Goette, Andreas, Bukowska, Alicja, Dobrev, Dobromir, Pfeiffenberger, Jan, Morawietz, Henning, Strugala, Denis, ...
Aims Patients with paroxysmal atrial fibrillation (AF) often present with typical angina pectoris and mildly elevated levels of cardiac troponin (non ST-segment elevation myocardial infarction)...
Eichhorn, Birgit, Muller, Gregor, Leuner, Anja, Sawamura, Tatsuya, Ravens, Ursula, Morawietz, Henning
Aims LOX-1 is a major vascular receptor for oxidized low-density lipoprotein (oxLDL). In this study, we analysed the impact of LOX-1 overexpression and high dietary fat intake on vascular function in...
Nabauer, Michael, Gerth, Andrea, Limbourg, Tobias, Schneider, Steffen, Oeff, Michael, Kirchhof, Paulus, ...
Aims The aim of this study was to describe the characteristics of patients with atrial fibrillation (AF) enrolled in the Central Registry of the German Competence NETwork on Atrial Fibrillation...
Kirchhof, Paulus, Bax, Jeroen, Blomstrom-Lundquist, Carina, Calkins, Hugh, Camm, A. John, Cappato, Ricardo, ...
Voigt, Niels, Maguy, Ange, Yeh, Yung-Hsin, Qi, Xiaoyan, Ravens, Ursula, Dobrev, Dobromir, ...
Aims Although atrial tachycardia (AT) remodelling promotes agonist-independent, constitutively active, acetylcholine-regulated K+-current (IK,ACh) that increases susceptibility to atrial fibrillation...
Role of potassium currents in cardiac arrhythmias (2008)
Ravens, Ursula, Cerbai, Elisabetta
Abnormal excitability of myocardial cells may give rise to ectopic beats and initiate re-entry around an anatomical or functional obstacle. As K+ currents control the repolarization process of the...
Kirchhof, Paulus, Auricchio, Angelo, Bax, Jeroen, Crijns, Harry, Camm, John, Diener, Hans-Christoph, ...
Atrial fibrillation (AF), the most common atrial arrhythmia, has a complex aetiology and causes relevant morbidity and mortality due to different mechanisms, including but not limited to stroke,...
Voigt, Niels, Friedrich, Adina, Bock, Manja, Wettwer, Erich, Christ, Torsten, Knaut, Michael, ...
Objective: In chronic atrial fibrillation (cAF) the potassium current IK,ACh develops agonist-independent constitutive activity. We hypothesized that abnormal phosphorylation-dependent regulation...
Voigt, Niels, Maguy, Ange, Yeh, Yung-Hsin, Qi, Xiaoyan, Ravens, Ursula, Dobrev, Dobromir, ...
Aims Although atrial tachycardia (AT) remodelling promotes agonist-independent, constitutively active, acetylcholine-regulated K+-current (IK,ACh) that increases susceptibility to atrial fibrillation...
Voigt, Niels, Maguy, Ange, Yeh, Yung-Hsin, Qi, Xiaoyan, Ravens, Ursula, Dobrev, Dobromir, ...
Aims Although atrial tachycardia (AT) remodelling promotes agonist-independent, constitutively active, acetylcholine-regulated K+-current (IK,ACh) that increases susceptibility to atrial fibrillation...
Kirchhof, Paulus, Auricchio, Angelo, Bax, Jeroen, Crijns, Harry, Camm, John, Diener, Hans-Christoph, ...
Atrial fibrillation (AF), the most common atrial arrhythmia, has a complex aetiology and causes relevant morbidity and mortality due to different mechanisms, including but not limited to stroke,...
Carvedilol blocks beta(2)- more than beta(1)-adrenoceptors in human heart (2006)
Molenaar, Peter, Christ, Torsten, Ravens, Ursula, Kaumann, Alberto
Objective: To understand the basis of the effectiveness of carvedilol in heart failure by determining its specific properties at human heart and beta(2)-adrenoceptors. Methods: The positive inotropic...
Carvedilol blocks beta(2)- more than beta(1)-adrenoceptors in human heart (2006)
Molenaar, Peter, Christ, Torsten, Ravens, Ursula, Kaumann, Alberto
Objective: To understand the basis of the effectiveness of carvedilol in heart failure by determining its specific properties at human heart and beta(2)-adrenoceptors. Methods: The positive inotropic...
Carvedilol blocks {beta}2- more than {beta}1-adrenoceptors in human heart (2006)
Molenaar, Peter, Christ, Torsten, Ravens, Ursula, Kaumann, Alberto
Objective: To understand the basis of the effectiveness of carvedilol in heart failure by determining its specific properties at human heart β1- and β2-adrenoceptors. Methods: The positive...
Radicke, Susanne, Cotella, Diego, Graf, Eva Maria, Banse, Ulrich, Jost, Norbert, Varró, András, ...
Objectives The function of Kv4.3 (KCND3) channels, which underlie the transient outward current Ito in human heart, can be modulated by several accessory subunits such as KChIP2 and KCNE1–KCNE5....
Update of the guidelines on sudden cardiac death of the European Society of Cardiology (2003)
Priori, Silvia G, Aliot, Etienne, Blomstrom-Lundqvist, Carina, Bossaert, Leo, Breithardt, Gunter, Brugada, Pedro, ...
Human inward rectifier potassium channels in chronic and postoperative atrial fibrillation (2002)
Dobrev, Dobromir, Wettwer, Erich, Kortner, Ariane, Knaut, Michael, Schüler, Stephan, Ravens, Ursula
Objective: We showed recently that the 825T allele of the G-protein β3-subunit C825T polymorphism is associated with large inward rectifier K+ currents IK1 but low acetylcholine-activated K+ current...
Heubach, Jürgen F, Trebeß, Ina, Wettwer, Erich, Himmel, Herbert M, Michel, Martin C, Kaumann, Alberto J, ...
Objectives: The reported increase in basal activity of hearts from transgenic mice (TG4) overexpressing the human β2-adrenoceptor (β2-AR) was explained by spontaneously active β2-ARs that...
Neumann, Till, Ravens, Ursula, Heusch, Gerd
Objective: In isolated cardiac preparations of non-failing hearts from different species, including man, there is a positive force–frequency relation which is reversed into a negative relation in...
Tachycardia-induced failure alters contractile properties of canine ventricular myocytes (1996)
Ravens, Ursula, Davia, Kerry, Davies, Crispin H., O'Gara, Peter, Drake-Holland, Angela J., Hynd, John W., ...
Objective Rapid cardiac pacing has been used as a model for experimentally-induced cardiomyopathy. However, its relevance to human heart failure is not clear at present because little is known about...
Transient outward current in human and rat ventricular myocytes (1993)
Wettwer, Erich, Amos, Gregory, Gath, Jennifer, Zerkowski, Hans-Reinhard, Reidemeister, Jürgen-Christoph, Ravens, Ursula
Objective: The aim was to investigate transient outward currents (Ito) in single myocytes isolated from human heart muscle specimens which were obtained either from patients in terminal heart failure...
Wettwer, Erich, Grundke, Martin, Ravens, Ursula
Objectives The effects of almokalant (4-[3-ethyl[3-(propylsulphinyl)propyl]-amino]-2-hydroxy-propoxyj-benzonitrile), E-4031 (1...
Rosskopf, Dieter, Manthey, Iris, Habich, Christiane, Kielbik, Marzena, Eisenhardt, Andreas, Nikula, Christiane, ...
The T-allele of a polymorphism (C825T) in the gene for the G-protein beta 3 subunit (GNB3) is associated with cardiovascular and metabolic disorders, distinct cellular features and altered drug...
Radicke, Susanne, Cotella, Diego, Graf, Eva Maria, Ravens, Ursula, Wettwer, Erich
Dipeptidyl-aminopeptidase-like protein 6 (DPPX) was recently shown in the brain to modulate the kinetics of transient A-type currents by accelerating inactivation and recovery from inactivation....
Electrophysiological properties of human mesenchymal stem cells
Heubach, Jürgen F, Graf, Eva M, Leutheuser, Judith, Bock, Manja, Balana, Bartosz, Zahanich, Ihor, ...
Human mesenchymal stem cells (hMSC) have gained considerable interest due to their potential use for cell replacement therapy and tissue engineering. One strategy is to differentiate these bone...
Rosskopf, Dieter, Manthey, Iris, Habich, Christiane, Kielbik, Marzena, Eisenhardt, Andreas, Nikula, Christiane, ...
The T-allele of a polymorphism (C825T) in the gene for the G-protein beta 3 subunit (GNB3) is associated with cardiovascular and metabolic disorders, distinct cellular features and altered drug...
Radicke, Susanne, Cotella, Diego, Graf, Eva Maria, Ravens, Ursula, Wettwer, Erich
Dipeptidyl-aminopeptidase-like protein 6 (DPPX) was recently shown in the brain to modulate the kinetics of transient A-type currents by accelerating inactivation and recovery from inactivation....
Electrophysiological properties of human mesenchymal stem cells
Heubach, Jürgen F, Graf, Eva M, Leutheuser, Judith, Bock, Manja, Balana, Bartosz, Zahanich, Ihor, ...
Human mesenchymal stem cells (hMSC) have gained considerable interest due to their potential use for cell replacement therapy and tissue engineering. One strategy is to differentiate these bone...
Dobrev, Dobromir, Milde, Alexander S, Andreas, Klaus, Ravens, Ursula
The putative inhibitory effects of verapamil and diltiazem on neuronal non-L-type Ca2+ channels were studied by investigating their effects on either K+- or veratridine-evoked [3H]-dopamine ([3H]-DA)...
Wettwer, Erich, Himmel, Herbert M, Amos, Gregory J, Li, Qi, Metzger, Franz, Ravens, Ursula
Tedisamil is a new antiarrhythmic drug with predominant class III action. The aim of the present study was to investigate the blocking pattern of the compound on the transient outward current (Ito)...
Gong, Haibin, Adamson, Dawn L, Ranu, Hardeep K, Koch, Walter J, Heubach, Jürgen F, Ravens, Ursula, ...
The atria and ventricles of transgenic mice (TGβ2) with cardiac overexpression of the human β2-adrenoceptor (β2AR) were initially reported to show maximum contractility in the absence of β-AR...
Heubach, Jürgen F, Graf, Eva M, Molenaar, Peter, Jäger, Andreas, Schröder, Frank, Herzig, Stefan, ...
The functional coupling of β2-adrenoceptors (β2-ARs) to murine L-type Ca2+ current (ICa(L)) was investigated with two different approaches. The β2-AR signalling cascade was activated either with...
Heubach, Jürgen F, Rau, Thomas, Eschenhagen, Thomas, Ravens, Ursula, Kaumann, Alberto J
Murine left atrium lacks inotropic β2-adrenoceptor function. We investigated whether β2-adrenoceptors are involved in the cardiostimulant effects of (−)-adrenaline on spontaneously beating right...
Pharmacodynamics of propiverine and three of its main metabolites on detrusor contraction
Wuest, Melinda, Hecht, Juliane, Christ, Torsten, Braeter, Manfred, Schoeberl, Christian, Hakenberg, Oliver W, ...
Besides its antimuscarinic effects, propiverine may possess an additional mode of action. We compared the effects of propiverine, three of its metabolites (M-5, M-6, M-14) and atropine in human, pig...
1. The effects of ouabain, digoxin, digoxigenin monodigitoxoside, digoxigenin bisdigitoxoside and digitoxigenin bisdigitoxoside on the force of contraction and on the transmembrane action potential...