Abdelwahab, A., Gardner, M., Parkash, R., Basta, M., Sapp, J., Veltmann, C., ...
Introduction: Scar-related ventricular tachycardia (VT) is often unmappable. Data regarding the outcomes of ablation for mappable vs unmappable VT are lacking. Methods: Catheter ablation of...
Anwendung von Impedanzspektroskopie und Mikroelektroden-Arrays in der zellbasierten Sensorik (2008)
Jäger, M., Poll, R., Bussek, A., Ravens, U., Sonntag, F., Müller, J., ...
Zellkulturen werden heute disziplinübergreifend als physiologisch relevante Modelle für Forschungszwecke und bei der Entwicklung neuer Medikamente und Wirkstoffe eingesetzt. Zur Erfassung der...
Wiese, C., Rolletschek, A., Kania, G., Navarrete-Santos, A., Anisimov, S. V., Steinfarz, B., ...
The intestinal epithelium has one of the greatest regenerative capacities in the body; however, neither stem nor progenitor cells have been successfully cultivated from the intestine. In this study,...
Carvedilol blocks beta(2)- more than beta(1)-adrenoceptors in human heart (2006)
Molenaar, P, Christ, T, Ravens, U, Kaumann, A
Objective: To understand the basis of the effectiveness of carvedilol in heart failure by determining its specific properties at human heart and beta(2)-adrenoceptors. Methods: The positive inotropic...
Mueller, M. P., Christ, T., Dobrev, D., Nitsche, I., Stehr, S. N., Ravens, U., ...
Background. Third-year students in the Dresden Medical School Programme undergo a 6 week course ‘Basics of Drug Therapy’ in a problem-based learning curriculum. As part of this course a practical...
Mueller, M. P., Christ, T., Dobrev, D., Nitsche, I., Stehr, S. N., Ravens, U., ...
Background. Third-year students in the Dresden Medical School Programme undergo a 6 week course ‘Basics of Drug Therapy’ in a problem-based learning curriculum. As part of this course a practical...
Priori, S. G., Aliot, E., Blømstrom-Lundqvist, C., Bossaert, L., Breithardt, G., Brugada, P., ...
The European Society of Cardiology has convened a Task Force on Sudden Cardiac Death in order to provide a comprehensive, educational document on this important topic. The main document has been...
Heubach, J. F., Graf, E. M., Molenaar, P., Jager, A., Schroder, F., Herzig, S., ...
1 The functional coupling of B-2-adrenoceptors (beta (2)-ARs) to murine L-type Ca2+ current (I-Ca(L)) was investigated with two different approaches. The beta (2)-AR signalling cascade was activated...
Heubach, J. F., Graf, E. M., Molenaar, P., Jager, A., Schroder, F., Herzig, S., ...
1 The functional coupling of B-2-adrenoceptors (beta (2)-ARs) to murine L-type Ca2+ current (I-Ca(L)) was investigated with two different approaches. The beta (2)-AR signalling cascade was activated...
Task Force on Sudden Cardiac Death of the European Society of Cardiology (2001)
Priori, S.G., Aliot, E., Blomstrom-Lundqvist, C., Bossaert, L., Breithardt, G., Brugada, P., ...
Foscarnet penetrates the blood-brain barrier: rationale for therapy of cytomegalovirus encephalitis.
Hengge, U R, Brockmeyer, N H, Malessa, R, Ravens, U, Goos, M
Foscarnet (phosphonoformate) is a potent virustatic drug against herpes-like viruses and is widely used in the therapy of cytomegalovirus infections in immunosuppressed patients. To obtain data on...
Differences between outward currents of human atrial and subepicardial ventricular myocytes.
Amos, G J, Wettwer, E, Metzger, F, Li, Q, Himmel, H M, Ravens, U
1. Outward currents were studied in myocytes isolated from human atrial and subepicardial ventricular myocardium using the whole-cell voltage clamp technique at 22 degrees C. The Na+ current was...
The effects of Anemonia sulcata toxin (ATX II) on action potentials and membrane currents were studied in single myocytes isolated from guinea-pig or bovine ventricles. Addition of ATX II (2-20 nM)...
Foscarnet penetrates the blood-brain barrier: rationale for therapy of cytomegalovirus encephalitis.
Hengge, U R, Brockmeyer, N H, Malessa, R, Ravens, U, Goos, M
Foscarnet (phosphonoformate) is a potent virustatic drug against herpes-like viruses and is widely used in the therapy of cytomegalovirus infections in immunosuppressed patients. To obtain data on...
Differences between outward currents of human atrial and subepicardial ventricular myocytes.
Amos, G J, Wettwer, E, Metzger, F, Li, Q, Himmel, H M, Ravens, U
1. Outward currents were studied in myocytes isolated from human atrial and subepicardial ventricular myocardium using the whole-cell voltage clamp technique at 22 degrees C. The Na+ current was...
The effects of Anemonia sulcata toxin (ATX II) on action potentials and membrane currents were studied in single myocytes isolated from guinea-pig or bovine ventricles. Addition of ATX II (2-20 nM)...
Heubach, JF, Graf, EM, Molenaar, P, Jager, A, Schroder, F, Herzig, S, ...
1 The functional coupling of B-2-adrenoceptors (beta (2)-ARs) to murine L-type Ca2+ current (I-Ca(L)) was investigated with two different approaches. The beta (2)-AR signalling cascade was activated...
Carvedilol blocks beta(2)- more than beta(1)-adrenoceptors in human heart
Molenaar, P, Christ, T, Ravens, U, Kaumann, A
Objective: To understand the basis of the effectiveness of carvedilol in heart failure by determining its specific properties at human heart and beta(2)-adrenoceptors. Methods: The positive inotropic...
Lüllmann, H, Peters, T, Ravens, U
1 The uptake, wash-out and exchange of [3H]-ouabain was studied in isolated, resting, and electrically stimulated papillary muscles of the guinea-pig. 2 At the equilibrium level of uptake, a...
Damarowsky, M., Lüllmann, H., Ravens, U.
1. The influence of the enantiomers and the racemate of the dihydropyridine derivative 202-791 [isopropyl 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-5-nitro-3- pyridinecarboxylate] on...
Armah, B. I., Pfeifer, T., Ravens, U.
1. We studied the interaction of the cardiotonic compound DPI 201-106 (4-[3'-(4''-benzhydryl-1''-piperazinyl)-2'-hydroxypropoxy]-1H-indole-2- carbonitrile; DPI) and its derivative BDF 8784...
Characterization of the interaction of R 56865 with cardiac Na- and L-type Ca channels.
Wilhelm, D., Himmel, H., Ravens, U., Peters, T.
1. In isolated cardiac muscle, submicromolar concentrations of R 56865 (N-[1-[4-(4-fluorophenoxy)-butyl]-4-piperidinyl]-N-methyl-2- benzothiazolamine) have been shown to attenuate the toxicity of...
Inhibition of the myocardial Ca(2+)-current (ICa) by the enantiomers of DPI 201-106 and BDF 8784.
Ravens, U., Pfeifer, T., Wettwer, E., Grundke, M.
1. We studied the stereoselectivity of the effects of the enantiomers of the cardiotonic agent DPI 201-106 (4-[3'-(4"-benzhydryl-1"-piperazinyl)-2'-hydroxypropoxy]-1H-indole-2- carbonitrile, DPI) and...
Ravens, U., Wettwer, E., Pfeifer, T., Himmel, H., Armah, B.
1. The cardiotonic agent BDF 9148 (4-[3'-(1''-benzhydryl-azetidine-3''-oxy)-2'-hydroxypropoxy]-1H-indole- 2-carbonitrile) is structurally related to DPI 201-106...
Lüllmann, H., Niehus, U., Pulss, W., Ravens, U.
The effects of digitoxin, 3 alpha-methyl-digitoxigenin-3 beta-monoglucoside (3 alpha-MDM), 3 alpha-methyl-digitoxigenin (3 alpha-MD), proscillaridin, 4, 5-methylene-procillaridin (4, 5-MP), and 3...