Modulation of cellular hypoxia responses through Notch signalling (2006)
Gustafsson, Maria, Lendahl, Urban, Bondesson, Bolin M., Poellinger, Lorenz, Pereira, Teresa, Ruas, Jorge, ...
Publication Number: WO/2006/085224; Publication Date: 17.08.2006; International Filing Date: 07.02.2006
Modulation of cellular hypoxia responses through Notch signalling (2006)
Gustafsson, Maria, Lendahl, Urban, Bondesson, Bolin M., Poellinger, Lorenz, Pereira, Teresa, Ruas, Jorge, ...
Publication Number: WO/2006/085224; Publication Date: 17.08.2006; International Filing Date: 07.02.2006
The European dimension for the mouse genome mutagenesis program. (2004)
Auwerx, Johan, Avner, Phil, Baldock, Richard, Ballabio, Andrea, Balling, Rudi, Barbacid, Mariano, ...
The European Mouse Mutagenesis Consortium is the European initiative contributing to the international effort on functional annotation of the mouse genome. Its objectives are to establish and...
About, Imad, Laurent-Maquin, Dominique, Lendahl, Urban, Mitsiadis, Thimios
Nestin is an intermediate filament most related to neurofilaments and expressed predominantly in the developing nervous system and muscles. In the present study we examined the in vivo distribution...
Ly49A expression on T cells alters T cell selection (2000)
Fahlén, Linda, Öberg, Linda, Brännström, Thomas, Khoo, Nelson K. S., Lendahl, Urban, Sentman, Charles L.
Ly49 receptors are inhibitory receptors expressed on subsets of both NK cells and NK1.1+ T cells. The function of these receptors on NK cells is believed to be important in maintaining...
Felli, Maria Pia, Maroder, Marella, Mitsiadis, Thimios A., Campese, Antonio F., Bellavia, Diana, Vacca, Alessandra, ...
The suggested role of Notch1 or its mutants in thymocyte differentiation and T cell tumorigenesis raises the question of how the different members of the Notch family influence distinct steps in T...
Arulampalam, Velmurugesan, Furebring, Christina, Samuelsson, Annika, Lendahl, Urban, Borrebaeck, Carl, Lundkvist, Inger, ...
To delineate the role of the IgH 3' enhancer in the regulation of Ig heavy (IgH) chain gene expression, mice harbouring rearranged IgH transgenes, with (PSVμ3) and without (PSVμ1) this element,...
Funakoshi, Hiroshi, Risling, Mårten, Carlstedt, Thomas, Lendahl, Urban, Timmusk, Tõnis, Metsis, Madis, ...
Peripheral nerve injury markedly regulates expression of neurotrophins and their receptors in the lesioned nerve. However, the role of endogenously produced neurotrophins in the process of nerve...
Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin
Kokaia, Merab, Holmberg, Kristina, Nanobashvili, Avtandil, Xu, Zhi-Qing D., Kokaia, Zaal, Lendahl, Urban, ...
The neuropeptide galanin has been shown to suppress epileptic seizures. In cortical and hippocampal areas, galanin is normally mainly expressed in noradrenergic afferents. We have generated a mouse...
Bellavia, Diana, Campese, Antonio F., Checquolo, Saula, Balestri, Anna, Biondi, Andrea, Cazzaniga, Giovanni, ...
Notch receptors are conserved regulators of cell fate and have been implicated in the regulation of T cell differentiation and lymphomagenesis. However, neither the generality of Notch involvement in...
Notch receptor cleavage depends on but is not directly executed by presenilins
Taniguchi, Yoshihito, Karlström, Helena, Lundkvist, Johan, Mizutani, Tomohiko, Otaka, Akira, Vestling, Monica, ...
Notch receptors undergo three distinct proteolytic cleavages during maturation and activation. The third cleavage occurs within the plasma membrane and results in the release and translocation of the...
Wallberg, Annika E., Pedersen, Kia, Lendahl, Urban, Roeder, Robert G.
Ligand activation of Notch receptors leads to release of the intracellular receptor domain (Notch IC), which translocates to the nucleus and interacts with the DNA-binding protein RBP-Jκ to control...
Karlström, Helena, Beatus, Paul, Dannaeus, Karin, Chapman, Gavin, Lendahl, Urban, Lundkvist, Johan
Notch receptors are single transmembrane receptors that contain a large number of epidermal growth factor-like repeats (EGF repeats) in their extracellular domains. Mutations in the EGF repeats of...
Constitutive activation of NF-κB and T-cell leukemia/lymphoma in Notch3 transgenic mice
Bellavia, Diana, Campese, Antonio F., Alesse, Edoardo, Vacca, Alessandra, Felli, Maria Pia, Balestri, Anna, ...
The multiplicity of Notch receptors raises the question of the contribution of specific isoforms to T-cell development. Notch3 is expressed in CD4–8– thymocytes and is down-regulated across the...
Funakoshi, Hiroshi, Risling, Mårten, Carlstedt, Thomas, Lendahl, Urban, Timmusk, Tõnis, Metsis, Madis, ...
Peripheral nerve injury markedly regulates expression of neurotrophins and their receptors in the lesioned nerve. However, the role of endogenously produced neurotrophins in the process of nerve...
Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin
Kokaia, Merab, Holmberg, Kristina, Nanobashvili, Avtandil, Xu, Zhi-Qing D., Kokaia, Zaal, Lendahl, Urban, ...
The neuropeptide galanin has been shown to suppress epileptic seizures. In cortical and hippocampal areas, galanin is normally mainly expressed in noradrenergic afferents. We have generated a mouse...
Bellavia, Diana, Campese, Antonio F., Checquolo, Saula, Balestri, Anna, Biondi, Andrea, Cazzaniga, Giovanni, ...
Notch receptors are conserved regulators of cell fate and have been implicated in the regulation of T cell differentiation and lymphomagenesis. However, neither the generality of Notch involvement in...
Notch receptor cleavage depends on but is not directly executed by presenilins
Taniguchi, Yoshihito, Karlström, Helena, Lundkvist, Johan, Mizutani, Tomohiko, Otaka, Akira, Vestling, Monica, ...
Notch receptors undergo three distinct proteolytic cleavages during maturation and activation. The third cleavage occurs within the plasma membrane and results in the release and translocation of the...
Wallberg, Annika E., Pedersen, Kia, Lendahl, Urban, Roeder, Robert G.
Ligand activation of Notch receptors leads to release of the intracellular receptor domain (Notch IC), which translocates to the nucleus and interacts with the DNA-binding protein RBP-Jκ to control...
Karlström, Helena, Beatus, Paul, Dannaeus, Karin, Chapman, Gavin, Lendahl, Urban, Lundkvist, Johan
Notch receptors are single transmembrane receptors that contain a large number of epidermal growth factor-like repeats (EGF repeats) in their extracellular domains. Mutations in the EGF repeats of...
Constitutive activation of NF-κB and T-cell leukemia/lymphoma in Notch3 transgenic mice
Bellavia, Diana, Campese, Antonio F., Alesse, Edoardo, Vacca, Alessandra, Felli, Maria Pia, Balestri, Anna, ...
The multiplicity of Notch receptors raises the question of the contribution of specific isoforms to T-cell development. Notch3 is expressed in CD4–8– thymocytes and is down-regulated across the...
Vaittinen, Samuli, Lukka, Riitta, Sahlgren, Cecilia, Rantanen, Jussi, Hurme, Timo, Lendahl, Urban, ...
The intermediate filament proteins nestin, vimentin, and desmin show a specific temporal expression pattern during the development of myofibers from myogenic precursor cells. Nestin and vimentin are...
Nestin Expression in Embryonic and Adult Human Teeth under Normal and Pathological Conditions
About, Imad, Laurent-Maquin, Dominique, Lendahl, Urban, Mitsiadis, Thimios A.
Nestin is an intermediate filament most related to neurofilaments and expressed predominantly in the developing nervous system and muscles. In the present study we examined the in vivo distribution...
Tsujimura, Tohru, Makiishi-Shimobayashi, Chiaki, Lundkvist, Johan, Lendahl, Urban, Nakasho, Keiji, Sugihara, Ayako, ...
It has recently been proposed that gastrointestinal stromal tumors (GISTs) originate from stem cells that differentiate toward a phenotype of interstitial cells of Cajal (ICCs). Nestin is a newly...
Heymann, Robert, About, Imad, Lendahl, Urban, Franquin, Jean-Claude, Öbrink, Björn, Mitsiadis, Thimios A.
Cadherins are calcium-dependent cell adhesion molecules involved in the regulation of various biological processes such as cell recognition, intercellular communication, cell fate, cell polarity,...
High levels of Notch signaling down-regulate Numb and Numblike
Chapman, Gavin, Liu, Lining, Sahlgren, Cecilia, Dahlqvist, Camilla, Lendahl, Urban
Inhibition of Notch signaling by Numb is critical for many cell fate decisions. In this study, we demonstrate a more complex relationship between Notch and the two vertebrate Numb homologues Numb and...
Blokzijl, Andries, Dahlqvist, Camilla, Reissmann, Eva, Falk, Anna, Moliner, Annalena, Lendahl, Urban, ...
The Notch and transforming growth factor-β (TGF-β) signaling pathways play critical roles in the control of cell fate during metazoan development. However, mechanisms of cross-talk and signal...
Pekny, Milos, Johansson, Clas B., Eliasson, Camilla, Stakeberg, Josefina, Wallén, Åsa, Perlmann, Thomas, ...
In response to injury of the central nervous system, astrocytes become reactive and express high levels of the intermediate filament (IF) proteins glial fibrillary acidic protein (GFAP), vimentin,...
Zheng, Xiaofeng, Linke, Sarah, Dias, José M., Zheng, Xiaowei, Gradin, Katarina, Wallis, Tristan P., ...
Cells adapt to hypoxia by a cellular response, where hypoxia-inducible factor 1α (HIF-1α) becomes stabilized and directly activates transcription of downstream genes. In addition to this...
Notch signaling mediates hypoxia-induced tumor cell migration and invasion
Sahlgren, Cecilia, Gustafsson, Maria V., Jin, Shaobo, Poellinger, Lorenz, Lendahl, Urban
Tumor hypoxia is linked to increased metastatic potential, but the molecular mechanisms coupling hypoxia to metastasis are poorly understood. Here, we show that Notch signaling is required to convert...