Trupti Joshi

Generation of Phaseolus vulgarisESTs and investigation of their regulation upon Uromyces appendiculatusinfection (2009)

Thibivilliers, Sandra, Joshi, Trupti, Campbell, Kimberly B, Scheffler, Brian, Xu, Dong, Cooper, Bret, ...

Abstract Background Phaseolus vulgaris (common bean) is the second most important legume crop in the world after soybean. Consequently, yield losses due to fungal infection, like Uromyces...

2004b) Genome-scale gene function prediction using multiple sources of high-throughput data in yeast Saccharomyces cerevisiae (2008)

Saccharomyces Cerevisiae, Trupti Joshi, Yu Chen, Jeffrey M. Becker, Nickolai Alexandrov, Dong Xu

Characterizing gene function is one of the major challenging tasks in the post-genomic era. To address this challenge, we have developed GeneFAS (Gene Function Annotation System), a new integrated...

A critical assessment of Mus musculusgene function prediction using integrated genomic evidence (2008)

Peña-Castillo, Lourdes, Tasan, Murat, Myers, Chad L, Lee, Hyunju, Joshi, Trupti, Zhang, Chao, ...

Abstract Background: Several years after sequencing the human genome and the mouse genome, much remains to be discovered about the functions of most human and mouse genes. Computational prediction of...

BIOINFORMATICS ORIGINAL PAPER (2008)

Gene Expression, Yong Wang, Trupti Joshi, Xiang-sun Zhang, Dong Xu, Luonan Chen

Inferring gene regulatory networks from multiple microarray datasets Vol. 22 no. 19 2006, pages 2413–2420 doi:10.1093/bioinformatics/btl396

Quantitative assessment of relationship between sequence similarity and function similarity (2007)

Joshi, Trupti, Xu, Dong

Abstract Background Comparative sequence analysis is considered as the first step towards annotating new proteins in genome annotation. However, sequence comparison may lead to creation and...

Inferring gene regulatory networks from multiple microarray datasets (2006)

Wang, Yong, Joshi, Trupti, Zhang, Xiang-Sun, Xu, Dong, Chen, Luonan

Motivation: Microarray gene expression data has increasingly become the common data source that can provide insights into biological processes at a system-wide level. One of the major problems with...

Single Feature Polymorphism Discovery in Rice

Kumar, Rajesh, Qiu, Jing, Joshi, Trupti, Valliyodan, Babu, Xu, Dong, Nguyen, Henry T.

The discovery of nucleotide diversity captured as single feature polymorphism (SFP) by using the expression array is a high-throughput and effective method in detecting genome-wide polymorphism. The...

FcγR-induced production of superoxide and inflammatory cytokines is differentially regulated by SHIP through its influence on PI3K and/or Ras/Erk pathways

Ganesan, Latha P., Joshi, Trupti, Fang, Huiqing, Kutala, Vijay Kumar, Roda, Julie, Trotta, Rossana, ...

Phagocytosis of IgG-coated particles via FcγR is accompanied by the generation of superoxide and inflammatory cytokines, which can cause collateral tissue damage in the absence of regulation....

Transcriptional and Physiological Responses of Bradyrhizobium japonicum to Desiccation-Induced Stress▿ †

Cytryn, Eddie J., Sangurdekar, Dipen P., Streeter, John G., Franck, William L., Chang, Woo-suk, Stacey, Gary, ...

The growth and persistence of rhizobia and bradyrhizobia in soils are negatively impacted by drought conditions. In this study, we used genome-wide transcriptional analyses to obtain a comprehensive...

Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical

Zhao, Xiaobin, Lapalombella, Rosa, Joshi, Trupti, Cheney, Carolyn, Gowda, Aruna, Hayden-Ledbetter, Martha S., ...

CD37 is a lineage-specific B-cell antigen that to date has been neglected as an attractive therapeutic target. To exploit this, novel CD37-specific small modular immunopharmaceuticals (CD37-SMIP)...

The PtdIns 3-Kinase/Akt Pathway Regulates Macrophage-Mediated ADCC against B Cell Lymphoma

Joshi, Trupti, Ganesan, Latha P., Cheney, Carolyn, Ostrowski, Michael C., Muthusamy, Natarajan, Byrd, John C., ...

Macrophages are important effectors in the clearance of antibody-coated tumor cells. However, the signaling pathways that regulate macrophage-induced ADCC are poorly defined. To understand the...

IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro

Gowda, Aruna, Roda, Julie, Hussain, Syed-Rehan A., Ramanunni, Asha, Joshi, Trupti, Schmidt, Susan, ...

Interleukin-21 (IL-21) is a recently identified γ-chain receptor cytokine family member that promotes B-cell apoptosis as well as activation of innate immune system. Based on this, we hypothesized...

B7-H1 Blockade Increases Survival of Dysfunctional CD8+ T Cells and Confers Protection against Leishmania donovani Infections

Joshi, Trupti, Rodriguez, Susana, Perovic, Vladimir, Cockburn, Ian A., Stäger, Simona

Experimental visceral leishmaniasis (VL) represents an exquisite model to study CD8+ T cell responses in a context of chronic inflammation and antigen persistence, since it is characterized by...

Establishment of a Protein Reference Map for Soybean Root Hair Cells1[W][OA]

Brechenmacher, Laurent, Lee, Joohyun, Sachdev, Sherri, Song, Zhao, Nguyen, Tran Hong Nha, Joshi, Trupti, ...

Root hairs are single tubular cells formed from the differentiation of epidermal cells on roots. They are involved in water and nutrient uptake and represent the infection site on leguminous roots by...

System Analysis of an Arabidopsis Mutant Altered in de Novo Fatty Acid Synthesis Reveals Diverse Changes in Seed Composition and Metabolism1[W][OA]

Chen, Mingjie, Mooney, Brian P., Hajduch, Martin, Joshi, Trupti, Zhou, Mingyi, Xu, Dong, ...

Embryo-specific overexpression of biotin carboxyl carrier protein 2 (BCCP2) inhibited plastid acetyl-coenzyme A carboxylase (ACCase), resulting in altered oil, protein, and carbohydrate composition...