Kong, Eric C., Woo, Katherine, Li, Haiyan, Lebestky, Tim, Mayer, Nasima, Sniffen, Melissa R., ...
Dopamine is a mediator of the stimulant properties of drugs of abuse, including ethanol, in mammals and in the fruit fly Drosophila. The neural substrates for the stimulant actions of ethanol in...
Printed in Great Britain © The Company of Biologists Limited 1995 (2008)
Françoise Chanut, Ulrike Heberlein
Role of the morphogenetic furrow in establishing polarity in the Drosophila eye
Nina Offenhäuser, Daniela Castelletti, Lisa Mapelli, Cristina Regondi, Paola Rossi, Carolina Frassoni, ...
ethanol required to induce the loss of righting reflex was determined using the “up
Nina Offenhäuser, Daniela Castelletti, Lisa Mapelli, Maria Cristina Regondi, Paola Rossi, Carolina Frassoni, ...
Dynamic modulation of the actin cytoskeleton is critical for synaptic plasticity, abnormalities of which are thought to contribute to mental illness and addiction. Here we report that mice lacking...
Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts (2006)
Wang, Hongyan, Somers, Gregory W., Bashirullah, Arash, Heberlein, Ulrike, Yu, Fengwei, Chia, William
The choice of self-renewal versus differentiation is a fundamental issue in stem cell and cancer biology. Neural progenitors of the Drosophila post-embryonic brain, larval neuroblasts (NBs), divide...
Lmo Mutants Reveal a Novel Role for Circadian Pacemaker Neurons in Cocaine-Induced Behaviors (2004)
Roland J. Bainton, Justin Blau, Ulrike Heberlein
Expression of the Drosophila LIM-only (LMO) gene in circadian pacemaker cells is required for the normal behavioral sensitivity of these animals to cocaine.
Lmo Mutants Reveal a Novel Role for Circadian Pacemaker Neurons in Cocaine-Induced Behaviors (2004)
Roland J. Bainton, Justin Blau, Ulrike Heberlein
Drosophila has been developed recently as a model system to investigate the molecular and neural mechanisms underlying responses to drugs of abuse. Genetic screens for mutants with altered...
Molecular Genetic Analysis of Ethanol Intoxication in Drosophila melanogaster1 (2004)
Ulrike Heberlein, Fred W. Wolf, Adrian Rothenfluh, Douglas J. Guarnieri
Molecular Genetic Analysis of Ethanol Intoxication in Drosophila melanogaster (2004)
Heberlein, Ulrike, Wolf, Fred W., Rothenfluh, Adrian, Guarnieri, Douglas J.
Recently, the fruit fly Drosophila melanogaster has been introduced as a model system to study the molecular bases of a variety of ethanol-induced behaviors. It became immediately apparent that the...
Prabhat S. Kunwar, Michelle Starz-Gaiano, Roland J. Bainton, Ulrike Heberlein, Ruth Lehmann
A novel G protein-coupled receptor (GPCR) is shown to be essential for transepithelial migration of Drosophila germ cells. Leukocyte transepithelial migration also requires GPCR signaling, suggesting...
Prabhat S. Kunwar, Michelle Starz-Gaiano, Roland J. Bainton, Ulrike Heberlein, Ruth Lehmann
In most organisms, germ cells are formed distant from the somatic part of the gonad and thus have to migrate along and through a variety of tissues to reach the gonad. Transepithelial migration...
Tre1, a G Protein-Coupled Receptor, Directs Transepithelial Migration of Drosophila Germ Cells
Kunwar, Prabhat S, Starz-Gaiano, Michelle, Bainton, Roland J, Heberlein, Ulrike, Lehmann, Ruth
In most organisms, germ cells are formed distant from the somatic part of the gonad and thus have to migrate along and through a variety of tissues to reach the gonad. Transepithelial migration...
Treisman, Jessica E., Luk, Alvin, Rubin, Gerald M., Heberlein, Ulrike
In Drosophila, pattern formation at multiple stages of embryonic and imaginal development depends on the same intercellular signaling pathways. We have identified a novel gene, eyelid (eld), which is...
Lmo Mutants Reveal a Novel Role for Circadian Pacemaker Neurons in Cocaine-Induced Behaviors
Tsai, Linus T.-Y, Bainton, Roland J, Blau, Justin, Heberlein, Ulrike
Drosophila has been developed recently as a model system to investigate the molecular and neural mechanisms underlying responses to drugs of abuse. Genetic screens for mutants with altered...
The hangover gene defines a stress pathway required for ethanol tolerance development
Scholz, Henrike, Franz, Mirjam, Heberlein, Ulrike
Repeated alcohol consumption leads to the development of tolerance, simply defined as an acquired resistance to the physiological and behavioral effects of the drug. This tolerance allows increased...
Chanut, Françoise, Woo, Katherine, Pereira, Shalini, Donohoe, Terrence J, Chang, Shang-Yu, Laverty, Todd R, ...
The regular organization of the ommatidial lattice in the Drosophila eye originates in the precise regulation of the proneural gene atonal (ato), which is responsible for the specification of the...
Tre1, a G Protein-Coupled Receptor, Directs Transepithelial Migration of Drosophila Germ Cells
Kunwar, Prabhat S, Starz-Gaiano, Michelle, Bainton, Roland J, Heberlein, Ulrike, Lehmann, Ruth
In most organisms, germ cells are formed distant from the somatic part of the gonad and thus have to migrate along and through a variety of tissues to reach the gonad. Transepithelial migration...
Treisman, Jessica E., Luk, Alvin, Rubin, Gerald M., Heberlein, Ulrike
In Drosophila, pattern formation at multiple stages of embryonic and imaginal development depends on the same intercellular signaling pathways. We have identified a novel gene, eyelid (eld), which is...
Lmo Mutants Reveal a Novel Role for Circadian Pacemaker Neurons in Cocaine-Induced Behaviors
Tsai, Linus T.-Y, Bainton, Roland J, Blau, Justin, Heberlein, Ulrike
Drosophila has been developed recently as a model system to investigate the molecular and neural mechanisms underlying responses to drugs of abuse. Genetic screens for mutants with altered...
Chanut, Françoise, Woo, Katherine, Pereira, Shalini, Donohoe, Terrence J, Chang, Shang-Yu, Laverty, Todd R, ...
The regular organization of the ommatidial lattice in the Drosophila eye originates in the precise regulation of the proneural gene atonal (ato), which is responsible for the specification of the...
Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts
Wang, Hongyan, Somers, Gregory W., Bashirullah, Arash, Heberlein, Ulrike, Yu, Fengwei, Chia, William
The choice of self-renewal versus differentiation is a fundamental issue in stem cell and cancer biology. Neural progenitors of the Drosophila post-embryonic brain, larval neuroblasts (NBs), divide...
GSK-3/Shaggy regulates olfactory habituation in Drosophila
Wolf, Fred W., Eddison, Mark, Lee, Seonok, Cho, William, Heberlein, Ulrike
Habituation is a universal form of nonassociative learning that results in the devaluation of sensory inputs that have little information content. Although habituation is found throughout nature and...
Genetic Dissociation of Ethanol Sensitivity and Memory Formation in Drosophila melanogaster
LaFerriere, Holly, Guarnieri, Douglas J., Sitaraman, Divya, Diegelmann, Soeren, Heberlein, Ulrike, Zars, Troy
The ad hoc genetic correlation between ethanol sensitivity and learning mechanisms in Drosophila could overemphasize a common process supporting both behaviors. To challenge directly the hypothesis...
Joseph, Ryan M., Devineni, Anita V., King, Ian F. G., Heberlein, Ulrike
Selection of appropriate oviposition sites is essential for progeny survival and fitness in generalist insect species, such as Drosphila melanogaster, yet little is known about the mechanisms...
Kong, Eric C., Woo, Katherine, Li, Haiyan, Lebestky, Tim, Mayer, Nasima, Sniffen, Melissa R., ...
Dopamine is a mediator of the stimulant properties of drugs of abuse, including ethanol, in mammals and in the fruit fly Drosophila. The neural substrates for the stimulant actions of ethanol in...
French, Rachael L., Heberlein, Ulrike
It has long been known that heavy alcohol consumption leads to neuropathology and neuronal death. While the response of neurons to an ethanol insult is strongly influenced by genetic background, the...