V. M. Wiegant

Spatial learning in pigs: effects of environmental enrichment and individual characteristics on behaviour and performance (2009)

Jansen, J., Bolhuis, J.E., Schouten, W.G.P., Spruijt, B.M., Wiegant, V.M.

This study investigated the effects of both environmental enrichment and individual behavioural characteristics on spatial cognitive capabilities of pigs, using a novel latent spatial learning...

Cortisol administration to pregnant sows affects behaviour of their piglets (2007)

Kranendonk, G., Mulder, E.J., Hopster, H., Wolthuis, M., Ekkel, E.D., Wiegant, V.M., ...

Effects of rearing and housing environment on behaviour and performance of pigs with different coping characteristics (2006)

Bolhuis, J.E., Schouten, W.G.P., Schrama, J.W., Wiegant, V.M.

The availability of a rooting substrate may profoundly affect behaviour and welfare of pigs. Apart from their actual housing environment, also the conditions present in early life and individual...

Stress, depression and hippocampal apoptosis (2006)

Lucassen, P.J., Heine, V.M., Muller, M.B., Wiegant, V.M., De Kloet, E.R., ...

In this review, we summarize and discuss recent studies on structural plasticity changes, particularly apoptosis, in the mammalian hippocampus in relation to stress and depression. Apoptosis...

Lower birth weight and attenuated adrenocortical response to ACTH in offspring from sows that orally received cortisol during gestation (2006)

Kranendonk, G., Hopster, H., Fillerup, M., Ekkel, E.D., Mulder, E.J.H., Wiegant, V.M., ...

Prenatal stress is known to affect several offspring characteristics, but its effects depend among other factors on the period of gestation in which it is applied. In the present study, oral...

Individual coping characteristics, aggressiveness and fighting strategies in pigs (2005)

Bolhuis, J.E., Schouten, W.G.P., Schrama, J.W., Wiegant, V.M.

Individual pigs, Sus scrofa, differ considerably in how aggressive they are during encounters with unfamiliar conspecifics. We examined whether individual coping characteristics of pigs were...

Behavioural development of pigs with different coping characteristics in barren and substrate-enriched housing conditions (2005)

Bolhuis, J.E., Schouten, W.G.P., Schrama, J.W., Wiegant, V.M.

Characterization of piglets based on the degree of resistance they display in a so-called Backtest is, to a certain extent, predictive of their coping responses to several challenges in later life....

Differential regulation of agouti-related protein and neuropeptide Y in hypothalamic neurons following a stressful event. (2005)

Kas, M.J.H., Bruijnzeel, A.W., Haanstra, JR, Wiegant, V.M., Adan, R.A.H.

Individual coping characteristics, rearing conditions and behavioural flexibility in pigs (2004)

Bolhuis, J.E., Schouten, W.G.P., Schrama, J.W., Wiegant, V.M.

Several studies suggest that classification of piglets early in life based on the degree of resistance they display in a so-called Backtest may be indicative of their coping style at a later age. In...

Effect of response to backtest and housing condition on cell-mediated and humoral immunity in adult pigs (2004)

Geverink, N.A., Parmentier, H.K., Schouten, W.G.P., Gort, G., Wiegant, V.M.

Backtest type and housing condition of pigs influence energy metabolism (2004)

Geverink, N.A., Heetkamp, M.J.W., Schouten, W.G.P., Wiegant, V.M., Schrama, J.W.

The behavioral response of piglets in a backtest early in life seems indicative of their coping strategy at a later age. Coping characteristics may depend on the interaction between backtest...

Neuronal Number, Volume, and Apoptosis of the Left Dentate Gyrus of Chronically Stressed Pigs Correlate Negatively With Basal Saliva Cortisol Levels (2004)

Wiegant, V.M., Schouten, W.G.P., Loijens, L.W.S., Plas, C., ...

Although the consequences of stress and hypercortisolemia for the rodent hippocampal dentate gyrus (DG) are well known, little is known about other species. For pigs, tethered housing represents a...

Neuronal number, volume, and apoptosis of the left dentate gyrus of chronically stressed pigs correlate negatively with basal saliva cortisol levels (2004)

Wiegant, V.M., Schouten, W.G., Loijens, L.W.S., Plas, C. Van Der, ...

Individual differences in behaviour, physiology and pathology in breeding gilts housed in groups or stalls. (2003)

Geverink, N.A., Schouten, W.G.P., Gort, G., Wiegant, V.M.

A number of studies in young pigs have demonstrated a relation between a variety of behavioural and physiological features and the degree of resistance displayed early in life in a so-called...

Relationship between aggressive behaviour at weaning and social rank of pigs with different coping characteristics (2003)

Bolhuis, J.E., Schouten, W.G.P., Schrama, J.W., Wiegant, V.M.

Effects of housing and individual coping characteristics in immune responses of pigs (2003)

Bolhuis, J.E., Parmentier, H.K., Schouten, W.G.P., Schrama, J.W., Wiegant, V.M.

The impact of environmental factors on immune responses may be influenced by coping characteristics of the individuals under study. The behavioral response of pigs in a so-called Backtest early in...

Anxious-retarded depression: Relation with plasma vasopressin and cortisol (2003)

Hemert, A.M. Van, Rijk, R.H. De, Zwinderman, A.H., Frankhuijzen-Sierevogel, J.C., Wiegant, V.M., ...

Long-lasting effects of neonatal dexamethasone treatment on spatial learning and hippocampal synaptic plasticity: involvement of the NMDA receptorcomplex (2003)

Gispen, W.H., Kamphuis, P.J., Gardoni, F., Kamal, A., Croiset, G., Bakker, J.M., ...

The aim of this study was to investigate long-term effects of neonatal treatment with the synthetic glucocorticoid (GC) hormone dexamethasone (DEX) on hippocampus functions in the rat. The questions...

Individual differences in behaviour, physiology and pathology in breedings gilts housed in groups or stalls (2003)

Geverink, N.A., Schouten, W.G.P., Gort, G., Wiegant, V.M.

A number of studies in young pigs have demonstrated a relation between a variety of behavioural and physiological features and the degree of resistance displayed early in life in a so-called...

Opioid activity in behavorial and heart rate responses of tethered pigs to acute stress (2002)

Loijens, L.W.S., Schouten, W.G.P., Wiegant, V.M.

In a longitudinal experiment, effects of long-term tether housing on heart rate and behavioral responses to an acute stressor (a 15-min challenge with a nosesling) were investigated in pigs. The...

Brain opioid receptor density reflects behavioral and heart rate responses in pigs (2002)

Loijens, L.W.S., Schouten, W.G.P., Wiepkema, P.R., Wiegant, V.M.

Results from our previous research indicate that long-term tether-housed pigs with high and low levels of stereotypies show differences in the density of endogenous opioid receptors in the...

Individual differences in behavioral and physiological responses to restraint stress in pigs (2002)

Geverink, N.A., Schouten, W.G.P., Gort, G., Wiegant, V.M.

Several recent studies on pigs have demonstrated a relationship between the degree of resistance displayed early in life in a so-called backtest and a variety of behavioural and physiological...

Opioid activity in behavioral and heart rate responses of tethered pigs to acute stress. (2002)

Loijens, L.W.S., Schouten, W.G.P., Wiegant, V.M.

In a longitudinal experiment, effects of long-term tether housing on heart rate and behavioral responses to an acute stressor (a 15-min challenge with a nosesling) were investigated in pigs. The...

Individual differences in aggression and physiology in peri-pubertal breeding gilts (2002)

Geverink, N.A., Schouten, W.G.P., Gort, G., Wiegant, V.M.

Several recent studies on pigs have demonstrated a relationship between the degree of resistance displayed in a so-called ''backtest'' and a variety of behavioural and physiological responses in...

Effect of housing conditions on vasopressin (VP) expression in the paraventricular nucleus (PNV) in pigs (2001)

Karman, A.G., Jousma, E., Wiegant, V.M.

The Stimulatory effect of vasopressin on the luteinizing hormone surge in ovariectomized, estradiol-treated rats is time-dependent (2001)

Palm, I.F., Wiegant, V.M., Buijs, R.M., Kalsbeek, A.

Control of the estradiol-induced prolactin surge by the suprachiasmatic nucleus (2001)

Palm, I.F., Swarts, H.J., Vliet, J.V., Wiegant, V.M., Buijs, R.M., ...

Regulation of cholecystokinin release from central nerve terminals (2001)

Leenders, A.G.M., Wiegant, V.M.

Weak 24-h periodicity of body temperature and increased plasma vasopressin in melancholic depression. (2001)

Londen, L. Van, Goekoop , J.G., Kerkhof, G.A., Zwindeman, K.H., Wiegant, V.M., Wied, D. De

Earlier work has shown that plasma vasopressin levels of depressed patients were higher than those of healthy controls. The aim of the present study was to determine whether plasma vasopressin levels...

Rearing conditions, coping characteristics and responses of pigs in a T-maze test (2000)

Bolhuis, J.E., Schouten, W.G.P., Wiegant, V.M.

Housing condition affects the correlation between volume of the dentate gyrus and the cortisol response to stress in pigs (2000)

Bolhuis, J.E., Karman, A.G., Wiegant, V.M.

Gonadal steroids and steroid receptors : The role of hypothalamus in reproductive aging (2000)

Franke, A.N., Swarts, J.J.M., Kastelijn, J., Wiegant, V.M.

Gonadal steroids and steroid receptors : The role of the hypothalamus in reproductive aging (2000)

Franke, A.N., Swarts, J.J.M., Kastelijn, J., Wiegant, V.M.

Effects of individual housing on immune response in gilts (2000)

Geverink, N.A., Schouten, W.G.P., Wiegant, V.M.

Detailed analysis of oxytocin, vasopressin and CRH containing neurons in pig hypothalamus (2000)

Karman, A.G., Swarts, H.J.M., Kastelijn, J., Wiegant, V.M.

Detailed analysis of oxytocin, vasopressin and CRH containing neurons in pig hypothalamus (2000)

Karman, A.G., Swarts, H.J.M., Kastelijn, J., Wiegant, V.M.

De-arousal effect of stereotypies in tethered sows (2000)

Schouten, W.G.P., Lensink, J., Lakwijk, N., Wiegant, V.M.

Responses to apomorphine of pigs with different coping characteristics (2000)

Bolhuis, J.E., Schouten, W.P.G., Schrama, J.W., Cools, A.R., Wiegant, V.M.

Rationale: Classification of pigs based on the degree of resistance they display in a so-called "backtest" seems, to a certain extent, predictive for their coping strategy. Objective: The present...

Central Administration of Antiserum to Vasoactive Intestinal Peptide Delays and Reduces Luteinizing Hormone and Prolactin Surgesin Ovariectomized, Estrogen-Treated Rats (1999)

Swarts, H.J.M., Wiegant, V.M.

Influence of housing conditions on responses of pigs to preslaughter treatment and consequences for meat quality (1999)

Geverink, N.A., Lambooij, E., Blokhuis, H.J., Wiegant, V.M.

The Effect of Shot Biopsy on Behavior, Salivary Cortisol, and Heart Rate in Slaughter Pigs (1999)

Geverink, N.A., Ruis, M.A.W., Eisen, R., Lambooij, E., Blokhuis, H.J., Wiegant, V.M.

Brain opioid receptor density relates to stereotypies in chronically stressed pigs (1999)

Loijens, L.W.S., Schouten, W.G.P., Wiepkema, P.R., Wiegant, V.M.

Vasopressin in the preoptic area induces a luteinizing hormone surge in ovariectomized, estradiol-treated rats with lesions of the suprachiasmatic nucleus (1999)

Palm, I.F., Wiegant, V.M., Buijs, R.M., Kalsbeek, A.

Vasopressin induces an LH surge in ovariectomized, estradiol-treated rats with lesions of the suprachiasmatic nucleus (1999)

Palm,I., Wiegant, V.M., Buijs, R.M., Kalsbeek, A.

Activity-dependent neurotransmitter release kinetics: correlation with changes in morphological distributions of small and large vesicles in central nerve terminals (1999)

Leenders, A.G.M., Scholten, G., Wiegant, V.M., Lopes Da Silva, F.H.

Effects of simulated lairage conditions on the physiology and behaviour of pigs. (1998)

Geverink, N.A., Bradshaw, R.H., Lambooij, E., Wiegant, V.M., Broom, D.M.

Responses of slaughter pigs to transport and Lairage sounds. (1998)

Geverink, N.A., Buhneman, A., Lambooij, E., Blokhuis, H.J., Wiegant, V.M.

Geverink, N.A., A. Bühnemann, J.A. van de Burgwal, E. Lambooij, H.J. Blokhuis and V.M. Wiegant. Responses of slaughter pigs to transport and lairage sounds. Physiol Behav 63(4) 667–673, 1998. The...

Effects of regular moving and handling on the behavioral and physiological responses of pigs to preslaughter treatment and consequences for subsequent meat quality. (1998)

Geverink, N.A., Kappers, A., Lambooij, E., Blokhuis, H.J., Wiegant, V.M.

Vasopressin in the preoptic area induces a luteinizing hormone surge in SCN-lesioned, ovariectomized estradiol-treated rats. (1998)

Palm, I.F., Kalsbeek, A., Feenstra, M., Wiegant, V.M., Buijs, R.M.

Gender specific apposition of SCN-derived vasopressin-containing axons on GnRH neurons int he preoptic area of adult rats. (1998)

Palm, I.F., Horvath, T.L., Kastelijn, J., Wiegant, V.M.

Individual differences in pigs: behavioural responses to Apomorphine. (1998)

Bolhuis, J.E., Schouten, W.G.P., Wiegant, V.M.

Differences between fast and slow neurotransmitter release in central nere terminals (1998)

Leenders, A.G.M., Wiegant, V.M., Lopes Da Silva, F.H.

Role of calcineurin in Ca2+ -induced release of all major neurotransmitter types (1998)

Hens, J.J.H., Wit, M. De, Leenders, A.G.M., Kissmehl, R., ...

Presynaptic modulation of Cholecystokinin release by protein kinase C in the rat hippocampus (1998)

Breukel, A.I.M., Wiegant, V.M., Lopes Da Silva, F.H.

Plasma arginine vasopressin and motor activity in major depression. (1998)

Wied, D. De, Wiegant, V.M., Frankhuijzen Sierevogel, A.C., Zwinderman, K.H., Goekoop, J.G., Kerkhof, G.A.

Investigated the relationship between the mean plasma concentration of arginine vasopressin (AVP), oxytocin (OT) and clinically rated psychomotor retardation. 48 inpatients and outpatients with major...

Role of calcineurin in Ca2+-induced release of catecholamines and neuropeptides (1998)

Gispen, W.H., Hens, J.J.H., Wit, M. De, Leenders, A.G., Boddeke, H.W., ...

Neurotransmission requires rapid docking, fusion, and recycling of neurotransmitter vesicles. Several of the proteins involved in this complex Ca2+-regulated mechanism have been identified as...

Plasma Arginine Vasopressin and motor activity in major depression (1998)

Londen, L. V., Kerkhof, G.A., Berg, F. V.d., Goedkoop, J.G., Zwinderman, A.H., Frankhuijzen-Siervogel, J.C., ...

Endogenous opioid peptides modulate the response of the GnRH induced LH release by the pituitary in vitro. (1997)

Dierx, J.A.J., Helmond, F.A., Wiegant, V.M.

Responses of slaughter pigs to lairage sounds. (1997)

Geverink, N.A., Lambooij, E., Wiegant, V.M.

Role of vasopressin in the MPOA in the estradiol-induced LH and PRL surge. (1997)

Palm, I.F., Kalsbeek, A., Wiegant, V.M., Buijs, R.M.

The role of vasopressin in the medial preoptic area in the estradiol-iduced luteinizing hormone and prolactin surge. (1997)

Palm, I.F., Kalsbeek, A., Wiegant, V.M., Buijs, R.M.

Inhibition of the LH surge by restraint stress in cyclic rats: Studies on the role of GABAA and GABAB receptors. (1997)

Roozendaal, M.M., Reuling, R.J.H., Threels, A., Swarts, J.J.M., Wiegant, V.M., ...

Inhibition of the LH surge in cyclic rats by stress is not mediated by opioids. (1997)

Roozendaal, M.M., Swarts, J.J.M., Wiegant, V.M., Mattheij, J.A.M.

The effects of intravenous (iv) administration of the opioid antagonists naloxone and naltrexone on the restraint-induced suppression of the pro-estrous LH surge were studied in cyclic female rats....

Activation of somatostatin neurons in the ventromedial and dorsomedial hypothalamus following sexual behavior, and colocalization with progesterone receptors. (1997)

Sannen, K.S., Coolen, L.M., Wiegant, V.M.

Evidence for a direct neuronal pathway from the suprachiasmatic nucleus to the gonadotropin-releasing hormone system: combined tracing and light- and electron microscopic immunocytochemical studies. (1997)

Horvath, T.L., Wiegant, V.M., Buijs, R.M.

Dynamics of progesterone receptor density in the hypothalamus during the sterous cycle of the rat. (1997)

Wiegant, V.M.

Synaptic contacts between Gonadotropin-releasing hormone-containing fibres and neurons in the suprachiasmatic nucleus and perichiasmatic area: an anatomical substrate for feedback regulation? (1997)

Wiegant, V.M., Den Hurk, R., Buijs, R.M.

The suprachiasmatic nucleus (SCN) is critically involved in the generation and entrainment of circadian rhythms in mammalian species. Both the occurrence and the timing of the luteinizing hormone...

Negative correlation between saliva cortisol and cell number in the dentate gyrus of chronically stressed pigs. (1997)

Benning, M., Schouten, W.G.P., Wiegant, V.M.

The effects of mixing on behavior and circadian parameters of salivary cortisol in pigs. (1997)

Ekkel, E.D., Savenije, B., Schouten, W.G.P., Wiegant, V.M., Tielen, M.J.M.

Ekkel, E. D., B. Savenije, W. G. P. Schouten, V. M. Wiegant and M. J. M. Tielen. The effects of mixing on behavior and circadian parameters of salivary cortisol in pigs. Physiol Behav 62(1)...

Individual responses to acute and chronic stress in pigs. (1997)

Schouten, W.G.P., Wiegant, V.M.

Synaptic contacts between gonadotropin-releasing hormone-containing fibers and neurons in the suprachiasmatic nucleus and perichiasmatic area: an anatomical substrate for feedback regulation? (1997)

Wiegant, V.M., Hurk, R. Van Den, Buijs, R.M.

Evidence for a direct neuronal pathway from the suprachiasmatic nucleus to the gonadotropin-releasing hormone system: combined tracing and light and electron microscopic immunocytochemical studies (1997)

Horvath, T.L., Wiegant, V.M., Hurk, R. Van Den, Buijs, R.M.

Functional recovery from sciatic nerve crush lesion in the rat correlates with individual differences in responses to chronic intermittent stress (1997)

Gispen, W.H., Meeteren, N.L.U., Brakkee, J.H., Helders, P.J.M., Wiegant, V.M.

The aim of the present study was to monitor the influence of chronic stress on functional recovery from a sciatic nerve crush lesion in the rat. Male Wistar rats underwent standard unilateral sciatic...

Recovery of function after sciatic nerve crush lesion in rats selected for diverging locomotor activity in the open field (1997)

Gispen, W.H., Brakkee, J.H., Helder, P.J.M., Croiset, G., Wiegant, V.M.

The relation between recovery of function following a sciatic nerve crush lesion and an individual behavioural characteristic, the locomotor activity in an open field, was investigated in rats. Ten...

The role of central melanocortin receptors in the activation of the hypothalamus pituitary adrenal axis and the induction of excessive grooming (1997)

Gispen, W.H., Frijtag, J.C. Von, Croiset, G., Adan, R.A.H., Wiegant, V.M.

In accord with previous studies intracerebroventricular (i.c.v.) injections of ACTH1-24 (1 g) induced a display of excessive grooming, and increased the plasma concentrations of ACTH and...

The premenstrual phase and reactions to aversive events: a study of hormonal influences on emotionality. (1996)

Frijda, N.H., Wiegant, V.M., Endert, E.

Fifty-eight normal cycle, healthy women were confronted with an aversive, anger-provoking situation in the laboratory. Eighteen women were tested in their follicular phase. A further 40 women were...

Experimental drug addiction selectively alters brain opioid receptor binding in rat. (1996)

Wiegant, V.M.

In vitro contractile responses to acetylcholine in jejunal and colonic tissue from stressed rats. (1996)

Stam, R., Kroese, A.B.A., Akkermans, L.M.A., Wiegant, V.M.

Effect of CRH on the preovulatory LH and FSH surge in the cyclic rat: a role for arginine vasopressin? (1996)

Roozendaal, M.M., Swarts, J.J.M., Wolters, W.B., Threels, A., Wiegant, V.M., Mattheij, J.A.M.

Distribution of Lys-P2-melanocyte-stimulating hormone-(Lys-P2-MSH)-like immunoreactivity in neuronalelements in the brain and perpiheral tissues of the rat. (1996)

Fodor, M., Sluiter, A., Frankhuijzen-Sierevogel, A., Wiegant, V.M., Hoogerhout, P., ...

Alterations of P-endorphine-like immunoreactivity in CSF following behavioral training using a passive avoidance procedure. (1996)

Wan, R.Q., Wiegant, V.M.

Observations on behaviour and skin damage of slaughter pigs and treatment during lairage. (1996)

Geverink, N.A., Engel, B., Lambooij, E., Wiegant, V.M.

In five Dutch and four Belgian slaughterhouses the following elements were studied: (1) slaughterhouse husbandry practice, (2) agonistic behaviour in groups of pigs, (3) indices of skin damage...

Sensitization of the colonic response to novel stress after previous stressful experience. (1996)

Stam, R., Croiset, G., Akkermans, L.M.A., Wiegant, V.M.

Experimental social fear: immunological, hormonal and autonomic concomitants. (1996)

Gerritsen, W., Heijnen, C.J., Wiegant, V.M., Bermond, B., Frijda, N.H.

Plasma arginine vasopressin and motor activity in patients with major depression and in healthy controls. (1996)

Kerkhof, G.A., Goekoop, J.G., Zwinderman, A.H., Frankhuijzen-Sierevogel, J.C., ...

Reproducibility of E and E+P induced LH and PRL surges in individual rats. (1996)

Swarts, J.J.M., Wiegant, V.M.

Foot shock stress in the rat sensitizes the colonic response to a novel stressor two weeks later. (1996)

Stam, R., Croiset, G., Akkermans, L.M.A., Wiegant, V.M.

Endogenous CRH inhibits vagal outflow during conditioned emotional stress. (1996)

Croiset, G., Diamant, M., Broekhoven, M.H., Wiegant, V.M.

Cholinergic hyperresponsiveness is not a key factor in stress-induced colonic sensitization. (1996)

Stam, R., Kroese, A.B.A., Akkermans, L.M.A., Wiegant, V.M.

Colocalization of progesterone receptors with somatostatin containing neurons in the caudal hypothalamus of male and female rats. (1996)

Sannen, K.S., Wiegant, V.M.

Changes in hypothalamic progesterone receptor density over the 4-day estrus cycle in the rat. (1996)

Wiegant, V.M.

ACTH and opioids are differentially involved in the behavioral response to novelty following emotional and physical stress. (1996)

Wolterink, G., Lamberts, R.R., Wiegant, V.M.

Sexual dimorphic activation of somatostatin neurons in the ventromedial and dorsomedial hypothalamus following sexual behavior. (1996)

Sannen, K.S., Coolen, L.M., Wiegant, V.M.

Characteristics of pulsatile LH-release during the first oestrous cycle after oestrous synchronisation in tethered and loose-housed sows. (1996)

Dierx, J.A.J., Kemp, B., Soede, N.M., Helmond, F.A., Wiegant, V.M.

Effects of stereotypies on sympatho-adrenal- and hypothalamic-pituitary-adrenal-axes change with parity in tethered sows. (1996)

Schouten, W.G.P., Kersten, A.M., Soede, N., Wiegant, V.M.

Experimental social fear: Immunological, hormonal, and autonomic concomitants (1996)

Gerritsen, W., Heinen, C.J., Wiegant, V.M., Bermond, B., Frijda, N.H.

nvestigated the relationship between emotions and immune responses by inducing social fear in 79 college students by having them give an oral presentation in front of an audience. 30 additional Ss...

Computer analysis of the Migrating Motility Complex of the small intestine recorded in freely moving rats. (1995)

Stam, R., Kroese, A.B.A., Croiset, G., Wiegant, V.M., Akkermans, L.M.A.

Effect of restraint stress on the preovulatory luteinizing hormone profile and ovulation in the rat. (1995)

Roozendaal, M.M., Swarts, J.J.M., Wiegant, V.M., Mattheij, J.A.M.

Effect of opioid antagonist naltrexone on pulsatile LH release in the luteal phase in gilts: A dose-response curve. (1995)

Dierx, J.A.J., Helmond, F.A., Wiegant, V.M.

Endogenous opioid regulation of the pulsatile LH release during the follicular phase in gilts. (1995)

Dierx, J.A.J., Helmond, F.A., Wiegant, V.M.

The effect of CRF on the LH release from superfused pig pituitary depends on the presence of the neurointermediate lobe. (1995)

Ten Hulscher, H.I., Lamberts, R.R., Dierx, J.A.J., Helmond, F.A., Wiegant, V.M.

Circadian regulation of the hypothalamus-pituitary-gonadal axis in the female rat: neuro-anatomical studies. (1995)

Buijs, R.M., Wiegant, V.M.

Central vip-antiserum injections alter the timing of an estrogen-induced LH surge. (1995)

Swarts, J.J.M., Wiegant, V.M.

Chronic stress and regulation of the pituitary adrenal axis in female pigs. (1995)

Helmond, F.A., Schouten, W.G.P., Wiegant, V.M.

The effect of chronic stress on plasma cortisol concentrations in cyclic female pigs depends on the time of day. (1995)

Helmond, F.A., Wiegant, V.M.

Chronic stress and pituitary-adrenocortical responses to corticotropin-releasing hormone and vasopressin in female pigs. (1995)

Helmond, F.A., Wiegant, V.M.

Chronic stress increases the opioid-mediated inhibition of the pituitary-adrenocortical response to acute stress in pigs. (1995)

Helmond, F.A., Loyens, L.W.S., Schouten, W.G.P., Wiegant, V.M.

Differential effects of melanocortin peptides on neural melanocortin receptors. (1995)

Adan, R.A.H., Oosterom, J., Wiegant, V.M., Burbach, J.P.H., Gispen, W.H.

Neurite outgrowth in Neuro 2A cells is stimulated by activation of melanocortin receptors. (1995)

Adan, R.A.H., Oosterom, J., Wiegant, V.M., Burbach, J.P.H., Gispen, W.H.

Ba2+ replaces Ca2+/calmodulin in the activation of protein phosphates and in exocytosis of all major transmitters (1995)

Verhage, M., Hens, J.J.H., Boomsma, F., Wiegant, V.M., Lopes Da Silva, F.H., ...

Ba2+ replaces Ca2+/calmodulin in the activation of protein phosphatases and in exocytosis of all major transmitters (1995)

Gispen, W.H., Verhage, M., Hens, J.J.H., Boomsma, F., Wiegant, V.M., ...

Chronic stress and pituitary-adrenal function in female pigs. (1994)

Helmond, F.A., Wiegant, V.M.

Increased cortisol response to exogenous adrenocorticotropic hormone in chronically stressed pigs: influence of housing conditions. (1994)

Helmond, F.A., Wiegant, V.M.

Preferential induction of c-fos immunoreactivity in vasoactive intestinal polypeptide-innervated gonadotropin-releasing hormone neurons during a steroid-induced luteinizing hormone surge in the female rat. (1994)

Buijs, R.M., Wiegant, V.M.

Preferential induction of C-FOS in VIP-innervated GNRH neurons during a steroid induced LH surge. (1994)

Wiegant, V.M., Buijs, R.M.

Reciprocal connections between vasopressin and ß-endorphin immunoreacitve neurons of the rat hypothlamic paraventricular (PVN) and arcuate nucleus (an). (1994)

Kiss, J., Görcs, T.J., Wiegant, V.M., Halász, B.

Pulsatile LH release during follicular phase in gilts: effects of restraint and endogenous opioids. (1994)

Dierx, J.A.J., Helmond, F.A., Wiegant, V.M.

Corticotropin-releasing hormone and stress-induced inhibition of the luteinizing hormone surge in the rat. (1994)

Roozendaal, M.M., Swarts, J.J.M., Wiegant, V.M., Mattheij, J.A.M.

The role of GABA in the inhibition of the LH and FSH surge by restraint stress in the rat. (1994)

Roozendaal, M.M., Swarts, J.J.M., Wiegant, V.M., Mattheij, J.A.M.

Effects of psychological stress on colonic and small bowel myoelectrical activity and behavior. (1994)

Stam, R., Croiset, G., Kroese, A.B.A., Akkermans, L.M.A., Wiegant, V.M.

Ultrastructural evidence for neuronal control of the SCN and perichiasmatic area by GNRH neurons. (1994)

Wiegant, V.M., Buijs, R.M.

Het aangebonden varken, een diermodel voor chronische stress. (1994)

Wiegant, V.M., Schouten, W.G.P., Helmond, F.A., Loyens, L.W.S.

Preferential induction of c-fos immunoreactivity in vasoactive intestinal polypeptide-innervated gonadotropin-releasing hormone neurons during a steroid induced LH surge in the female rat (1994)

Buijs, R.M., Hurk, R. Van Den, Wiegant, V.M.

Ultrastructural evidence for neuronal control of the SCN and perichiasmatic area by GNRH neurons (1994)

Wiegant, V.M., Buijs, R.M.

Preferential induction of C-fos in VIP-innervated GNRH neurons during a steroid induced LH surge (1994)

Wiegant, V.M., Buijs, R.M.

Acute restraint stress with respect to the surge of LH and FSH on the day of pro-oestrus, and subsequent ovulation in the rat. (1993)

Mattheij, J.A.M., Wiegant, V.M.

Evidence for a direct pathway from the SCN to the GnRH system in the female rat. (1993)

Wiegant, V.M., Buijs, R.M.

GABA-A receptor-mediated inhibition of the luteinizing hormone and follicle stimulating hormone surge during pro-oestrus in the rat. (1993)

Roozendaal, M.M., Reuling, R.J.H., Swarts, J.J.M., Mattheij, J.A.M., Wiegant, V.M.

Gamma-aminobutyric acid can suppress the surge of gonadotropins during pro-oestrus in the rat. (1993)

Roozendaal, M.M., Reuling, R.J.H., Swarts, J.J.M., Mattheij, J.A.M., Wiegant, V.M.

Influence of chronic stress on cortisol, prolactin and reproductive hormones during the oestrous cycle of the pig. (1993)

Houwing, H., Helmond, F.A., Wiegant, V.M.

Lesions of the suprachiasmatic nucleus indicate the presence of a direct VIP containing projection to gonadotrophin releasing hormone neurons in the female rat. (1993)

Wiegant, V.M., Buijs, R.M.

Opioid neuropeptide receptors and stereotypies of pigs during chronic stress. (1993)

Loyens, L.W.S., Wiegant, V.M., Schouten, W.G.P., Wiepkema, P.R.

Opioid-receptoren. (1993)

Wiegant, V.M., Heijna, M.H.

Opioids and stereotypies in coping with chronic stress. (1993)

Wiegant, V.M., Schouten, W.G.P., Helmond, F.A., Loyens, L.W.S.

The effect of chronic stress on respoductive hormones, cortisol and prolactin during the oestrous cycle of the pig. (1993)

Houwing, H., Helmond, F.A., Wiegant, V.M.

The effects of stress on gastric emptying as measured by electrical impedance tomography (EIT). (1993)

Akkermans, L.M.A., Tekamp, F.A., Roelofs, J.M.M., Wiegant, V.M.

Gestoord gedrag bij varkens: omgaan met stress. (1993)

Schouten, W.G.P., Wiegant, V.M.

Opioid neuropeptide receptors and disturbed behaviour of pigs during chronic stress. (1993)

Loyens, L.W.S., Wiegant, V.M., Wiepkema, P.R., Schouten, W.G.P.

Lesions of the suprachiasmatic nucleus indicate the presence of a direct vasoactive intestinal polypeptide-containing projection to gonadotropin-releasing hormone neurons in the female rat (1993)

Wiegant, V.M., Hurk, R. Van Den, Buijs, R.M.

Evidence for a role of protein kinase C substrate B 50 (GAP 43) in Ca2+-induced neuropeptide cholecystokinin-8 release from permeated synaptosomes (1993)

Gispen, W.H., Hens, J.J.H., Dimjati, W., Wiegant, V.M., Oestreicher, A.B., ...

Nasal administration of an ACTH(4-9) peptide analogue with dimethyl-b-cyclodextrin as absorption enhancer in rats and rabbits: pharmacokinetics and dynamics (1993)

Gispen, W.H., Schipper, N.G.M., Verhoef, C.J., Lannoy, L.M. De, Romeijn, S.G., Brakkee, J.H., ...

Involvement of endogenous opioids in the plasma cortisol response to acute stress in chronically stressed pigs. (1992)

Loyens, L.W.S., Schouten, W.G.P., Helmond, F.A., Wiegant, V.M.

Naloxone-induced increase in the plasma cortisol response to acute stress in chronically stressed pigs. (1992)

Loyens, L.W.S., Schouten, W.G.P., Helmond, F.A., Wiegant, V.M.

Fc-mediated nonspecific staining of the procine brain with rabbit antisera in immunocytochemistry is prevented by pre-incubation of the sera with protein A and G. (1992)

Pool, Ch.W., Sluiter, A.A., ...

Involvement of endogenous opioids in the plasma cortisol response to acute stress in chronically stressed pigs. (1992)

Loyens, L.W.S., Schouten, W.G.P., Helmond, F.A., Wiegant, V.M.

Naloxone-induced increase in the plasma corticol response to acute stress in chronically stressed pigs. (1992)

Loyens, L.W.S., Schouten, W.G.P., Helmond, F.A., Wiegant, V.M.

Endogenous opioid dependent plasma cortisol response to acute stress in chronically stressed pigs. (1992)

Loyens, L.W.S., Schouten, W.G.P., Helmond, F.A., Wiegant, V.M.

Inhibition of LH secretion by corticotropin-releasing hormone during the prooestrus in the rat. (1992)

Roozendaal, M.M., Wolbers, W.B., Swarts, J.J.M., Mattheij, J.A.M., Wiegant, V.M.

Inhibition of luteinizing hormone secretion by corticotropin-releasing hormone during the pro-oestrus in the rat. (1992)

Roozendaal, M.M., Wolbers, W.B., Swarts, J.J.M., Mattheij, J.A.M., Wiegant, V.M.

Do pigs develop opioid dependent stereotypies to suppress heart rate responses when challenged? (1992)

Schouten, W.G.P., Wiegant, V.M., Loyens, L.W.S., Oosterlaak, A.K.

Opioid-dependent stereotypies suppress acute heart rate responses in chronically stressed pigs; a form of coping behavior? (1992)

Schouten, W.G.P., Loyens, L.W.S., Oosterlaak, A.K., Wiegant, V.M.

Over spanning. (1991)

Wiegant, V.M.

Increased plasma cortisol response to ACTH in tethered gilts. (1991)

Helmond, F.A., Wiegant, V.M.

Over spanning. (1990)

Wiegant, V.M.

Increased plasma cortisol levels in tethered gilts. (1990)

Houwing, H., Helmond, F.H., Oudenaarden, C.P.J., Wiegant, V.M.

Plasma concentrations of cortisol during the estrous cycle in pigs. (1990)

Houwing, H., Helmond, F.H., Oudenaarden, C., Wiegant, V.M.

Role of vasopressin in the regulation of the brain POMC-system. (1990)

Wiegant, V.M.

Aanpassing: variatie op het thema overleven. (1990)

Wiegant, V.M.

Melanocortins in peripheral nerve regeneration : influence of dosage forms and routes of administration (1990)

Gispen, W.H., Wiegant, V.M.

Characterization of β-endorphin-immunoreactivity in limbic brain structures of rats self-administering heroin or cocaine (1988)

Sweep, C.G.J., Ree, J.M. Van, Wiegant, V.M.

The effects of intravenous self-administration of 30 μg infusions of either heroin or cocaine, or saline on the concentrations of β-endorphin-immunoreactivity (βE-IR) in the anterior part of the...

ACTH and brain cAMP and phosphoproteins (1986)

Gispen, W.H., Wiegant, V.M., Oestreicher, A.B., Zwiers, H.

ACTH and signal transduction in the neuronal membrane (1986)

Gispen, W.H., Wiegant, V.M., Verhaagen, J., Aloyo, V.J.

N[alpha]-acetyl-[gamma]-endorphin is an endogenous non-opioid neuropeptide with biological activity (1985)

Wiegant, V.M., Verhoef, J., Burbach, J.P.H., Amerongen, A. Van, Gaffori, O., Sitsen, J.M.A., ...

Nα-acetyl-γ-endorphin (AcγE) was identified in the rat neurointermediate pituitary, based on its immunological properties, comigration with synthetic AcγE on HPLC and resistance to...

Tetanic stimulation affects the metabolism of phosphoinositides in hippocampal slices (1984)

Gispen, W.H., Bär, P.R., Wiegant, V.M., Lopes Da Silva, F.H.

Tetanic but not low frequency stimulation of the perforant path in rat hippocampal slices results in changes in the metabolism of phosphoinositides and phosphatidic acid. The phosphorylation of...

Isolation and characterization of α-endorphin and γ-endorphin from single human pituitary glands (1984)

Burbach, J.P.H., Wiegant, V.M.

Modulation of adenylate cyclase by protein phosphorylation: Effects of ACTH (1982)

Gispen, W.H., Wiegant, V.M.

Neuropeptides and brain cAMP and phosphoprotein (1981)

Gispen, W.H., Wiegant, V.M., Zwiers, H.

A simple technique for rapid implantation of a permanent cannula into the rat brain ventricular system (1979)

Gispen, W.H., Brakkee, J.H., Wiegant, V.M.

ACTH like neurotropic peptides: Possible regulators of rat brain cyclic AMP (1979)

Gispen, W.H., Wiegant, V.M., Dunn, A.J., Schotman, P.

ACTH sensitive protein kinase from rat brain membranes (1979)

Gispen, W.H., Zwiers, H., Tonnaer, J., Wiegant, V.M., Schotman, P.

Intracerebroventricular ACTH activates the pituitary adrenal system: Dissociation from a behavioral response (1979)

Gispen, W.H., Wiegant, V.M., Jolles, J., Colbern, D.L., Zimmermann, E.

The behaviorally active neuropeptide ACTH as neurohormone and neuromodulator: The role of cyclic nucleotides and membrane phosphoproteins (1979)

Gispen, W.H., Zwiers, H., Wiegant, V.M., Schotman, P., Wilson, J.E.

ACTH induced inhibition of endogenous rat brain protein phosphorylation in vitro: Structure activity study (1978)

Gispen, W.H., Zwiers, H., Wiegant, V.M., Schotman, P.

Differential behavioral effects of ACTH(4 10) and (D Phe7) ACTH(4 10) (1978)

Gispen, W.H., Wiegant, V.M., Colbern, D.

Distinct dopaminergic systems in ACTH induced grooming (1978)

Gispen, W.H., Cools, A.R., Wiegant, V.M.

Endogenous phosphorylation of rat brain synaptosomal plasma membranes in vitro: Some methodological aspects (1978)

Gispen, W.H., Wiegant, V.M., Zwiers, H., Schotman, P.

Peptides and rat brain membrane phosphoproteins (1978)

Gispen, W.H., Zwiers, H., Wiegant, V.M., Oestreicher, A.B., Schotman, P.

Reduced behavioral effectiveness of ACTH1-24 after a second administration: Interaction with opiates (1978)

Gispen, W.H., Jolles, J., Wiegant, V.M.

ß-Endorphin grooming in the rat: Single dose tolerance (1978)

Gispen, W.H., Wiegant, V.M., Jolles, J.

Beta-endorphin grooming in the rat: single dose tolerance (1978)

Wiegant, V.M., Jolles, J., Gispen, W.H.

ACTH induced excessive grooming in the rat: latent activity of ACTH4-10 (1977)

Gispen, W.H., Wiegant, V.M.

ACTH induced excessive grooming involves brain dopamine (1977)

Gispen, W.H., Wiegant, V.M., Cools, A.R.

ACTH like peptides and morphine: interaction at the level of the CNS (1977)

Gispen, W.H., Wiegant, V.M., Terenius, L., Wied, D. De

CNS and ACTH like peptides: Neurochemical response and interaction with opiates (1977)

Gispen, W.H., Reith, M.E.A., Schotman, P., Wiegant, V.M., Zwiers, H., Wied, D. De

Intraventricular administered ACTH and changes in rat brain protein phosphorylation: A preliminary report (1977)

Gispen, W.H., Zwiers, H., Wiegant, V.M., Schotman, P.

Cyclic nucleotides and nerve function (1976)

Gispen, W.H., Wiegant, V.M.

Induction of excessive grooming in the rat by fragments of lipotropin (1976)

Gispen, W.H., Wiegant, V.M., Bradbury, A.F., Hulme, E.C., Smyth, D.G., Snell, C.R., ...

Interaction between ACTH fragments, brain opiate receptors and morphine induced analgesia (1976)

Gispen, W.H., Buitelaar, J.K., Wiegant, V.M., Terenius, L., Wied, D. De

Neuropeptides, brain and behavior (1976)

Gispen, W.H., Reith, M.E.A., Schotman, P., Wiegant, V.M., Zwiers, H., Bohus, B., ...

Opiate antagonists suppress ACTH1-24 induced excessive grooming in the rat (1976)

Gispen, W.H., Wiegant, V.M.

The induction of excessive grooming in the rat by intraventricular application of peptides derived from ACTH. Structure-activity studies (1975)

Gispen, W.H., Wiegant, V.M., Greven, H.M., Wied, D. De

Pituitary, peptides and brain function (1974)

Gispen, W.H., Kloet, E.R. De, Reith, M.E.A., Wiegant, V.M., Schotman, P.

Role of vasopressin in the medial preoptic area in the estradiol-induced luteinizing hormone and prolactin surge

Palm, I.F., Kalsbeek, A., Hermes, M., Wiegant, V.M., Buijs, R.M.

Trauma and the gut: interactions between stressful experience and intestinal function.

Stam, R, Akkermans, L M, Wiegant, V M

Alpha-methyldopa induces a naltrexone-insensitive antinociception and hypomotility in rats.

Van Giersbergen, P. L., Van Duinkerken, E., Sweep, C. G., Wiegant, V. M., Van Ree, J. M., De Jong, W.

1. This study served to investigate whether endogenous opioid peptides play a role in the putative antinociceptive and the sedative actions of alpha-methyldopa. 2. In conscious normotensive rats,...

Nasal administration of an ACTH(4-9) peptide analogue with dimethyl-beta-cyclodextrin as an absorption enhancer: pharmacokinetics and dynamics.

Schipper, N. G., Verhoef, J. C., De Lannoy, L. M., Romeijn, S. G., Brakkee, J. H., Wiegant, V. M., ...

1. The systemic absorption and the neurotrophic effect of the metabolically stabilized ACTH (4-9) analogue, Org2766, were investigated following intranasal (i.n.) administration. 2. Without additives...