Petersohn, Anja, Bernhardt, Jörg, Gerth, Ulf, Höper, Dirk, Koburger, Torsten, Völker, Uwe, ...
A consensus-directed search for ςB promoters was used to locate potential candidates for new ςB-dependent genes in Bacillus subtilis. Screening of those candidates by oligonucleotide hybridizations...
Pummi, Tiina, Leskelä, Soile, Wahlström, Eva, Gerth, Ulf, Tjalsma, Harold, Hecker, Michael, ...
Identification and characterization of a suppressor mutation, sup-15, which partially restored secretion in the protein secretion-deficient Bacillus subtilis ecsA26 mutant, led us to discover a novel...
Fine-Tuning in Regulation of Clp Protein Content in Bacillus subtilis†
Gerth, Ulf, Kirstein, Janine, Mostertz, Jörg, Waldminghaus, Torsten, Miethke, Marcus, Kock, Holger, ...
Clp-controlled proteolysis in Bacillus subtilis seems to play a substantial role, particularly under stress conditions. Calibrated Western blot analyses were used to estimate the approximate numbers...
The ClpP Peptidase Is the Major Determinant of Bulk Protein Turnover in Bacillus subtilis
Kock, Holger, Gerth, Ulf, Hecker, Michael
Measurements of overall protein degradation rates in wild-type and clpP mutant Bacillus subtilis cells revealed that stress- or starvation-induced bulk protein turnover depends virtually exclusively...
Kirstein, Janine, Zühlke, Daniela, Gerth, Ulf, Turgay, Kürşad, Hecker, Michael
The soil bacterium Bacillus subtilis possesses a fine-tuned and complex heat stress response system. The repressor CtsR, whose activity is regulated by its modulators McsA and McsB, controls the...
Involvement of Bacillus subtilis ClpE in CtsR Degradation and Protein Quality Control
Miethke, Marcus, Hecker, Michael, Gerth, Ulf
The heat-inducible CtsR regulon of Bacillus subtilis codes for three Clp proteins with chaperone or protease activity. While the importance of ClpC and ClpP has been elucidated for a wide range of...
Petersohn, Anja, Bernhardt, Jörg, Gerth, Ulf, Höper, Dirk, Koburger, Torsten, Völker, Uwe, ...
A consensus-directed search for ςB promoters was used to locate potential candidates for new ςB-dependent genes in Bacillus subtilis. Screening of those candidates by oligonucleotide hybridizations...
Pummi, Tiina, Leskelä, Soile, Wahlström, Eva, Gerth, Ulf, Tjalsma, Harold, Hecker, Michael, ...
Identification and characterization of a suppressor mutation, sup-15, which partially restored secretion in the protein secretion-deficient Bacillus subtilis ecsA26 mutant, led us to discover a novel...
Fine-Tuning in Regulation of Clp Protein Content in Bacillus subtilis†
Gerth, Ulf, Kirstein, Janine, Mostertz, Jörg, Waldminghaus, Torsten, Miethke, Marcus, Kock, Holger, ...
Clp-controlled proteolysis in Bacillus subtilis seems to play a substantial role, particularly under stress conditions. Calibrated Western blot analyses were used to estimate the approximate numbers...
The ClpP Peptidase Is the Major Determinant of Bulk Protein Turnover in Bacillus subtilis
Kock, Holger, Gerth, Ulf, Hecker, Michael
Measurements of overall protein degradation rates in wild-type and clpP mutant Bacillus subtilis cells revealed that stress- or starvation-induced bulk protein turnover depends virtually exclusively...
Kirstein, Janine, Zühlke, Daniela, Gerth, Ulf, Turgay, Kürşad, Hecker, Michael
The soil bacterium Bacillus subtilis possesses a fine-tuned and complex heat stress response system. The repressor CtsR, whose activity is regulated by its modulators McsA and McsB, controls the...
Involvement of Bacillus subtilis ClpE in CtsR Degradation and Protein Quality Control
Miethke, Marcus, Hecker, Michael, Gerth, Ulf
The heat-inducible CtsR regulon of Bacillus subtilis codes for three Clp proteins with chaperone or protease activity. While the importance of ClpC and ClpP has been elucidated for a wide range of...
ClpP Modulates the Activity of the Bacillus subtilis Stress Response Transcription Factor, σB▿
Reeves, Adam, Gerth, Ulf, Völker, Uwe, Haldenwang, W. G.
The general stress regulon of Bacillus subtilis is controlled by the activity state of σB, a transcription factor that is switched on following exposure to either physical or nutritional stress....
The tyrosine kinase McsB is a regulated adaptor protein for ClpCP
Kirstein, Janine, Dougan, David A, Gerth, Ulf, Hecker, Michael, Turgay, Kürşad
Cells of the soil bacterium Bacillus subtilis have to adapt to fast environmental changes in their natural habitat. Here, we characterized a novel system in which cells respond to heat shock by...
Gerth, Ulf, Kock, Holger, Kusters, Ilja, Michalik, Stephan, Switzer, Robert L., Hecker, Michael
Entry into stationary phase in Bacillus subtilis is linked not only to a redirection of the gene expression program but also to posttranslational events such as protein degradation. Using 35S-labeled...