© 1999 Khmer Academic Publishers. Printed in the Netherlands. (2008)
U. Rueffer, M. Sieber, A. Josting, K. Breuer, F. J. Grotenhermen, H. Bredenfeld, ...
Prognostic factors for subdiaphragmatic involvement in clinical stage I—II supradiaphragmatic Hodgkin's disease: A retrospective analysis of the GHSG
Sieniawski, M., Reineke, T., Josting, A., Nogova, L., Behringer, K., Halbsguth, T., ...
Background: Infertility is one of the most significant side-effects in long-term survivors of successfully treated Hodgkin's lymphoma (HL). Patients and methods: The fertility status was assessed in...
Klimm, B, Eich, HT, Haverkamp, H, Lohri, A, Koch, P, Boissevain, F, ...
Background: The optimal treatment of elderly patients with Hodgkin's lymphoma (HL) is still a matter of debate. Since many of these patients receive combined modality treatment, we evaluated the...
Franklin, J, Pluetschow, A, Paus, M, Specht, L, Anselmo, A-P, Aviles, A, ...
Background: Despite several investigations, second malignancy risks (SMR) following radiotherapy alone (RT), chemotherapy alone (CT) and combined chemoradiotherapy (CRT) for Hodgkin's lymphoma (HL)...
Franklin, J., Pluetschow, A., Paus, M., Specht, L., Aviles, A., ...
Background: Despite several investigations, second malignancy risks (SMR) following radiotherapy alone (RT), chemotherapy alone (CT) and combined chemoradiotherapy (CRT) for Hodgkin's lymphoma (HL)...
Klimm, B., Eich, H. T., Haverkamp, H., Lohri, A., Koch, P., Boissevain, F., ...
Background: The optimal treatment of elderly patients with Hodgkin's lymphoma (HL) is still a matter of debate. Since many of these patients receive combined modality treatment, we evaluated the...
Franklin, J., Pluetschow, A., Paus, M., Specht, L., Aviles, A., ...
Background: Despite several investigations, second malignancy risks (SMR) following radiotherapy alone (RT), chemotherapy alone (CT) and combined chemoradiotherapy (CRT) for Hodgkin's lymphoma (HL)...
Klimm, B., Eich, H. T., Haverkamp, H., Lohri, A., Koch, P., Boissevain, F., ...
Background: The optimal treatment of elderly patients with Hodgkin's lymphoma (HL) is still a matter of debate. Since many of these patients receive combined modality treatment, we evaluated the...
Cheson, BD, Pfistner, B, Juweid, ME, Specht, L, Rosen, ST, Gascoyne, R, ...
Knaebel, HP, Märten, A, Schmidt, J, Hoffmann, K, Seiler, C, Lindel, K, ...
Abstract After surgical intervention with curative intention in specialised centres the five-year survival of patients with carcinoma of the exocrine pancreas is only 15%. The ESPAC-1 trial showed an...
Josting, A., Sieniawski, M., Staak, O., Nogova, L., Peters, N., ...
Background: Combination chemotherapy can cure patients with non-Hodgkin's lymphoma (NHL), but those who suffer treatment failure or relapse still have a poor prognosis. High-dose chemotherapy (HDCT)...
Josting, A., Rudolph, C., Mapara, M., Sienawski, M., Sieber, M., ...
Background: We designed a dose- and time-intensified high-dose sequential chemotherapy regimen for patients with relapsed and refractory Hodgkin lymphoma (HD). Patients and methods: Eligibility...
Ballova, V., Haverkamp, H., Pfistner, B., Müller-Hermelink, H. K., Dühmke, E., ...
In contrast to younger patients, the prognosis of elderly patients with advanced Hodgkin's disease (HD) has not improved substantially over the last 20 years. We thus carried out a prospectively...
Nogová, L., Reineke, T., Eich, H. T., Josting, A., Müller-Hermelink, H. K., Wingbermühle, K., ...
Background: Since there are no randomized studies, the treatment of choice for patients with early stage lymphocyte-predominant Hodgkin's lymphoma (LPHL) remains unclear. We thus reviewed all LPHL...
Josting, A., Sieniawski, M., Staak, O., Nogova, L., Peters, N., ...
Background: Combination chemotherapy can cure patients with non-Hodgkin's lymphoma (NHL), but those who suffer treatment failure or relapse still have a poor prognosis. High-dose chemotherapy (HDCT)...
Nogová, L., Reineke, T., Eich, H. T., Josting, A., Müller-Hermelink, H. K., Wingbermühle, K., ...
Background: Since there are no randomized studies, the treatment of choice for patients with early stage lymphocyte-predominant Hodgkin's lymphoma (LPHL) remains unclear. We thus reviewed all LPHL...
Artificial sweeteners--do they bear a carcinogenic risk? (2004)
Artificial sweeteners are added to a wide variety of food, drinks, drugs and hygiene products. Since their introduction, the mass media have reported about potential cancer risks, which has...
Sieber, M., Tesch, H., Pfistner, B., Rueffer, U., Paulus, U., Munker, R., ...
Background: The purpose of this study was to compare the efficacy of the hybrid chemotherapeutic regimen COPP/ABV/IMEP...
Behringer, K., Josting, A., Schiller, P., Eich, H. T., Bredenfeld, H., Diehl, V., ...
Background: Long-term survivors of successfully treated Hodgkin's disease (HD) are at risk for late complications. Among these, secondary solid tumors are most serious because they are often fatal....
European Code Against Cancer and scientific justification: third version (2003) (2003)
Boyle, P., Autier, P., Bartelink, H., Baselga, J., Boffetta, P., Burn, J., ...
BEACOPP therapeutic regimen for patients with Hodgkin's disease and HIV infection (2003)
Hartmann, P., Rehwald, U., Salzberger, B., Franzen, C., Sieber, M., Wöhrmann, A., ...
Background: Hodgkin’s disease (HD) is the most common non-AIDS-defining tumor diagnosed in HIV-infected patients. Antineoplastic treatment is difficult considering the underlying immunodeficiency...
Schmitz, N., Pfistner, B., Sextro, M., Sieber, M., Carella, A.M., Haenel, M., ...
Background: High-dose chemotherapy followed by transplantation of autologous haemopoietic stem cells (BEAMHSCT) is frequently used to treat patients with relapsed Hodgkin's disease. We aimed to...
Pfister, K., Wittig, B.M., Jüngling, B., Ecker, K.W., Barth, S., Huhn, M., ...
Background and aims: In chronic inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis an aberrant mucosal immune regulation is observed accompanied by upregulation of...
Quantitative molecular monitoring of residual tumor cells in chronic lymphocytic leukemia (2002)
Pfitzner, T., Reiser, M., Barth, S., Borchmann, P., Schulz, H., Schinköthe, T., ...
New therapeutic approaches for the treatment of B-cell chronic lymphocytic leukemia (B-CLL) can induce remarkable responses. Molecular remissions have been observed occasionally after high-dose...
Genetic instability in Hodgkin's lymphoma (2002)
Re, D., Zander, T., Diehl, V., Wolf, J.
Genetic instability is a characteristic feature of the malignant Hodgkin and Reed–Sternberg (HRS) cells in classical Hodgkin's lymphoma and the lymphocytic and histiocytic (L & H) cells in...
Carde, P., Koscielny, S., Franklin, J., Axdorph, U., Raemaekers, J., Diehl, V., ...
Background: Early adjustment of treatment may benefit the patient. In order to guide treatment adjustment, use of early response (ER) or early complete response (ECR), judged after the few...
Current clinical trials for the treatment of advanced-stage Hodgkin's disease: BEACOPP (2002)
Background: The bleomycin–etoposide–doxorubicin–cyclophosphamide–vincristine–procarbazine–prednisone (BEACOPP) regimen was developed to investigate the potential of moderate dose...
Josting, A., Rudolph, C., Reiser, M., Mapara, M., Sieber, M., Kirchner, H. H., ...
Background: An important variable affecting outcome in relapsed and refractory Hodgkin’s disease (HD) is the potential of conventional salvage chemotherapy to reduce tumor volume before high-dose...
Male gonadal dysfunction in patients with Hodgkin's disease prior to treatment (2001)
Rueffer, U., Breuer, K., Josting, A., Lathan, B., Sieber, M., Manzke, O., ...
Infertility after treatment of patients with Hodgkin's disease (HD) is considered as a side effect of alkylating agent containing chemotherapy regimens To investigate whether gonadal failure is...
Borchmann, P., Schnell, R., Knippertz, R., Staak, J. O., Camboni, G. M., Bernareggi, A., ...
Background: BBR 2778 is a novel aza-anthracenedione showing no cardiotoxicity and superior activity compared to doxorubicin and mitoxantrone in animal models. Objectives of this phase I study...
Pfreundschuh, M., Hasenclever, D., Loeffler, M., Ehninger, G., Schmitz, N., Kirchner, H., ...
Background The magnitude of chemotherapy dose escalation made possible by the use of recombinant haematopoietic growth factors has not been quantified in a randomized trial Patients and methods...
Barth, S., Huhn, M., Matthey, B., Tawadros, S., Schnell, R., Diehl, V., ...
Guillain-Barre syndrome in a patient with non-Hodgkin's lymphoma (2000)
Re, D., Schwenk, A., Hegener, P., Bamborschke, S., Diehl, V., Tesch, H.
We describe a case of Guillain-Barré syndrome (GBS) in a patient with non-Hodgkin's lymphoma (NHL). A 21-year-old woman with a newly diagnosed stage IV high-grade lymphoma (precursor T-cell NHL...
Sieber, M., Engert, A., Diehl, V.
Background: Treatment strategies in Hodgkin's disease (HD) are changing fundamentally over the last decades. Both radiotherapy and combination chemotherapy are effective treatment modalities....
Franklin, J., Paulus, U., Lieberz, D., Breuer, K., Tesch, H., Diehl, V., ...
Background: The seven-factor International Prognostic Score (IPS) has been developed and verified for patients with advanced stage Hodgkin's disease (HD). This report aims to assess the predictive...
Engel, C., Loeffler, M., Schmitz, S., Tesch, H., Diehl, V.
Background: Evidence is recently accumulating that the novel BEACOPP (bleomycin (B), etoposide (E), adriamycin (A), cyclophosphamide (C), vincristine (O), procarbazine (P), prednisone (P))...
Rueffer, U., Sieber, M., Josting, A., Breuer, K., Grotenhermen, F. J., Bredenfeld, H., ...
Background: Staging laparotomy and splenectomy were routinely performed in patients with early-stage Hodgkin's disease (HD) qualifying for radiotherapy alone to determine the exact extent of disease....
Sieber, M., Rüffer, U., Jostin, A., Diehl, V.
At present over 90% of early stage Hodgkin's disease patients will be cured. Both radiotherapy and combination chemotherapy are effective treatment modalities. However, the optimal choice of...
New drugs in the treatment of Hodgkin's disease (1998)
Borchmann, P., Schnell, R., Diehl, V., Engert, A.
In the treatment of Hodgkin's disease (HD) remission rates of 80% have been achieved with combination regimens such as COPP/ABVD; 30%–50% of these patients relapse, however, and less than 25% of...
Flechtner, H., Henry-Amar, M., Mellink, W. A. M., Sieber, M., Fermé, C., ...
Previous reports from available trials have dealt with negative long-term sequelae in Hodgkin's disease (HD) survivors. There is, however, a lack of longitudinal data showing the correlation between...
Lymphocyte predominant Hodgkin's disease: Pathology and clinical implication (1998)
Franklin, J., Tesch, H., Diehl, V.
The special nature and course of lymphocyte rich variants of Hodgkin's disease (HD) has been the subject of pathological and clinical studies since the 1930s. Patients with lymphocyte predominant...
BEACOPP: A new regimen for advanced Hodgkin's disease (1998)
Diehl, V., Franklin, J., Hasenclever, D., Tesch, H., Pfreundschuh, M., Lathan, B., ...
The BEACOPP chemotherapy regimen for advanced Hodgkin's disease employs a rearranged schedule permitting a shortened three-week cycle. With haematological growth factor support, the dosages of...
Model based development of the BEACOPP regimen for advanced stage Hodgkin's disease (1998)
Loeffler, M., Hasenclever, D., Diehl, V.
In this article we summarize the theoretical arguments which led us in the German Hodgkin's Disease Study Group to introduce the BEACOPP-regimen and to initiate a large randomised trial to...
Wolf, J., Tesch, H., Parsa-Parsi, R., Engert, A., Diehl, V.
Strategies in the treatment of adult Hodgkin's disease (HD) are changing strikingly in current clinical trials. In early as well as in intermediate stage HD a common aim of most study groups now is...
Staib, P., Lathan, B., Knöppel-Schwark, S., Tesch, H., Voliotis, D., Steinmetz, H. T., ...
Background: Elderly patients (age ≥ 60 years) with acute myeloid leukemia (AML) have unfavourable prognoses when polychemotherapy regimens are used, because therapy response is characterized by low...
Jox, A., Zander, T., Kornacker, M., Kanzler, H., Küppers, R., Diehl, V., ...
Background: The malignant nature of Hodgkin-Reed Sternberg (H-RS) cells has been questioned due to their scarcity in lymphoma tissues. Recently, using micromanipulation of H-RS cells and single cell...
Josting, A., Kátay, I., Rueffer, U., Winter, S., Tesch, H., Engert, A., ...
Background: Disease status before high-dose chemotherapy with autologous bone marrow transplantation (ABMT) or peripheral blood stem cell transplantation (PBSCT) is an important predictor of...
BEACOPP: An intensified chemotherapy regimen in advanced Hodgkin's disease (1997)
Diehl, V., Sieber, M., Rüffer, U., Lathan, B., Hasenclever, D., Pfreundschuh, M., ...
Purpose: At present, treatment results for patients with advanced-stage Hodgkin's disease remain unsatisfactory. Standard chemotherapy M(C)OPP (nitrogen mustard (cyclophosphamide), vincristine,...
Jox, A., Rohen, C., Belge, G., Bartnitzke, S., Pawlita, M., Diehl, V., ...
Background Several lymphomas are associated with Epstein-Barr virus (EBV) infection. However EBV is not detectable in 100% of cases using standard staining techniques. It still remains an open...
The emerging role of immunotoxins in leukemia and lymphoma (1997)
Winkler, U., Barth, S., Schnell, R., Diehl, V., Engert, A.
Despite important advances in conventional cancer therapy, there is still a strong need for new approaches in order to reduce cancer death rates, which have not been drastically influenced in the...
Lymphocyte predominant Hodgkin's disease -- a workshop report (1996)
Sextro, M., Diehl, V., Franklin, J., Anagnostopoulos, I., Marafioti, T., ...
Since lymphocyte predominant Hodgkin's disease (LPHD) may comprise more than one entity, diagnostic criteria, clinical features, and treatment strategies are still being controversially discussed....
Hasenclever, D., Loeffler, M., Diehl, V.
Which strategy is more promising to improve the outcome of primary conventional chemotherapy in advanced Hodgkin's disease (HD): a moderate dose escalation or treatment intensification by shortening...
Serum cytokine levels correlate with clinical parameters in Hodgkin's disease (1995)
Gorschlüter, M., Bohlen, H., Hasenclever, D., Diehl, V., Tesch, H.
Background: It has been suggested that cytokines are involved in the pathogenesis of Hodgkin's disease. Enhanced expression of various cytokines has been demonstrated in cell lines and biopsy...
Diehl, V., Loeffler, M., Pfreundschuh, M., Ruehl, U., Hasenclever, D., Nisters-Backes, H., ...
Objective It was the aim of this prospective randomized multicenter study to compare chemotherapy and radiotherapy as consolidation treatments in patients achieving complete remission (CR) after 6...
BARTELS, C., HÖNIG, R., BURGER, G., DIEHL, V., VIVIE, R. DE
Postpericardiotomy syndrome (PPS) is a frequent complication after cardiac surgery. In a recent study, elevated anticardiolipin antibody (ACLA) titres were observed in patients with PPS. Tlie value...
Is Hodgkin's disease an infectious disease? (1994)
Several lines of evidence question the concept of Hodgkin's disease (HD) starting as a true malignant disorder of the lymphatic system: (i) In early stages HD exerts pronounced clinical and...
Kapp, U., Düx, A., Schell-Frederick, E., Banik, N., Hummel, M., Mücke, S., ...
Local tumor growth has been reported after subcutaneous and intraperitoneal injection of Hodgkin's disease (HD) derived cell lines into different immunodeficient mouse strains. An animal model with...
Trümper, L., Jung, W., Dahl, G., Diehl, V., Gause, A., Pfreundschuh, M.
In a search for specific serum markers with prognostic impact, we evaluated the clinical significance of IL-4, IL-7, and IL-8 as well as TNF receptor levels and soluble p53 in the serum of patients...
Immunotoxins:Is there a clinical value? (1994)
Gottstein, C., Winkler, U., Bohlen, H., Diehl, V., Engert, A.
Drug targeting is an attractive new approach to killing malignant cells, thereby leaving normal tissue unharmed. A decisive breakthrough was the advent of hybridoma technology, making monoclonal...
Shipman, R, Brüggen, J, Tarcsay, L, ...
In this study, the expression of the novel intermediate filament protein Restin in human tissues was analyzed. Restin expression was studied by immunohistochemistry using polyclonal and monoclonal...
Mautner, J, Koch, K, Eick, D, Diehl, V, ...
The human c-fps/fes proto-oncogene is expressed as a transcript of about 3.0 kb in both normal and leukemic myeloid cells. We have detected truncated c-fps/fes transcripts of about 0.9 kb in a panel...
Strohscheer, I., Kleinert, R., Westphal, C., Schüller, J., Werner, K., Anders, O., ...
Peer Reviewed
Preliminary report: Growth of Hodgkin's lymphoma derived cells in immune compromised mice (1992)
Kapp, U., Wolf, J., Von Kalle, C., Tawadros, S., Röttgen, A., Engert, A., ...
Until now there has been no satisfactory animal host for the in vivo growth of Hodgkin lymphoma cells. With the exception of one mutant subline (L540Cy) none of the other Hodgkin derived cell lines...
Gause, A., Jung, W., Schmits, R., Tschiersch, A., Scholz, R., Pohl, C., ...
In a search for serum markers with prognostic value and specificity for disease activity in Hodgkin's lymphoma, we evaluated the clinical significance of soluble suppressor/cytotoxic T-cell antigen...
Costa, L. Da, Carde, P., Lumbroso, J. D., Ricard, M., Pfreundschuh, M., Bosq, J., ...
Immunoscintigraphy (IS) using the HRS-3 Hodgkin associated monoclonal antibody (MoAb) was performed in 18 patients with Hodgkin's Disease (HD) at staging or re.staging. Either F(ab')2 fragments (14...
Role of additional radiotherapy in advance stages of Hodgkin's disease (1992)
Meerwaldt, J. H., Coleman, C. N., Fischer, R. I., Lister, T. A., Diehl, V.
Although radiotherapy is widely used as additional treatment following chemotherapy, its precise role has never been clearly proven. Relapses tend to occur in previously involved bulky sites....
Workshop III: Recommendations for future clinical trials (1992)
Pfreundschuh, M., Lathan, B., Löffler, M., Röffer, U., Hasenclever, D., Diehl, V.
In the opinion of the participants of the workshop, the following problems should be addressed with high priority: 1st, a clear definition of the 10%–15% of patients who should receive radiotherapy...
Felsenberg, D., Behles, C., Seibt-Jung, H., Mielcarek, M., Diehl, V., ...
Only limited data is currently available on long-term gonadal toxicity and its impact on bone mineralization in men and women treated for Hodgkin's disease. The present study was therefore conducted...
Activation of cytokines in Hodgkin's disease (1992)
Tesch, H., Feller, A. C., Jücker, M., Klein, S., Merz, H., Diehl, V.
The complex histological pattern in Hodgkin's disease and in part in large cell anaplastic lymphomas (ALCL) suggests that close interactions exist between the tumor cells and reactive bystander...
Experimental therapy in Hodgkin's disease (1992)
Engert, A., Pohl, C., Diehl, V.
Hodgkin/Reed-Sternberg (H-RS) cells express lymphoid activation markers like CD25 and CD30 which are present only on a small minority of normal cells. Currently, most experimental approaches in...
Serum erythropoietin levels in patients with Hodgkin's lymphoma at the time of diagnosis (1992)
Pohl, C., Schobert, I., Moter, A., Woll, E. M., Schwonzen, M., Hiersche, A., ...
Gause, A., Verpoort, K., Roschansky, V., Tschiersch, A., Hasenclever, D., Schmits, R., ...
Increased suppressor T-cell activity has been observed in patients with Hodgkin's disease. In order to evaluate the clinical significance of soluble CD8 antigen (sCD8), which is released from...
Kube, D., Vockerodt, M., Weber, O., Hell, K., Wolf, J., Haier, B., ...
Epstein-Barr virus is associated with several human malignancies including Burkitt’s lymphoma, nasopharyngeal carcinoma, and Hodgkin’s disease (HD). To examine the effect of Epstein-Barr virus...
Franzen, C, Müller, A, Hegener, P, Salzberger, B, Hartmann, P, Fätkenheuer, G, ...
Intestinal microsporidiosis has been implicated as a major cause of chronic diarrhea in human immunodeficiency virus (HIV)-infected patients. So far diagnosis depends on direct visualization of the...
Invasive amoebiasis in two patients with AIDS and cytomegalovirus colitis.
Fätkenheuer, G, Arnold, G, Steffen, H M, Franzen, C, Schrappe, M, Diehl, V, ...
Homosexual persons or human immunodeficiency virus (HIV)-infected patients frequently excrete cysts of nonpathogenic strains of Entamoeba histolytica ("Entamoeba dispar"). However, invasive...
Franzen, C, Altfeld, M, Hegener, P, Hartmann, P, Arendt, G, Jablonowski, H, ...
Cerebral toxoplasmosis is a common, opportunistic, and often life-threatening disease in HIV-infected patients. Diagnosis is supported mainly by clinical evidence and computerized tomography or...
Gissmann, L, Diehl, V, Schultz-Coulon, H J, Zur Hausen, H
Papilloma virus DNA from a laryngeal papilloma was cloned in phage lambda L 47 and characterized after cleavage with different restriction enzymes. Hybridization with the DNAs of human papilloma...
Lectin activity as a marker for Hodgkin disease cells.
Paietta, E, Stockert, R J, Morell, A G, Diehl, V, Wiernik, P H
Treatment of cultured Hodgkin disease (HD) cells with neuraminidase results in decreased reactivity of monoclonal antibody VIM-D5 with its antigen, the X hapten, a fucosyl-N-acetyllactosamine. The...
Unique antigen of cultured Hodgkin's cells. A putative sialyltransferase.
Paietta, E, Stockert, R J, Morell, A G, Diehl, V, Wiernik, P H
Hodgkin's disease-derived giant cell lines (HD-cells) express high levels of ectosialyltransferase activity presumed to be a galactose-specific lectin recognizing the desialylated...
Newcom, S R, Kadin, M E, Ansari, A A, Diehl, V
Nodular sclerosing Hodgkin's disease is characterized by dense collagen fibrosis. Although transforming growth factor-beta (TGF-beta) is an important bifunctional growth factor for fibroblasts and is...
Tissue diagnosis of intestinal microsporidiosis using a fluorescent stain with Uvitex 2B.
Franzen, C, Müller, A, Salzberger, B, Fätkenheuer, G, Eidt, S, Mahrle, G, ...
AIMS--To detect intestinal microsporidiosis in paraffin wax embedded biopsy specimens using a fluorescence technique incorporating optical brighteners. METHODS--Eight HIV infected patients with...
Knaebel, HP, Märten, A, Schmidt, J, Hoffmann, K, Seiler, C, Lindel, K, ...
After surgical intervention with curative intention in specialised centres the five-year survival of patients with carcinoma of the exocrine pancreas is only 15%. The ESPAC-1 trial showed an...
Kube, D., Vockerodt, M., Weber, O., Hell, K., Wolf, J., Haier, B., ...
Epstein-Barr virus is associated with several human malignancies including Burkitt’s lymphoma, nasopharyngeal carcinoma, and Hodgkin’s disease (HD). To examine the effect of Epstein-Barr virus...
Franzen, C, Müller, A, Hegener, P, Salzberger, B, Hartmann, P, Fätkenheuer, G, ...
Intestinal microsporidiosis has been implicated as a major cause of chronic diarrhea in human immunodeficiency virus (HIV)-infected patients. So far diagnosis depends on direct visualization of the...
Invasive amoebiasis in two patients with AIDS and cytomegalovirus colitis.
Fätkenheuer, G, Arnold, G, Steffen, H M, Franzen, C, Schrappe, M, Diehl, V, ...
Homosexual persons or human immunodeficiency virus (HIV)-infected patients frequently excrete cysts of nonpathogenic strains of Entamoeba histolytica ("Entamoeba dispar"). However, invasive...
Franzen, C, Altfeld, M, Hegener, P, Hartmann, P, Arendt, G, Jablonowski, H, ...
Cerebral toxoplasmosis is a common, opportunistic, and often life-threatening disease in HIV-infected patients. Diagnosis is supported mainly by clinical evidence and computerized tomography or...
Gissmann, L, Diehl, V, Schultz-Coulon, H J, Zur Hausen, H
Papilloma virus DNA from a laryngeal papilloma was cloned in phage lambda L 47 and characterized after cleavage with different restriction enzymes. Hybridization with the DNAs of human papilloma...
Lectin activity as a marker for Hodgkin disease cells.
Paietta, E, Stockert, R J, Morell, A G, Diehl, V, Wiernik, P H
Treatment of cultured Hodgkin disease (HD) cells with neuraminidase results in decreased reactivity of monoclonal antibody VIM-D5 with its antigen, the X hapten, a fucosyl-N-acetyllactosamine. The...
Unique antigen of cultured Hodgkin's cells. A putative sialyltransferase.
Paietta, E, Stockert, R J, Morell, A G, Diehl, V, Wiernik, P H
Hodgkin's disease-derived giant cell lines (HD-cells) express high levels of ectosialyltransferase activity presumed to be a galactose-specific lectin recognizing the desialylated...
Newcom, S R, Kadin, M E, Ansari, A A, Diehl, V
Nodular sclerosing Hodgkin's disease is characterized by dense collagen fibrosis. Although transforming growth factor-beta (TGF-beta) is an important bifunctional growth factor for fibroblasts and is...
Tissue diagnosis of intestinal microsporidiosis using a fluorescent stain with Uvitex 2B.
Franzen, C, Müller, A, Salzberger, B, Fätkenheuer, G, Eidt, S, Mahrle, G, ...
AIMS--To detect intestinal microsporidiosis in paraffin wax embedded biopsy specimens using a fluorescence technique incorporating optical brighteners. METHODS--Eight HIV infected patients with...
Knaebel, HP, Märten, A, Schmidt, J, Hoffmann, K, Seiler, C, Lindel, K, ...
After surgical intervention with curative intention in specialised centres the five-year survival of patients with carcinoma of the exocrine pancreas is only 15%. The ESPAC-1 trial showed an...
Von Wasielewski, R., Werner, M., Fischer, R., Hansmann, M. L., Hübner, K., Hasenclever, D., ...
There is wide consensus that lymphocyte predominance Hodgkin's disease (LPHD) represents a distinct clinicopathological entity of B-cell origin. However, inconsistent results of immunophenotyping...
Classical Hodgkin's disease. Clinical impact of the immunophenotype.
Von Wasielewski, R., Mengel, M., Fischer, R., Hansmann, M. L., Hübner, K., Franklin, J., ...
Antibodies against CD15, -30, and -20 are often used to support morphological diagnosis of Hodgkin's Disease (HD). The classical HD, i.e., the non-lymphocyte-predominance types, are CD15+, CD30+, and...
Expression of interleukin-2R alpha and interleukin-2R beta in Hodgkin's disease.
Tesch, H., Günther, A., Abts, H., Jücker, M., Klein, S., Krueger, G. R., ...
Hodgkin and Reed-Sternberg cells, the putative malignant cells of Hodgkin's disease (HD), carry regularly the CD25 antigen that forms one chain of the interleukin-2 (IL-2) receptor (IL-2R alpha). To...
Peter, H H, Kalden, J R, Seeland, P, Diehl, V, Eckert, G
Based on 51Cr release from an allogeneic human melanoma cell (M1) cell-mediated (CMC) and antibody-dependent cellular cytotoxicity (ADCC) were determined in twenty-eight melanoma patients, thirty-one...
HOMBACH, A, TILLMANN, T, JENSEN, M, HEUSER, C, SIRCAR, R, DIEHL, V, ...
Specific activation of resting lymphocytes for tumour targeting can be achieved by bispecific monoclonal antibodies (bi-MoAbs) with specificity for tumour antigens and T cell-activating antigens in...
Klein, G., Pearson, G., Henle, G., Henle, W., Diehl, V., Niederman, J. C.
Blastoid cell cultures derived from leukocytes of patients in the acute stage of infectious mononucleosis (IM) and harboring Epstein-Barr (EB) virus in at least 1% of the cells were found to possess...
Disseminated Neocosmospora vasinfecta infection in a patient with acute nonlymphocytic leukemia.
Cornely, O. A., Chemnitz, J., Brochhagen, H. G., Lemmer, K., Schütt, H., Söhngen, D., ...
We report Neocosmospora vasinfecta infection following chemotherapy for acute nonlymphocytic leukemia. N. vasinfecta, a plant pathogen, was identified by culture and genetic sequencing....
Schwonzen, M., Schmits, R., Baldus, S. E., Vierbuchen, M., Hanisch, F. G., Pfreundschuh, M., ...
Mucus glycoproteins of human amniotic fluid were used to generate a monoclonal antibody (MAb) FW6, which stained the intestine of a 24 week stage fetus. In adults, 76% of colonic adenocarcinomas...
Klimka, A, Barth, S, Matthey, B, Roovers, R C, Lemke, H, Hansen, H, ...
Loss of heterozygosity in the Hodgkin-Reed Sternberg cell line L1236
Staratschek-Jox, A, Thomas, R Kurt, Zander, T, Massoudi, N, Kornacker, M, Bullerdiek, J, ...
Hodgkin-Reed Sternberg cells are derived from germinal centre B-cells in most cases. Somatic mutations affecting their rearranged immunoglobulin genes were detected, rendering potential functional...
Preclinical evaluation of the antiproliferative potential of STI571 in Hodgkin's disease
Re, D, Wickenhauser, C, Ahmadi, T, Buchdunger, E, Kochanek, M, Diehl, V, ...
STI571 is a selective tyrosine kinase inhibitor with proven therapeutic potential in malignancies expressing c-kit. A strong c-kit and stem cell factor expression was detected in the Hodgkin and Reed...