A genome-wide association study for late-onset Alzheimer's disease using DNA pooling (2008)
Abraham, Richard, Moskvina, Valentina, Sims, Rebecca, Hollingworth, Paul, Morgan, Angharad, Georgieva, Lyudmila, ...
Abstract Background Late-onset Alzheimer's disease (LOAD) is an age related neurodegenerative disease with a high prevalence that places major demands on healthcare resources in societies with...
Buxbaum, J. D., Georgieva, Lyudmila, Young, J. J., Plescia, C., Kajiwara, Y., Jiang, Y., ...
Neuregulin and the neuregulin receptor ERBB4 have been genetically and functionally implicated in schizophrenia. In this study, we used the yeast two-hybrid system to identify proteins that interact...
Buxbaum, J. D., Georgieva, Lyudmila, Young, J. J., Plescia, C., Kajiwara, Y., Jiang, Y., ...
Neuregulin and the neuregulin receptor ERBB4 have been genetically and functionally implicated in schizophrenia. In this study, we used the yeast two-hybrid system to identify proteins that interact...
Identification of loci associated with schizophrenia by genome-wide association and follow-up (2008)
Donovan, Michael C., Craddock, Nicholas, Norton, Nadine, Williams, Hywel, Peirce, Timothy, Moskvina, Valentina, ...
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong...
Glaser, Beate, Nikolov, Ivan, Chubb, Daniel, Hamshere, Marian L, Segurado, Ricardo, Moskvina, Valentina, ...
Abstract Using parametric and nonparametric techniques, our study investigated the presence of single locus and pairwise effects between 20 markers of the Genetic Analysis Workshop 15 (GAW15) North...
Segurado, Ricardo, Hamshere, Marian L, Glaser, Beate, Nikolov, Ivan, Moskvina, Valentina, Holmans, Peter A
Abstract We have used the genome-wide marker genotypes from Genetic Analysis Workshop 15 Problem 2 to explore joint evidence for genetic linkage to rheumatoid arthritis across several samples. The...
Large-scale linkage analysis of 1302 affected relative pairs with rheumatoid arthritis (2007)
Hamshere, Marian L, Segurado, Ricardo, Moskvina, Valentina, Nikolov, Ivan, Glaser, Beate, Holmans, Peter A
Abstract Rheumatoid arthritis is the most common systematic autoimmune disease and its etiology is believed to have both strong genetic and environmental components. We demonstrate the utility of...
Strong evidence that GNB1L is associated with schizophrenia (2007)
Williams, Nigel Melville, Glaser, Beate, Norton, Nadine, Williams, Hywel John, Pierce, Timothy, Moskvina, Valentina, ...
Evidence that a gene or genes on chromosome 22 is involved in susceptibility to schizophrenia comes from two sources: the increased incidence of schizophrenia in individuals with 22q11 deletion...
Cardon, Lon R, Craddock, Nick, Deloukas, Panos, Duncanson, Audrey, Kwiatkowski, Dominic P, ...
There is increasing evidence that genome-wide association ( GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA study...
Moskvina, Valentina, O'Donovan, Michael Conlon
OBJECTIVES: Genetic association studies are usually based upon restricted sets of 'tag' markers selected to represent the total sequence variation. Tag selection is often determined by some threshold...
Georgieva, Lyudmila, Moskvina, Valentina, Peirce, Timothy Rowan, Norton, Nadine, Bray, Nicholas John, Jones, Lesley, ...
Abnormal oligodendrocyte function has been postulated as a primary etiological event in schizophrenia. Oligodendrocyte lineage transcription factor 2 (OLIG2) encodes a transcription factor central to...
Jones, Lesley, Goldstein, Darlene R, Hughes, Gareth, Strand, Andrew D, Collin, Francois, Dunnett, Stephen B, ...
Abstract Background Gene expression microarray experiments are expensive to conduct and guidelines for acceptable quality control at intermediate steps before and after the samples are hybridised to...
Moskvina, Valentina, Craddock, Nicholas John, Holmans, Peter Alan, Owen, Michael John, O'Donovan, Michael Conlon
Objectives: It is well known that genotyping error adversely affects the power of genetic case-control association studies but there is little research on its effects on type I error, and none that...
Moskvina, Valentina, Craddock, Nicholas John, Holmans, Peter Alan, Owen, Michael John, O'Donovan, Michael Conlon
Objectives: It is well known that genotyping error adversely affects the power of genetic case-control association studies but there is little research on its effects on type I error, and none that...
Pooled DNA genotyping on Affymetrix SNP genotyping arrays (2006)
Kirov, George, Nikolov, Ivan, Georgieva, Lyudmila, Moskvina, Valentina, Owen, Michael J, O'Donovan, Michael C
Abstract Background Genotyping technology has advanced such that genome-wide association studies of complex diseases based upon dense marker maps are now technically feasible. However, the cost of...
Pooled DNA genotyping on Affymetrix SNP genotyping arrays (2006)
Kirov, George, Nikolov, Ivan, Georgieva, Lyudmila, Moskvina, Valentina, Owen, Michael John, O'Donovan, Michael Conlon
BACKGROUND: Genotyping technology has advanced such that genome-wide association studies of complex diseases based upon dense marker maps are now technically feasible. However, the cost of such...
Peirce, Timothy Rowan, Bray, Nicholas John, Williams, Nigel Melville, Norton, Nadine, Moskvina, Valentina, Preece, Anna Charlotte, ...
Context Convergent data make 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) a candidate gene for schizophrenia. Reduced expression has been reported in the schizophrenic brain. The CNP gene maps...
Peirce, Timothy Rowan, Bray, Nicholas John, Williams, Nigel Melville, Norton, Nadine, Moskvina, Valentina, Preece, Anna Charlotte, ...
Context Convergent data make 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) a candidate gene for schizophrenia. Reduced expression has been reported in the schizophrenic brain. The CNP gene maps...
Jones, Lesley, Goldstein, Darlene, Hughes, Gareth, Strand, Andrew, Collin, Francois, Dunnett, Stephen, ...
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Hamshere, Marian L, MacGregor, Stuart, Moskvina, Valentina, Nikolov, Ivan N, Holmans, Peter A
Abstract Background We evaluate a method for the incorporation of covariates into linkage analysis using the Genetic Analysis Workshop 14 simulated data. Focusing on a randomly chosen replicate (42)...
Bray, Nicholas John, Preece, Anna Charlotte, Williams, Nigel Melville, Moskvina, Valentina, Buckland, Paul Robert, Owen, Michael John, ...
The DTNBP1 gene, encoding dysbindin, is now generally considered to be a susceptibility gene for schizophrenia. However, the confidence with which this hypothesis can be held has to be tempered by...
Streamlined analysis of pooled genotype data in SNP-based association studies (2005)
Moskvina, Valentina, Norton, Nadine, Williams, Nigel Melville, Holmans, Peter Alan, Owen, Michael John, O'Donovan, Michael Conlon
Several groups have developed methods for estimating allele frequencies in DNA pools as a fast and cheap way for detecting allelic association between genetic markers and disease. To obtain accurate...
Cope, Natalie, Harold, Denise, Hill, Gary, Moskvina, Valentina, Stevenson, Jim, Holmans, Peter, ...
Linkage between developmental dyslexia (DD) and chromosome 6p has been replicated in a number of independent samples. Recent attempts to identify the gene responsible for the linkage have produced...
Bray, Nicholas J., Preece, Anna, Williams, Nigel M., Moskvina, Valentina, Buckland, Paul R., Owen, Michael J., ...
The DTNBP1 gene, encoding dysbindin, is now generally considered to be a susceptibility gene for schizophrenia. However, the confidence with which this hypothesis can be held has to be tempered by...
Bray, Nicholas J., Preece, Anna, Williams, Nigel M., Moskvina, Valentina, Buckland, Paul R., Owen, Michael J., ...
The DTNBP1 gene, encoding dysbindin, is now generally considered to be a susceptibility gene for schizophrenia. However, the confidence with which this hypothesis can be held has to be tempered by...
Familiarity of symptom dimensions in depression. (2004)
Korszun, Ania, Moskvina, Valentina, Brewster, Shyama, Craddock, Nicholas John, Ferrero, Francois, Gill, Michael, ...
Familiarity of symptom dimensions in depression. (2004)
Korszun, Ania, Moskvina, Valentina, Brewster, Shyama, Craddock, Nicholas John, Ferrero, Francois, Gill, Michael, ...
Williams, Nigel M., Preece, Anna Charlotte, Morris, D. W., Spurlock, Gillian, Bray, Nicholas John, Stephens, Mark Keith, ...
Context Recent research suggests that variation in the gene encoding dystrobrevin binding protein (DTNBP1) confers susceptibility to schizophrenia. Thus far, no specific risk haplotype has been...
Williams, Nigel Melville, Preece, Anna Charlotte, Morris, D. W., Spurlock, Gillian, Bray, Nicholas John, Stephens, Mark Keith, ...
Context Recent research suggests that variation in the gene encoding dystrobrevin binding protein (DTNBP1) confers susceptibility to schizophrenia. Thus far, no specific risk haplotype has been...
Allelic expression of APOE in human brain: effects of epsilon status and promoter haplotypes (2004)
Bray, Nicholas J., Jehu, Luke, Moskvina, Valentina, Buxbaum, Joseph D., Dracheva, Stella, Haroutunian, Vahram, ...
The ϵ4 haplotype of APOE is the only undisputed genetic risk factor for late onset Alzheimer's disease (LOAD). It has been proposed that at least two other polymorphisms in the promoter of the...
Allelic expression of APOE in human brain: effects of epsilon status and promoter haplotypes (2004)
Bray, Nicholas J., Jehu, Luke, Moskvina, Valentina, Buxbaum, Joseph D., Dracheva, Stella, Haroutunian, Vahram, ...
The ϵ4 haplotype of APOE is the only undisputed genetic risk factor for late-onset Alzheimer's disease (LOAD). It has been proposed that at least two other polymorphisms in the promoter of the...
Allelic expression of APOE in human brain: effects of epsilon status and promoter haplotypes (2004)
Bray, Nicholas J., Jehu, Luke, Moskvina, Valentina, Buxbaum, Joseph D., Dracheva, Stella, Haroutunian, Vahram, ...
The ϵ4 haplotype of APOE is the only undisputed genetic risk factor for late onset Alzheimer's disease (LOAD). It has been proposed that at least two other polymorphisms in the promoter of the...
Approximate projectors in singular spectrum analysis (2003)
Moskvina, Valentina, Schmidt, Karl Michael
Singular spectrum analysis (SSA) is a method of time-series analysis based on the singular value decomposition of an associated Hankel matrix. We present an approach to SSA using an effective and...
Pooled DNA genotyping on Affymetrix SNP genotyping arrays
Kirov, George, Nikolov, Ivan, Georgieva, Lyudmila, Moskvina, Valentina, Owen, Michael J, O'Donovan, Michael C
Jones, Lesley, Goldstein, Darlene R, Hughes, Gareth, Strand, Andrew D, Collin, Francois, Dunnett, Stephen B, ...
Strong Evidence That KIAA0319 on Chromosome 6p Is a Susceptibility Gene for Developmental Dyslexia
Cope, Natalie, Harold, Denise, Hill, Gary, Moskvina, Valentina, Stevenson, Jim, Holmans, Peter, ...
Linkage between developmental dyslexia (DD) and chromosome 6p has been replicated in a number of independent samples. Recent attempts to identify the gene responsible for the linkage have produced...
Pooled DNA genotyping on Affymetrix SNP genotyping arrays
Kirov, George, Nikolov, Ivan, Georgieva, Lyudmila, Moskvina, Valentina, Owen, Michael J, O'Donovan, Michael C
Jones, Lesley, Goldstein, Darlene R, Hughes, Gareth, Strand, Andrew D, Collin, Francois, Dunnett, Stephen B, ...
Georgieva, Lyudmila, Moskvina, Valentina, Peirce, Tim, Norton, Nadine, Bray, Nicholas J., Jones, Lesley, ...
Abnormal oligodendrocyte function has been postulated as a primary etiological event in schizophrenia. Oligodendrocyte lineage transcription factor 2 (OLIG2) encodes a transcription factor central to...
Glaser, Beate, Nikolov, Ivan, Chubb, Daniel, Hamshere, Marian L, Segurado, Ricardo, Moskvina, Valentina, ...
Using parametric and nonparametric techniques, our study investigated the presence of single locus and pairwise effects between 20 markers of the Genetic Analysis Workshop 15 (GAW15) North American...
Large-scale linkage analysis of 1302 affected relative pairs with rheumatoid arthritis
Hamshere, Marian L, Segurado, Ricardo, Moskvina, Valentina, Nikolov, Ivan, Glaser, Beate, Holmans, Peter A
Rheumatoid arthritis is the most common systematic autoimmune disease and its etiology is believed to have both strong genetic and environmental components. We demonstrate the utility of including...
Segurado, Ricardo, Hamshere, Marian L, Glaser, Beate, Nikolov, Ivan, Moskvina, Valentina, Holmans, Peter A
We have used the genome-wide marker genotypes from Genetic Analysis Workshop 15 Problem 2 to explore joint evidence for genetic linkage to rheumatoid arthritis across several samples. The data...