Renner, Marcus, Bergmann, Gaby, Krebs, Inge, End, Caroline, Lyer, Stefan, Hilberg, Frank, ...
BACKGROUND & AIMS: Impaired mucosal defense plays an important role in the pathogenesis of Crohn's disease (CD), one of the main subtypes of inflammatory bowel disease (IBD). Deleted in malignant...
Tissue localization of human trefoil factors 1, 2, and 3 (2007)
Madsen, Jens, Nielsen, Ole, Tornøe, Ida, Thim, Lars, Holmskov, Uffe
Trefoil factors (TTFs) are small, compact proteins coexpressed with mucins in the gastrointestinal tract. Three trefoil factors are known in mammals: TFF1, TFF2, and TFF3. They are implicated to play...
Hartshorn, Kevan L, White, Mitchell R, Tecle, Tesfaldet, Tornoe, Ida, Sorensen, Grith L, Crouch, Erika C, ...
Abstract Background Surfactant protein D (SP-D) plays important roles in innate host defense against influenza A virus (IAV) infection. Common human polymorphisms of SP-D have been found in many...
Surfactant protein D in atopic dermatitis and psoriasis (2006)
Hohwy, Thomas, Otkjaer, Kristian, Madsen, Jens, Søerensen, Gritt, Nielsen, Ole, Vestergaard, Christian, ...
The collectin surfactant protein-D (SP-D) shows antimicrobial and immuno-regulatory properties and has recently been detected in the basal layers of normal human skin. This molecule potentially plays...
Leth-Larsen, Rikke, Garred, Peter, Jensenius, Henriette, Meschi, Joseph, Hartshorn, Kevan, Madsen, Jens, ...
Surfactant protein D (SP-D) plays important roles in the host defense against infectious microorganisms and in regulating the innate immune response to a variety of pathogen-associated molecular...
Kang, Weiqun, Nielsen, Ole, Fenger, Claus, Leslie, R. Graham Q., Holmskov, Uffe, Reid, Kenneth B. M.
Abnormalities in the expression of DMBT1 (deleted in malignant brain tumors 1) have been implicated in the development of esophageal, gastric and colorectal cancers of the alimentary tract, but the...
Kang, Weiqun, Nielsen, Ole, Fenger, Claus, Leslie, Graham, Holmskov, Uffe, Reid, Kenneth B.M.
Abnormalities in the expression of DMBT1 (deleted in malignant brain tumors 1) have been implicated in the development of esophageal, gastric and colorectal cancers of the alimentary tract, but the...
Genomic and molecular characterization of bovine surfactant protein D (SP-D) (2004)
Gjerstorff, Morten, Madsen, Jens, Bendixen, Christian, Holmskov, Uffe, Hansen, Soren
Collectins are a group of C-type lectins involved in the innate host defense against pathogens. They selectively recognize non-self glyco-conjugates on the surface of microorganisms and induce lysis,...
Expression and localization of lung surfactant protein A in human tissues (2003)
Madsen, Jens, Tornøe, Ida, Nielsen, Ole, Koch, Claus, Steinhilber, Wolfram, Holmskov, Uffe
Lung surfactant protein A (SP-A) is a collectin produced by alveolar type II cells and Clara cells. It binds to carbohydrate structures on microorganisms, initiating effector mechanisms of innate...
Mollenhauer, Jan, Herbertz, Stephan, Helmke, Burkhard, Kollender, Gaby, Krebs, Inge, Madsen, Jens, ...
Deleted in Malignant Brain Tumors 1 (DMBT1) has been proposed as a candidate tumor suppressor gene for brain, lung, and digestive tract cancer. In particular, alterations of the gene and/or a loss of...
Purification and characterization of bovine mannan-binding protein (1993)
Holmskov, Uffe, Holt, Palle, Reid, Kenneth B.M., Willis, Anthony C., Teisner, Borge, Jensenius, Jens Christian
Bovine mannan-binding protein (bMBP) was observed in serum by its Ca2+ -dependent binding to mannan and by an Mrof 28 kDa under reducing conditions on sodium dodecyl sulphate—polyacrylamide gel...
Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D
Holmskov, Uffe, Mollenhauer, Jan, Madsen, Jens, Vitved, Lars, Grønlund, Jørn, Tornøe, Ida, ...
Surfactant protein D (SP-D) is an oligomeric C type lectin that promotes phagocytosis by binding to microbial surface carbohydrates. A 340-kDa glycoprotein (gp-340) has been shown to bind SP-D in the...
Distinctive anti-influenza properties of recombinant collectin 43.
Hartshorn, Kevan L, Holmskov, Uffe, Hansen, Soren, Zhang, Pengnian, Meschi, Joseph, Mogues, Tirsit, ...
Collectins play important roles in innate defence against viral, fungal and bacterial pathogens. CL-43, a bovine serum collectin, which appears to have evolutionarily evolved from surfactant protein...
Hartshorn, Kevan L., Ligtenberg, Antoon, White, Mitchell R., Van Eijk, Martin, Hartshorn, Max, Pemberton, Lily, ...
We previously found that scavenger receptor cysteine-rich gp-340 (glycoprotein-340), isolated from lung or saliva, directly inhibits human IAVs (influenza A viruses). We now show that salivary gp-340...
Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D
Holmskov, Uffe, Mollenhauer, Jan, Madsen, Jens, Vitved, Lars, Grønlund, Jørn, Tornøe, Ida, ...
Surfactant protein D (SP-D) is an oligomeric C type lectin that promotes phagocytosis by binding to microbial surface carbohydrates. A 340-kDa glycoprotein (gp-340) has been shown to bind SP-D in the...
Distinctive anti-influenza properties of recombinant collectin 43.
Hartshorn, Kevan L, Holmskov, Uffe, Hansen, Soren, Zhang, Pengnian, Meschi, Joseph, Mogues, Tirsit, ...
Collectins play important roles in innate defence against viral, fungal and bacterial pathogens. CL-43, a bovine serum collectin, which appears to have evolutionarily evolved from surfactant protein...
Hartshorn, Kevan L., Ligtenberg, Antoon, White, Mitchell R., Van Eijk, Martin, Hartshorn, Max, Pemberton, Lily, ...
We previously found that scavenger receptor cysteine-rich gp-340 (glycoprotein-340), isolated from lung or saliva, directly inhibits human IAVs (influenza A viruses). We now show that salivary gp-340...
Soerensen, Charlotte M, Holmskov, Uffe, Aalbaek, Bent, Boye, Mette, Heegaard, Peter M, Nielsen, Ole L
Surfactant protein D (SP-D) is a pattern-recognition molecule of the innate immune system that recognizes various microbial surface-specific carbohydrate and lipid patterns. In vitro data has...
Husby, Steffen, Herskind, Anne Maria, Jensenius, Jens Christian, Holmskov, Uffe
The collectins mannan-binding lectin (MBL) and lung surfactant protein D (SP-D) play a significant role in innate immunity. Structural as wells as promoter variants are known for MBL and different...
Reduced influenza viral neutralizing activity of natural human trimers of surfactant protein D
Hartshorn, Kevan L, White, Mitchell R, Tecle, Tesfaldet, Tornoe, Ida, Sorensen, Grith L, Crouch, Erika C, ...
Jensen, Charlotte Harken, Jauho, Eva Irene, Santoni-Rugiu, Eric, Holmskov, Uffe, Teisner, Børge, Tygstrup, Niels, ...
Hepatic regeneration from toxic or surgical injury to the adult mammalian liver, endorses different cellular responses within the hepatic lineage. The molecular mechanisms determining commitment of a...
Bisgaard, Hanne Cathrine, Holmskov, Uffe, Santoni-Rugiu, Eric, Nagy, Peter, Nielsen, Ole, Ott, Peter, ...
The regenerative capacity of mammalian adult liver reflects the ability of a number of cell populations within the hepatic lineage to take action. Limited information is available regarding factors...
Hansen, Soren, Lo, Bernice, Evans, Kathy, Neophytou, Pavlos, Holmskov, Uffe, Wright, Jo Rae
Surfactant protein D (SP-D) is a secreted pattern recognition molecule associated with lung surfactant and mediates the clearance of pathogens in multiple ways. SP-D is an established part of the...
Species Differences in the Carbohydrate Binding Preferences of Surfactant Protein D
Crouch, Erika C., Smith, Kelly, McDonald, Barbara, Briner, David, Linders, Bruce, McDonald, Joseph, ...
Interactions of surfactant protein D (SP-D) with micro-organisms and organic antigens involve binding to the trimeric neck plus carbohydrate recognition domain (neck+CRD). In these studies, we...