarni, Nalini H, Yamamoto, Akihiko H, Robinson, Kellie O, Mackay, Trudy F C, Anholt, Robert R H
Previously, we generated P-element insert lines in Drosophila melanogaster with impaired olfactory behavior. One of these smell-impaired (smi) mutants, smi60E, contains a P[lArB] transposon in the...
hairy: A quantitative trait locus for drosophila sensory bristle number.
Robin, Charles, Lyman, Richard F, Long, Anthony D, Langley, Charles H, Mackay, Trudy F C
Advances in medicine, agriculture, and an understanding of evolution depend on resolving the genetic architecture of quantitative traits, which is challenging since variation for complex traits is...
Vanaso is a candidate quantitative trait gene for Drosophila olfactory behavior.
Fanara, Juan José, Robinson, Kellie O, Rollmann, Stephanie M, Anholt, Robert R H, Mackay, Trudy F C
Most animals depend on olfaction for survival and procreation. Odor-guided behavior is a quantitative trait, with phenotypic variation due to multiple segregating quantitative trait loci (QTL)....
The genetic architecture of Drosophila sensory bristle number.
Dilda, Christy L, Mackay, Trudy F C
We have mapped quantitative trait loci (QTL) for Drosophila mechanosensory bristle number in six recombinant isogenic line (RIL) mapping populations, each of which was derived from an isogenic...
Novel loci control variation in reproductive timing in Arabidopsis thaliana in natural environments.
Weinig, Cynthia, Ungerer, Mark C, Dorn, Lisa A, Kane, Nolan C, Toyonaga, Yuko, Halldorsdottir, Solveig S, ...
Molecular biologists are rapidly characterizing the genetic basis of flowering in model species such as Arabidopsis thaliana. However, it is not clear how the developmental pathways identified in...
Borrás, Teresa, Morozova, Tatiana V, Heinsohn, Stefanie L, Lyman, Richard F, Mackay, Trudy F C, Anholt, Robert R H
The availability of the human genome sequence together with sequenced genomes of several model organisms provides an unprecedented opportunity to utilize comparative genomic approaches for the...
Scribble is essential for olfactory behavior in Drosophila melanogaster.
Ganguly, Indrani, Mackay, Trudy F C, Anholt, Robert R H
The ability to discriminate and respond to chemical signals from the environment is an almost universal prerequisite for survival. Here, we report that the scaffold protein Scribble is essential for...
Heterogeneous selection at specific loci in natural environments in Arabidopsis thaliana.
Weinig, Cynthia, Dorn, Lisa A, Kane, Nolan C, German, Zachary M, Halldorsdottir, Solveig S, Ungerer, Mark C, ...
Genetic variation for quantitative traits is often greater than that expected to be maintained by mutation in the face of purifying natural selection. One possible explanation for this observed...
Ungerer, Mark C, Halldorsdottir, Solveig S, Purugganan, Michael D, Mackay, Trudy F C
Phenotypic plasticity and genotype-environment interactions (GEI) play a prominent role in plant morphological diversity and in the potential functional capacities of plant life-history traits. The...
Genissel, Anne, Pastinen, Tomi, Dowell, Andrea, Mackay, Trudy F C, Long, Anthony D
We test the hypothesis that naturally occurring nonsynonymous variants in the Delta ligand of the Notch signaling pathway contribute to standing variation in sternopleural and/or abdominal bristle...
Quantitative trait loci affecting starvation resistance in Drosophila melanogaster.
Harbison, Susan T, Yamamoto, Akihiko H, Fanara, Juan J, Norga, Koenraad K, Mackay, Trudy F C
The ability to withstand periods of scarce food resources is an important fitness trait. Starvation resistance is a quantitative trait controlled by multiple interacting genes and exhibits...
Quantitative trait loci for sexual isolation between Drosophila simulans and D. mauritiana.
Moehring, Amanda J, Li, Jian, Schug, Malcolm D, Smith, Shelly G, DeAngelis, Matthew, Mackay, Trudy F C, ...
Sexual isolating mechanisms that act before fertilization are often considered the most important genetic barriers leading to speciation in animals. While recent progress has been made toward...
The quantitative genetic basis of male mating behavior in Drosophila melanogaster.
Moehring, Amanda J, Mackay, Trudy F C
Male mating behavior is an important component of fitness in Drosophila and displays segregating variation in natural populations. However, we know very little about the genes affecting naturally...
Wilson, Rhonda H., Morgan, Theodore J., Mackay, Trudy F. C.
Limited life span and senescence are near-universal characteristics of eukaryotic organisms, controlled by many interacting quantitative trait loci (QTL) with individually small effects, whose...
Quantitative Genomics of Aggressive Behavior in Drosophila melanogaster
Edwards, Alexis C, Rollmann, Stephanie M, Morgan, Theodore J, Mackay, Trudy F. C
Aggressive behavior is important for animal survival and reproduction, and excessive aggression is an enormous social and economic burden for human society. Although the role of biogenic amines in...
Quantitative Trait Loci for Locomotor Behavior in Drosophila melanogaster
Jordan, Katherine W., Morgan, Theodore J., Mackay, Trudy F. C.
Locomotion is an integral component of most animal behaviors and many human diseases and disorders are associated with locomotor deficits, but little is known about the genetic basis of natural...
Sex-specific quantitative trait loci affecting longevity in Drosophila melanogaster
Nuzhdin, Sergey V., Pasyukova, Elena G., Dilda, Christy L., Zeng, Zhao-Bang, Mackay, Trudy F. C.
Senescence, the decline in survivorship and fertility with increasing age, is a near-universal property of organisms. Senescence and limited lifespan are thought to arise because weak natural...
Genetics and genomics of Drosophila mating behavior
Mackay, Trudy F. C., Heinsohn, Stefanie L., Lyman, Richard F., Moehring, Amanda J., Morgan, Theodore J., Rollmann, Stephanie M.
The first steps of animal speciation are thought to be the development of sexual isolating mechanisms. In contrast to recent progress in understanding the genetic basis of postzygotic isolating...
Transposable Element-Induced Response to Artificial Selection in DROSOPHILA MELANOGASTER
The P family of transposable elements in Drosophila melanogaster transpose with exceptionally high frequency when males from P strains carrying multiple copies of these elements are crossed to...
The Effect of Combining Alleles into Electrophoretic Classes on Detecting Linkage Disequilibrium
Zouros, E., Golding, G. B., MacKay, Trudy F. C.
When alleles are combined into few detectable classes, linkage correlations are underestimated most of the time. The probability that the linkage correlation will be underestimated is a function of...
Mackay, Trudy F. C., Lyman, Richard F., Lawrence, Faye
Our ability to predict long-term responses to artificial and natural selection, and understand the mechanisms by which naturally occurring variation for quantitative traits is maintained, depends on...
Quantitative Trait Loci With Age-Specific Effects on Fecundity in Drosophila melanogaster
Leips, Jeff, Gilligan, Paul, Mackay, Trudy F. C.
Life-history theory and evolutionary theories of aging assume the existence of alleles with age-specific effects on fitness. While various studies have documented age-related changes in the genetic...
Carbone, Mary Anna, Llopart, Ana, DeAngelis, Matthew, Coyne, Jerry A., Mackay, Trudy F. C.
Using quantitative trait locus (QTL) mapping, we studied the genetic basis of the difference in pigmentation between two sister species of Drosophila: Drosophila yakuba, which, like other members of...
Moehring, Amanda J., Llopart, Ana, Elwyn, Susannah, Coyne, Jerry A., Mackay, Trudy F. C.
A major unresolved challenge of evolutionary biology is to determine the nature of the allelic variants of “speciation genes”: those alleles whose interaction produces inviable or infertile...
Moehring, Amanda J., Llopart, Ana, Elwyn, Susannah, Coyne, Jerry A., Mackay, Trudy F. C.
Sexual isolating mechanisms that act before fertilization are often considered the most important genetic barriers leading to speciation in animals. While progress has been made toward understanding...
Quantitative trait loci for inflorescence development in Arabidopsis thaliana.
Ungerer, Mark C, Halldorsdottir, Solveig S, Modliszewski, Jennifer L, Mackay, Trudy F C, Purugganan, Michael D
Variation in inflorescence development patterns is a central factor in the evolutionary ecology of plants. The genetic architectures of 13 traits associated with inflorescence developmental timing,...
Kulkarni, Nalini H, Yamamoto, Akihiko H, Robinson, Kellie O, Mackay, Trudy F C, Anholt, Robert R H
Previously, we generated P-element insert lines in Drosophila melanogaster with impaired olfactory behavior. One of these smell-impaired (smi) mutants, smi60E, contains a P[lArB] transposon in the...
hairy: A quantitative trait locus for drosophila sensory bristle number.
Robin, Charles, Lyman, Richard F, Long, Anthony D, Langley, Charles H, Mackay, Trudy F C
Advances in medicine, agriculture, and an understanding of evolution depend on resolving the genetic architecture of quantitative traits, which is challenging since variation for complex traits is...
Vanaso is a candidate quantitative trait gene for Drosophila olfactory behavior.
Fanara, Juan José, Robinson, Kellie O, Rollmann, Stephanie M, Anholt, Robert R H, Mackay, Trudy F C
Most animals depend on olfaction for survival and procreation. Odor-guided behavior is a quantitative trait, with phenotypic variation due to multiple segregating quantitative trait loci (QTL)....
The genetic architecture of Drosophila sensory bristle number.
Dilda, Christy L, Mackay, Trudy F C
We have mapped quantitative trait loci (QTL) for Drosophila mechanosensory bristle number in six recombinant isogenic line (RIL) mapping populations, each of which was derived from an isogenic...
Novel loci control variation in reproductive timing in Arabidopsis thaliana in natural environments.
Weinig, Cynthia, Ungerer, Mark C, Dorn, Lisa A, Kane, Nolan C, Toyonaga, Yuko, Halldorsdottir, Solveig S, ...
Molecular biologists are rapidly characterizing the genetic basis of flowering in model species such as Arabidopsis thaliana. However, it is not clear how the developmental pathways identified in...
Borrás, Teresa, Morozova, Tatiana V, Heinsohn, Stefanie L, Lyman, Richard F, Mackay, Trudy F C, Anholt, Robert R H
The availability of the human genome sequence together with sequenced genomes of several model organisms provides an unprecedented opportunity to utilize comparative genomic approaches for the...
Scribble is essential for olfactory behavior in Drosophila melanogaster.
Ganguly, Indrani, Mackay, Trudy F C, Anholt, Robert R H
The ability to discriminate and respond to chemical signals from the environment is an almost universal prerequisite for survival. Here, we report that the scaffold protein Scribble is essential for...
Heterogeneous selection at specific loci in natural environments in Arabidopsis thaliana.
Weinig, Cynthia, Dorn, Lisa A, Kane, Nolan C, German, Zachary M, Halldorsdottir, Solveig S, Ungerer, Mark C, ...
Genetic variation for quantitative traits is often greater than that expected to be maintained by mutation in the face of purifying natural selection. One possible explanation for this observed...
Ungerer, Mark C, Halldorsdottir, Solveig S, Purugganan, Michael D, Mackay, Trudy F C
Phenotypic plasticity and genotype-environment interactions (GEI) play a prominent role in plant morphological diversity and in the potential functional capacities of plant life-history traits. The...
Genissel, Anne, Pastinen, Tomi, Dowell, Andrea, Mackay, Trudy F C, Long, Anthony D
We test the hypothesis that naturally occurring nonsynonymous variants in the Delta ligand of the Notch signaling pathway contribute to standing variation in sternopleural and/or abdominal bristle...
Quantitative trait loci affecting starvation resistance in Drosophila melanogaster.
Harbison, Susan T, Yamamoto, Akihiko H, Fanara, Juan J, Norga, Koenraad K, Mackay, Trudy F C
The ability to withstand periods of scarce food resources is an important fitness trait. Starvation resistance is a quantitative trait controlled by multiple interacting genes and exhibits...
Quantitative trait loci for sexual isolation between Drosophila simulans and D. mauritiana.
Moehring, Amanda J, Li, Jian, Schug, Malcolm D, Smith, Shelly G, DeAngelis, Matthew, Mackay, Trudy F C, ...
Sexual isolating mechanisms that act before fertilization are often considered the most important genetic barriers leading to speciation in animals. While recent progress has been made toward...
The quantitative genetic basis of male mating behavior in Drosophila melanogaster.
Moehring, Amanda J, Mackay, Trudy F C
Male mating behavior is an important component of fitness in Drosophila and displays segregating variation in natural populations. However, we know very little about the genes affecting naturally...
Wilson, Rhonda H., Morgan, Theodore J., Mackay, Trudy F. C.
Limited life span and senescence are near-universal characteristics of eukaryotic organisms, controlled by many interacting quantitative trait loci (QTL) with individually small effects, whose...
Quantitative Genomics of Aggressive Behavior in Drosophila melanogaster
Edwards, Alexis C, Rollmann, Stephanie M, Morgan, Theodore J, Mackay, Trudy F. C
Aggressive behavior is important for animal survival and reproduction, and excessive aggression is an enormous social and economic burden for human society. Although the role of biogenic amines in...
Quantitative Trait Loci for Locomotor Behavior in Drosophila melanogaster
Jordan, Katherine W., Morgan, Theodore J., Mackay, Trudy F. C.
Locomotion is an integral component of most animal behaviors and many human diseases and disorders are associated with locomotor deficits, but little is known about the genetic basis of natural...
Dynamic Genetic Interactions Determine Odor-Guided Behavior in Drosophila melanogaster
Sambandan, Deepa, Yamamoto, Akihiko, Fanara, Juan-José, Mackay, Trudy F. C., Anholt, Robert R. H.
Understanding the genetic architecture of complex traits requires identification of the underlying genes and characterization of gene-by-gene and genotype-by-environment interactions. Behaviors that...
Drosophila bristles and the nature of quantitative genetic variation
Mackay, Trudy F.C, Lyman, Richard F
Numbers of Drosophila sensory bristles present an ideal model system to elucidate the genetic basis of variation for quantitative traits. Here, we review recent evidence that the genetic architecture...
The Early Developmental Gene Semaphorin 5c Contributes to Olfactory Behavior in Adult Drosophila
Rollmann, Stephanie M., Yamamoto, Akihiko, Goossens, Tim, Zwarts, Liesbeth, Callaerts-Végh, Zsuzsanna, Callaerts, Patrick, ...
Behaviors are complex traits influenced by multiple pleiotropic genes. Understanding the mechanisms that give rise to complex behaviors requires an understanding of how variation in transcriptional...
Wang, Ping, Lyman, Richard F., Shabalina, Svetlana A., Mackay, Trudy F. C., Anholt, Robert R. H.
Adaptive evolution of animals depends on behaviors that are essential for their survival and reproduction. The olfactory system of Drosophila melanogaster has emerged as one of the best characterized...
Sambandan, Deepa, Carbone, Mary Anna, Anholt, Robert R. H., Mackay, Trudy F. C.
Genotype by environment interactions (GEI) play a major part in shaping the genetic architecture of quantitative traits and are confounding factors in genetic studies, for example, in attempts to...
Pleiotropic Effects of Drosophila neuralized on Complex Behaviors and Brain Structure
Rollmann, Stephanie M., Zwarts, Liesbeth, Edwards, Alexis C., Yamamoto, Akihiko, Callaerts, Patrick, Norga, Koenraad, ...
Understanding how genotypic variation influences variation in brain structures and behavioral phenotypes represents a central challenge in behavioral genetics. In Drosophila melanogaster, the...
Carbone, Mary Anna, Ayroles, Julien F., Yamamoto, Akihiko, Morozova, Tatiana V., West, Steven A., Magwire, Michael M., ...
Neurogenetic networks for startle-induced locomotion in Drosophila melanogaster
Yamamoto, Akihiko, Zwarts, Liesbeth, Callaerts, Patrick, Norga, Koenraad, Mackay, Trudy F. C., Anholt, Robert R. H.
Understanding how the genome empowers the nervous system to express behaviors remains a critical challenge in behavioral genetics. The startle response is an attractive behavioral model for studies...
Quantitative Trait Loci for Aggressive Behavior in Drosophila melanogaster
Edwards, Alexis C., Mackay, Trudy F. C.
Aggressive behavior is observed across animal taxa and is likely to be evolutionarily conserved. Although potentially advantageous, aggression can have social and health consequences in humans, and...
Plasticity of the Chemoreceptor Repertoire in Drosophila melanogaster
Zhou, Shanshan, Stone, Eric A., Mackay, Trudy F. C., Anholt, Robert R. H.
For most organisms, chemosensation is critical for survival and is mediated by large families of chemoreceptor proteins, whose expression must be tuned appropriately to changes in the chemical...