Prenatal N-acetylcysteine prevents cigarette smoke-induced lung cancer in neonatal mice (2009)
Balansky, Roumen, Ganchev, Gancho, Iltcheva, Marietta, Steele, Vernon E., De Flora, Silvio
Certain adult diseases may have their origin early in life, and perinatal exposures may contribute to cancers both during childhood and later in life. We recently demonstrated that mainstream...
Alyaqoub, Fadel S., Tao, Lianhui, Kramer, Paula M., Steele, Vernon E., Lubet, Ronald A., Gunning, William T., ...
Potent carcinogenicity of cigarette smoke in mice exposed early in life (2007)
Balansky, Roumen, Ganchev, Gancho, Iltcheva, Marietta, Steele, Vernon E., D'Agostini, Francesco, De Flora, Silvio
In spite of the dominant role of cigarette smoke (CS) in cancer epidemiology, all studies performed during the past 60 years have shown that this complex mixture is either negative or weakly...
Modulation by budesonide of a CpG endonuclease in mouse lung tumors (2007)
Li, Long, Tao, Lianhui, Lubet, Ronald A., Steele, Vernon E., Pereira, Michael A.
CpG endonuclease activity was identified in nuclear extracts obtained from mouse lung tumors. Enzyme activity was determined using a 333 bp polymerase chain reaction product of the estrogen...
McCormick, David L., Johnson, William D., Kozub, Nicole M., Rao, K.V.N., Lubet, Ronald A., Steele, Vernon E., ...
Dehydroepiandrosterone (DHEA) is a potent inhibitor of prostate carcinogenesis in rats. However, concerns related to the possible androgenicity of DHEA may preclude its use for chemoprevention of...
Alyaqoub, Fadel S., Tao, Lianhui, Kramer, Paula M., Steele, Vernon E., Lubet, Ronald A., Gunning, William T., ...
Budesonide (an anti-inflammatory glucocorticoid), R115777 (a farnesyl transferase inhibitor, Zarnestra, Tipifarnib) or combinations of them were evaluated for prevention of lung tumors and for...
Modulation by Budesonide of a CpG Endonuclease in Mouse Lung Tumors (2007)
Li, Long, Tao, Lianhui, Lubet, Ronald A., Steele, Vernon E., Pereira, Michael A.
CpG endonuclease activity was identified in nuclear extracts obtained from mouse lung tumors. Enzyme activity was determined using a 333bp PCR-Product of the estrogen receptor-α gene that contained...
Extrapolation of Inhaled Particulate Toxicity Data from Experimental Animals to Humans (2006)
Morgan, Daniel L., Steele, Vernon E., Hatch, Gary E.
Significant progress has been made over the past three years to develop methodology and assess various tissues and tissue sensitivity endpoints with the ultimate goal of validating a proposed...
Sharma, Sheela, Gao, Pu, Steele, Vernon E.
This study explored the efficacy of oltipraz, a dithiolthione to prevent lung cancer by delivering it directly to the lung as inhaled particulates to obtain maximum efficacy with no toxicity. Two...
Alyaqoub, Fadel S., Tao, Lianhui, Kramer, Paula M., Steele, Vernon E., Lubet, Ronald A., Gunning, William T., ...
Budesonide (an anti-inflammatory glucocorticoid), R115777 (a farnesyl transferase inhibitor, Zarnestra, Tipifarnib), or combinations of them were evaluated for prevention of lung tumors and for...
Alyaqoub, Fadel S., Tao, Lianhui, Kramer, Paula M., Steele, Vernon E., Lubet, Ronald A., Gunning, William T., ...
Budesonide (an anti-inflammatory glucocorticoid), R115777 (a farnesyl transferase inhibitor, Zarnestra, Tipifarnib), or combinations of them were evaluated for prevention of lung tumors and for...
Alyaqoub, Fadel S., Tao, Lianhui, Kramer, Paula M., Steele, Vernon E., Lubet, Ronald A., Gunning, William T., ...
Budesonide (an anti-inflammatory glucocorticoid), R115777 (a farnesyl transferase inhibitor, Zarnestra, Tipifarnib), or combinations of them were evaluated for prevention of lung tumors and for...
McCormick, David L., Johnson, William D., Kozub, Nicole M., Rao, K. V. N., Lubet, Ronald A., Steele, Vernon E., ...
Dehydroepiandrosterone (DHEA) is a potent inhibitor of prostate carcinogenesis in rats. However, concerns related to the possible androgenicity of DHEA may preclude its use for chemoprevention of...
Alyaqoub, Fadel S., Tao, Lianhui, Kramer, Paula M., Steele, Vernon E., Lubet, Ronald A., Gunning, William T., ...
Budesonide (an anti-inflammatory glucocorticoid), R115777 (a farnesyl transferase inhibitor, Zarnestra, Tipifarnib) or combinations of them were evaluated for prevention of lung tumors and for...
Sharma, Sheela, Gao, Pu, Steele, Vernon E.
This study explored the efficacy of oltipraz, a dithiolthione to prevent lung cancer by delivering it directly to the lung as inhaled particulates to obtain maximum efficacy with no toxicity. Two...
Lubet, Ronald A., Huebner, Kay, Fong, Louise Y.Y., Altieri, Dario C., Steele, Vernon E., Kopelovich, Levy, ...
The administration of 4-hydroxybutyl(butyl)nitrosamine (OH-BBN) to male B6D2F1 mice yielded a high incidence of large palpable urinary bladder cancers. Since prior studies demonstrated...
Lubet, Ronald A., Christov, Konstantin, Nunez, Nomeli P., Hursting, Steven D., Steele, Vernon E., Juliana, M.Margaret, ...
Various aspects of the chemopreventive and chemotherapeutic properties of the RXR receptor agonist Targretin (LGD 1069) were examined in the methylnitrosourea (MNU)-induced model of mammary cancer....
Simeone, Ann-Marie, Deng, Chu-Xia, Kelloff, Gary J., Steele, Vernon E., Johnson, Marcella M., Tari, Ana M.
Women with germline mutations in the breast cancer susceptibility gene BRCA1 are at increased risk of developing breast cancer. The synthetic retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) has been...
Crist, Keith A., Zhang, Zhongqiu, You, Ming, Gunning, William T., Conran, Phillip B., Steele, Vernon E., ...
Human ovarian cancer is predominantly of epithelial cell origin (>90% of malignant tumors) and most often presents at advanced stage with poor prognosis. Most animal models of ovarian carcinoma yield...
Simeone, Ann-Marie, Deng, Chu-Xia, Kelloff, Gary J., Steele, Vernon E., Johnson, Marcella M., Tari, Ana M.
Women with germline mutations in the breast cancer susceptibility gene BRCA1 are at an increased risk of developing breast cancer. The synthetic retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) has...
Crist, Keith A., Zhang, Zhongqiu, You, Ming, Gunning, William T., Conran, Phillip B., Steele, Vernon E., ...
Human ovarian cancer is predominantly of epithelial cell origin (>90% of malignant tumors) and most often presents at an advanced stage with poor prognosis. Most animal models of ovarian carcinoma...
Pereira, Michael A., Tao, Lianhui, Wang, Wei, Li, Yingzhe, Umar, Asad, Steele, Vernon E., ...
The ability of celecoxib and α-difluoromethylornithine (DFMO) to modulate the DNA hypomethylation and the hypermethylation of the estrogen receptor (ER)-α gene in colon tumors was evaluated as...
Pereira, Michael A., Tao, Lianhui, Wang, Wei, Li, Yingzhe, Umar, Asad, Steele, Vernon E., ...
The ability of celecoxib and α-difluoromethylornithine (DFMO) to modulate the DNA hypomethylation and the hypermethylation of the estrogen receptor-α gene in colon tumors was evaluated as potential...
Lubet, Ronald A., Christov, Konstantin, Nunez, Naomoli, Hursting, Stephen D., Steele, Vernon E., Juliana, M. Margaret, ...
Various aspects of the chemopreventive and chemotherapeutic properties of the RXR receptor agonist targretin (LCD 1069) were examined in the methylnitrosourea (MNU)-induced model of mammary cancer....
Lubet, Ronald A., Huebner, Kay, Fong, Louise Y. Y., Altieri, Dario C., Steele, Vernon E., Kopelovich, Levy, ...
The administration of OH-BBN to male B6D2F1 mice yielded a high incidence of large palpable urinary bladder cancers that were characterized for expression of certain cancer related genes (FHIT,...
Tao, Lianhui, Kramer, Paula M., Wang, Wei, Yang, Siming, Lubet, Ronald A., Steele, Vernon E., ...
Modulation of gene expression in tumors has the potential of being a surrogate end-point biomarker for chemoprevention. Thus, we determined the modulation by chemopreventive agents of the protein and...
Prevention of mouse lung tumors by budesonide and its modulation of biomarkers (2002)
Pereira, Michael A., Li, Yingzhe, Gunning, William T., Kramer, Paula M., Al-Yaqoub, Fadel, Lubet, Ronald A., ...
Chemopreventive drugs have the potential to decrease the morbidity and mortality of lung cancer. The development of these drugs could be expedited by the application of surrogate end-point biomarkers...
Induction of Atypical Ductal Hyperplasia in Mouse Mammary Gland Organ Culture (2001)
Mehta, Rajendra G., Bhat, Krishna P. L., Hawthorne, Michael E., Kopelovich, Levy, Mehta, Rajeshwari R., Christov, Konstantin, ...
Gupta, Ashok, Nines, Ron, Rodrigo, Kapila A., Aziz, Robeena A., Carlton, Peter S., Gray, Deborah L., ...
Background: 9-cis-Retinoic acid (9-cis-RA) and N-(4-hydroxyphenyl)retinamide (4-HPR) are effective chemopreventive agents against epithelial tumors in the oral cavity, breast, and prostate. We tested...
Wargovich, Michael J., Jimenez, Arnaldo, McKee, Kathy, Steele, Vernon E., Velasco, Marco, Woods, Johnnie, ...
We assessed the effects of 78 potential chemopreventive agents in the F344 rat using two assays in which the inhibition of carcinogen-induced aberrant crypt foci (ACF) in the colon was the measure of...
Steele, Vernon E., Kelloff, Gary J., Balentine, Douglas, Boone, Charles W., Mehta, Rajendra, Bagheri, Donya, ...
Black tea extracts (hot aqueous, polyphenols and theaflavins) and green tea extracts (hot aqueous, polyphenols, epicatechin, epicatechin gallate, epigallocatechin and epigallocatechin gallate) were...
Yang, Kan, Lamprecht, Sergio A., Liu, Yanhui, Shinozaki, Hiroharu, Fan, Kunhua, Leung, Denis, ...
In this study we investigated the chemopreventive effects of quercetin and rutin when added to standard AIN-76A diet and fed to normal and azoxymethane (AOM)-treated mice. Early changes in colonic...
Li, Hong, Schut, Herman A.J., Conran, Philip, Kramer, Paula M., Lubet, Ronald A., Steele, Vernon E., ...
The dose–response relationship in male F344 rats was determined for the ability of aspirin administered in the diet to prevent azoxymethane (AOM)-induced colon cancer and aberrant crypt foci (ACF)...
Zheng, Ye, Kramer, Paula M., Lubet, Ronald A., Steele, Vernon E., Kelloff, Gary J., Pereira, Michael A.
We have previously reported that the retinoids, 4-(hydroxyphenyl)retinamide (4-HPR) and 9-cis-retinoic acid (RA) prevented azoxymethane (AOM)-induced colon tumors and along with...
Rodríguez-Burford, Cristina, Lubet, Ronald A., Eto, Isao, Juliana, M. Margaret, Kelloff, Gary J., Grubbs, Clinton J., ...
These studies examined whether the small to moderate reductions in body weight gain (⩽15%) affect mammary carcinogenesis. Beginning 1 week prior to methylnitrosourea (MNU) administration...
Pereira, Michael A., Barnes, Leta H., Steele, Vernon E., Kelloff, Gary V., Lubet, Ronald A.
Piroxicam has been shown to prevent azoxymethane (AOM)-induced aberrant crypt foci and colon cancer in rats. In this communication we evaluate whether piroxicam can also cause regression of...
Pereira, Michael A., Grubbs, Clinton J., Barnes, Leta H., Li, Hong, Olson, Greg R., Eto, Isao, ...
Curcumin and quercetin were evaluated in rats for their ability to modulate the carcinogenic activity of azoxy-methane (AOM) in the colon and 7, 12-dimethyl-benz[a]anthracene (DMBA) in the mammary...
Rao, Kandala V.N., Detrisac, Carol J., Steele, Vernon E., Hawk, Ernest T., Kelloff, Gary J., McCormick, David L.
In vivo studies were conducted to compare the activity of three non-steroidal anti-inflammatory drugs as inhibitors of urinary bladder carcinogenesis induced in B6D2F1 (BDF) mice by...
Matzinger, Steven A., Crist, Keith A., Stoner, Gary D., Anderson, Marshall W., Pereira, Michael A., Steele, Vernon E., ...
The purpose of this study was to evaluate the effects of the loss of a p53 allele and phenethyl isothiocyanate (PEITC) pre-treatment on the tumorigenicity of...
Pereira, Michael A., Barnes, Leta H., Rassman, Vicki L., Kelloff, Gary V., Steele, Vernon E.
Foci of aberrant and/or hexosaminidase-negative crypts in rat colon are putative precancerous lesions that have been proposed as biomarkers for Short-term bioassays for chemical carcinogens and...
Steele, Vernon E., Arnold, Julia T., Mass, Marc J.
The initial stages of neoplastic transformation in respiratory tract epithelial cells were defined and studied by characterizing a series of morphologically transformed cell colonies from...
Mass, Marc J., Lasley, Jessica A., Marr, Clyde M., Arnold, Julia T., Steele, Vernon E.
The phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), teleocidin and two polyacetate tumor promoters (aplysiatoxin and debromoaplysiatoxin) have been tested for their effect on colony forming...
Neoplastic transformation of primary tracheal epithelial cell cultures (1983)
Pai, S.Balakrishna, Steele, Vernon E., Nettesheim, Paul
Primary cultures of rat tracheal epithelial cells were treated with the chemical carcinogen N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) to quantitatively study the early events during neoplastic...
Pai, S.Balakrishna, Steele, Vernon E., Nettesheim, Paul
The purpose of our studies was to determine whether specific differences in nutritional and/or substrate requirements exist between normal and carcinogen treated tracheal epithelial cells....
Tumor promotion studies in rat tracheal epithelium
Steele, Vernon E., Topping, Douglas C., Pai, S. Balakrishna
The tracheal epithelium of the Fischer 344 rat is histologically very similar to that of the human bronchus. Also, carcinomas of tracheal origin in F-344 rats are similar in morphology to human...
Sharma, Sheela, Wilkinson, Betty P, Gao, Pu, Steele, Vernon E
A model to study the effectiveness of potential chemopreventive agents that inhibit neoplastic process by different mechanisms has been used to test the efficacy of seven nitric oxide synthase (NOS)...
Sharma, Sheela, Wilkinson, Betty P, Gao, Pu, Steele, Vernon E
A model to study the effectiveness of potential chemopreventive agents that inhibit neoplastic process by different mechanisms has been used to test the efficacy of seven nitric oxide synthase (NOS)...
Tumor promotion studies in rat tracheal epithelium
Steele, Vernon E., Topping, Douglas C., Pai, S. Balakrishna
The tracheal epithelium of the Fischer 344 rat is histologically very similar to that of the human bronchus. Also, carcinomas of tracheal origin in F-344 rats are similar in morphology to human...