Uwe T. Bornscheuer

A one-pot, simple methodology for cassette randomisation and recombination for focused directed evolution (2008)

Hidalgo, Aurelio, Schließmann, Anna, Molina, Rafael, Hermoso, Juan, Bornscheuer, Uwe T.

Protein engineering is currently performed either by rational design, focusing in most cases on only a few positions modified by site-directed mutagenesis, or by directed molecular evolution, in...

Highly enantioselective kinetic resolution of two tertiary alcohols using mutants of an esterase from Bacillus subtilis (2007)

Heinze, Birgit, Kourist, Robert, Fransson, Linda, Hult, Karl, Bornscheuer, Uwe T.

Enzyme-catalyzed kinetic resolutions of secondary alcohols are a standard procedure today and several lipases and esterases have been described to show high activity and enantioselectivity. In...

Highly enantioselective kinetic resolution of two tertiary alcohols using mutants of an esterase from Bacillus subtilis (2007)

Heinze, Birgit, Kourist, Robert, Fransson, Linda, Hult, Karl, Bornscheuer, Uwe T.

Enzyme-catalyzed kinetic resolutions of secondary alcohols are a standard procedure today and several lipases and esterases have been described to show high activity and enantioselectivity. In...

Recombinant porcine intestinal carboxylesterase: cloning from the pig liver esterase gene by site-directed mutagenesis, functional expression and characterization (2003)

Musidlowska-Persson, Anna, Bornscheuer, Uwe T.

It was shown recently that proline‐β‐naphthylamidase from pig liver resembles the γ‐subunit of pig liver esterase (PLE), which could be functionally expressed in the yeast Pichia...

Heterologous Production of Functional Forms of Rhizopus oryzae Lipase in Escherichia coli

Di Lorenzo, Mirella, Hidalgo, Aurelio, Haas, Michael, Bornscheuer, Uwe T.

To date, expression of the lipase from Rhizopus oryzae (ROL) in Escherichia coli always led to the formation of inclusion bodies and inactive protein. However, the production of active ROL and its...

Heterologous Production of Functional Forms of Rhizopus oryzae Lipase in Escherichia coli

Di Lorenzo, Mirella, Hidalgo, Aurelio, Haas, Michael, Bornscheuer, Uwe T.

To date, expression of the lipase from Rhizopus oryzae (ROL) in Escherichia coli always led to the formation of inclusion bodies and inactive protein. However, the production of active ROL and its...

Enhancement of the Stability of a Prolipase from Rhizopus oryzae toward Aldehydes by Saturation Mutagenesis▿

Di Lorenzo, Mirella, Hidalgo, Aurelio, Molina, Rafael, Hermoso, Juan A., Pirozzi, Domenico, Bornscheuer, Uwe T.

A prolipase from Rhizopus oryzae (proROL) was engineered in order to increase its stability toward lipid oxidation products such as aldehydes with the aim of improving its performance in oleochemical...

Cloning, Expression, Characterization, and Biocatalytic Investigation of the 4-Hydroxyacetophenone Monooxygenase from Pseudomonas putida JD1▿ †

Rehdorf, Jessica, Zimmer, Christian L., Bornscheuer, Uwe T.

While the number of available recombinant Baeyer-Villiger monooxygenases (BVMOs) has grown significantly over the last few years, there is still the demand for other BVMOs to expand the biocatalytic...