Vadim I. Pivniouk

Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells (2003)

Pivniouk, Vadim I., Snapper, Scott B., Kettner, Alexander, Alenius, Harri, Laouini, Dhafer, Falet, Hervé, ...

Wiskott–Aldrich syndrome protein (WASP) is the product of the gene deficient in boys with X‐linked Wiskott–Aldrich syndrome. We assessed the role of WASP in signaling through the...

Adapter proteins SLP-76 and BLNK both are expressed by murine macrophages and are linked to signaling via Fcγ receptors I and II/III

Bonilla, Francisco A., Fujita, Ross M., Pivniouk, Vadim I., Chan, Andrew C., Geha, Raif S.

The SLP-76 (Src homology 2 domain-containing leukocyte protein of 76 kDa) adapter protein is expressed in T cells and myeloid cells, whereas its homologue BLNK (B cell linker protein) is expressed in...

SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells

Pivniouk, Vadim I., Martin, Thomas R., Lu-Kuo, Jennifer M., Katz, Howard R., Oettgen, Hans C., Geha, Raif S.

SLP-76 is an adapter protein expressed in T cells and myeloid cells that is a substrate for ZAP-70 and Syk. SLP-76–deficient mice exhibit a profound block in T-cell development. We found that...

Adapter proteins SLP-76 and BLNK both are expressed by murine macrophages and are linked to signaling via Fcγ receptors I and II/III

Bonilla, Francisco A., Fujita, Ross M., Pivniouk, Vadim I., Chan, Andrew C., Geha, Raif S.

The SLP-76 (Src homology 2 domain-containing leukocyte protein of 76 kDa) adapter protein is expressed in T cells and myeloid cells, whereas its homologue BLNK (B cell linker protein) is expressed in...

SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells

Pivniouk, Vadim I., Martin, Thomas R., Lu-Kuo, Jennifer M., Katz, Howard R., Oettgen, Hans C., Geha, Raif S.

SLP-76 is an adapter protein expressed in T cells and myeloid cells that is a substrate for ZAP-70 and Syk. SLP-76–deficient mice exhibit a profound block in T-cell development. We found that...

WIP Regulates Signaling via the High Affinity Receptor for Immunoglobulin E in Mast Cells

Kettner, Alexander, Kumar, Lalit, Antón, Inés M., Sasahara, Yoji, De La Fuente, Miguel, Pivniouk, Vadim I., ...

Wiskott-Aldrich syndrome protein–interacting protein (WIP) stabilizes actin filaments and is important for immunoreceptor-mediated signal transduction leading to actin cytoskeleton rearrangement in...

Allelic Exclusion of the T Cell Receptor β Locus Requires the Sh2 Domain–Containing Leukocyte Protein (Slp)-76 Adaptor Protein

Aifantis, Iannis, Pivniouk, Vadim I., Gärtner, Frank, Feinberg, Jacqueline, Swat, Wojciech, Alt, Frederick W., ...

Signaling via the pre-T cell receptor (TCR) is required for the proliferative expansion and maturation of CD4−CD8− double-negative (DN) thymocytes into CD4+CD8+ double-positive (DP) cells and for...