Ulrike Protzer

Interferon gene transfer by a hepatitis B virus vector efficiently suppresses wild-type virus infection

Protzer, Ulrike, Nassal, Michael, Chiang, Pei-Wen, Kirschfink, Michael, Schaller, Heinz

Hepatitis B viruses specifically target the liver, where they efficiently infect quiescent hepatocytes. Here we show that human and avian hepatitis B viruses can be converted into vectors for...

Endotoxin Stimulates Liver Macrophages To Release Mediators That Inhibit an Early Step in Hepadnavirus Replication

Klöcker, Uta, Schultz, Ursula, Schaller, Heinz, Protzer, Ulrike

Hepadnaviruses are known to be sensitive to various extracellular mediators. Therefore, bacterial endotoxin, which induces the secretion of proinflammatory mediators in the liver, was studied for its...

Transfer of Hepatitis B Virus Genome by Adenovirus Vectors into Cultured Cells and Mice: Crossing the Species Barrier

Sprinzl, Martin Franz, Oberwinkler, Heike, Schaller, Heinz, Protzer, Ulrike

For the study of hepatitis B virus infection, no permissive cell line or small animal is available. Stably transfected cell lines and transgenic mice which contain hepadnavirus genomes produce virus,...

Presence of Replicating Virus in Recombinant Hepadnavirus Stocks Results from Recombination and Can Be Eliminated by the Use of a Packaging Cell Line

Klöcker, Uta, Oberwinkler, Heike, Kürschner, Timo, Protzer, Ulrike

Mutant hepatitis B viruses are useful tools to study the viral life cycle and viral pathogenesis. Furthermore, recombinant hepatitis B viruses are candidate vectors for liver-directed gene therapy....

Inhibition of Cellular Proteasome Activities Enhances Hepadnavirus Replication in an HBX-Dependent Manner

Zhang, Zhensheng, Protzer, Ulrike, Hu, Zongyi, Jacob, James, Liang, T. Jake

The X protein (HBX) of the hepatitis B virus (HBV) is not essential for the HBV life cycle in vitro but is important for productive infection in vivo. Our previous study suggests that interaction of...

Liver-Directed Gamma Interferon Gene Delivery in Chronic Hepatitis C

Shin, Eui-Cheol, Protzer, Ulrike, Untergasser, Andreas, Feinstone, Stephen M., Rice, Charles M., Hasselschwert, Dana, ...

Gamma interferon (IFN-γ) has been shown to inhibit replication of subgenomic and genomic hepatitis C virus (HCV) RNAs in vitro and to noncytolytically suppress hepatitis B virus (HBV) replication in...

Interferon gene transfer by a hepatitis B virus vector efficiently suppresses wild-type virus infection

Protzer, Ulrike, Nassal, Michael, Chiang, Pei-Wen, Kirschfink, Michael, Schaller, Heinz

Hepatitis B viruses specifically target the liver, where they efficiently infect quiescent hepatocytes. Here we show that human and avian hepatitis B viruses can be converted into vectors for...

Endotoxin Stimulates Liver Macrophages To Release Mediators That Inhibit an Early Step in Hepadnavirus Replication

Klöcker, Uta, Schultz, Ursula, Schaller, Heinz, Protzer, Ulrike

Hepadnaviruses are known to be sensitive to various extracellular mediators. Therefore, bacterial endotoxin, which induces the secretion of proinflammatory mediators in the liver, was studied for its...

Transfer of Hepatitis B Virus Genome by Adenovirus Vectors into Cultured Cells and Mice: Crossing the Species Barrier

Sprinzl, Martin Franz, Oberwinkler, Heike, Schaller, Heinz, Protzer, Ulrike

For the study of hepatitis B virus infection, no permissive cell line or small animal is available. Stably transfected cell lines and transgenic mice which contain hepadnavirus genomes produce virus,...

Presence of Replicating Virus in Recombinant Hepadnavirus Stocks Results from Recombination and Can Be Eliminated by the Use of a Packaging Cell Line

Klöcker, Uta, Oberwinkler, Heike, Kürschner, Timo, Protzer, Ulrike

Mutant hepatitis B viruses are useful tools to study the viral life cycle and viral pathogenesis. Furthermore, recombinant hepatitis B viruses are candidate vectors for liver-directed gene therapy....

Inhibition of Cellular Proteasome Activities Enhances Hepadnavirus Replication in an HBX-Dependent Manner

Zhang, Zhensheng, Protzer, Ulrike, Hu, Zongyi, Jacob, James, Liang, T. Jake

The X protein (HBX) of the hepatitis B virus (HBV) is not essential for the HBV life cycle in vitro but is important for productive infection in vivo. Our previous study suggests that interaction of...

Liver-Directed Gamma Interferon Gene Delivery in Chronic Hepatitis C

Shin, Eui-Cheol, Protzer, Ulrike, Untergasser, Andreas, Feinstone, Stephen M., Rice, Charles M., Hasselschwert, Dana, ...

Gamma interferon (IFN-γ) has been shown to inhibit replication of subgenomic and genomic hepatitis C virus (HCV) RNAs in vitro and to noncytolytically suppress hepatitis B virus (HBV) replication in...

Induction of Antiviral Cytidine Deaminases Does Not Explain the Inhibition of Hepatitis B Virus Replication by Interferons▿

Jost, Stéphanie, Turelli, Priscilla, Mangeat, Bastien, Protzer, Ulrike, Trono, Didier

Interferons (IFNs) play a major role in the control of hepatitis B virus (HBV), whether as endogenous cytokines limiting the spread of the virus during the acute phase of the infection or as drugs...

Long-Term Suppression of Hepatitis B Virus Replication by Short Hairpin RNA Expression Using the Scaffold/Matrix Attachment Region-Based Replicating Vector System pEPI-1▿

Jenke, Andreas C. W., Wilhelm, Andreas D., Orth, Valerie, Lipps, Hans Joachim, Protzer, Ulrike, Wirth, Stefan

Since the emergence of viral resistance of hepatitis B virus (HBV) during treatment is becoming an important issue even with newer drugs, there is a need for alternative treatment options such as,...