Vanessa Ortiz

Unfolding a Linker between Helical Repeats (2008)

Vanessa Ortiz, Steven O. Nielsen, Michael L. Klein, Dennis E. Discher

Multi-domain proteins prove to be a dominant fraction of the proteome, 1 but the physical roles of linkers between domains as domain separators and/or connectors are not always clear. Multirepeat

HIGHLIGHT Computer Simulation of Aqueous Block Copolymer Assemblies: Length Scales and Methods (2006)

Vanessa Ortiz, Steven O. Nielsen, Michael L. Klein, Dennis E. Discher, Vanessa Ortiz, Steven O. Nielsen, ...

ABSTRACT: Atomistic, coarsegrain, and mesoscopic computer simulation methods applied recently to the study of block copolymer assemblies in solution are reviewed. At the atomic level, particle-based...

Lipid Bilayer Perturbations around a Transmembrane Nanotube: A Coarse Grain Molecular Dynamics Study (2005)

Steve O. Nielsen, Bernd Ensing, Vanessa Ortiz, Michael L. Klein

ABSTRACT The perturbations induced in a lipid bilayer by the presence of a transmembrane nanotube are investigated using coarse grained molecular dynamics. Meniscus formation by the lipids and...

Research (1981-1988)" (1990)

Phuong B. Luu, Vanessa Ortiz, Paul R. Barnes, John E. Greenleaf, Phuong B. Luu, Vanessa Ortiz, ...

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Lipid Bilayer Perturbations around a Transmembrane Nanotube: A Coarse Grain Molecular Dynamics Study

Nielsen, Steve O., Ensing, Bernd, Ortiz, Vanessa, Moore, Preston B., Klein, Michael L.

The perturbations induced in a lipid bilayer by the presence of a transmembrane nanotube are investigated using coarse grained molecular dynamics. Meniscus formation by the lipids and tilting of the...

Lipid Bilayer Perturbations around a Transmembrane Nanotube: A Coarse Grain Molecular Dynamics Study

Nielsen, Steve O., Ensing, Bernd, Ortiz, Vanessa, Moore, Preston B., Klein, Michael L.

The perturbations induced in a lipid bilayer by the presence of a transmembrane nanotube are investigated using coarse grained molecular dynamics. Meniscus formation by the lipids and tilting of the...

Pathogenic proline mutation in the linker between spectrin repeats: disease caused by spectrin unfolding

Johnson, Colin P., Gaetani, Massimiliano, Ortiz, Vanessa, Bhasin, Nishant, Harper, Sandy, Gallagher, Patrick G., ...

Pathogenic mutations in α and β spectrin result in a variety of syndromes, including hereditary elliptocytosis (HE), hereditary pyropoikilocytosis (HPP), and hereditary spherocytosis (HS). Although...