Recently, systematic reviews have found quantitative evidence that low study quality may have introduced a bias into preclinical stroke research. Monitoring, auditing, and standard operating...
Good laboratory practice: preventing introduction of bias at the bench (2009)
Macleod, Malcolm R., Fisher, Marc, O'Collins, Victoria, Sena, Emily S., Dirnagl, Ulrich, Bath, Philip M.W., ...
Background and Purpose—As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human...
Dreier, Jens P., Major, Sebastian, Manning, Andrew, Woitzik, Johannes, Drenckhahn, Chistoph, Steinbrink, Jens, ...
The term cortical spreading depolarization (CSD) describes a wave of mass neuronal depolarization associated with net influx of cations and water. Clusters of prolonged CSDs were measured time-locked...
Crossley, Nicolas A, Sena, Emily, Goehler, Jos, Horn, Jannekke, Van Der Worp, Bart, Bath, Philip M.W., ...
Background and Purpose—At least part of the failure in the transition from experimental to clinical studies in stroke has been attributed to the imprecision introduced by problems in the design of...
Crossley, Nicolas A., Sena, Emily S., Goehler, Jos, Horn, Jannekke, Van Der Worp, H. Bart, Bath, Philip M.W., ...
Background and Purpose—At least part of the failure in the transition from experimental to clinical studies in stroke has been attributed to the imprecision introduced by problems in the design of...
Ruscher, Karsten, Rzeczinski, Stefan, Thein, Elisabeth, Freyer, Dorette, Victorov, Ilya V, Lam, Tim T, ...
Abstract is not available
Windmüller, Olaf, Lindauer, Ute, Foddis, Marco, Einhäupl, Karl M., Dirnagl, Ulrich, Heinemann, Uwe, ...
In rats, cortical spreading hyperaemia is coupled to a spreading neuroglial depolarization wave (spreading depression) under physiological conditions, whereas cortical spreading ischaemia is coupled...
Wehner,Tim, Böntert,Matthias, Eyüpoglu,Ilker, Prass,Konstantin, Prinz,Marco, Klett,Francisco Fernández, ...
Wehner, Tim, Böntert, Matthias, Eyüpoglu, Ilker, Prass, Konstantin, Prinz, Marco, Klett, Francisco Fernández, ...
Dreier, Jens P., Kleeberg, Jörg, Petzold, Gabor, Priller, Josef, Windmüller, Olaf, Orzechowski, Hans-Dieter, ...
According to the ‘neuronal’ theory, cortical spreading depression (CSD) is the pathophysiological correlate of migrainous aura. However, the ‘vascular’ theory has implicated altered vascular...
München, Univ., Diss., 1988.
Malonek, Dov, Dirnagl, Ulrich, Lindauer, Ute, Yamada, Katsuya, Kanno, Iwao, Grinvald, Amiram
Modern functional neuroimaging methods, such as positron-emission tomography (PET), optical imaging of intrinsic signals, and functional MRI (fMRI) utilize activity-dependent hemodynamic changes to...
ZK200775: A phosphonate quinoxalinedione AMPA antagonist for neuroprotection in stroke and trauma
Turski, Lechoslaw, Huth, Andreas, Sheardown, Malcolm, McDonald, Fiona, Neuhaus, Roland, Schneider, Herbert H., ...
Stroke and head trauma are worldwide public health problems and leading causes of death and disability in humans, yet, no adequate neuroprotective treatment is available for therapy. Glutamate...
Angstwurm, Klemens, Hanisch, Uwe-Karsten, Gassemi, Tarraneh, Bille, Margrethe Bastholm, Prinz, Marco, Dirnagl, Ulrich, ...
Bacterial meningitis is an acute inflammatory disease of the central nervous system with a mortality rate of up to 30%. Excessive stimulation of the host immune system by bacterial surface components...
Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase
Endres, Matthias, Biniszkiewicz, Detlev, Sobol, Robert W., Harms, Christoph, Ahmadi, Michael, Lipski, Andreas, ...
Uracil-DNA glycosylase (UNG) is involved in base excision repair of aberrant uracil residues in nuclear and mitochondrial DNA. Ung knockout mice generated by gene targeting are viable, fertile, and...
Malonek, Dov, Dirnagl, Ulrich, Lindauer, Ute, Yamada, Katsuya, Kanno, Iwao, Grinvald, Amiram
Modern functional neuroimaging methods, such as positron-emission tomography (PET), optical imaging of intrinsic signals, and functional MRI (fMRI) utilize activity-dependent hemodynamic changes to...
ZK200775: A phosphonate quinoxalinedione AMPA antagonist for neuroprotection in stroke and trauma
Turski, Lechoslaw, Huth, Andreas, Sheardown, Malcolm, McDonald, Fiona, Neuhaus, Roland, Schneider, Herbert H., ...
Stroke and head trauma are worldwide public health problems and leading causes of death and disability in humans, yet, no adequate neuroprotective treatment is available for therapy. Glutamate...
Angstwurm, Klemens, Hanisch, Uwe-Karsten, Gassemi, Tarraneh, Bille, Margrethe Bastholm, Prinz, Marco, Dirnagl, Ulrich, ...
Bacterial meningitis is an acute inflammatory disease of the central nervous system with a mortality rate of up to 30%. Excessive stimulation of the host immune system by bacterial surface components...
Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase
Endres, Matthias, Biniszkiewicz, Detlev, Sobol, Robert W., Harms, Christoph, Ahmadi, Michael, Lipski, Andreas, ...
Uracil-DNA glycosylase (UNG) is involved in base excision repair of aberrant uracil residues in nuclear and mitochondrial DNA. Ung knockout mice generated by gene targeting are viable, fertile, and...
Ischaemia triggered by spreading neuronal activation is inhibited by vasodilators in rats
Dreier, Jens P, Petzold, Gabor, Tille, Katrin, Lindauer, Ute, Arnold, Guy, Heinemann, Uwe, ...
It has been previously shown that spreading neuronal activation can generate a cortical spreading ischaemia (CSI) in rats. The purpose of the present study was to investigate whether vasodilators...
Prass, Konstantin, Meisel, Christian, Höflich, Conny, Braun, Johann, Halle, Elke, Wolf, Tilo, ...
Infections are a leading cause of death in stroke patients. In a mouse model of focal cerebral ischemia, we tested the hypothesis that a stroke-induced immunodeficiency increases the susceptibility...
Neogenesis of cerebellar Purkinje neurons from gene-marked bone marrow cells in vivo
Priller, Josef, Persons, Derek A., Klett, Francisco F., Kempermann, Gerd, Kreutzberg, Georg W., Dirnagl, Ulrich
The versatility of stem cells has only recently been fully recognized. There is evidence that upon adoptive bone marrow (BM) transplantation (BMT), donor-derived cells can give rise to neuronal...
Preventive Antibacterial Therapy in Acute Ischemic Stroke: A Randomized Controlled Trial
Harms, Hendrik, Prass, Konstantin, Meisel, Christian, Klehmet, Juliane, Rogge, Witold, Drenckhahn, Christoph, ...
Dreier, Jens P., Major, Sebastian, Manning, Andrew, Woitzik, Johannes, Drenckhahn, Chistoph, Steinbrink, Jens, ...
The term cortical spreading depolarization (CSD) describes a wave of mass neuronal depolarization associated with net influx of cations and water. Clusters of prolonged CSDs were measured time-locked...