TWJ Huizinga

Juvenile-onset systemic lupus erythematosus: different clinical and serological pattern than adult-onset systemic lupus erythematosus (2009)

Hoffman, IEA, Lauwerys, BR, De Keyser, Filip, Huizinga, TWJ, Isenberg, D, Cebecauer, L, ...

Objective: To investigate differences in clinical signs and symptoms, and in antinuclear antibodies ( ANA), between patients with juvenile-onset and adult-onset systemic lupus erythematosus (SLE)....

Time to treatment as an important factor for the response to methotrexate in juvenile idiopathic arthritis (2008)

Albers, HM, Wessels, JAM, Straaten, RJH, Brinkman, DMC, Suijlekom-Smit, LWA, Kamphuis, SSM, ...

No abstract available.

The TRAF1/C5 region is a risk factor for polyarthritis in juvenile idiopathic arthritis (2008)

Albers, HM, Kurreeman, FAS, Houwing-Duistermaat, JJ, Brinkman, DMC, Kamphuis, SSM, Girschick, HJ, ...

No abstract available.

Fine-specificity of the antibodies against citrullinated protein response is influenced by shared epitope alleles (2007)

Verpoort, KN, Cheung, K, Ioan-Facsinay, A, De Vries, RRP, Breedveld, FC, ...

No abstract available.

Altered composition of CD97 splice variants in rheumatoid synovial tissue (2005)

Van Gaalen, FA, Nelissen, RGHH, Huizinga, TWJ, Verweij, CL

No abstract available.

Functional regulatory immune responses against human cartilage glycoprotein-39 in health versus proinflammatory responses in rheumatoid arthritis (2005)

Van Bilsen, JHM, Van Dongen, H, Lard, LR, Van Der Voort, EIH, Elferink, DG, Bakker, AM, ...

No abstract available.

The invasiveness of fibroblast-like synoviocytes is of relevance for the rate of joint destruction in patients with rheumatoid arthritis and is a patient characteristic (2005)

Tolboom, TCA, Nelissen, RGHH, Breedveld, FC, Toes, REM, Huizinga, TWJ

No abstract available.

Gene expression profiling provides a link between high inflammatory synovitis and myofibroblast-like synoviocytes (2005)

Timmer, TCG, Kasperkovitz, PV, Van Baarsen, LGM, Tak, P-P, Huizinga, TWJ, ...

No abstract available.

PTPN22 as a rheumatoid arthritis susceptibility but not severity gene (2005)

Wesoly, J, Carlton, VEH, Chokkalingam, A, Toes, REM, Begovic, AB, ...

No abstract available.

Role of IL-10 as a susceptibility factor for rheumatoid arthritis and cardiovascular disease (2005)

Kurreeman, FAS, De Vries, J, Westendorp, R, Van Den Biggelaar, AH, Schonkeren, JJM, Toes, REM, ...

No abstract available.

Identification of genes associated with the presence of ectopic lymphoid structures in rheumatoid arthritis synovial tissues (2005)

Baltus, B, Mebius, RE, Vondenhoff, M, Huizinga, TWJ, Tak, PP, Verweij, CL, ...

No abstract available.

MPP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis (2005)

Tchetverikov, I, Lohmander, LS, Verzijl, N, Huizinga, TWJ, TeKoppele, JM, Hanemaaijer, R, ...

Abstract is not available.

Presence of rheumatoid factor and antibodies to citrullinated peptides in systemic lupus erythematosus (2005)

Hoffman, Ilse, Peene, Isabelle, CEBECAUER, L, ISENBERG, D, HUIZINGA, TWJ, Union, Ann, ...

Rheumatoid arthritis: a heterogeneous disease evaluated by DNA-microarray technology (2004)

Kasperkovitz, PV, Timmer, T, Smeets, T, Tak, PP, Huizinga, TWJ, Firestein, GS, ...

No abstract available.

Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCP) affects severity of rheumatoid arthritis (2004)

Van Gaalen, FA, Van Aken, J, Huizinga, TWJ, Schreuder, GMTh, Breedveld, FC, Zanelli, E, ...

No abstract available.

CD25+regulatory T cells can be used therapeutically in collagen-induced arthritis (2004)

Morgan, ME, Flierman, R, Witteveen, HJ, Huizinga, TWJ, De Vries, RRP, Toes, REM

No abstract available.

Fibroblast-like synoviocytes derived from patients with rheumatoid arthritis show the imprint of synovial tissue heterogeneity: evidence for the existence of distinctive pathways relevant to disease (2004)

Kasperkovitz, PV, Verbeet, NL, Smeets, T, Tak, PP, Huizinga, TWJ, Baltus, B, ...

No abstract available.

Specific antinuclear antibodies are associated with clinical features in systemic lupus erythematosus (2004)

Hoffman, Ilse, PEENE, ISABELLE, MEHEUS, L, HUIZINGA, TWJ, CEBECAUER, L, ISENBERG, D, ...

Fibroblast-like synoviocytes obtained from different joints at different times from one patient show similar invasiveness in vitro (2003)

Tolboom, TCA, Nelissen, R, Toes, REM, Huizinga, TWJ

No abstract available.

Pro-MMP levels and severity of RA (2003)

Tchetverikov, I, Lard, L, Hanemaaijer, R, Huizinga, TWJ

No abstract available.

Presence of anti-RNP-A and anti-RNP-C antibodies is inversely associated with renal symptoms of systemic lupus erythematosus (2003)

Hoffman, I, Peene, I, Meheus, L, Bosschere, K De, Hulstaert, F, Huizinga, TWJ, ...

No abstract available.

Autoantibodies to GPI are predominantly present in extra-articular complications of human rheumatoid arthritis (2003)

Van Gaalen, FA, Toes, REM, Ditzel, HJ, Schaller, M, Verweij, CL, Huizinga, TWJ

No abstract available.

A polymorphism in the IL-10 promoter affects autoantibody production and subsequent joint destruction in rheumatoid arthritis (2003)

Van Gaalen, FA, Lard, L, Schonkeren, J, Pieterman, E, Stoeken, G, Vos, K, ...

No abstract available.

Autoantibodies predict progression to rheumatoid arthritis in undifferentiated arthritis: a prospective cohort study (2003)

Van Gaalen, FA, Linn-Rasker, SP, Van Venrooij, WJ, De Jong, BA, Breedveld, FC, Verweij, CL, ...

No abstract available.

Presence of anti-RNP-A and anti-RNP-C antibodies is inversely associated with renal symptoms of systemic lupus erythematosus (2003)

HOFFMAN, I, PEENE, ISABELLE, MEHEUS, L, DE BOSSCHERE, K, HULSTAERT, F, HUIZINGA, TWJ, ...

Effects of TIMP-1 and TIMP-3 gene transfer on invasiveness, proliferation and apoptosis of rheumatoid arthritis (RA) synovial fibroblasts (RA-SF) (2002)

Pap, T, Drynda, A, Seemayer, CA, Quax, PHA, Verheijen, JH, Drynda, S, ...

No abstract available.

Fibroblast-like synoviocytes from rheumatoid arthritis patients express less flice-inhibitory protein than FLS from osteoarthritis, trauma and prosthesis loosening patie (2002)

Tolboom, TCA, Medema, JP, Pieterman, EJ, Breedveld, FC, Huizinga, TWJ, Toes, REM

No abstract available.

Discovery of distinctive gene expression profiles in human arthritides by cDNA micro-array analysis (2002)

Van Gaalen, FA, Kasperkovitz, P, Verbeet, N, Alizadeh, AA, Fero, M, ...

No abstract available.

Transfer of protease inhibitors to inhibit cartilage destruction (2001)

Van Der Laan, WH, Pap, T, Quax, PHA, TeKoppele, JM, Breedveld, FC, Gay, S, ...

No abstract available.

Factors influencing adenoviral gene transfer (2001)

Huizinga, TWJ, Goossens, P, Pieterman, E, Vogels, R, Havenga, M

No abstract available.

Elevated IL-16 level is a non-genetic characteristic of patients with severe systemic lupus erythematosus (2001)

Lard, LR, Roep, BO, Huizinga, TWJ

No abstract available.

Association between TNF -308A and systemic lupus erythematosus in relation to HLA-DR3 and six microsatellite markers on the short arm of chromosome VI (2001)

Van Der Linden, MW, Pieterman, E, Zanelli, E, Giphart, MJ, Breedveld, FC, ...

No abstract available.

A single nucleotide polymorphism on the IL-10 locus defines an expression polymorphism and a possible risk factor to develop RA (2001)

Lard, LR, Schonkeren, JJM, Pieterman, E, Westendorp, R, Breedveld, FC, Huizinga, TWJ

No abstract available.

Invasion of synoviocytes is inhibited by gene transfer of TNF-BP or IL10 in an in vitro invasion model (2001)

Pieterman, E, Goossens, PH, Van Der Laan, WH, Huidekoper, AL, Rabelink, MJM, Hoeben, RC, ...

No abstract available.

MMP-1, MMP-3 and MMP-10 are involved in the degradation of cartilage (2001)

Tolboom, TCA, Pieterman, E, Van Der Laan, WH, Huidekoper, AL, Nelissen, RGHH, Breedveld, FC, ...

No abstract available.

Adenoviral gene transfer of tissue inhibitors of metalloproteinases (TIMPs) reduces the invasive behaviour of rheumatoid fibroblast-like synovicytes (2001)

Van Der Laan, WH, Huisman, L, Pieterman, E, Quax, PHA, TeKoppele, JM, Breedveld, FC, ...

No abstract available.

Early treatment of recent-onset rheumatoid arthritis patients impairs the effect of HLA class II antigents on the progression of joint destruction (2001)

Lard, LR, Hazes, JMW, Breedveld, FC, Schreuder, GMTh, De Vries, RRP, Zanelli, E, ...

No abstract available.

Anaemia and seizures at disease onset are associated with a poor prognosis in childhood-onset SLE (1997)

Rood, MJ, Hertzberger, R, Van Rossum, Marc; U0016325, Ouwerkerk, F, DenOuden, E, Breedveld, FC, ...

Targeted therapies in rheumatoid arthritis: Focus on rituximab

Teng, YKO, Huizinga, TWJ, Van Laar, JM

B-cell depletion is a new strategy for treating patients with rheumatoid arthritis (RA). In the past years, several studies have proven the efficacy of anti-CD20 mediated B-cell depletion with...