Approaches to Target Conserved Conformational Epitopes in HIV Envelope (2005)
Srivastava, Indresh K, Sharma, Victoria, Kan, Elaine, Sun, Yide, Lian, Ying, Connolly, Michael, ...
No abstract available.
Mu-Like Prophage in Serogroup B Neisseria meningitidis Coding for Surface-Exposed Antigens
Masignani, Vega, Giuliani, Marzia Monica, Tettelin, Hervé, Comanducci, Maurizio, Rappuoli, Rino, Scarlato, Vincenzo
Sequence analysis of the genome of Neisseria meningititdis serogroup B revealed the presence of an ∼35-kb region inserted within a putative gene coding for an ABC-type transporter. The region...
Tettelin, Hervé, Masignani, Vega, Cieslewicz, Michael J., Eisen, Jonathan A., Peterson, Scott, Wessels, Michael R., ...
The 2,160,267 bp genome sequence of Streptococcus agalactiae, the leading cause of bacterial sepsis, pneumonia, and meningitis in neonates in the U.S. and Europe, is predicted to encode 2,175 genes....
Giuliani, Marzia Monica, Santini, Laura, Brunelli, Brunella, Biolchi, Alessia, Aricò, Beatrice, Di Marcello, Federica, ...
GNA 1870 is a novel surface-exposed lipoprotein, identified by genome analysis of Neisseria meningitidis strain MC58, which induces bactericidal antibodies. Three sequence variants of the protein...
Tettelin, Hervé, Masignani, Vega, Cieslewicz, Michael J., Donati, Claudio, Medini, Duccio, Ward, Naomi L., ...
The development of efficient and inexpensive genome sequencing methods has revolutionized the study of human bacterial pathogens and improved vaccine design. Unfortunately, the sequence of a single...
Identification of a Universal Group B Streptococcus Vaccine by Multiple Genome Screen
Maione, Domenico, Margarit, Immaculada, Rinaudo, Cira D., Masignani, Vega, Mora, Marirosa, Scarselli, Maria, ...
Group B Streptococcus (GBS) is a multiserotype bacterial pathogen representing a major cause of life-threatening infections in newborns. To develop a broadly protective vaccine, we analyzed the...
Mu-Like Prophage in Serogroup B Neisseria meningitidis Coding for Surface-Exposed Antigens
Masignani, Vega, Giuliani, Marzia Monica, Tettelin, Hervé, Comanducci, Maurizio, Rappuoli, Rino, Scarlato, Vincenzo
Sequence analysis of the genome of Neisseria meningititdis serogroup B revealed the presence of an ∼35-kb region inserted within a putative gene coding for an ABC-type transporter. The region...
Tettelin, Hervé, Masignani, Vega, Cieslewicz, Michael J., Eisen, Jonathan A., Peterson, Scott, Wessels, Michael R., ...
The 2,160,267 bp genome sequence of Streptococcus agalactiae, the leading cause of bacterial sepsis, pneumonia, and meningitis in neonates in the U.S. and Europe, is predicted to encode 2,175 genes....
Giuliani, Marzia Monica, Santini, Laura, Brunelli, Brunella, Biolchi, Alessia, Aricò, Beatrice, Di Marcello, Federica, ...
GNA 1870 is a novel surface-exposed lipoprotein, identified by genome analysis of Neisseria meningitidis strain MC58, which induces bactericidal antibodies. Three sequence variants of the protein...
Tettelin, Hervé, Masignani, Vega, Cieslewicz, Michael J., Donati, Claudio, Medini, Duccio, Ward, Naomi L., ...
The development of efficient and inexpensive genome sequencing methods has revolutionized the study of human bacterial pathogens and improved vaccine design. Unfortunately, the sequence of a single...
Streptococcus pneumoniae Pilus Subunits Protect Mice against Lethal Challenge▿
Gianfaldoni, Claudia, Censini, Stefano, Hilleringmann, Markus, Moschioni, Monica, Facciotti, Claudia, Pansegrau, Werner, ...
Streptococcus pneumoniae is a major public health threat worldwide. The recent discovery that this pathogen possesses pili led us to investigate their protective abilities in a mouse model of...
A universal vaccine for serogroup B meningococcus
Giuliani, Marzia M., Adu-Bobie, Jeannette, Comanducci, Maurizio, Aricò, Beatrice, Savino, Silvana, Santini, Laura, ...
Meningitis and sepsis caused by serogroup B meningococcus are two severe diseases that still cause significant mortality. To date there is no universal vaccine that prevents these diseases. In this...
Pneumococcal Pili Are Composed of Protofilaments Exposing Adhesive Clusters of Rrg A
Hilleringmann, Markus, Giusti, Fabiola, Baudner, Barbara C., Masignani, Vega, Covacci, Antonello, Rappuoli, Rino, ...
Pili have been identified on the cell surface of Streptococcus pneumoniae, a major cause of morbidity and mortality worldwide. In contrast to Gram-negative bacteria, little is known about the...
Vaccination against Neisseria meningitidis Using Three Variants of the Lipoprotein GNA1870
Masignani, Vega, Comanducci, Maurizio, Giuliani, Marzia Monica, Bambini, Stefania, Adu-Bobie, Jeannette, Aricò, Beatrice, ...
Sepsis and meningitis caused by serogroup B meningococcus are devastating diseases of infants and young adults, which cannot yet be prevented by vaccination. By genome mining, we discovered GNA1870,...
NadA, a Novel Vaccine Candidate of Neisseria meningitidis
Comanducci, Maurizio, Bambini, Stefania, Brunelli, Brunella, Adu-Bobie, Jeannette, Aricò, Beatrice, Capecchi, Barbara, ...
Neisseria meningitidis is a human pathogen, which, in spite of antibiotic therapy, is still a major cause of mortality due to sepsis and meningitis. Here we describe NadA, a novel surface antigen of...
Bagnoli, Fabio, Moschioni, Monica, Donati, Claudio, Dimitrovska, Valentina, Ferlenghi, Ilaria, Facciotti, Claudia, ...
Analysis of publicly available genomes of Streptococcus pneumoniae has led to the identification of a new genomic element containing genes typical of gram-positive pilus islets (PIs). Here, we...