V. M. Heine

Stress, depression and hippocampal apoptosis (2006)

Lucassen, P.J., Heine, V.M., Muller, M.B., Wiegant, V.M., De Kloet, E.R., ...

In this review, we summarize and discuss recent studies on structural plasticity changes, particularly apoptosis, in the mammalian hippocampus in relation to stress and depression. Apoptosis...

Stress, Depression and Hippocampal Apoptosis. (2006)

Lucassen, P.J., Heine, V.M., Beek, E. Van Der, Wiegant, V., Kloet, E.R. De, Joels, M., ...

In this review, we summarize and discuss recent studies on structural plasticity changes, particularly apoptosis, in the mammalian hippocampus in relation to stress and depression. Apoptosis...

Chronic stress in the adult dentate gyrus reduces cell proliferation near the vasculature and VEGF and Flk-1 protein expression (2005)

Heine, V.M., Zareno, J., Maslam, S., Joels, M., Lucassen, P.J.

Recent evidence has shown that cell proliferation in the adult hippocampal dentate gyrus occurs in tight clusters located near the vasculature. Also, changes in neurogenesis often appear parallel to...

Adult hippocampal cell birth and death in relation to stress, aging and the vasculature (2004)

Heine, V.M.

Effects of chronic stress on structure and cell function in rat hippocampus and hypothalamus (2004)

Joels, M., Karst, H., Alfarez, D.N., Heine, V.M., Qin, Y.J., Riel, E. Van, ...

It has become increasingly clear that the increase in corticosteroid levels, e.g. after a brief stressor induce molecular and cellular changes in brain, including the hippocampal formation. These...

Prominent decline of newborn cell proliferation, differentiation, and apoptosis in the aging dentate gyrus, in absence of an age-related hypothalamus-pituitary-adrenal axis activation (2004)

Heine, V.M., Maslam, S., Joels, M., Lucassen, P.J.

Increased P27KIP1 protein expression in the dentate gyrus of chronically stressed rats indicates G(1) arrest involvement (2004)

Heine, V.M., Maslam, S., Joels, M., Lucassen, P.J.

Various chronic stress paradigms decrease new cell proliferation in the hippocampal dentate gyrus, yet the exact underlying mechanism is still unclear. In the first gap (G1) phase of the cell cycle,...

Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversible (2004)

Heine, V.M., Maslam, S, Zareno, J, Joëls, M, Lucassen, P.J.

Acute stress suppresses new cell birth in the hippocampus in several species. Relatively little is known, however, on how chronic stress affects the turnover, i.e. proliferation and apoptosis, of the...

Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversible (2004)

Heine, V.M., Maslam, S., Zareno, J., Joels, M., Lucassen, P.J.

Acute stress suppresses new cell birth in the hippocampus in several species. Relatively little is known, however, on how chronic stress affects the turnover, i.e. proliferation and apoptosis, of the...

Gene expression patterns in rat dentate granule cells: comparison between fresh and fixed tissue. (2003)

Qin, Y.J., Heine, V.M., Karst, H., Lucassen, P.J., Joels, M.

Neural Degeneration (2002)

Lucassen, P.J., Heine, V.M., Boekhoorn, K., Krugers, H.